Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4281 | 0.4281 |
Giardia lamblia | Kinase, PLK | 0.0114 | 1 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6347 | 0.6347 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6347 | 0.6347 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | kinase | 0.0058 | 0.4546 | 0.4546 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4281 | 0.4281 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.4281 | 0.4281 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.4281 | 0.4281 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6347 | 0.6347 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.