Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0126 | 0.3563 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0126 | 0.3563 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0126 | 0.3563 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0126 | 0.3563 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0126 | 0.3563 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0126 | 0.3563 | 0.5 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0126 | 0.3563 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0126 | 0.3563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.