Detailed information for compound 1582204

Basic information

Technical information
  • TDR Targets ID: 1582204
  • Name: 3-methyl-6-(phenylamino)-1H-pyrimidine-2,4-di one
  • MW: 217.224 | Formula: C11H11N3O2
  • H donors: 2 H acceptors: 2 LogP: 0.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(Nc2ccccc2)[nH]c(=O)n1C
  • InChi: 1S/C11H11N3O2/c1-14-10(15)7-9(13-11(14)16)12-8-5-3-2-4-6-8/h2-7,12H,1H3,(H,13,16)
  • InChiKey: SSNRJYADPZFASQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-6-(phenylamino)uracil
  • Oprea1_053931
  • 6-anilino-3-methyl-2,4(1H,3H)-pyrimidinedione
  • MLS001163430
  • SMR000496722
  • Oprea1_356420
  • STK249743

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0196 0.0724 0.2151
Echinococcus granulosus mothers against decapentaplegic 5 0.0139 0.0456 0.1353
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0244 1
Echinococcus granulosus GPCR family 2 0.0678 0.3023 0.8975
Trypanosoma brucei PAB1-binding protein , putative 0.0206 0.0775 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0196 0.0724 0.9341
Giardia lamblia Kinase, PLK 0.0095 0.0244 0.5
Schistosoma mansoni tar DNA-binding protein 0.0647 0.2873 0.4244
Brugia malayi RNA recognition motif domain containing protein 0.0647 0.2873 0.2873
Brugia malayi isocitrate dehydrogenase 0.0196 0.0724 0.0724
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Loa Loa (eye worm) glutaminase 2 0.0291 0.1177 0.1177
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0056 0.0499
Echinococcus multilocularis smad 0.0139 0.0456 0.1353
Trypanosoma cruzi PAB1-binding protein , putative 0.0206 0.0775 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0456 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0001 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0678 0.3023 0.3023
Schistosoma mansoni alpha glucosidase 0.0044 0.0001 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0093 0.0234 0.0694
Schistosoma mansoni smad1 5 8 and 0.0139 0.0456 0.0673
Onchocerca volvulus 0.0467 0.2018 0.5954
Brugia malayi Probable ClpP-like protease 0.0084 0.0194 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0751 0.3368 0.4974
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0001 0.0007
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.1465 0.677 0.677
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0194 0.0576
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0084 0.0194 0.0194
Loa Loa (eye worm) transcription factor SMAD2 0.2042 0.9518 0.9518
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0724 0.2151
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0196 0.0724 0.107
Brugia malayi MH1 domain containing protein 0.0077 0.0159 0.0159
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.073 0.2167
Schistosoma mansoni hypothetical protein 0.0678 0.3023 0.4464
Schistosoma mansoni Smad4 0.0062 0.0089 0.0132
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0678 0.3023 0.8975
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0244 0.0725
Echinococcus granulosus tar DNA binding protein 0.0647 0.2873 0.8533
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.073 0.073
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0001 0.0011
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.5
Loa Loa (eye worm) glutaminase 0.0291 0.1177 0.1177
Leishmania major hypothetical protein, conserved 0.0206 0.0775 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0244 0.072
Loa Loa (eye worm) MH1 domain-containing protein 0.0139 0.0456 0.0456
Echinococcus granulosus mothers against decapentaplegic 2 0.0062 0.0089 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0647 0.2873 0.4244
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0755 0.3388 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0194 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0001 0.0007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0001 0.0011
Echinococcus multilocularis mothers against decapentaplegic 6 0.0062 0.0089 0.0265
Toxoplasma gondii LsmAD domain-containing protein 0.0206 0.0775 1
Loa Loa (eye worm) RNA binding protein 0.0647 0.2873 0.2873
Loa Loa (eye worm) hypothetical protein 0.0467 0.2018 0.2018
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0244 0.0244
Schistosoma mansoni Smad4 0.0062 0.0089 0.0132
Toxoplasma gondii isocitrate dehydrogenase 0.0196 0.0724 0.9341
Brugia malayi glutaminase DH11.1 0.0291 0.1177 0.1177
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0056 0.2874
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0196 0.0724 0.2151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0751 0.3368 1
Loa Loa (eye worm) Smad1 0.0139 0.0456 0.0456
Brugia malayi MH1 domain containing protein 0.0139 0.0456 0.0456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0751 0.3368 0.4974
Echinococcus multilocularis mothers against decapentaplegic 2 0.0062 0.0089 0.0265
Schistosoma mansoni hypothetical protein 0.0678 0.3023 0.4464
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.1646
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0001 0.0007
Brugia malayi hypothetical protein 0.0467 0.2018 0.2018
Schistosoma mansoni hypothetical protein 0.1465 0.677 1
Schistosoma mansoni tar DNA-binding protein 0.0647 0.2873 0.4244
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0196 0.0724 0.9341
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0678 0.3023 0.8975
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.073 0.073
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0089 0.0089
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0244 0.3146
Schistosoma mansoni hypothetical protein 0.0678 0.3023 0.4464
Trypanosoma cruzi PAB1-binding protein , putative 0.0206 0.0775 1
Brugia malayi MH1 domain containing protein 0.0139 0.0456 0.0456
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0678 0.3023 0.8975
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0093 0.0234 0.0694
Loa Loa (eye worm) MH2 domain-containing protein 0.2042 0.9518 0.9518
Brugia malayi MH1 domain containing protein 0.0077 0.0159 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0724 0.2151
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0139 0.0456 0.0673
Schistosoma mansoni hypothetical protein 0.0093 0.0234 0.0345
Echinococcus multilocularis isocitrate dehydrogenase 0.0196 0.0724 0.2151
Echinococcus granulosus TGF beta signal transducer SmadC 0.0139 0.0456 0.1353
Schistosoma mansoni tar DNA-binding protein 0.0647 0.2873 0.4244
Toxoplasma gondii isocitrate dehydrogenase 0.0196 0.0724 0.9341
Trypanosoma brucei glucosidase, putative 0.0044 0.0001 0.0011
Brugia malayi MH2 domain containing protein 0.0062 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Loa Loa (eye worm) TAR-binding protein 0.0647 0.2873 0.2873
Schistosoma mansoni tar DNA-binding protein 0.0647 0.2873 0.4244
Echinococcus granulosus Smad4 0.0139 0.0456 0.1353
Schistosoma mansoni smad 0.0062 0.0089 0.0132
Brugia malayi MH2 domain containing protein 0.2042 0.9518 0.9518
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0056 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Echinococcus multilocularis tar DNA binding protein 0.0647 0.2873 0.8533
Schistosoma mansoni smad1 5 8 and 0.0139 0.0456 0.0673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0751 0.3368 1
Mycobacterium ulcerans glutaminase 0.0291 0.1177 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0196 0.0724 0.9121
Echinococcus multilocularis GPCR, family 2 0.0678 0.3023 0.8975
Brugia malayi hypothetical protein 0.0206 0.0775 0.0775
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0244 0.0725
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0724 0.9341
Brugia malayi mothers against decapentaplegic homolog 3 0.0062 0.0089 0.0089
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0016 0.0138
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0001 0.0007
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.5
Schistosoma mansoni hypothetical protein 0.0678 0.3023 0.4464
Echinococcus multilocularis Smad4 0.0139 0.0456 0.1353
Schistosoma mansoni kinase 0.0048 0.0022 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0206 0.0775 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0196 0.0724 0.6492
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0016 0.0138
Loa Loa (eye worm) hypothetical protein 0.0077 0.0159 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0751 0.3368 0.3368
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0194 0.2499
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Schistosoma mansoni smad 0.0139 0.0456 0.0673
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0724 0.9341
Brugia malayi Isocitrate dehydrogenase 0.0196 0.0724 0.0724
Brugia malayi MH2 domain containing protein 0.0139 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0206 0.0775 0.0775
Brugia malayi RNA binding protein 0.0647 0.2873 0.2873
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0244 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0001 0.0007
Loa Loa (eye worm) nuclear factor I 0.0077 0.0159 0.0159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0678 0.3023 0.3023
Schistosoma mansoni alpha-glucosidase 0.0169 0.0599 0.0885
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.073 0.2167
Brugia malayi Smad1 0.0139 0.0456 0.0456
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.073 0.2167
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0001 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0751 0.3368 1
Brugia malayi N-terminal motif family protein 0.0755 0.3388 0.3388
Schistosoma mansoni glutaminase 0.0291 0.1177 0.1739
Loa Loa (eye worm) hypothetical protein 0.0062 0.0089 0.0089
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0194 0.0576
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0678 0.3023 0.8975
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0678 0.3023 0.3023
Brugia malayi MH2 domain containing protein 0.0139 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0755 0.3388 0.3388
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0194 0.1646
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0647 0.2873 0.2873
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0678 0.3023 0.3023
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0056 0.0165
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0196 0.0724 0.9341
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0194 0.2499
Loa Loa (eye worm) hypothetical protein 0.2143 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0206 0.0775 1
Schistosoma mansoni Smad4 0.0139 0.0456 0.0673
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0001 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0724 0.2151
Echinococcus granulosus mothers against decapentaplegic 6 0.0062 0.0089 0.0265
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0139 0.0456 0.1353
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0056 0.0499
Echinococcus granulosus smad 0.0139 0.0456 0.1353
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0194 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0751 0.3368 0.3368
Trypanosoma brucei polo-like protein kinase 0.0095 0.0244 0.3146
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0089 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2143 1 1
Brugia malayi hypothetical protein 0.0133 0.0427 0.0427
Echinococcus multilocularis mothers against decapentaplegic 5 0.0139 0.0456 0.1353
Schistosoma mansoni alpha-glucosidase 0.0169 0.0599 0.0885
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.2143 1 1
Onchocerca volvulus 0.0114 0.0335 0.0988
Trichomonas vaginalis glutaminase, putative 0.0291 0.1177 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0244 0.2072
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0244 0.3146
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0062 0.0089 0.0263
Plasmodium vivax ataxin-2 like protein, putative 0.0206 0.0775 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0196 0.0724 0.0724
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0244 0.036
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0001 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0751 0.3368 1
Brugia malayi latrophilin 2 splice variant baaae 0.1465 0.677 0.677
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0724 0.9341
Brugia malayi TAR-binding protein 0.0647 0.2873 0.2873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0751 0.3368 0.4974
Schistosoma mansoni smad1 5 8 and 0.0139 0.0456 0.0673
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1116 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0194 0.2499
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0244 0.3146
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0001 0.0007

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8437 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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