TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 445.921 | Formula: C17H24ClN5O5S
H donors: 0 H acceptors: 6 LogP: 1.06 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(N(C1CCS(=O)(=O)C1)C(=O)Cn1c(Cl)nc2c1c(=O)n(C)c(=O)n2C)C
InChi: 1S/C17H24ClN5O5S/c1-5-10(2)23(11-6-7-29(27,28)9-11)12(24)8-22-13-14(19-16(22)18)20(3)17(26)21(4)15(13)25/h10-11H,5-9H2,1-4H3
InChiKey: JEYSLSCDMJIGEU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	topoisomerase	0.0061	0.0107	0.0105
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0118	0.045	0.6831
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0046	0.0018	0.0017
Entamoeba histolytica	hypothetical protein	0.0061	0.0107	0.1397
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0146	0.0613	0.3871
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0061	0.0107	0.0781
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0154	0.0663	0.4184
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0205	0.0969	0.5999
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0023	0.0066
Echinococcus granulosus	geminin	0.0205	0.0967	0.2971
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0052	0.0053	0.0642
Schistosoma mansoni	hypothetical protein	0.0205	0.0967	0.2716
Mycobacterium ulcerans	glutaminase	0.0268	0.1349	0.835
Schistosoma mansoni	smad1 5 8 and	0.0117	0.044	0.1233
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0117	0.044	0.1349
Echinococcus multilocularis	Smad4	0.0117	0.044	0.1349
Schistosoma mansoni	chromosome transmission fidelity factor	0.0061	0.0107	0.0296
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0108	0.0387	0.2306
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0118	0.045	0.2838
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0061	0.0107	0.0673
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0118	0.045	0.1379
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0046	0.0018	0.0127
Loa Loa (eye worm)	MH1 domain-containing protein	0.0052	0.0053	0.0052
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0061	0.0107	0.0652
Schistosoma mansoni	tar DNA-binding protein	0.0586	0.3252	0.9142
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0118	0.045	0.3326
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0118	0.045	0.2831
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0046	0.0018	0.0106
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0061	0.0107	0.0781
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0308	0.1584	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0313	0.1615	1
Brugia malayi	MH1 domain containing protein	0.0117	0.044	0.0439
Brugia malayi	DKFZp564C0469 protein	0.0061	0.0107	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0586	0.3252	0.9142
Echinococcus multilocularis	sentrin specific protease 1	0.0046	0.0018	0.0053
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0313	0.1615	0.4965
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0118	0.045	0.1261
Brugia malayi	MH1 domain containing protein	0.0117	0.044	0.0439
Loa Loa (eye worm)	MH2 domain-containing protein	0.1712	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0057	0.0358
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0117	0.044	0.1233
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.045	0.3326
Echinococcus granulosus	sentrin specific protease 1	0.0046	0.0018	0.0053
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0061	0.0107	0.0781
Schistosoma mansoni	hypothetical protein	0.0295	0.1507	0.4235
Echinococcus multilocularis	ubiquitin specific protease 41	0.0118	0.045	0.1379
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0118	0.045	0.1261
Brugia malayi	Smad1	0.0117	0.044	0.0439
Echinococcus granulosus	Smad4	0.0117	0.044	0.1349
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0061	0.0107	0.0105
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0023	0.0061
Trypanosoma cruzi	PAB1-binding protein , putative	0.0154	0.0663	0.4184
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0931	0.5323	0.5322
Loa Loa (eye worm)	hypothetical protein	0.0178	0.081	0.0808
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0107	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1507	0.1506
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0295	0.1507	0.1506
Toxoplasma gondii	hypothetical protein	0.005	0.0038	0.0228
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0069	0.0154	0.0471
Brugia malayi	RNA recognition motif domain containing protein	0.0586	0.3252	0.3251
Schistosoma mansoni	topbp1	0.0061	0.0107	0.0296
Toxoplasma gondii	ATPase, AAA family protein	0.0061	0.0107	0.0652
Brugia malayi	N-terminal motif family protein	0.0178	0.081	0.0808
Brugia malayi	Pax transcription activation domain interacting protein	0.0061	0.0107	0.0105
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0118	0.045	0.1379
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0001	0.0008
Brugia malayi	TAR-binding protein	0.0586	0.3252	0.3251
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Plasmodium vivax	sentrin-specific protease 1, putative	0.0046	0.0018	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Schistosoma mansoni	peptidase Clp (S14 family)	0.0313	0.1615	0.4539
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0107	0.0781
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0313	0.1615	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0313	0.1615	1
Brugia malayi	hypothetical protein	0.0061	0.0107	0.0105
Brugia malayi	hypothetical protein	0.0099	0.0336	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Echinococcus granulosus	nibrin	0.0061	0.0107	0.0324
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0107	0.0673
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0152	0.0649	0.1994
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0118	0.045	0.1379
Entamoeba histolytica	hypothetical protein	0.0152	0.0649	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0118	0.045	0.0448
Schistosoma mansoni	Smad4	0.0117	0.044	0.1233
Toxoplasma gondii	hypothetical protein	0.0108	0.0387	0.2387
Schistosoma mansoni	smad1 5 8 and	0.0117	0.044	0.1233
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0117	0.044	0.1349
Loa Loa (eye worm)	glutaminase 2	0.0268	0.1349	0.1348
Trypanosoma brucei	PAB1-binding protein , putative	0.0154	0.0663	0.4184
Brugia malayi	glutaminase DH11.1	0.0268	0.1349	0.1348
Toxoplasma gondii	LsmAD domain-containing protein	0.0154	0.0663	0.4098
Onchocerca volvulus		0.0155	0.0673	0.8304
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0023	0.0066
Schistosoma mansoni	DNA ligase IV	0.0061	0.0107	0.0296
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0308	0.1584	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.044	0.0439
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Brugia malayi	RNA binding protein	0.0586	0.3252	0.3251
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0931	0.5323	0.5322
Echinococcus granulosus	tar DNA binding protein	0.0586	0.3252	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0001	0.0008
Echinococcus granulosus	mothers against decapentaplegic 2	0.0052	0.0053	0.016
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0118	0.045	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0023	0.0061
Brugia malayi	hypothetical protein	0.0061	0.0107	0.0105
Echinococcus multilocularis	geminin	0.0205	0.0967	0.2971
Schistosoma mansoni	topbp1	0.0061	0.0107	0.0296
Loa Loa (eye worm)	nuclear factor I	0.0065	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0931	0.5323	0.5322
Echinococcus multilocularis	smad	0.0117	0.044	0.1349
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0205	0.0969	0.2978
Echinococcus multilocularis	GPCR, family 2	0.0295	0.1507	0.4632
Brugia malayi	hypothetical protein	0.0152	0.0649	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0118	0.045	0.0448
Echinococcus granulosus	replication factor c subunit 1	0.0061	0.0107	0.0324
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0061	0.0107	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Echinococcus multilocularis	nibrin	0.0061	0.0107	0.0324
Schistosoma mansoni	tar DNA-binding protein	0.0586	0.3252	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0107	0.0781
Leishmania major	mitochondrial DNA polymerase beta	0.0308	0.1584	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0931	0.5323	0.5322
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0295	0.1507	0.4632
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0052	0.0053	0.016
Loa Loa (eye worm)	RNA binding protein	0.0586	0.3252	0.3251
Brugia malayi	hypothetical protein	0.0154	0.0663	0.0662
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0001	0.0008
Entamoeba histolytica	hypothetical protein	0.0152	0.0649	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0205	0.0969	0.6895
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0295	0.1507	0.4632
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0046	0.0018	0.0048
Mycobacterium ulcerans	hypothetical protein	0.0162	0.0712	0.4402
Plasmodium falciparum	ataxin-2 like protein, putative	0.0154	0.0663	0.4035
Entamoeba histolytica	hypothetical protein	0.0152	0.0649	1
Schistosoma mansoni	hypothetical protein	0.0295	0.1507	0.4235
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0023	0.0066
Schistosoma mansoni	hypothetical protein	0.0205	0.0967	0.2716
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0061	0.0107	0.1397
Echinococcus granulosus	mothers against decapentaplegic 5	0.0117	0.044	0.1349
Trichomonas vaginalis	replication factor C large subunit, putative	0.0061	0.0107	0.0781
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0052	0.0053	0.016
Echinococcus granulosus	GPCR family 2	0.0295	0.1507	0.4632
Brugia malayi	latrophilin 2 splice variant baaae	0.0637	0.3557	0.3556
Schistosoma mansoni	transcription factor LCR-F1	0.0152	0.0649	0.1823
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0313	0.1615	1
Schistosoma mansoni	smad1 5 8 and	0.0117	0.044	0.1233
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0069	0.0154	0.0471
Brugia malayi	MH1 domain containing protein	0.0065	0.0127	0.0126
Loa Loa (eye worm)	glutaminase	0.0268	0.1349	0.1348
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0061	0.0107	0.0652
Plasmodium falciparum	ataxin-2 like protein, putative	0.0154	0.0663	0.4035
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0118	0.045	0.3326
Trypanosoma cruzi	FHA domain containing protein, putative	0.0061	0.0107	0.0673
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0117	0.044	0.1349
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0108	0.0387	0.2387
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0023	0.0022
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0146	0.0613	0.3871
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0162	0.0712	0.506
Onchocerca volvulus		0.0061	0.0107	0.1302
Brugia malayi	MH2 domain containing protein	0.0117	0.044	0.0439
Echinococcus granulosus	ubiquitin specific protease 41	0.0118	0.045	0.1379
Brugia malayi	mothers against decapentaplegic homolog 3	0.0052	0.0053	0.0052
Brugia malayi	Latrophilin receptor protein 2	0.0295	0.1507	0.1506
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0061	0.0107	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0107	0.0105
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.1405	1
Schistosoma mansoni	hypothetical protein	0.0069	0.0154	0.043
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0146	0.0613	0.3866
Leishmania major	hypothetical protein, conserved	0.0154	0.0663	0.4179
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0152	0.0649	0.1994
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0023	0.0066
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0313	0.1615	0.4965
Loa Loa (eye worm)	Smad1	0.0117	0.044	0.0439
Brugia malayi	MH2 domain containing protein	0.0117	0.044	0.0439
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0308	0.1584	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0673	0.0671
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0108	0.0387	0.1856
Schistosoma mansoni	hypothetical protein	0.0295	0.1507	0.4235
Schistosoma mansoni	Smad4	0.0052	0.0053	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0663	0.0662
Plasmodium falciparum	replication factor C subunit 1, putative	0.0061	0.0107	0.0552
Schistosoma mansoni	glutaminase	0.0268	0.1349	0.379
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0023	0.0022
Loa Loa (eye worm)	transcription factor SMAD2	0.1712	1	1
Schistosoma mansoni	Smad4	0.0052	0.0053	0.0146
Schistosoma mansoni	hypothetical protein	0.0637	0.3557	1
Schistosoma mansoni	tar DNA-binding protein	0.0586	0.3252	0.9142
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0295	0.1507	0.4632
Schistosoma mansoni	hypothetical protein	0.0152	0.0649	0.1823
Brugia malayi	hypothetical protein	0.0155	0.0673	0.0671
Echinococcus multilocularis	replication factor c subunit 1	0.0061	0.0107	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0053	0.0052
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0586	0.3252	0.3251
Echinococcus multilocularis	tar DNA binding protein	0.0586	0.3252	1
Entamoeba histolytica	hypothetical protein	0.0152	0.0649	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0061	0.0107	0.0781
Loa Loa (eye worm)	MH1 domain-containing protein	0.0117	0.044	0.0439
Echinococcus granulosus	peptidase Clp S14 family	0.0205	0.0969	0.2978
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0108	0.0387	0.2387
Schistosoma mansoni	hypothetical protein	0.0295	0.1507	0.4235
Schistosoma mansoni	smad	0.0052	0.0053	0.0146
Schistosoma mansoni	smad	0.0117	0.044	0.1233
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0107	0.0781
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0295	0.1507	0.4632
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0118	0.045	0.2838
Brugia malayi	MH2 domain containing protein	0.0052	0.0053	0.0052
Echinococcus granulosus	mothers against decapentaplegic 6	0.0052	0.0053	0.016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0023	0.0061
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0295	0.1507	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0018	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0127	0.0126
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0046	0.0018	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0313	0.1615	0.1614
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0313	0.1615	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0107	0.0673
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0107	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0637	0.3557	0.3556
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0178	0.081	1
Trichomonas vaginalis	glutaminase, putative	0.0268	0.1349	1
Brugia malayi	Probable ClpP-like protease	0.0313	0.1615	0.1614
Loa Loa (eye worm)	MH2 domain-containing protein	0.0052	0.0053	0.0052
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0205	0.0969	0.6895
Echinococcus granulosus	smad	0.0117	0.044	0.1349
Plasmodium vivax	replication factor C subunit 1, putative	0.0061	0.0107	0.0652
Loa Loa (eye worm)	TAR-binding protein	0.0586	0.3252	0.3251
Brugia malayi	MH1 domain containing protein	0.0065	0.0127	0.0126
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0118	0.045	0.2838
Plasmodium vivax	ataxin-2 like protein, putative	0.0154	0.0663	0.4098
Schistosoma mansoni	tar DNA-binding protein	0.0586	0.3252	0.9142
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0118	0.045	0.1379

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1891689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1582984