Detailed information for compound 1583302

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.512 | Formula: C25H28N4O7
  • H donors: 2 H acceptors: 4 LogP: 1.14 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C(=O)COC(=O)Cc1cccc(c1)OC
  • InChi: 1S/C25H28N4O7/c1-34-12-11-28(20(30)16-36-21(31)14-18-9-6-10-19(13-18)35-2)22-23(26)29(25(33)27-24(22)32)15-17-7-4-3-5-8-17/h3-10,13H,11-12,14-16,26H2,1-2H3,(H,27,32,33)
  • InChiKey: FICXPDWSNZPYIB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0606 0.1293
Schistosoma mansoni [ACP] S-malonyltransferase 0.0031 0.0228 0.0487
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.003 0.0223 0.5182
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0084 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.003 0.0223 0.0136
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0031 0.0228 0.1312
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.003 0.0223 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.015 0.1531 0.1868
Mycobacterium ulcerans Type I modular polyketide synthase 0.0487 0.5225 0.6594
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0325 0.1709
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0155 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Toxoplasma gondii type I fatty acid synthase 0.0075 0.071 0.1258
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0031 0.0228 0.1312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0118 0.0868
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.003 0.0223 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Echinococcus granulosus cpg binding protein 0.0032 0.0248 0.0529
Echinococcus granulosus geminin 0.0187 0.1946 0.4151
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.003 0.0223 0.0188
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0088 0.01
Mycobacterium ulcerans quinone oxidoreductase 0.003 0.0223 0.0136
Brugia malayi Cathepsin L-like precursor 0.0012 0.0023 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0088 0.0096
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0077 0.0164
Giardia lamblia Methyltransferase like 2 0.0147 0.1498 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.064 0.52
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0727 0.7862 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0077 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0438 0.4688 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0084 0.0089
Toxoplasma gondii cathepsin CPL 0.0018 0.0088 0.0137
Schistosoma mansoni DNA polymerase eta 0.0021 0.0118 0.0252
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0197 0.2048 0.2532
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0325 0.0694
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.0868
Echinococcus multilocularis geminin 0.0187 0.1946 0.207
Plasmodium vivax vivapain-2 0.0018 0.0088 0.0096
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.003 0.0223 0.0188
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0431 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0075 0.071 0.0813
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0496 0.0496
Leishmania major quinone oxidoreductase, putative 0.003 0.0223 0.1027
Entamoeba histolytica cysteine protease, putative 0.0018 0.0088 0.2048
Toxoplasma gondii type I fatty acid synthase, putative 0.0517 0.5556 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0118 0.0126
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0122 0.123 0.2625
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0084 0.0585
Onchocerca volvulus Fatty acid synthase homolog 0.0877 0.9505 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0026
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0084 0.0048
Schistosoma mansoni hypothetical protein 0.0017 0.0083 0.0177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0077 0.0082
Mycobacterium ulcerans oxidoreductase 0.003 0.0223 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1498 1
Onchocerca volvulus 0.0018 0.0088 0.0068
Mycobacterium ulcerans dehydrogenase 0.003 0.0223 0.0136
Trypanosoma cruzi oxidoreductase, putative 0.003 0.0223 0.1813
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0431 0.0403
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0122 0.123 0.8114
Mycobacterium tuberculosis Possible dehydrogenase 0.003 0.0223 0.0188
Mycobacterium ulcerans polyketide synthase Pks9 0.0322 0.3418 0.4262
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0487 0.5225 0.6594
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0122 0.123 0.2197
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.003 0.0223 0.0136
Loa Loa (eye worm) cysteine protease 0.0018 0.0088 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0084 0.0679
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0078
Echinococcus multilocularis AMP dependent ligase 0.0049 0.0431 0.0458
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0083 0.0094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0118 0.096
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0049 0.0431 0.0403
Leishmania major zinc-binding dehydrogenase-like protein 0.003 0.0223 0.1027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0229 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0431 1
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.003 0.0223 0.0188
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0455 0.4874 0.6162
Trypanosoma brucei acyl transferase-like protein 0.0031 0.0228 0.1774
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0122 0.123 1
Schistosoma mansoni cpg binding protein 0.0031 0.0229 0.0488
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0292
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0077 0.0082
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0118 0.0126
Echinococcus granulosus AMP dependent ligase 0.0049 0.0431 0.0918
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0049 0.0431 0.0403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0155 0.0155
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0325 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0325 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0118 0.0252
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.003 0.0223 0.1813
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0049 0.0431 0.2059
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0517 0.5556 0.6981
Leishmania major cathepsin L-like protease 0.0068 0.064 0.396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0133
Leishmania major cathepsin L-like protease 0.0068 0.064 0.396
Mycobacterium ulcerans polyketide synthase 0.0517 0.5556 0.7022
Mycobacterium tuberculosis Probable oxidoreductase 0.003 0.0223 0.0188
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.003 0.0223 0.0188
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0406 0.4336 0.5384
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0088 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Trypanosoma brucei oxidoreductase, putative 0.003 0.0223 0.173
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.01
Brugia malayi AMP-binding enzyme family protein 0.015 0.1531 0.1531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0012 0.0082
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0049 0.0431 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.003 0.0223 0.0136
Loa Loa (eye worm) ctsf protein 0.0018 0.0088 0.01
Loa Loa (eye worm) acyl carrier protein 0.0224 0.2344 0.2649
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0472 0.5061 0.6402
Leishmania major hypothetical protein, conserved 0.0147 0.1498 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0122 0.123 0.2625
Trichomonas vaginalis alcohol dehydrogenase, putative 0.003 0.0223 0.1489
Mycobacterium ulcerans thioesterase TesA 0.0406 0.4336 0.5446
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0118 0.0962
Echinococcus granulosus cathepsin l1 0.0018 0.0088 0.0188
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0049 0.0431 0.0454
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0325 0.1747
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0088 0.0717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0487 0.5225 0.6547
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0155 0.1036
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0119 0.1195 0.1436
Schistosoma mansoni hypothetical protein 0.0017 0.0083 0.0177
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0252
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0727 0.7862 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0122 0.123 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0248 0.0264
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.003 0.0223 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.003 0.0223 0.5182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0083 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium ulcerans oxidoreductase FadB5 0.003 0.0223 0.0136
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0292
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0088 0.0068
Mycobacterium ulcerans thioesterase 0.0406 0.4336 0.5446
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0325 0.756
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0252
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0431 0.0271
Mycobacterium ulcerans acyl carrier protein 0.0049 0.0431 0.0403
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0014
Loa Loa (eye worm) alcohol dehydrogenase class III 0.003 0.0223 0.0252
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0083 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0077 0.0082
Toxoplasma gondii acyl carrier protein ACP 0.0049 0.0431 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Brugia malayi CXXC zinc finger family protein 0.0031 0.0229 0.0229
Toxoplasma gondii type I fatty acid synthase, putative 0.0346 0.3688 0.663
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0084 0.0585
Schistosoma mansoni cpg binding protein 0.0032 0.0248 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0084 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0517 0.5556 0.6981
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0487 0.5225 0.6612
Onchocerca volvulus 0.0018 0.0088 0.0068
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0049 0.0431 0.0271
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0075 0.071 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0049 0.0431 0.0429
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0084 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.064 0.52
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0325 0.2571
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0325 0.0694
Echinococcus granulosus dna polymerase eta 0.0021 0.0118 0.0252
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.003 0.0223 0.0136
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Mycobacterium leprae Polyketide synthase Pks13 0.0727 0.7862 1
Schistosoma mansoni hypothetical protein 0.0017 0.0083 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.003 0.0223 0.0188
Leishmania major cathepsin L-like protease 0.0068 0.064 0.396
Mycobacterium tuberculosis Conserved protein 0.0147 0.1498 0.1826
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0118 0.096
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.003 0.0223 0.1813
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0118 0.0118
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0122 0.123 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0049 0.0431 0.0454
Brugia malayi cathepsin L-like precursor 0.0012 0.0023 0.0023
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0246 0.2587 0.4644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Loa Loa (eye worm) hypothetical protein 0.0038 0.0305 0.0345
Trichomonas vaginalis alcohol dehydrogenase, putative 0.003 0.0223 0.1489
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0325 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Mycobacterium ulcerans quinone oxidoreductase 0.003 0.0223 0.0136
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0118 0.0252
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.003 0.0223 0.0188
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0122 0.123 0.123
Entamoeba histolytica hypothetical protein 0.0024 0.0155 0.3606
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0049 0.0431 0.0454
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0088 0.2048
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0122 0.123 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0316 0.3351 0.6023
Schistosoma mansoni hypothetical protein 0.0038 0.0305 0.065
Onchocerca volvulus Putative alcohol dehydrogenase 0.003 0.0223 0.0211
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0049 0.0431 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium ulcerans Type I modular polyketide synthase 0.0487 0.5225 0.6594
Echinococcus multilocularis NADH dehydrogenase 0.0049 0.0431 0.0458
Leishmania major hypothetical protein, conserved 0.0031 0.0228 0.1065
Echinococcus granulosus GPCR family 2 0.0017 0.0083 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0031 0.0228 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1292 0.1459
Mycobacterium tuberculosis Probable thioesterase TesA 0.0406 0.4336 0.547
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0084 0.0084
Schistosoma mansoni [ACP] S-malonyltransferase 0.0031 0.0228 0.0487
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0122 0.123 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0325 0.0694
Loa Loa (eye worm) acyl carrier protein 0.0049 0.0431 0.0486
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0325 0.2172
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.003 0.0223 0.5182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.053 0.0933
Onchocerca volvulus 0.0018 0.0088 0.0068
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0118 0.0126
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.003 0.0223 0.173
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0868 0.94 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0496 0.0561
Trypanosoma cruzi acyl transferase-like protein, putative 0.0031 0.0228 0.1857
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0277 0.2924 0.3656
Leishmania major oxidoreductase, putative 0.003 0.0223 0.1027
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0392 0.4183 0.5249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Onchocerca volvulus 0.0018 0.0088 0.0068
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.003 0.0223 0.0188
Onchocerca volvulus 0.003 0.0223 0.0211
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.003 0.0223 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0077 0.0082
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0049 0.0431 0.0403
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0084 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Plasmodium falciparum acyl carrier protein 0.0049 0.0431 0.3064
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0049 0.0431 0.0454
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0118 0.0133
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0077 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0088 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0084 0.0585
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0431 0.0454
Mycobacterium ulcerans polyketide synthase Pks13 0.0727 0.7862 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0118 0.0289
Toxoplasma gondii acyl transferase domain-containing protein 0.0031 0.0228 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0118 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0023 0.0155
Schistosoma mansoni alcohol dehydrogenase 0.003 0.0223 0.0476
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0431 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0118 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0084 0.0094
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0122 0.123 0.1436
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0517 0.5556 0.7022
Mycobacterium ulcerans polyketide synthase 0.0487 0.5225 0.6594
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0167 0.1725 0.2117
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0049 0.0431 0.0431
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0656 0.5021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium ulcerans polyketide synthase MbtC 0.0122 0.123 0.1436
Loa Loa (eye worm) hypothetical protein 0.0273 0.288 0.3254
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0122 0.123 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0088 0.01
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0122 0.123 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0392 0.4183 0.5183
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.003 0.0223 0.1813
Plasmodium vivax vivapain-2 0.0018 0.0088 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0228 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0455 0.4874 0.4874
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0049 0.0431 0.3499
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0083 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.0868
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0252
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0084 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0023 0.0155
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0155 0.0331
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.003 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0438 0.4688 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0075 0.071 0.0813
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0084 0.0178
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0084 0.0679
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0155 0.0165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0077 0.0082
Onchocerca volvulus 0.0847 0.9174 0.9651
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0078
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0084 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0031 0.0228 0.0243
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.003 0.0223 0.0188
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0084 0.0585
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0083 0.0177
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0088 0.0188
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.003 0.0223 0.0136
Schistosoma mansoni hypothetical protein 0.0017 0.0083 0.0177
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0088 0.0188
Trypanosoma cruzi oxidoreductase, putative 0.003 0.0223 0.1813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0134
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0455 0.4874 0.5507
Mycobacterium tuberculosis Possible dehydrogenase 0.003 0.0223 0.0188
Onchocerca volvulus 0.0031 0.0229 0.0217
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0049 0.0431 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Echinococcus multilocularis cysteine protease 0.0018 0.0088 0.0094
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0088 0.0094
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0084 0.0129
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0084 0.0046
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0084 0.0683
Echinococcus granulosus NADH dehydrogenase 0.0049 0.0431 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0077 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Schistosoma mansoni hypothetical protein 0.0049 0.0431 0.0918
Leishmania major DNA polymerase eta, putative 0.0021 0.0118 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0084 0.0046
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0155 0.0331
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0398 0.4253 0.5364
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0031 0.0228 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0084 0.0679
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.003 0.0223 0.0223
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0088 0.0096
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0078
Leishmania major cathepsin L-like protease 0.0018 0.0088 0.0078
Trypanosoma cruzi oxidoreductase, putative 0.003 0.0223 0.1813
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0487 0.5225 0.5225
Echinococcus granulosus dna polymerase kappa 0.0021 0.0118 0.0252
Mycobacterium ulcerans Type I modular polyketide synthase 0.0487 0.5225 0.6594
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0118 0.0118
Mycobacterium ulcerans short-chain dehydrogenase 0.003 0.0223 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Mycobacterium ulcerans oxidoreductase 0.003 0.0223 0.0136
Plasmodium vivax acyl carrier protein, putative 0.0049 0.0431 0.3064
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0122 0.123 0.139
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0049 0.0431 0.0454
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0077 0.0532
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0084 0.0679
Echinococcus multilocularis cysteine protease 0.0018 0.0088 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0292
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0077 0.0627
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0118 0.0053
Mycobacterium ulcerans hypothetical protein 0.0049 0.0431 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Schistosoma mansoni cpg binding protein 0.0032 0.0248 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0322 0.3418 0.4183
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.0868
Leishmania major zinc binding dehydrogenase-like protein 0.003 0.0223 0.1027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0083 0.0088
Brugia malayi isocitrate dehydrogenase 0.0017 0.0077 0.0077
Leishmania major DNA polymerase kappa, putative 0.0021 0.0118 0.0289
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0023 0.0541
Mycobacterium ulcerans polyketide synthase MbtD 0.015 0.1531 0.1825
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0031 0.0228 0.0228
Onchocerca volvulus 0.0018 0.0088 0.0068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0084 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0088 0.2048
Brugia malayi Cathepsin L-like precursor 0.0012 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0075 0.071 0.0802
Schistosoma mansoni [ACP] S-malonyltransferase 0.0031 0.0228 0.0487
Trypanosoma cruzi nuclear receptor binding factor, putative 0.003 0.0223 0.1813
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0084 0.1942
Schistosoma mansoni acyl carrier protein 0.0049 0.0431 0.0918
Toxoplasma gondii quinone oxidoreductase, putative 0.003 0.0223 0.038
Brugia malayi MH2 domain containing protein 0.0128 0.1292 0.1292
Trichomonas vaginalis alcohol dehydrogenase, putative 0.003 0.0223 0.1489
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.003 0.0223 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0325 0.2172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0118 0.0053
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0153 0.1567 0.1914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0049 0.0431 0.0403
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0118 0.096
Onchocerca volvulus 0.003 0.0223 0.0211
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.064 0.52
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0082
Trypanosoma cruzi acyl transferase-like protein 0.0031 0.0228 0.1857
Loa Loa (eye worm) hypothetical protein 0.0818 0.8851 1
Trypanosoma brucei unspecified product 0.0021 0.0118 0.0868
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.035 0.3723 0.4683
Chlamydia trachomatis acyl carrier protein 0.0049 0.0431 0.2016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0118 0.096
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0088 0.0094
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0084 0.0178
Leishmania major acyl carrier protein, putative 0.0049 0.0431 0.2487
Mycobacterium leprae Probable polyketide synthase Pks1 0.0517 0.5556 0.6981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0088 0.0589
Mycobacterium ulcerans fatty acid synthase Fas 0.0153 0.1567 0.1871
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0026
Onchocerca volvulus 0.0018 0.0088 0.0068
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0049 0.0431 0.3433
Schistosoma mansoni hypothetical protein 0.0187 0.1946 0.4151
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0084 0.0178
Loa Loa (eye worm) fatty acid synthase 0.048 0.5154 0.5823
Schistosoma mansoni methyltransferase-related 0.0147 0.1498 0.3196
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0084 0.1942
Giardia lamblia DINP protein human, muc B family 0.0021 0.0118 0.0244
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0088 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0083 0.0083
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0122 0.123 0.1436
Schistosoma mansoni zinc binding dehydrogenase 0.003 0.0223 0.0476
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0118 0.2744
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0083 0.0088
Trypanosoma brucei oxidoreductase, putative 0.003 0.0223 0.173
Echinococcus granulosus acyl carrier protein mitochondrial 0.0049 0.0431 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0496 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.0868
Brugia malayi Methyltransferase-like protein 4 0.0147 0.1498 0.1498
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0325 0.2172
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.048 0.3899
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.003 0.0223 0.0237
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0088 0.0094
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0325 0.0346
Echinococcus granulosus cathepsin l1 0.0012 0.0023 0.005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0075 0.071 0.0813
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0155 0.1262
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0325 0.0325
Onchocerca volvulus 0.0455 0.4874 0.5116
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0049 0.0431 0.0458
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0077 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0431 0.0454
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0118 0.0788
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.003 0.0223 0.1813
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.064 0.52
Mycobacterium tuberculosis Hypothetical protein 0.0147 0.1498 0.1826
Leishmania major d-xylulose reductase, putative 0.003 0.0223 0.1027
Mycobacterium ulcerans acyl carrier protein 0.0049 0.0431 0.0403
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0023 0.0023
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0325 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0517 0.5556 0.7038
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0075 0.071 0.0637
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0088 0.0068
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.003 0.0223 0.0136
Onchocerca volvulus 0.0018 0.0088 0.0068
Brugia malayi Phosphopantetheine attachment site family protein 0.0049 0.0431 0.0431
Trypanosoma cruzi nuclear receptor binding factor, putative 0.003 0.0223 0.1813
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0049 0.0431 0.0454
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0084 0.0178
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0153 0.1567 0.1759
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0023 0.005
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0325 0.0694
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0077 0.0627
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0487 0.5225 0.6612
Treponema pallidum acyl carrier protein 0.0049 0.0431 0.5
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.003 0.0223 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.003 0.0223 0.0136
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0049 0.0431 0.0403
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0088 0.0096
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.003 0.0223 0.1027
Leishmania major nuclear receptor binding factor-like protein 0.003 0.0223 0.1027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0155 0.1173
Schistosoma mansoni hypothetical protein 0.0187 0.1946 0.4151
Leishmania major oxidoreductase-like protein 0.003 0.0223 0.1027
Onchocerca volvulus 0.0049 0.0431 0.0429
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0517 0.5556 0.7022
Loa Loa (eye worm) hypothetical protein 0.0075 0.071 0.0802
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0122 0.123 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0487 0.5225 0.6612
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0049 0.0431 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0517 0.5556 0.7038
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0325 0.2645
Mycobacterium ulcerans quinone reductase Qor 0.003 0.0223 0.0136
Brugia malayi Alcohol dehydrogenase class III 0.003 0.0223 0.0223
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0084 0.0046
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0472 0.5061 0.6402
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.0561
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0088 0.0094
Echinococcus multilocularis GPCR, family 2 0.0017 0.0083 0.0088
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0077 0.0532
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0325 0.2645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.064 0.5152
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0118 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0088 0.0589
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1292 0.1459
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.4688 0.4987
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0322 0.3418 0.4262
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0575 0.4673
Plasmodium vivax hypothetical protein, conserved 0.007 0.0656 0.5021
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0031 0.0228 0.0053
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0517 0.5556 0.7038
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.003 0.0223 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558
Brugia malayi Cathepsin L-like precursor 0.0018 0.0088 0.0088
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0088 0.0078
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0487 0.5225 0.6547
Loa Loa (eye worm) fibroinase 0.0018 0.0088 0.01
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0088 0.0068
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0392 0.4183 0.5249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0084 0.0558

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1778 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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