Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0349 | 1 |
Onchocerca volvulus | 0.027 | 0.5845 | 1 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0349 | 0.0349 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0265 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0349 | 0.0349 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.032 | 0.032 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0265 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.119 | 0.119 |
Trichomonas vaginalis | set domain proteins, putative | 0.027 | 0.5845 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0238 | 0.5082 | 0.5082 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.2682 | 0.3371 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.2682 | 0.2682 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.2682 | 0.2682 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.119 | 0.119 |
Echinococcus multilocularis | muscleblind protein | 0.0449 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0349 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0349 | 0.0349 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0265 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0265 | 0.5 |
Echinococcus granulosus | geminin | 0.0361 | 0.7956 | 0.7956 |
Echinococcus multilocularis | geminin | 0.0361 | 0.7956 | 0.7956 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.7956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0957 | 0.0957 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0265 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.7956 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.2682 | 0.2682 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0349 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0957 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0514 | 0.0514 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0449 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0349 | 0.0349 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.2682 | 0.2682 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.119 | 0.5 |
Brugia malayi | hypothetical protein | 0.007 | 0.119 | 0.119 |
Brugia malayi | Pre-SET motif family protein | 0.0238 | 0.5082 | 0.5082 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.119 | 0.1496 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.2682 | 0.3371 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0349 | 0.0439 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0514 | 0.0514 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0957 | 0.0957 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.2682 | 0.3371 |
Brugia malayi | hypothetical protein | 0.003 | 0.0265 | 0.0265 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.119 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0957 | 0.0957 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0514 | 0.0646 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.2682 | 0.3371 |
Echinococcus granulosus | muscleblind protein | 0.0449 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0349 | 0.0439 |
Brugia malayi | RNA binding protein | 0.0134 | 0.2682 | 0.2682 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.2682 | 0.2682 |
Brugia malayi | hypothetical protein | 0.002 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0265 | 0.0265 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.119 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0265 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0349 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.2682 | 0.2682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.2682 | 0.3371 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.2682 | 0.2682 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.119 | 0.1496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.