TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.465 | Formula: C29H29Cl2N3O3
H donors: 2 H acceptors: 3 LogP: 5.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: C[C@@H]([C@H]1[C@H](C[C@@H]2N(C1=O)CCc1c2cc(cc1)c1ccccc1)N(C(=O)Nc1cc(Cl)cc(c1)Cl)C)O
InChi: 1S/C29H29Cl2N3O3/c1-17(35)27-26(33(2)29(37)32-23-14-21(30)13-22(31)15-23)16-25-24-12-20(18-6-4-3-5-7-18)9-8-19(24)10-11-34(25)28(27)36/h3-9,12-15,17,25-27,35H,10-11,16H2,1-2H3,(H,32,37)/t17-,25-,26-,27-/m0/s1
InChiKey: YXEMMESQVKZTOH-NPFRWRFASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0102	0.09	0.0925
Loa Loa (eye worm)	Smad1	0.001	0.0034	0.0035
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0121	0.0405
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0023	0.0078
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0029	0.0029
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0096
Leishmania major	arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490	0.0036	0.0277	0.0123
Brugia malayi	larval opioid receptor	0.0009	0.0029	0.0029
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.0063	0.0536	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0277	0.1197
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0023	0.01
Echinococcus granulosus	7TM GPCR rhodopsin	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Brugia malayi	Protein arginine N-methyltransferase	0.0036	0.0277	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0102	0.09	0.0925
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0024
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0039	0.0311	0.032
Schistosoma mansoni	hypothetical protein	0.0041	0.0327	0.1417
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	sex peptide receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0039	0.0311	0.0311
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0124
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0009	0.0029	0.0096
Echinococcus granulosus	7tm_1 domain containing protein	0.0009	0.0029	0.0096
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0023	0.0078
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	serotonin receptor	0.0009	0.0029	0.0096
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Trypanosoma cruzi	Histone-lysine N-methyltransferase, H3 lysine-76 specific	0.0032	0.0243	0.0603
Echinococcus granulosus	methyltransferase protein 5	0.0036	0.0277	0.0929
Brugia malayi	G protein-coupled receptor F59B2.13	0.0009	0.0029	0.0029
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0124
Trypanosoma cruzi	histone-lysine N-methyltransferase, putative	0.0032	0.0243	0.0603
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0239	0.1034
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0506	0.052
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	allatostatin A receptor	0.0009	0.0029	0.0096
Brugia malayi	follicle stimulating hormone receptor	0.0009	0.0029	0.0029
Echinococcus granulosus	spermidine synthase	0.0324	0.2977	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0121	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0099	0.087	0.0894
Mycobacterium tuberculosis	Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY)	0.0276	0.2521	1
Echinococcus multilocularis	spermidine synthase	0.0324	0.2977	1
Brugia malayi	Melatonin receptor type 1A	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0023	0.01
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0023	0.0078
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0029	0.0096
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0063	0.0536	0.2318
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0239	0.0802
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0036	0.0277	0.0284
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0009	0.0029	0.0124
Brugia malayi	hypothetical protein	0.0099	0.087	0.0894
Loa Loa (eye worm)	melatonin receptor type 1A	0.0009	0.0029	0.0029
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus multilocularis	smad	0.001	0.0034	0.0115
Loa Loa (eye worm)	spermidine synthase	0.0324	0.2977	0.306
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Plasmodium vivax	protein arginine N-methyltransferase 1, putative	0.0063	0.0536	0.1084
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0039	0.0311	0.032
Leishmania major	hypothetical protein, conserved	0.005	0.0408	0.0605
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	TYRA-2 protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0121	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0009	0.0029	0.0096
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0175	0.1585	0.1585
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0096
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0039	0.0311	0.0249
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	GPCR family 2	0.0019	0.0121	0.0405
Echinococcus granulosus	orexin receptor type 2	0.0009	0.0029	0.0096
Echinococcus granulosus	protein arginine methyltransferase	0.0063	0.0536	0.18
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0023	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0311	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	putative neuropeptide receptor	0.0009	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0124
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0009	0.0029	0.0096
Brugia malayi	G-protein coupled receptor	0.0009	0.0029	0.0029
Echinococcus multilocularis	orexin receptor type 2	0.0009	0.0029	0.0096
Schistosoma mansoni	growth hormone secretagogue receptor	0.0009	0.0029	0.0124
Schistosoma mansoni	smad	0.001	0.0034	0.0148
Brugia malayi	sulfakinin receptor protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0009	0.0029	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1291	0.1327
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0039	0.0311	0.0249
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0036	0.0277	0.4944
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0029	0.0029
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0039	0.0311	0.0249
Echinococcus multilocularis	dro:myosuppressin receptor	0.0009	0.0029	0.0096
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0239	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0023	0.0023
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0036	0.0277	0.0929
Schistosoma mansoni	myosin xvIII	0.0009	0.0029	0.0124
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0311	0.1346
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0023	0.0024
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0311	0.1346
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	Carm1-pending protein	0.0036	0.0277	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0034	0.0148
Echinococcus multilocularis	protein arginine methyltransferase	0.0063	0.0536	0.18
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0063	0.0536	0.0843
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0124
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0124
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0099	0.087	0.2157
Trypanosoma brucei	Thiopurine S-methyltransferase (TPMT), putative	0.005	0.0408	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0311	0.032
Leishmania major	protein kinase A catalytic subunit	0.0039	0.0311	0.0249
Schistosoma mansoni	histamine h1 receptor	0.0009	0.0029	0.0124
Brugia malayi	neuropeptide F receptor	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Onchocerca volvulus		0.0009	0.0029	0.0029
Onchocerca volvulus		0.0009	0.0029	0.0029
Brugia malayi	GnHR receptor homolog	0.0009	0.0029	0.0029
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0099	0.087	1
Trypanosoma cruzi	spermidine synthase, putative	0.0324	0.2977	0.7382
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0096
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0121	0.0124
Schistosoma mansoni	hypothetical protein	0.0019	0.0121	0.0522
Trypanosoma cruzi	spermidine synthase, putative	0.0324	0.2977	0.7382
Echinococcus granulosus	dro:myosuppressin receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Echinococcus granulosus	somatostatin receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	G protein coupled receptor 139	0.0009	0.0029	0.0096
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0096
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	G protein coupled receptor 139	0.0009	0.0029	0.0096
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0009	0.0029	0.0096
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0009	0.0029	0.0029
Brugia malayi	MH1 domain containing protein	0.001	0.0034	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Onchocerca volvulus		0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	Pre-SET motif family protein	0.0032	0.0239	0.0246
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0124
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1585	0.1629
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0124
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0009	0.0029	0.0029
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0023	0.0024
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0029	0.0096
Onchocerca volvulus		0.0009	0.0029	0.0029
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0009	0.0029	0.0029
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0121	0.0405
Echinococcus multilocularis	sex peptide receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Entamoeba histolytica	arginine N-methyltransferase 1, putative	0.0036	0.0277	0.3179
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Echinococcus granulosus	neuropeptide FF receptor 2	0.0009	0.0029	0.0096
Echinococcus multilocularis	histone h3 methyltransferase	0.0253	0.2311	0.7763
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0009	0.0029	0.0029
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0239	0.0802
Plasmodium vivax	spermidine synthase, putative	0.0324	0.2977	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0096
Echinococcus granulosus	fmrfamide receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0327	0.0337
Brugia malayi	hypothetical protein	0.0102	0.09	0.0925
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Brugia malayi	neuropeptide F receptor	0.0009	0.0029	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0009	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0124
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0124
Brugia malayi	Serotonin receptor	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	Dopamine receptor protein 2	0.0009	0.0029	0.0029
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.0063	0.0536	0.18
Brugia malayi	Pre-SET motif family protein	0.1046	0.9729	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0039	0.0311	0.0771
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0096
Toxoplasma gondii	hypothetical protein	0.0032	0.0243	0.429
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0096
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0029	0.0029
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0009	0.0029	0.0124
Trypanosoma cruzi	Thiopurine S-methyltransferase (TPMT), putative	0.005	0.0408	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0063	0.0536	0.2318
Mycobacterium ulcerans	spermidine synthase	0.0276	0.2521	1
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Toxoplasma gondii	AGC kinase	0.0039	0.0311	0.5616
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0023	0.0078
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0009	0.0029	0.0096
Brugia malayi	AKH receptor	0.0009	0.0029	0.0029
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0124
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0036	0.0277	0.0277
Brugia malayi	MH2 domain containing protein	0.0144	0.1291	0.1327
Trypanosoma cruzi	arginine N-methyltransferase, type III	0.0036	0.0277	0.0686
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0036	0.0277	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	histone h3 methyltransferase	0.0253	0.2311	0.7763
Brugia malayi	hypothetical protein	0.0009	0.0023	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0029	0.0124
Brugia malayi	Dopamine receptor protein 1	0.0009	0.0029	0.0029
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	g-protein coupled receptor	0.0009	0.0029	0.0096
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus multilocularis	neuropeptide s receptor	0.0009	0.0029	0.0096
Brugia malayi	Serotonin receptor	0.0009	0.0029	0.0029
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0239	0.0802
Brugia malayi	DIX domain containing protein	0.0009	0.0023	0.0024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0036	0.0277	0.0929
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0023	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0096
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0032	0.0243	0.0603
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Onchocerca volvulus		0.0009	0.0029	0.0029
Schistosoma mansoni	protein arginine n-methyltransferase	0.0036	0.0277	0.1197
Echinococcus multilocularis	serotonin receptor	0.0009	0.0029	0.0096
Trichomonas vaginalis	set domain proteins, putative	0.1075	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0023	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0009	0.0029	0.0096
Brugia malayi	Histone-lysine N-methyltransferase, H3 lysine-79 specific	0.0253	0.2311	0.2375
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0009	0.0029	0.0096
Brugia malayi	MH1 domain containing protein	0.001	0.0034	0.0035
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0124
Brugia malayi	ORL1-like opioid receptor	0.0009	0.0029	0.0029
Echinococcus multilocularis	geminin	0.0165	0.1482	0.4978
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0034	0.0035
Echinococcus granulosus	neuropeptide receptor A26	0.0009	0.0029	0.0096
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0036	0.0277	0.0686
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0034	0.0115
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0023	0.01
Loa Loa (eye worm)	hypothetical protein	0.0102	0.09	0.0925
Onchocerca volvulus		0.0009	0.0029	0.0029
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0009	0.0029	0.0124
Trypanosoma cruzi	protein arginine n-methyltransferase 7	0.0036	0.0277	0.0686
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0034	0.0115
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0023	0.0078
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0009	0.0029	0.0096
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0239	0.1034
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0327	0.0337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.006	0.0506	0.052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0036	0.0277	0.0686
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1291	0.1327
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0036	0.0277	0.4944
Onchocerca volvulus		0.0102	0.09	0.09
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0029	0.0096
Onchocerca volvulus		0.0009	0.0023	0.0023
Toxoplasma gondii	AGC kinase	0.0039	0.0311	0.5616
Schistosoma mansoni	neuropeptide f receptor 76f	0.0009	0.0029	0.0124
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0311	0.3575
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0506	0.052
Onchocerca volvulus		0.0009	0.0029	0.0029
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0039	0.0311	0.5616
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0036	0.0277	0.0929
Onchocerca volvulus		0.0009	0.0029	0.0029
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0036	0.0277	0.0277
Brugia malayi	Carm1-pending protein	0.0036	0.0277	0.0284
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0023	0.0078
Echinococcus granulosus	geminin	0.0165	0.1482	0.4978
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0009	0.0029	0.0124
Echinococcus multilocularis	somatostatin receptor	0.0009	0.0029	0.0096
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0034	0.0035
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0029	0.0124
Echinococcus multilocularis	Smad4	0.001	0.0034	0.0115
Brugia malayi	MH2 domain containing protein	0.001	0.0034	0.0035
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0039	0.0311	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0024
Brugia malayi	putative neuropeptide receptor NPR1	0.0009	0.0029	0.0029
Echinococcus granulosus	smad	0.001	0.0034	0.0115
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1046	0.9729	1
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0036	0.0277	0.0277
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Schistosoma mansoni	smad1 5 8 and	0.001	0.0034	0.0148
Brugia malayi	MH2 domain containing protein	0.001	0.0034	0.0035
Trypanosoma cruzi	Thiopurine S-methyltransferase (TPMT), putative	0.005	0.0408	0.1013
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	histone J3 methyltransferase	0.0253	0.2311	1
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0019	0.0121	0.0522
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0029	0.0096
Brugia malayi	Spermidine synthase	0.0324	0.2977	0.306
Schistosoma mansoni	hypothetical protein	0.0165	0.1482	0.6413
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0039	0.0307	0.1031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Schistosoma mansoni	hypothetical protein	0.0019	0.0121	0.0522
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0124
Echinococcus multilocularis	serotonin receptor	0.0009	0.0029	0.0096
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0009	0.0029	0.0029
Trypanosoma brucei	spermidine synthase	0.0324	0.2977	1
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0023	0.0078
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0029	0.0096
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0063	0.0536	0.0536
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0032	0.0243	0.0603
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0029	0.0096
Leishmania major	spermidine synthase	0.0324	0.2977	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0009	0.0029	0.0029
Trypanosoma brucei	protein arginine n-methyltransferase 7	0.0036	0.0277	0.0123
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0039	0.0311	0.0771
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0009	0.0029	0.0096
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0121	0.0405
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0096
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0121	0.0124
Schistosoma mansoni	smad1 5 8 and	0.001	0.0034	0.0148
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0239	0.1034
Schistosoma mansoni	dep domain containing protein	0.0009	0.0023	0.01
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0009	0.0029	0.0029
Brugia malayi	Smad1	0.001	0.0034	0.0035
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0124
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0009	0.0029	0.0029
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0034	0.0115
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0506	0.052
Schistosoma mansoni	dishevelled	0.0009	0.0023	0.01
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0239	0.4208
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0024
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0099	0.087	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0102	0.09	0.0925
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0009	0.0029	0.0096
Giardia lamblia	Kinase, AGC PKA	0.0039	0.0311	0.5
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0039	0.0311	0.0249
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0121	0.0405
Brugia malayi	G-protein coupled receptor	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	RE15519p	0.0009	0.0029	0.0029
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0039	0.0311	0.0264
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0023	0.0078
Trypanosoma brucei	Thiopurine S-methyltransferase (TPMT), putative	0.005	0.0408	0.0605
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0029	0.0124
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0099	0.087	0.2157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0096
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0039	0.0311	0.0771
Brugia malayi	G protein-coupled receptor	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0124
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0039	0.0311	0.032
Echinococcus multilocularis	g-protein coupled receptor	0.0009	0.0029	0.0096
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0009	0.0029	0.0029
Trypanosoma cruzi	hypothetical protein	0.0437	0.4033	1
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0023	0.0024
Schistosoma mansoni	hypothetical protein	0.0165	0.1482	0.6413
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0009	0.0029	0.0124
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0036	0.0277	0.4944
Schistosoma mansoni	dishevelled	0.0009	0.0023	0.01
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0009	0.0029	0.0124
Echinococcus granulosus	protein arginine N methyltransferase 8	0.0063	0.0536	0.18
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0009	0.0029	0.0096
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0124
Onchocerca volvulus		0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0009	0.0023	0.0024
Echinococcus granulosus	hypothetical protein	0.0009	0.0029	0.0096
Echinococcus granulosus	Smad4	0.001	0.0034	0.0115
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0096
Onchocerca volvulus		0.0009	0.0029	0.0029
Brugia malayi	N-terminal motif family protein	0.0175	0.1585	0.1629
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0096
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0063	0.0536	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0029	0.0124
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Leishmania major	arginine N-methyltransferase, type I	0.0036	0.0277	0.0123
Entamoeba histolytica	hypothetical protein	0.0099	0.087	1
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	neuropeptide receptor A26	0.0009	0.0029	0.0096
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0029
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0096
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0311	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0121	0.0124
Brugia malayi	Dopamine receptor	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0023	0.0024
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0124
Leishmania major	arginine N-methyltransferase-like protein	0.0063	0.0536	0.1071
Trypanosoma cruzi	spermidine synthase, putative	0.0324	0.2977	0.7382
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0311	0.3575
Schistosoma mansoni	smad1 5 8 and	0.001	0.0034	0.0148
Echinococcus granulosus	allatostatin A receptor	0.0009	0.0029	0.0096
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0063	0.0536	0.0536
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0009	0.0029	0.0029
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0124
Trypanosoma cruzi	spermidine synthase, putative	0.0324	0.2977	0.7382
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0253	0.2311	0.2375
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0096
Echinococcus granulosus	neuropeptide s receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0029	0.0096
Schistosoma mansoni	hypothetical protein	0.0019	0.0121	0.0522
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0214	0.0717
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0063	0.0536	0.0536
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0009	0.0029	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Onchocerca volvulus		0.0032	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0239	0.0246
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0034	0.0115
Plasmodium falciparum	spermidine synthase	0.0324	0.2977	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0124
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0039	0.0311	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029
Schistosoma mansoni	Smad4	0.001	0.0034	0.0148
Schistosoma mansoni	adenoreceptor	0.0009	0.0029	0.0124
Onchocerca volvulus		0.0009	0.0029	0.0029
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0096
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0039	0.0307	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0029

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1885423

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1583446