Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | HP12 protein homolog, putative | 0.0582 | 0.3465 | 0.3111 |
Entamoeba histolytica | hypothetical protein | 0.0164 | 0.0749 | 0.6931 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0127 | 0.0514 | 0.3687 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Onchocerca volvulus | Dipeptidase C homolog | 0.0127 | 0.0514 | 0.3687 |
Toxoplasma gondii | methionine aminopeptidase | 0.1007 | 0.6223 | 0.6018 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1589 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | peptidase | 0.0127 | 0.0514 | 0.0825 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0206 | 0.1022 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Giardia lamblia | Methionine aminopeptidase | 0.0127 | 0.0514 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0206 | 0.1022 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 0.6018 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0345 | 0.1924 | 0.1847 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0099 | 0.0332 | 0.646 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0387 | 0.2197 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0552 | 0.0462 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0127 | 0.0514 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | hypothetical protein | 0.0236 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | DNA-binding protein | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0206 | 0.1022 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.1007 | 0.6223 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0141 | 0.0604 | 0.5294 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1589 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.1589 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1589 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0069 | 0.0134 | 0.004 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.1007 | 0.6223 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative | 0.0127 | 0.0514 | 0.0423 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0881 | 0.5407 | 0.8689 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Trypanosoma cruzi | aminopeptidase P, putative | 0.0127 | 0.0514 | 0.0423 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0141 | 0.0604 | 0.5294 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.1007 | 0.6223 | 0.6018 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Onchocerca volvulus | 0.0263 | 0.1393 | 1 | |
Brugia malayi | Pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.1393 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0069 | 0.0134 | 0.0134 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.131 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0164 | 0.0749 | 0.6931 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0127 | 0.0514 | 0.0384 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1589 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Leishmania major | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1218 | 0.1134 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0181 | 0.0863 | 0.0863 |
Entamoeba histolytica | peptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0069 | 0.0134 | 0.0216 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0091 | 0.028 | 0.1637 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.1007 | 0.6223 | 1 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0127 | 0.0514 | 0.0513 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.1007 | 0.6223 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Plasmodium vivax | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0199 | 0.0982 | 0.9555 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0206 | 0.1022 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Brugia malayi | initiation factor 2-associated protein. | 0.0127 | 0.0514 | 0.0513 |
Onchocerca volvulus | 0.0127 | 0.0514 | 0.3687 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0206 | 0.1022 | 0.1022 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Toxoplasma gondii | hypothetical protein | 0.0582 | 0.3465 | 0.3111 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0127 | 0.0514 | 0.3687 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | Facilitates chromatin transcription complex subunit spt16 | 0.0127 | 0.0514 | 0.0384 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trypanosoma brucei | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0384 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0158 | 0.0064 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.1233 | 0.1261 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1589 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Chlamydia trachomatis | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0133 | 0.0552 | 0.0552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 200 nM | Binding affinity of the compound against PCP receptor | ChEMBL. | 1322987 |
Ki (binding) | = 690 nM | Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand. | ChEMBL. | 1322987 |
Ki (binding) | = 1340 nM | Binding affinity of the compound against sigma opioid receptor using [3H]-(+)-3-PPP as radioligand. | ChEMBL. | 1322987 |
Ratio (binding) | = 0.149 | Ratio of binding affinities of pcp receptor(ki(nM)) to sigma opioid receptor(ki(nM)) | ChEMBL. | 1322987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.