Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Onchocerca volvulus | 0.0168 | 0.2502 | 0.4682 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | nAChR subunit | 0.0099 | 0.1108 | 0.2096 |
Schistosoma mansoni | cyclin B | 0.0085 | 0.083 | 0.3319 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1242 | 0.2278 |
Schistosoma mansoni | integrin alpha-ps | 0.0109 | 0.1316 | 0.5262 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0099 | 0.1108 | 0.2096 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0045 | 0.0048 | 0.0194 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0053 | 0.0201 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0308 | 0.5288 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0053 | 0.0201 | 0.0291 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0099 | 0.1108 | 0.2023 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0045 | 0.0048 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Onchocerca volvulus | 0.0085 | 0.083 | 0.1492 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0045 | 0.0048 | 0.0092 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0099 | 0.1108 | 0.2096 |
Trichomonas vaginalis | cyclins, putative | 0.0085 | 0.083 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0544 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0099 | 0.1108 | 0.2096 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0099 | 0.1108 | 0.2096 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0099 | 0.1108 | 0.2096 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0085 | 0.083 | 0.1492 |
Trichomonas vaginalis | cyclins, putative | 0.0085 | 0.083 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0308 | 0.5288 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0308 | 0.5288 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0168 | 0.2502 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Trichomonas vaginalis | cyclin A, putative | 0.0085 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0099 | 0.1108 | 0.443 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1316 | 0.242 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0099 | 0.1108 | 0.443 |
Mycobacterium leprae | conserved hypothetical protein | 0.0544 | 1 | 0.5 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0053 | 0.0201 | 0.0291 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0308 | 0.5288 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.009 | 0.0933 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0053 | 0.0201 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0383 | 0.0639 |
Brugia malayi | Cation transporter family protein | 0.0168 | 0.2502 | 0.4682 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0168 | 0.2502 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0085 | 0.083 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0099 | 0.1108 | 0.2096 |
Trichomonas vaginalis | cyclin B, putative | 0.0085 | 0.083 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0152 | 0.2175 | 0.4114 |
Echinococcus granulosus | cyclin B | 0.0085 | 0.083 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0074 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1242 | 0.2278 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0045 | 0.0048 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | integrin alpha ps | 0.009 | 0.0933 | 0.1764 |
Onchocerca volvulus | 0.0168 | 0.2502 | 0.4682 | |
Entamoeba histolytica | cyclin, putative | 0.0085 | 0.083 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.083 | 0.1492 |
Onchocerca volvulus | 0.0099 | 0.1108 | 0.2023 | |
Schistosoma mansoni | integrin alpha-ps | 0.009 | 0.0933 | 0.373 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0099 | 0.1108 | 0.2096 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.5288 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0308 | 0.5288 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.5288 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0544 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0053 | 0.0201 | 0.0803 |
Loa Loa (eye worm) | ACC-1 protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0308 | 0.5288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0099 | 0.1108 | 0.443 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0099 | 0.1108 | 0.2096 |
Trichomonas vaginalis | cyclins, putative | 0.0085 | 0.083 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0099 | 0.1108 | 0.2096 |
Echinococcus granulosus | integrin alpha ps | 0.0152 | 0.2175 | 0.4114 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0099 | 0.1108 | 0.2096 |
Onchocerca volvulus | 0.0099 | 0.1108 | 0.2023 | |
Leishmania major | cyclin | 0.0085 | 0.083 | 0.5 |
Onchocerca volvulus | 0.0099 | 0.1108 | 0.2023 | |
Trichomonas vaginalis | cyclin B, putative | 0.0085 | 0.083 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0099 | 0.1108 | 0.2023 |
Trichomonas vaginalis | cyclin B, putative | 0.0085 | 0.083 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0053 | 0.0201 | 0.0291 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0085 | 0.083 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.5288 | 1 |
Onchocerca volvulus | 0.0053 | 0.0201 | 0.0291 | |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0105 | 0.1242 | 0.2278 |
Onchocerca volvulus | 0.0053 | 0.0201 | 0.0291 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Schistosoma mansoni | nAChR subunit | 0.0045 | 0.0048 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.2502 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0085 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0126 | 0.0148 |
Brugia malayi | Cation transporter family protein | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0099 | 0.1108 | 0.443 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0085 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Mycobacterium tuberculosis | Conserved protein | 0.0544 | 1 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0045 | 0.0048 | 0.0092 |
Echinococcus multilocularis | cyclin B | 0.0085 | 0.083 | 0.157 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1594 | 0.295 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Loa Loa (eye worm) | LGC-31 protein | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0099 | 0.1108 | 0.2023 |
Onchocerca volvulus | 0.0168 | 0.2502 | 0.4682 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0045 | 0.0048 | 0.0194 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0099 | 0.1108 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.2502 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0053 | 0.0201 | 0.0803 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0099 | 0.1108 | 0.2096 |
Loa Loa (eye worm) | ACC-1 protein | 0.0099 | 0.1108 | 0.2023 |
Trypanosoma cruzi | cyclin 6, putative | 0.0085 | 0.083 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0544 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.083 | 0.1492 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Echinococcus multilocularis | nAChR subunit | 0.0053 | 0.0201 | 0.038 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0099 | 0.1108 | 0.2023 |
Echinococcus granulosus | nAChR subunit | 0.0053 | 0.0201 | 0.038 |
Echinococcus granulosus | nAChR subunit | 0.0099 | 0.1108 | 0.2096 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.009 | 0.0933 | 0.1688 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0085 | 0.083 | 0.1492 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | Cation transporter family protein | 0.0099 | 0.1108 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0201 | 0.0291 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0045 | 0.0048 | 0.0092 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0099 | 0.1108 | 0.2023 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0099 | 0.1108 | 0.2096 |
Schistosoma mansoni | nAChR subunit | 0.0045 | 0.0048 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5288 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0085 | 0.083 | 1 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0045 | 0.0048 | 0.0092 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0085 | 0.083 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Schistosoma mansoni | integrin alpha | 0.009 | 0.0933 | 0.373 |
Trypanosoma cruzi | cyclin, putative | 0.0085 | 0.083 | 0.5 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0099 | 0.1108 | 0.2023 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0099 | 0.1108 | 0.2023 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0045 | 0.0048 | 0.0194 |
Trypanosoma cruzi | cyclin, putative | 0.0085 | 0.083 | 0.5 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0053 | 0.0201 | 0.0291 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1108 | 0.2023 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0099 | 0.1108 | 0.2096 |
Schistosoma mansoni | nAChR subunit | 0.0099 | 0.1108 | 0.443 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.