TDR Targets

Basic information

Technical information

TDR Targets ID: 1583574
Name: 3-[(2-fluorophenyl)methyl]-4-oxo-N-[2-(triflu oromethyl)phenyl]spiro[1,3-benzoxazine-2,4'-p iperidine]-1'-carboxamide
MW: 513.483 | Formula: C27H23F4N3O3
H donors: 1 H acceptors: 2 LogP: 4.96 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCC2(CC1)Oc1ccccc1C(=O)N2Cc1ccccc1F)Nc1ccccc1C(F)(F)F
InChi: 1S/C27H23F4N3O3/c28-21-10-4-1-7-18(21)17-34-24(35)19-8-2-6-12-23(19)37-26(34)13-15-33(16-14-26)25(36)32-22-11-5-3-9-20(22)27(29,30)31/h1-12H,13-17H2,(H,32,36)
InChiKey: AXQQTRQWLLMZDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(2-fluorophenyl)methyl]-4-oxo-N-[2-(trifluoromethyl)phenyl]-1'-spiro[1,3-benzoxazine-2,4'-piperidine]carboxamide
3-(2-fluorobenzyl)-4-keto-N-[2-(trifluoromethyl)phenyl]spiro[1,3-benzoxazine-2,4'-piperidine]-1'-carboxamide
C794-1633
NCGC00113535-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0023	0.0041	0.0058
Entamoeba histolytica	replication factor A protein 1, putative	0.0389	0.4174	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Brugia malayi	beta-lactamase	0.0037	0.0199	0.0199
Leishmania major	hypothetical protein, conserved	0.0025	0.0061	0.013
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0045	0.0283	0.0283
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0045	0.0283	0.0283
Giardia lamblia	Aspartyl-tRNA synthetase	0.0045	0.0283	0.222
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0045	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.0313
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.2466	1
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0045	0.0283	0.0283
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Plasmodium falciparum	nucleic acid binding protein, putative	0.0045	0.0283	0.0604
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0283
Giardia lamblia	Hypothetical protein	0.0132	0.1274	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.005	0.0342	0.0342
Trypanosoma cruzi	asparaginyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Loa Loa (eye worm)	multisynthetase complex auxiliary component p43	0.0054	0.0389	0.0389
Echinococcus granulosus	snurportin 1	0.0305	0.323	0.323
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0041	0.0041
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0313	0.0313
Trypanosoma cruzi	Replication factor A protein 1	0.0433	0.4678	1
Brugia malayi	RNA, U transporter 1	0.0081	0.0698	0.0698
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0041	0.0087
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0303	0.0303
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0064	0.0504	0.1173
Schistosoma mansoni	ran	0.0021	0.0017	0.0017
Schistosoma mansoni	lysyl-tRNA synthetase	0.0045	0.0283	0.0283
Toxoplasma gondii	aspartate-tRNA ligase	0.0045	0.0283	0.0604
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0017	0.0036
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0386	0.0386
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0061	0.013
Schistosoma mansoni	hypothetical protein	0.0045	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0283	0.0283
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0102	0.0218
Entamoeba histolytica	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.064
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0041	0.0041
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0199	0.0199
Leishmania major	asparaginyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Toxoplasma gondii	lysine-tRNA ligase	0.0045	0.0283	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0088	0.077	0.077
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0041	0.0087
Plasmodium falciparum	lysine--tRNA ligase	0.0045	0.0283	0.0604
Schistosoma mansoni	importin beta-1	0.0029	0.0102	0.0102
Brugia malayi	Aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Giardia lamblia	Asparaginyl-tRNA synthetase	0.0045	0.0283	0.222
Plasmodium vivax	replication protein A1, large subunit, putative	0.0433	0.4678	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Entamoeba histolytica	hypothetical protein	0.0045	0.0283	0.064
Echinococcus multilocularis	lysyl tRNA synthetase	0.0045	0.0283	0.0283
Entamoeba histolytica	asparaginyl-tRNA synthetase, putative	0.0045	0.0283	0.064
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0045	0.0283	0.0604
Brugia malayi	lysyl-tRNA synthetase	0.0045	0.0283	0.0283
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0433	0.4678	0.4678
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.005	0.0342	0.0342
Wolbachia endosymbiont of Brugia malayi	aspartyl-tRNA synthetase	0.0045	0.0283	0.5
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0017	0.0017
Schistosoma mansoni	replication factor A 1 rfa1	0.0904	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0199	0.0199
Mycobacterium ulcerans	aspartyl-tRNA synthetase	0.0045	0.0283	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0303	0.0303
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0199	0.0199
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0045	0.0283	0.0283
Plasmodium falciparum	replication protein A1, large subunit	0.0433	0.4678	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0303	0.0303
Schistosoma mansoni	methionine-tRNA synthetase	0.0064	0.0504	0.0504
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0313	0.0313
Echinococcus multilocularis	snurportin 1	0.0305	0.323	0.323
Plasmodium falciparum	importin beta, putative	0.0029	0.0102	0.0218
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0199	0.0199
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0283	0.0604
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0064	0.0504	0.0504
Leishmania major	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Plasmodium falciparum	asparagine--tRNA ligase	0.0045	0.0283	0.0604
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0045	0.0283	0.0283
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0017
Brugia malayi	beta-lactamase family protein	0.0037	0.0199	0.0199
Trypanosoma cruzi	replication Factor A 28 kDa subunit, putative	0.0045	0.0283	0.0604
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0386	0.0386
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0199	0.0199
Toxoplasma gondii	OB-fold nucleic acid binding domain-containing protein	0.0227	0.2347	0.5017
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Brugia malayi	hypothetical protein	0.0025	0.0061	0.0061
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0313	0.0313
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0017	0.0036
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0045	0.0283	0.0604
Leishmania major	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Schistosoma mansoni	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Toxoplasma gondii	ABC1 family protein	0.0037	0.0199	0.0426
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0313	0.0313
Brugia malayi	mbt repeat family protein	0.0047	0.0313	0.0313
Schistosoma mansoni	hypothetical protein	0.0305	0.323	0.323
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0102	0.0102
Brugia malayi	methionyl-tRNA synthetase	0.0064	0.0504	0.0504
Brugia malayi	mbt repeat family protein	0.0047	0.0313	0.0313
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0102	0.0218
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0199	0.0199
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.1882	0.1882
Schistosoma mansoni	lysyl-tRNA synthetase	0.0045	0.0283	0.0283
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0303	0.0303
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0102	0.0218
Toxoplasma gondii	hypothetical protein	0.0095	0.0852	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0386	0.0386
Leishmania major	replication Factor A 28 kDa subunit, putative	0.0045	0.0283	0.0604
Loa Loa (eye worm)	BRCA2 repeat family protein	0.0183	0.1843	0.1843
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0313	0.0313
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Loa Loa (eye worm)	MBCTL1	0.0054	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0061	0.0061
Plasmodium vivax	lysine--tRNA ligase, putative	0.0045	0.0283	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0504	0.0504
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0904	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0303	0.0303
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0313	0.013
Leishmania major	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0386	0.0386
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0045	0.0283	0.0283
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0102	0.0218
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0283
Trypanosoma brucei	asparaginyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Plasmodium falciparum	asparagine--tRNA ligase	0.0045	0.0283	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0102	0.0102
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0061	0.013
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0386	0.0386
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0859	0.9496	0.9496
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0036
Brugia malayi	BRCA2 repeat family protein	0.0183	0.1843	0.1843
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0791	0.8722	0.8722
Leishmania major	GTP-binding protein, putative	0.0021	0.0017	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0199	0.0426
Trichomonas vaginalis	esterase, putative	0.0037	0.0199	0.0199
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0045	0.0283	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.323	0.323
Leishmania major	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0433	0.4678	1
Brugia malayi	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0199	0.0426
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0313	0.0313
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Plasmodium vivax	aspartate--tRNA ligase, putative	0.0045	0.0283	0.0604
Entamoeba histolytica	hypothetical protein	0.0045	0.0283	0.064
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.1882	0.1882
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0199	0.0199
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0303	0.0303
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase)	0.0045	0.0283	0.0368
Trichomonas vaginalis	ran, putative	0.0021	0.0017	0.0017
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0045	0.0283	1
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Entamoeba histolytica	replication factor A, putative	0.0088	0.077	0.1811
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0061	0.013
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0045	0.0283	0.0604
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0904	1	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0199	0.0199
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0017	0.0017
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0061	0.013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0303	0.0303
Echinococcus multilocularis	glycyl tRNA synthetase	0.005	0.0342	0.0342
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0088	0.077	0.0653
Leishmania major	replication factor A, 51kDa subunit, putative	0.0433	0.4678	1
Schistosoma mansoni	hypothetical protein	0.0287	0.3024	0.3024
Brugia malayi	beta-lactamase family protein	0.0037	0.0199	0.0199
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0017
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Leishmania major	hypothetical protein, conserved	0.0037	0.0199	0.0426
Chlamydia trachomatis	methionine--tRNA ligase	0.0064	0.0504	1
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0064	0.0504	0.0504
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0386	0.0386
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0131
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0045	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Brugia malayi	Importin beta-1 subunit	0.0029	0.0102	0.0102
Trypanosoma brucei	Replication factor A protein 1	0.0433	0.4678	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Mycobacterium leprae	PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE)	0.0045	0.0283	1
Onchocerca volvulus		0.0047	0.0313	0.013
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Echinococcus granulosus	glycyl tRNA synthetase	0.005	0.0342	0.0342
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Schistosoma mansoni	ran	0.0021	0.0017	0.0017
Giardia lamblia	Lysyl-tRNA synthetase	0.0045	0.0283	0.222
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0904	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0313	0.0313
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0904	1	1
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0809	0.8927	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0199	0.0199
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0303	0.0303
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0604
Treponema pallidum	methionyl-tRNA synthetase	0.0064	0.0504	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0386	0.0386
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0303	0.0303
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0045	0.0283	0.0283
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0045	0.0283	1
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0904	1	1
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0313	0.0313
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Loa Loa (eye worm)	63kd antigen	0.0045	0.0283	0.0283
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0199	0.0426
Plasmodium falciparum	aspartate--tRNA ligase	0.0045	0.0283	0.0604
Echinococcus granulosus	lysyl tRNA synthetase	0.0045	0.0283	0.0283
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0102	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0199	0.0426
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase)	0.0045	0.0283	0.0368

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3548 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1889166

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1583574