Detailed information for compound 1584115

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 214.283 | Formula: C13H10OS
  • H donors: 0 H acceptors: 1 LogP: 3.41 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)C=Cc1cccs1
  • InChi: 1S/C13H10OS/c14-13(11-5-2-1-3-6-11)9-8-12-7-4-10-15-12/h1-10H
  • InChiKey: VLDDOTFTMZJIEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) G-protein coupled receptor 0.0627 0.1424 0.1898
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0071 0.0191
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0175 0.0175
Schistosoma mansoni neuropeptide f receptor 76f 0.0627 0.1424 0.1424
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0507 0.1136 0.18
Echinococcus multilocularis GPCR, family 2 0.0319 0.0685 0.1084
Onchocerca volvulus 0.0627 0.1424 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Schistosoma mansoni hypothetical protein 0.0627 0.1424 0.1424
Entamoeba histolytica tubulin family protein 0.0497 0.1112 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.0796 0.1061
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0092 0.014 0.022
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0146 0.0408
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Echinococcus multilocularis fmrfamide receptor 0.0627 0.1424 0.2255
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Giardia lamblia Beta tubulin 0.0497 0.1112 1
Echinococcus granulosus Tubulin beta 2C chain 0.0497 0.1112 0.1761
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0071 0.0191
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0071 0.0191
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0627 0.1424 0.1898
Plasmodium falciparum plasmepsin V 0.0365 0.0796 0.2295
Trichomonas vaginalis tubulin epsilon chain, putative 0.0497 0.1112 0.3219
Echinococcus granulosus glutamate NMDA receptor subunit 0.0261 0.0547 0.0865
Schistosoma mansoni hypothetical protein 0.0319 0.0685 0.0685
Echinococcus multilocularis neuropeptide Y receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) tubulin beta chain 0.0497 0.1112 0.1482
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0627 0.1424 0.1424
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0071 0.0191
Brugia malayi G-protein coupled receptor 0.0627 0.1424 0.1897
Schistosoma mansoni amine GPCR 0.0627 0.1424 0.1424
Echinococcus multilocularis somatostatin receptor 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0627 0.1424 1
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni hypothetical protein 0.0627 0.1424 0.1424
Echinococcus granulosus beta tubulin 0.0497 0.1112 0.1761
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Schistosoma mansoni cyclin B3 0.0065 0.0075 0.0075
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.014 0.014
Brugia malayi G protein-coupled receptor F59B2.13 0.0627 0.1424 0.1897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Trypanosoma cruzi cdc2-related kinase 3 0.0092 0.014 0.1219
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0071 0.0093
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus multilocularis beta tubulin 0.0497 0.1112 0.1761
Echinococcus granulosus sex peptide receptor 0.0627 0.1424 0.2255
Trichomonas vaginalis cyclins, putative 0.008 0.0111 0.0319
Plasmodium falciparum cyclin 0.0065 0.0075 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus granulosus G protein coupled receptor 139 0.0627 0.1424 0.2255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0627 0.1424 0.2255
Entamoeba histolytica cyclin, putative 0.0129 0.0229 0.1523
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Loa Loa (eye worm) beta-tubulin 0.0497 0.1112 0.1482
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.1472 0.3451 1
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.0005 0.0006
Onchocerca volvulus 0.0627 0.1424 1
Brugia malayi Dopamine receptor protein 1 0.0627 0.1424 0.1897
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0319 0.0685 0.1084
Schistosoma mansoni amine GPCR 0.0627 0.1424 0.1424
Echinococcus granulosus cyclin B 0.0129 0.0229 0.0362
Loa Loa (eye worm) BEN-1 protein 0.0497 0.1112 0.1482
Echinococcus granulosus neuropeptide receptor 0.0627 0.1424 0.2255
Trichomonas vaginalis cyclin B, putative 0.0129 0.0229 0.0662
Plasmodium vivax aspartyl proteinase, putative 0.1472 0.3451 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0063 0.0071 0.0093
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0068 0.0106
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0032 0.0032
Brugia malayi larval opioid receptor 0.0627 0.1424 0.1897
Schistosoma mansoni hypothetical protein 0.0627 0.1424 0.1424
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0627 0.1424 0.2255
Brugia malayi putative neuropeptide receptor NPR1 0.0627 0.1424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0071 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0071 0.0202
Echinococcus granulosus neuropeptide receptor 0.2662 0.6309 1
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0247 0.0513 0.0811
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni cathepsin D (A01 family) 0.42 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0627 0.1424 0.2255
Entamoeba histolytica tubulin family protein 0.0497 0.1112 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0092 0.014 0.0185
Onchocerca volvulus 0.0627 0.1424 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Brugia malayi Cyclin, N-terminal domain containing protein 0.0065 0.0075 0.0096
Brugia malayi neuropeptide F receptor 0.0627 0.1424 0.1897
Trypanosoma brucei beta tubulin 0.0497 0.1112 0.5998
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Trypanosoma brucei beta tubulin 0.0497 0.1112 0.5998
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0611 0.1385 0.1847
Echinococcus granulosus neuropeptide s receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Plasmodium falciparum plasmepsin X 0.0527 0.1185 0.3422
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0071 0.0111
Brugia malayi G-protein coupled receptor 0.0627 0.1424 0.1897
Echinococcus multilocularis Tubulin beta 2C chain 0.0497 0.1112 0.1761
Echinococcus granulosus orexin receptor type 2 0.0627 0.1424 0.2255
Brugia malayi Cam kinase protein 1 0.0063 0.0071 0.0091
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0627 0.1424 0.1898
Trichomonas vaginalis cyclins, putative 0.0129 0.0229 0.0662
Echinococcus multilocularis serine:threonine protein kinase 0.0247 0.0513 0.0811
Trypanosoma brucei RNA helicase, putative 0.0786 0.1806 1
Schistosoma mansoni protein kinase 0.0507 0.1136 0.1136
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0064 0.0099
Echinococcus granulosus neuropeptide Y receptor 0.0627 0.1424 0.2255
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.0005 0.0006
Echinococcus granulosus tubulin subunit beta 0.0497 0.1112 0.1761
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Echinococcus granulosus biogenic amine 5HT receptor 0.0627 0.1424 0.2255
Trichomonas vaginalis cyclin B, putative 0.0065 0.0075 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0627 0.1424 0.2255
Echinococcus granulosus cyclin dependent kinase 1 0.0092 0.014 0.022
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0129 0.0229 0.1597
Loa Loa (eye worm) hypothetical protein 0.0689 0.1574 0.2099
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0627 0.1424 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0627 0.1424 0.1897
Onchocerca volvulus Neuropeptide F receptor homolog 0.0627 0.1424 1
Plasmodium vivax plasmepsin V, putative 0.0365 0.0796 0.2295
Plasmodium falciparum plasmepsin I 0.1472 0.3451 1
Trichomonas vaginalis cyclin B, putative 0.0129 0.0229 0.0662
Brugia malayi Cyclin, N-terminal domain containing protein 0.0129 0.0229 0.0303
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Schistosoma mansoni furin-1 (S08 family) 0.0063 0.007 0.007
Schistosoma mansoni neuropeptide receptor 0.0627 0.1424 0.1424
Echinococcus granulosus g protein coupled receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis 0.0117 0.0199 0.0314
Loa Loa (eye worm) hypothetical protein 0.0129 0.0229 0.0305
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3156 0.7495 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0627 0.1424 0.1898
Leishmania major beta tubulin 0.0497 0.1112 1
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0184 0.029
Echinococcus multilocularis cyclin dependent kinase 5 0.0092 0.014 0.022
Brugia malayi Dopamine receptor 0.0627 0.1424 0.1897
Brugia malayi Angiotensin-converting enzyme family protein 0.0611 0.1385 0.1845
Brugia malayi hypothetical protein 0.0365 0.0796 0.1059
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0627 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Echinococcus granulosus cyclin dependent kinase 0.0092 0.014 0.022
Brugia malayi Latrophilin receptor protein 2 0.0319 0.0685 0.0911
Echinococcus multilocularis neuropeptide receptor A26 0.0627 0.1424 0.2255
Echinococcus granulosus cyclin b3 0.0065 0.0075 0.0117
Echinococcus granulosus tm gpcr rhodopsin 0.0627 0.1424 0.2255
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0289 0.0289
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0032 0.0048
Echinococcus granulosus somatostatin receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0064 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2442 0.5782 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0627 0.1424 1
Onchocerca volvulus 0.0627 0.1424 1
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni neuropeptide receptor 0.2662 0.6309 0.6309
Schistosoma mansoni opsin-like receptor 0.0627 0.1424 0.1424
Loa Loa (eye worm) aspartic protease BmAsp-2 0.1472 0.3451 0.4604
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0107 0.0175 0.0275
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Trichomonas vaginalis cyclin B, putative 0.0129 0.0229 0.0662
Schistosoma mansoni myosin xvIII 0.0627 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Brugia malayi endoprotease bli-4 precursor 0.0145 0.0266 0.0352
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.2467 0.584 0.9258
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0627 0.1424 0.1424
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Trypanosoma brucei cdc2-related kinase 1 0.0092 0.014 0.0398
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 0.0063
Brugia malayi GnHR receptor homolog 0.0627 0.1424 0.1897
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0627 0.1424 0.1424
Echinococcus granulosus neuropeptide Y receptor 0.0627 0.1424 0.2255
Schistosoma mansoni neuropeptide F-like receptor 0.0627 0.1424 0.1424
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Schistosoma mansoni biogenic amine (5HT) receptor 0.0627 0.1424 0.1424
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.009 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0627 0.1424 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0075 0.0213
Echinococcus multilocularis neuropeptide FF receptor 2 0.0627 0.1424 0.2255
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0324 0.2261
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0001 0.0001
Toxoplasma gondii aspartyl protease ASP3 0.0527 0.1185 0.3422
Onchocerca volvulus 0.0627 0.1424 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0627 0.1424 0.2255
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0032 0.0048
Onchocerca volvulus 0.0627 0.1424 1
Echinococcus granulosus furin 0.0145 0.0266 0.042
Schistosoma mansoni hypothetical protein 0.0319 0.0685 0.0685
Entamoeba histolytica cell division protein kinase 2, putative 0.0092 0.014 0.0664
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.2467 0.584 0.9258
Loa Loa (eye worm) hypothetical protein 0.0071 0.009 0.0118
Leishmania major beta tubulin 0.0497 0.1112 1
Schistosoma mansoni biogenic amine receptor 0.0627 0.1424 0.1424
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0627 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0319 0.0685 0.0913
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0507 0.1136 0.18
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.1472 0.3451 0.3451
Brugia malayi Protein kinase domain containing protein 0.0092 0.014 0.0184
Onchocerca volvulus 0.0627 0.1424 1
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Brugia malayi aspartic protease BmAsp-1, identical 0.0365 0.0796 0.1059
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0092 0.014 0.0391
Echinococcus granulosus cyclins 0.0065 0.0075 0.0117
Leishmania major beta tubulin 0.0497 0.1112 1
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.014 0.0403
Echinococcus multilocularis Tubulin beta 2C chain 0.0497 0.1112 0.1761
Echinococcus multilocularis cyclin dependent kinase 0.0092 0.014 0.022
Brugia malayi aspartic protease BmAsp-2, identical 0.0365 0.0796 0.1059
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.011 0.0074
Echinococcus granulosus beta tubulin 0.0497 0.1112 0.1761
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.1472 0.3451 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0627 0.1424 0.1424
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0444 0.0985 0.1311
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0012 0.0015
Trichomonas vaginalis cyclin D, putative 0.0065 0.0075 0.0213
Loa Loa (eye worm) hypothetical protein 0.3156 0.7495 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0129 0.0229 0.1704
Brugia malayi neuropeptide F receptor 0.0627 0.1424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Trypanosoma cruzi cdc2-related kinase 1 0.0092 0.014 0.1219
Schistosoma mansoni hypothetical protein 0.0131 0.0233 0.0233
Echinococcus granulosus Tubulin beta 2C chain 0.0497 0.1112 0.1761
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Trypanosoma cruzi cdc2-related kinase 3 0.0092 0.014 0.1219
Onchocerca volvulus 0.0365 0.0796 0.5585
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Leishmania major beta tubulin 0.0497 0.1112 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0175 0.0175
Leishmania major beta tubulin 0.0497 0.1112 1
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Loa Loa (eye worm) TYRA-2 protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0176
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) tubulin beta-1 chain 0.0497 0.1112 0.1482
Plasmodium vivax aspartyl protease, putative 0.0365 0.0796 0.2295
Trypanosoma brucei beta tubulin 0.0497 0.1112 0.5998
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0071 0.0191
Echinococcus multilocularis cyclin B 0.0129 0.0229 0.0362
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0107 0.0175 0.0275
Giardia lamblia Cyclin A 0.0065 0.0075 0.025
Echinococcus multilocularis sex peptide receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Brugia malayi sulfakinin receptor protein 0.0627 0.1424 0.1897
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0365 0.0796 0.5585
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0233 0.0368
Loa Loa (eye worm) animal heme peroxidase 0.0035 0.0003 0.0002
Brugia malayi putative neuropeptide receptor 0.0627 0.1424 0.1897
Echinococcus granulosus cyclin B3 1 0.0065 0.0075 0.0117
Schistosoma mansoni neuropeptide receptor 0.0627 0.1424 0.1424
Echinococcus granulosus cyclin dependent kinase 5 0.0092 0.014 0.022
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0146 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Echinococcus granulosus 7tm_1 domain containing protein 0.0627 0.1424 0.2255
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0627 0.1424 0.2255
Schistosoma mansoni protein kinase 0.0507 0.1136 0.1136
Brugia malayi Tubulin beta-1 chain 0.0497 0.1112 0.1481
Schistosoma mansoni cyclin B 0.0129 0.0229 0.0229
Brugia malayi beta-tubulin, identical 0.0497 0.1112 0.1481
Loa Loa (eye worm) neuropeptide F receptor 0.0627 0.1424 0.1898
Trypanosoma brucei cdc2-related kinase 3 0.0092 0.014 0.0398
Schistosoma mansoni biogenic amine receptor 0.0627 0.1424 0.1424
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0003 0.0002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0146 0.0408
Echinococcus granulosus cyclins 0.0065 0.0075 0.0117
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0261 0.0547 0.0865
Loa Loa (eye worm) melatonin receptor type 1A 0.0627 0.1424 0.1898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Leishmania major protein kinase, putative 0.0063 0.0071 0.0594
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0627 0.1424 0.1898
Entamoeba histolytica cyclin family protein 0.0065 0.0075 0.0037
Plasmodium falciparum plasmepsin III 0.0365 0.0796 0.2295
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) hypothetical protein 0.0057 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Toxoplasma gondii aspartyl protease ASP1 0.1472 0.3451 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0032 0.0048
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2442 0.5782 1
Loa Loa (eye worm) hypothetical protein 0.1472 0.3451 0.4604
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.014 0.014
Echinococcus multilocularis G-protein coupled receptor, putative 0.0627 0.1424 0.2255
Echinococcus multilocularis beta tubulin 0.0497 0.1112 0.1761
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0346 0.0998
Echinococcus granulosus Tubulin beta 2C chain 0.0497 0.1112 0.1761
Brugia malayi Melibiase family protein 0.0071 0.009 0.0116
Echinococcus multilocularis cyclin dependent kinase 1 0.0092 0.014 0.022
Echinococcus multilocularis serotonin receptor 0.0627 0.1424 0.2255
Brugia malayi neuroendocrine convertase 1 precursor 0.0091 0.0137 0.018
Schistosoma mansoni amine GPCR 0.0627 0.1424 0.1424
Plasmodium vivax tubulin beta chain, putative 0.0497 0.1112 0.3211
Trichomonas vaginalis tubulin alpha chain, putative 0.0497 0.1112 0.3219
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0071 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0032 0.0048
Plasmodium falciparum plasmepsin VIII, putative 0.0365 0.0796 0.2295
Echinococcus multilocularis neuropeptides capa receptor 0.0627 0.1424 0.2255
Leishmania major beta tubulin 0.0497 0.1112 1
Brugia malayi ORL1-like opioid receptor 0.0627 0.1424 0.1897
Schistosoma mansoni hypothetical protein 0.0319 0.0685 0.0685
Schistosoma mansoni lipoxygenase 0.01 0.0158 0.0158
Echinococcus granulosus neuropeptides capa receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis tubulin subunit beta 0.0497 0.1112 0.1761
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0627 0.1424 0.2255
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0536 0.0712
Trypanosoma cruzi cyclin 6, putative 0.0129 0.0229 0.2026
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0627 0.1424 0.1424
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0627 0.1424 1
Leishmania major beta tubulin 0.0497 0.1112 1
Brugia malayi latrophilin 2 splice variant baaae 0.0689 0.1574 0.2097
Echinococcus granulosus serotonin receptor 0.0627 0.1424 0.2255
Leishmania major cyclin 0.0129 0.0229 0.2026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0627 0.1424 0.2255
Echinococcus granulosus fmrfamide receptor 0.0627 0.1424 0.2255
Trypanosoma brucei mitotic cyclin 6 0.0129 0.0229 0.0913
Loa Loa (eye worm) hypothetical protein 0.0145 0.0266 0.0354
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Toxoplasma gondii melibiase subfamily protein 0.0107 0.0175 0.0492
Echinococcus granulosus glutamate receptor 2 0.0047 0.0032 0.0048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0071 0.0111
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0092 0.014 0.1219
Brugia malayi Calcitonin receptor-like protein seb-1 0.1008 0.234 0.3119
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0365 0.0796 0.2295
Brugia malayi Serotonin receptor 0.0627 0.1424 0.1897
Schistosoma mansoni amine GPCR 0.0627 0.1424 0.1424
Trypanosoma cruzi cyclin, putative 0.0129 0.0229 0.2026
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0071 0.0191
Echinococcus multilocularis neuropeptide receptor 0.2662 0.6309 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0444 0.0985 0.1312
Echinococcus multilocularis cyclin dependent kinase 1 0.0092 0.014 0.022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0146 0.0408
Schistosoma mansoni cyclins 0.0065 0.0075 0.0075
Schistosoma mansoni amine GPCR 0.0627 0.1424 0.1424
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0319 0.0685 0.0911
Schistosoma mansoni serine-type protease inhibitor 0.2612 0.6188 0.6188
Echinococcus multilocularis dro:myosuppressin receptor 0.0627 0.1424 0.2255
Schistosoma mansoni memapsin-2 (A01 family) 0.0365 0.0796 0.0796
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0107 0.0175 0.0275
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Echinococcus multilocularis tubulin beta 1 chain 0.0497 0.1112 0.1761
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Loa Loa (eye worm) BEN-1 protein 0.0497 0.1112 0.1482
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Plasmodium vivax protein kinase Crk2 0.0092 0.014 0.0391
Plasmodium falciparum protein kinase 5 0.0092 0.014 0.0391
Echinococcus multilocularis Tubulin beta 2C chain 0.0497 0.1112 0.1761
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Echinococcus granulosus cyclins 0.0065 0.0075 0.0117
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Toxoplasma gondii aspartyl protease 0.0365 0.0796 0.2295
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.014 0.0403
Echinococcus granulosus g protein coupled receptor 0.0627 0.1424 0.2255
Leishmania major beta tubulin 0.0497 0.1112 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0627 0.1424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0064 0.0074 0.0097
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0071 0.0191
Onchocerca volvulus 0.0036 0.0005 0.0019
Toxoplasma gondii beta-1 tubulin, putative 0.0497 0.1112 0.3211
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 0.0408
Trichomonas vaginalis cyclin A, putative 0.0129 0.0229 0.0662
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0088 0.013 0.0205
Schistosoma mansoni biogenic amine (5HT) receptor 0.0627 0.1424 0.1424
Brugia malayi Cyclin, N-terminal domain containing protein 0.0129 0.0229 0.0303
Loa Loa (eye worm) hypothetical protein 0.0129 0.0229 0.0305
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.1472 0.3451 0.547
Plasmodium vivax aspartyl proteinase, putative 0.0365 0.0796 0.2295
Brugia malayi cell division control protein 2 homolog 0.0092 0.014 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.013 0.0374
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Plasmodium vivax plasmepsin IV, putative 0.1472 0.3451 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0071 0.0191
Echinococcus granulosus tm gpcr rhodopsin 0.0627 0.1424 0.2255
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0233 0.0368
Brugia malayi celfurPC protein 0.0117 0.0199 0.0262
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0145 0.0266 0.0266
Echinococcus multilocularis orexin receptor type 2 0.0627 0.1424 0.2255
Echinococcus multilocularis g protein coupled receptor 0.0627 0.1424 0.2255
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0175 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.014 0.0403
Echinococcus granulosus hypothetical protein 0.0627 0.1424 0.2255
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0088 0.013 0.0205
Trichomonas vaginalis cyclins, putative 0.0129 0.0229 0.0662
Echinococcus granulosus GPCR family 2 0.0319 0.0685 0.1084
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0289 0.0456
Brugia malayi Eukaryotic aspartyl protease family protein 0.0365 0.0796 0.1059
Echinococcus multilocularis cyclin B3 1 0.0065 0.0075 0.0117
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.1472 0.3451 0.547
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0071 0.0111
Trypanosoma cruzi cdc2-related kinase 1 0.0092 0.014 0.1219
Loa Loa (eye worm) hypothetical protein 0.0094 0.0146 0.0193
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0627 0.1424 0.1898
Plasmodium falciparum plasmepsin IX 0.0527 0.1185 0.3422
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0627 0.1424 0.2255
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0289 0.0289
Leishmania major beta tubulin 0.0497 0.1112 1
Loa Loa (eye worm) G-protein coupled receptor 0.0627 0.1424 0.1898
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0146 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0146 0.0146
Leishmania major beta tubulin 0.0497 0.1112 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0261 0.0412
Brugia malayi follicle stimulating hormone receptor 0.0627 0.1424 0.1897
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0261 0.0412
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0324 0.0935
Leishmania major beta tubulin 0.0497 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni neuropeptide F-like receptor 0.0627 0.1424 0.1424
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Onchocerca volvulus 0.0627 0.1424 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0627 0.1424 0.1424
Onchocerca volvulus 0.0627 0.1424 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0497 0.1112 0.3219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1008 0.234 0.3121
Toxoplasma gondii beta-tubulin, putative 0.0497 0.1112 0.3211
Schistosoma mansoni hypothetical protein 0.0036 0.0005 0.0005
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Echinococcus granulosus alpha 1A adrenergic receptor 0.0627 0.1424 0.2255
Schistosoma mansoni hypothetical protein 0.0689 0.1574 0.1574
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0627 0.1424 0.1424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Schistosoma mansoni hypothetical protein 0.0627 0.1424 0.1424
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Brugia malayi Melatonin receptor type 1A 0.0627 0.1424 0.1897
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0627 0.1424 0.2255
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0627 0.1424 0.1424
Echinococcus granulosus dro:myosuppressin receptor 0.0627 0.1424 0.2255
Schistosoma mansoni biogenic amine receptor 0.0627 0.1424 0.1424
Giardia lamblia Beta tubulin 0.0497 0.1112 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0071 0.0191
Schistosoma mansoni lipoxygenase 0.0142 0.0261 0.0261
Echinococcus granulosus serine:threonine protein kinase 0.0247 0.0513 0.0811
Brugia malayi Serotonin receptor 0.0627 0.1424 0.1897
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0065 0.0075 0.0117
Giardia lamblia Beta tubulin 0.0497 0.1112 1
Echinococcus granulosus Tubulin beta 2C chain 0.0497 0.1112 0.1761
Brugia malayi Pepsin A precursor 0.0365 0.0796 0.1059
Echinococcus granulosus 7TM GPCR rhodopsin 0.0627 0.1424 0.2255
Onchocerca volvulus 0.0627 0.1424 1
Brugia malayi Dopamine receptor protein 2 0.0627 0.1424 0.1897
Schistosoma mansoni glutamate receptor NMDA 0.0261 0.0547 0.0547
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Brugia malayi hypothetical protein 0.0365 0.0796 0.1059
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0627 0.1424 0.2255
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0071 0.0191
Echinococcus granulosus cyclins 0.0065 0.0075 0.0117
Plasmodium falciparum plasmepsin II 0.1472 0.3451 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0092 0.014 0.1219
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0146 0.0229
Trichomonas vaginalis cyclin B, putative 0.0129 0.0229 0.0662
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0536 0.0714
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0536 0.155
Echinococcus multilocularis g protein coupled receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis cyclin b3 0.0065 0.0075 0.0117
Echinococcus granulosus tubulin beta 1 chain 0.0497 0.1112 0.1761
Loa Loa (eye worm) hypothetical protein 0.0365 0.0796 0.1061
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0068 0.0106
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Plasmodium falciparum tubulin beta chain 0.0497 0.1112 0.3211
Schistosoma mansoni hypothetical protein 0.0319 0.0685 0.0685
Leishmania major beta tubulin 0.0497 0.1112 1
Echinococcus multilocularis g protein coupled receptor 0.0627 0.1424 0.2255
Echinococcus granulosus rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Schistosoma mansoni serine-type protease inhibitor 0.2612 0.6188 0.6188
Schistosoma mansoni tubulin subunit beta 0.0497 0.1112 0.1112
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0092 0.014 0.0185
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0032 0.0048
Schistosoma mansoni neuropeptide receptor 0.0627 0.1424 0.1424
Leishmania major beta tubulin 0.0497 0.1112 1
Echinococcus granulosus g-protein coupled receptor 0.0627 0.1424 0.2255
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0627 0.1424 0.2255
Brugia malayi Probable ClpP-like protease 0.0094 0.0146 0.0191
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0129 0.0229 0.2026
Trichomonas vaginalis tubulin beta chain, putative 0.0497 0.1112 0.3219
Echinococcus multilocularis fmrfamide receptor 0.0627 0.1424 0.2255
Brugia malayi G protein-coupled receptor 0.0627 0.1424 0.1897
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0627 0.1424 0.1424
Brugia malayi Kringle domain containing protein 0.0036 0.0005 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0627 0.1424 0.1424
Echinococcus granulosus neuropeptide FF receptor 2 0.0627 0.1424 0.2255
Leishmania major beta tubulin 0.0497 0.1112 1
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0627 0.1424 0.2255
Echinococcus multilocularis neuropeptide Y receptor 0.0627 0.1424 0.2255
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0627 0.1424 0.1897
Trypanosoma cruzi cyclin, putative 0.0129 0.0229 0.2026
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus granulosus Tubulin beta 2C chain 0.0497 0.1112 0.1761
Echinococcus granulosus peroxidasin 0.0035 0.0003 0.0002
Leishmania major beta tubulin 0.0497 0.1112 1
Entamoeba histolytica cyclin, putative 0.0065 0.0075 0.0037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0071 0.0111
Plasmodium vivax aspartyl protease, putative 0.0527 0.1185 0.3422
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0071 0.009 0.0257
Trichomonas vaginalis cyclins, putative 0.0129 0.0229 0.0662
Loa Loa (eye worm) endoprotease bli-4 0.0145 0.0266 0.0354
Echinococcus granulosus allatostatin A receptor 0.0627 0.1424 0.2255
Echinococcus granulosus peptide allatostatin:somatostatin 0.0627 0.1424 0.2255
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0319 0.0685 0.1084
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2442 0.5782 1
Echinococcus multilocularis peroxidasin 0.0035 0.0003 0.0002
Echinococcus multilocularis Tubulin beta 2C chain 0.0497 0.1112 0.1761
Echinococcus multilocularis allatostatin A receptor 0.0627 0.1424 0.2255
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0627 0.1424 0.1424
Loa Loa (eye worm) neuropeptide F receptor 0.0627 0.1424 0.1898
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0365 0.0796 0.1061
Echinococcus multilocularis Tubulin beta 2C chain 0.0497 0.1112 0.1761
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0175 0.0175
Plasmodium falciparum plasmepsin VI 0.1472 0.3451 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0627 0.1424 0.1897
Trichomonas vaginalis tubulin, putative 0.0497 0.1112 0.3219
Plasmodium falciparum plasmepsin VII 0.0365 0.0796 0.2295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0627 0.1424 0.2255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0627 0.1424 0.2255
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0184 0.029
Brugia malayi RE15519p 0.0627 0.1424 0.1897
Echinococcus multilocularis neuroendocrine convertase 2 0.0091 0.0137 0.0216
Echinococcus multilocularis neuropeptide receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) cyclin domain-containing protein 0.0065 0.0075 0.0098
Trypanosoma cruzi CYC2-like cyclin, putative 0.0129 0.0229 0.2026
Echinococcus granulosus tubulin beta 4A class IVa 0.0497 0.1112 0.1761
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0627 0.1424 0.2255
Echinococcus multilocularis neuropeptides capa receptor 0.0627 0.1424 0.2255
Schistosoma mansoni histamine h1 receptor 0.0627 0.1424 0.1424
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0319 0.0685 0.0913
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Entamoeba histolytica cell division protein kinase 2, putative 0.0092 0.014 0.0664
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Trypanosoma brucei beta tubulin 0.0497 0.1112 0.5998
Echinococcus multilocularis cyclins 0.0065 0.0075 0.0117
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Entamoeba histolytica cyclin family protein 0.0065 0.0075 0.0037
Trichomonas vaginalis cyclin D, putative 0.0065 0.0075 0.0213
Echinococcus granulosus neuropeptide receptor A26 0.0627 0.1424 0.2255
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0346 0.0998
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0071 0.0191
Trichomonas vaginalis tubulin epsilon chain, putative 0.0497 0.1112 0.3219
Trichomonas vaginalis cyclins, putative 0.0065 0.0075 0.0213
Loa Loa (eye worm) aspartyl protease 6 0.0365 0.0796 0.1061
Echinococcus multilocularis g-protein coupled receptor 0.0627 0.1424 0.2255
Leishmania major beta tubulin 0.0497 0.1112 1
Brugia malayi Protein kinase domain containing protein 0.0036 0.0005 0.0004
Loa Loa (eye worm) tubulin beta-4 chain 0.0497 0.1112 0.1482
Leishmania major beta tubulin 0.0497 0.1112 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0627 0.1424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Toxoplasma gondii hypothetical protein 0.0049 0.0037 0.0093
Plasmodium vivax aspartyl protease, putative 0.0527 0.1185 0.3422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0627 0.1424 0.1424
Trypanosoma cruzi beta tubulin, putative 0.0497 0.1112 1
Schistosoma mansoni protein kinase 0.0507 0.1136 0.1136
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0032 0.0048
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0065 0.0075 0.0117
Schistosoma mansoni growth hormone secretagogue receptor 0.0627 0.1424 0.1424
Giardia lamblia Kinase, CMGC CDK 0.0092 0.014 0.0864
Trichomonas vaginalis cyclin B3, putative 0.0065 0.0075 0.0213
Brugia malayi hypothetical protein 0.0627 0.1424 0.1897
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0071 0.0191
Brugia malayi proprotein convertase 2 0.0091 0.0137 0.018
Schistosoma mansoni opsin-like receptor 0.0627 0.1424 0.1424
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0627 0.1424 0.1424
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0184 0.029
Giardia lamblia Hypothetical protein 0.0065 0.0075 0.025
Echinococcus granulosus g protein coupled receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0071 0.0093
Schistosoma mansoni opsin-like receptor 0.0627 0.1424 0.1424
Echinococcus multilocularis neuropeptide s receptor 0.0627 0.1424 0.2255
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Echinococcus multilocularis G protein coupled receptor 139 0.2662 0.6309 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0146 0.0137
Echinococcus granulosus neuroendocrine convertase 2 0.0091 0.0137 0.0216
Leishmania major beta tubulin 0.0497 0.1112 1
Onchocerca volvulus 0.0627 0.1424 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0365 0.0796 0.0796
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0071 0.0091
Onchocerca volvulus 0.0627 0.1424 1
Echinococcus multilocularis serotonin receptor 0.0627 0.1424 0.2255
Echinococcus granulosus cyclins 0.0065 0.0075 0.0117
Schistosoma mansoni hypothetical protein 0.0786 0.1806 0.1806
Toxoplasma gondii beta tubulin 0.0497 0.1112 0.3211
Trichomonas vaginalis cyclins, putative 0.0129 0.0229 0.0662
Echinococcus granulosus tachykinin peptides receptor 99D 0.0627 0.1424 0.2255
Brugia malayi AKH receptor 0.0627 0.1424 0.1897
Echinococcus granulosus neuropeptides capa receptor 0.0627 0.1424 0.2255
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0032 0.0048
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0497 0.1112 0.1761
Schistosoma mansoni adenoreceptor 0.0627 0.1424 0.1424
Giardia lamblia Kinase, CMGC CDK 0.0092 0.014 0.0864
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.013 0.0374
Onchocerca volvulus 0.0627 0.1424 1
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0247 0.0513 0.0811
Plasmodium falciparum plasmepsin IV 0.1472 0.3451 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0627 0.1424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0627 0.1424 0.1898
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0092 0.014 0.0185
Loa Loa (eye worm) tubulin beta-2A chain 0.0497 0.1112 0.1482

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7667 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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