Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0614 | 0.0974 | 0.1881 |
Onchocerca volvulus | 0.0369 | 0 | 0.5 | |
Onchocerca volvulus | 0.0369 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0614 | 0.0974 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0614 | 0.0974 | 0.0974 |
Schistosoma mansoni | choline o-acyltransferase | 0.0369 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1674 | 0.5176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2891 | 1 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1674 | 0.5176 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0614 | 0.0974 | 0.1881 |
Onchocerca volvulus | 0.0369 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0369 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1674 | 0.5176 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1674 | 0.5176 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0614 | 0.0974 | 0.1881 |
Onchocerca volvulus | 0.0369 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1674 | 0.5176 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0614 | 0.0974 | 0.1881 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0614 | 0.0974 | 0.0974 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.