Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.9719 | 0.9719 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.9719 | 0.9719 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.9719 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.9719 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0377 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0377 | 0.0377 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.9719 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0377 | 0.0388 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.9719 | 0.9719 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.9719 | 1 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0377 | 0.0388 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.9719 | 0.9719 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0377 | 0.0377 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0377 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.9719 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.9719 | 0.9719 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0377 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.9719 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0377 | 0.0377 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0377 | 0.0388 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0377 | 0.0388 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0377 | 0.0377 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.1818 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.9719 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0377 | 0.0388 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0377 | 0.0388 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.9719 | 0.9719 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.0377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 69.513 uM | PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.