Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.012 | 0.4859 | 0.4859 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1989 | 0.1989 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0083 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0083 | 0.0083 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0551 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0551 | 0.0551 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0083 | 0.0102 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1989 | 0.1989 |
Brugia malayi | hypothetical protein | 0.002 | 0.0029 | 0.0029 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0551 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.4859 | 0.598 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.4859 | 0.598 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0083 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.012 | 0.4859 | 0.4859 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1069 | 0.1315 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1989 | 0.1989 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0083 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0083 | 0.0102 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0083 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0551 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0551 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1069 | 0.1069 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.4859 | 0.598 |
Echinococcus granulosus | geminin | 0.0187 | 0.8126 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0083 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.4859 | 0.598 |
Echinococcus multilocularis | geminin | 0.0187 | 0.8126 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.012 | 0.4859 | 0.4859 |
Echinococcus granulosus | tar DNA binding protein | 0.012 | 0.4859 | 0.598 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0226 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0083 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.8126 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0083 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1989 | 0.1989 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0083 | 0.0102 |
Echinococcus multilocularis | tar DNA binding protein | 0.012 | 0.4859 | 0.598 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.8126 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0551 | 1 |
Brugia malayi | TAR-binding protein | 0.012 | 0.4859 | 0.4859 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0083 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0083 | 0.0102 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0551 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | TAR-binding protein | 0.012 | 0.4859 | 0.4859 |
Schistosoma mansoni | tar DNA-binding protein | 0.012 | 0.4859 | 0.598 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1069 | 0.1069 |
Brugia malayi | RNA recognition motif domain containing protein | 0.012 | 0.4859 | 0.4859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3962 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.