Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.024 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3523 | 0.3523 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.024 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.024 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 0.6105 | 0.5 | |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.024 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0213 | 0.8159 | 0.8159 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.024 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.024 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3523 | 0.3523 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0119 | 0.1841 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0213 | 0.8159 | 0.8159 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.024 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0119 | 0.1841 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0092 | 0 | 0.5 |
Treponema pallidum | flavodoxin | 0.0092 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0148 | 0.3805 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0213 | 0.8159 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.024 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0148 | 0.3805 | 0.3805 |
Brugia malayi | hypothetical protein | 0.0182 | 0.6105 | 0.6105 |
Giardia lamblia | Hypothetical protein | 0.0213 | 0.8159 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.024 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0092 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3523 | 0.3523 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.024 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.024 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0121 | 0.1964 | 0.0151 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.024 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.024 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0092 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.024 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0148 | 0.3805 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.024 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0213 | 0.8159 | 0.8159 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.024 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.024 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6105 | 0.6105 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.024 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0148 | 0.3805 | 0.3805 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0092 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0092 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.024 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.