TDR Targets

Basic information

Technical information

TDR Targets ID: 1584204
Name: 3,3-dimethyl-1,5-di(phenyl)pentane-1,5-dione
MW: 280.361 | Formula: C19H20O2
H donors: 0 H acceptors: 2 LogP: 4.04 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)CC(CC(=O)c1ccccc1)(C)C
InChi: 1S/C19H20O2/c1-19(2,13-17(20)15-9-5-3-6-10-15)14-18(21)16-11-7-4-8-12-16/h3-12H,13-14H2,1-2H3
InChiKey: KOPUUBMUPHKMTM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

42052-44-8
NSC109934

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0071	0.0076	0.1566
Echinococcus granulosus	cytohesin 1	0.0071	0.0076	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.1648	0.6388	1
Brugia malayi	probable spectrin beta chain	0.0071	0.0076	0.0075
Onchocerca volvulus		0.0071	0.0076	1
Echinococcus granulosus	GRB2 associated binding protein 3	0.0071	0.0076	0.0114
Schistosoma mansoni	vav2	0.0071	0.0076	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Entamoeba histolytica	hypothetical protein	0.0089	0.015	0.0074
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0071	0.0076	0.0114
Onchocerca volvulus	outspread protein homolog	0.0071	0.0076	1
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Brugia malayi	Dynamin	0.0071	0.0076	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0101	0.0198	0.0296
Loa Loa (eye worm)	plexin A	0.0062	0.004	0.0038
Schistosoma mansoni	serine/threonine-protein kinase	0.1719	0.6673	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0068	0.0063	0.0094
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0101	0.0198	0.0296
Echinococcus multilocularis	oxysterol binding protein 9	0.0071	0.0076	0.0114
Schistosoma mansoni	voltage-gated potassium channel	0.0081	0.0115	0.0171
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.2479	0.9715	0.9715
Trypanosoma brucei	Flagellar Member 6	0.0068	0.0063	0.0009
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Plasmodium vivax	PH domain containing protein	0.0071	0.0076	0.0022
Echinococcus multilocularis	nervana 2	0.1629	0.6315	0.9464
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0068	0.0063	0.0092
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Schistosoma mansoni	dynamin	0.0071	0.0076	0.0112
Brugia malayi	Oxysterol-binding protein	0.0071	0.0076	0.0075
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Echinococcus granulosus	beta 1 syntrophin	0.0071	0.0076	0.0114
Echinococcus granulosus	DCC interacting protein 13 beta	0.0071	0.0076	0.0114
Mycobacterium ulcerans	hypothetical protein	0.0068	0.0063	0.5
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0068	0.0063	0.0094
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0068	0.0063	0.0092
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0068	0.0063	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0849	0.3192	0.3192
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Onchocerca volvulus	Protein melted homolog	0.0071	0.0076	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0513	0.1844	0.2763
Echinococcus multilocularis	Pleckstrin y	0.0071	0.0076	0.0114
Echinococcus multilocularis	plexin a4	0.0062	0.004	0.0059
Leishmania major	protein kinase, putative	0.0086	0.0136	0.8434
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0071	0.0076	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.015	0.0074
Schistosoma mansoni	centaurin alpha	0.0071	0.0076	0.0112
Echinococcus multilocularis	protein kinase c epsilon type	0.0849	0.3192	0.4784
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0849	0.3192	0.3192
Echinococcus granulosus	Pleckstrin y	0.0071	0.0076	0.0114
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0071	0.0076	0.0114
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1719	0.6673	0.6647
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	protein kinase c iota type	0.0849	0.3192	0.4784
Brugia malayi	MAX-1A	0.0071	0.0076	0.0075
Echinococcus multilocularis	actin binding protein anillin	0.0071	0.0076	0.0114
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0071	0.0076	0.0114
Echinococcus granulosus	hyperpolarization activated cyclic	0.0101	0.0198	0.0296
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0101	0.0198	0.0296
Schistosoma mansoni	goodpasture antigen-binding protein	0.0071	0.0076	0.0112
Trichomonas vaginalis	protein transport protein sec7, putative	0.0071	0.0076	0.0014
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0148	0.0386	0.0385
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.015	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Treponema pallidum	cyclic nucleotide binding protein	0.0068	0.0063	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0101	0.0198	0.0294
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0513	0.1844	0.1843
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0071	0.0076	0.0014
Treponema pallidum	catabolite gene activator	0.0068	0.0063	0.5
Echinococcus multilocularis	cytohesin 1	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0849	0.3192	0.315
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0068	0.0063	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0068	0.0063	0.0092
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0068	0.0063	0.0092
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0849	0.3192	0.3192
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0089	0.015	0.0132
Treponema pallidum	catabolite gene activator (Crp)	0.0068	0.0063	0.5
Schistosoma mansoni	atypical protein kinase C	0.0849	0.3192	0.4783
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0148	0.0386	0.0579
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0849	0.3192	0.4784
Onchocerca volvulus		0.0071	0.0076	1
Echinococcus granulosus	pdz domain containing protein	0.0071	0.0076	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Schistosoma mansoni	hypothetical protein	0.0071	0.0076	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0071	0.0076	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0445	0.1573	0.1572
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0071	0.0076	0.0022
Schistosoma mansoni	zinc finger protein	0.0071	0.0076	0.0112
Mycobacterium ulcerans	hypothetical protein	0.0068	0.0063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0063	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0071	0.0076	0.0114
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Entamoeba histolytica	hypothetical protein	0.0089	0.015	0.0074
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0068	0.0063	0.8185
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0068	0.0063	0.0092
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.015	0.0074
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0086	0.0136	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0071	0.0076	0.0114
Entamoeba histolytica	protein kinase, putative	0.255	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1719	0.6673	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0089	0.015	0.009
Toxoplasma gondii	AGC kinase	0.2479	0.9715	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0849	0.3192	0.4784
Plasmodium falciparum	cGMP-dependent protein kinase	0.0086	0.0136	0.0116
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0071	0.0076	0.0014
Mycobacterium tuberculosis	Conserved protein	0.0068	0.0063	0.5
Onchocerca volvulus		0.0071	0.0076	1
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	Protein kinase C brain isozyme	0.0849	0.3192	0.4784
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0068	0.0063	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0849	0.3192	0.315
Echinococcus granulosus	Pleckstrin y	0.0071	0.0076	0.0114
Echinococcus multilocularis	rac serine:threonine kinase	0.1719	0.6673	1
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0071	0.0076	0.0114
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0089	0.015	1
Onchocerca volvulus		0.0071	0.0076	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0101	0.0198	0.0296
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0068	0.0063	0.0092
Trypanosoma cruzi	PH domain containing protein, putative	0.0071	0.0076	0.0021
Echinococcus granulosus	NDR protein kinase	0.0849	0.3192	0.4784
Echinococcus granulosus	serine:threonine protein kinase N2	0.0849	0.3192	0.4784
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.1648	0.6388	0.9573
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0086	0.0136	0.0204
Onchocerca volvulus		0.0068	0.0063	0.8185
Brugia malayi	Uncoordinated protein 104	0.0071	0.0076	0.0075
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0071	0.0076	0.0075
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0101	0.0198	0.0294
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0076	0.0022
Brugia malayi	Syntrophin-1	0.0071	0.0076	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	serine threonine protein kinase	0.0849	0.3192	0.4784
Brugia malayi	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus granulosus	calcium dependent secretion activator 1	0.0071	0.0076	0.0114
Schistosoma mansoni	voltage-gated potassium channel	0.056	0.2032	0.3044
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0071	0.0076	0.0022
Loa Loa (eye worm)	rho-GTPase-activating	0.0071	0.0076	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0071	0.0076	0.0114
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0089	0.015	0.0097
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0068	0.0063	0.0094
Leishmania major	protein kinase, putative	0.0086	0.0136	0.8434
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0086	0.0136	0.0076
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.1629	0.6315	0.9464
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Echinococcus granulosus	nervana 2	0.1629	0.6315	0.9464
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0089	0.015	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0071	0.0076	0.0112
Schistosoma mansoni	hypothetical protein	0.0071	0.0076	0.0112
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0071	0.0076	0.0114
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0068	0.0063	0.0092
Schistosoma mansoni	voltage-gated potassium channel	0.0101	0.0198	0.0294
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Onchocerca volvulus		0.0071	0.0076	1
Echinococcus granulosus	Rho GTPase activating protein 24	0.0071	0.0076	0.0114
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0101	0.0198	0.0294
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0071	0.0076	0.0021
Schistosoma mansoni	hypothetical protein	0.0071	0.0076	0.0112
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0071	0.0076	0.0075
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0101	0.0198	0.0296
Echinococcus granulosus	nervana 2	0.1629	0.6315	0.9464
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0071	0.0076	0.0014
Brugia malayi	TBC domain containing protein	0.0071	0.0076	0.0075
Trypanosoma cruzi	PH domain containing protein, putative	0.0071	0.0076	0.0021
Toxoplasma gondii	AtPH1 family protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0849	0.3192	0.4784
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0513	0.1844	0.2763
Trypanosoma cruzi	PH domain containing protein, putative	0.0071	0.0076	0.0021
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0071	0.0076	0.0114
Echinococcus multilocularis	voltage gated potassium channel	0.0148	0.0386	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0068	0.0063	0.0094
Brugia malayi	PH domain containing protein	0.0071	0.0076	0.0075
Brugia malayi	Pleckstrin Homology Domain	0.0071	0.0076	0.0075
Brugia malayi	Cadps2 protein	0.0071	0.0076	0.0075
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0071	0.0076	0.0114
Echinococcus multilocularis	oxysterol binding protein 1	0.0071	0.0076	0.0114
Schistosoma mansoni	dynamin	0.0071	0.0076	0.0112
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0101	0.0198	0.0294
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0136	0.0202
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0068	0.0063	0.0094
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0071	0.0076	0.0075
Echinococcus granulosus	myotubularin protein 13	0.0071	0.0076	0.0114
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0068	0.0063	0.5
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0089	0.015	0.0088
Echinococcus granulosus	protein kinase C gamma type	0.0849	0.3192	0.4784
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0071	0.0076	0.0114
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0089	0.015	0.0097
Trypanosoma brucei	PH domain containing protein, putative	0.0071	0.0076	0.0023
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.1648	0.6388	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0071	0.0076	0.0014
Brugia malayi	Dynamin	0.0071	0.0076	0.0075
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0071	0.0076	0.0075
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0849	0.3192	0.3192
Onchocerca volvulus	Putative zinc finger protein	0.0071	0.0076	1
Echinococcus multilocularis	pdz domain containing protein	0.0071	0.0076	0.0114
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0068	0.0063	0.0092
Plasmodium falciparum	oxysterol-binding protein, putative	0.0071	0.0076	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0849	0.3192	0.3192
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0101	0.0198	0.0196
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0849	0.3192	0.4784
Entamoeba histolytica	protein kinase, putative	0.0089	0.015	0.0074
Echinococcus granulosus	Pleckstrin y	0.0071	0.0076	0.0114
Trypanosoma brucei	protein kinase A regulatory subunit	0.0068	0.0063	0.0009
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0071	0.0076	1
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Trichomonas vaginalis	AGC family protein kinase	0.0849	0.3192	0.315
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0089	0.015	0.0138
Schistosoma mansoni	serine/threonine protein kinase	0.0849	0.3192	0.4783
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0068	0.0063	0.0061
Onchocerca volvulus		0.0071	0.0076	1
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	serine/threonine protein kinase	0.1719	0.6673	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0068	0.0063	0.5
Echinococcus granulosus	plexin a4	0.0062	0.004	0.0059
Loa Loa (eye worm)	AGC/AKT protein kinase	0.255	1	1
Trichomonas vaginalis	centaurin gamma, putative	0.0071	0.0076	0.0014
Trypanosoma cruzi	hypothetical protein	0.0071	0.0076	0.0021
Leishmania major	protein kinase, putative	0.0089	0.015	1
Echinococcus multilocularis	oxysterol binding protein 3	0.0071	0.0076	0.0114
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0849	0.3192	0.4784
Entamoeba histolytica	p21-activated kinase	0.0089	0.015	0.0074
Echinococcus granulosus	dynamin 1	0.0071	0.0076	0.0114
Loa Loa (eye worm)	syntrophin-1	0.0071	0.0076	0.0075
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Entamoeba histolytica	protein kinase, putative	0.2479	0.9715	0.9713
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0386	0.0385
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0068	0.0063	0.0094
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0089	0.015	0.0138
Trichomonas vaginalis	protein transport protein sec7, putative	0.0071	0.0076	0.0014
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0089	0.015	1
Trichomonas vaginalis	kinesin light chain, putative	0.0071	0.0076	0.0014
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0071	0.0076	0.0112
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0479	0.1709	0.1656
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0071	0.0076	0.0114
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0068	0.0063	0.0009
Trypanosoma cruzi	NIMA-related kinase, putative	0.0089	0.015	0.0132
Brugia malayi	Protein kinase domain containing protein	0.0849	0.3192	0.3192
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Loa Loa (eye worm)	Plekhf2 protein	0.0071	0.0076	0.0075
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0071	0.0076	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Leishmania major	protein kinase, putative	0.0089	0.015	1
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0068	0.0063	0.0061
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0068	0.0063	0.5
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0068	0.0063	0.0094
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0089	0.015	0.0132
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0071	0.0076	0.0022
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0849	0.3192	0.4784
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.0921	0.3477	0.3436
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	nervana 2	0.1629	0.6315	0.9464
Schistosoma mansoni	zinc finger protein	0.0071	0.0076	0.0112
Loa Loa (eye worm)	oxysterol binding protein	0.0071	0.0076	0.0075
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0148	0.0386	0.0579
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0071	0.0076	0.0014
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0071	0.0076	0.0021
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0101	0.0198	0.0294
Schistosoma mansoni	voltage-gated potassium channel	0.056	0.2032	0.3044
Trypanosoma brucei	cAMP binding protein, putative	0.0068	0.0063	0.0009
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Brugia malayi	Egg laying defective protein 4	0.0086	0.0136	0.0135
Onchocerca volvulus		0.0068	0.0063	0.8185
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0831	0.3119	0.3076
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0071	0.0076	0.0114
Brugia malayi	protein kinase C II.	0.0849	0.3192	0.3192
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0849	0.3192	0.4784
Echinococcus granulosus	voltage gated potassium channel	0.0148	0.0386	0.0579
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0071	0.0076	0.0112
Schistosoma mansoni	hypothetical protein	0.0068	0.0063	0.0092
Loa Loa (eye worm)	uncoordinated protein 104	0.0071	0.0076	0.0075
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0513	0.1844	0.1843
Brugia malayi	Cytohesin 3	0.0071	0.0076	0.0075
Echinococcus granulosus	oxysterol binding protein 3	0.0071	0.0076	0.0114
Echinococcus multilocularis	Pleckstrin y	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	hyperpolarization activated cyclic	0.0101	0.0198	0.0296
Echinococcus granulosus	serine threonine protein kinase nrc	0.1648	0.6388	0.9573
Toxoplasma gondii	Oxysterol-binding protein	0.0071	0.0076	0.0014
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0071	0.0076	0.0022
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0068	0.0063	0.0061
Schistosoma mansoni	myotubularin-related protein	0.0071	0.0076	0.0112
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0849	0.3192	0.3192
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0071	0.0076	0.0112
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0071	0.0076	0.0114
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0068	0.0063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0071	0.0076	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0198	0.0196
Schistosoma mansoni	syntrophin	0.0071	0.0076	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.1629	0.6315	0.9464
Echinococcus granulosus	Glutaredoxin protein 5	0.1629	0.6315	0.9464
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Echinococcus multilocularis	Oxysterol binding protein 11	0.0071	0.0076	0.0114
Trypanosoma cruzi	PH domain containing protein, putative	0.0071	0.0076	0.0021
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0071	0.0076	0.0021
Entamoeba histolytica	protein kinase, putative	0.0849	0.3192	0.314
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0849	0.3192	0.4784
Schistosoma mansoni	serine/threonine kinase	0.0849	0.3192	0.4783
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0071	0.0076	0.0114
Brugia malayi	Protein kinase domain containing protein	0.0849	0.3192	0.3192
Echinococcus multilocularis	Pleckstrin y	0.0071	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.015	0.0074
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0101	0.0198	0.0296
Plasmodium falciparum	PH domain-containing protein, putative	0.0071	0.0076	0.0022
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.1648	0.6388	0.9573
Brugia malayi	Variant SH3 domain containing protein	0.0071	0.0076	0.0075
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0086	0.0136	0.0204
Trypanosoma cruzi	NIMA-related kinase, putative	0.0089	0.015	0.0132
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0071	0.0076	0.0022
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0089	0.015	0.0097
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0089	0.015	0.0132
Trichomonas vaginalis	hypothetical protein	0.0071	0.0076	0.0014
Schistosoma mansoni	voltage-gated potassium channel	0.0148	0.0386	0.0577
Mycobacterium leprae	Conserved hypothetical protein	0.0068	0.0063	0.5
Mycobacterium ulcerans	transcriptional regulatory protein	0.0068	0.0063	0.5
Echinococcus granulosus	oxysterol binding protein 9	0.0071	0.0076	0.0114
Brugia malayi	Oxysterol binding protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0089	0.015	0.0132
Echinococcus granulosus	protein kinase c epsilon type	0.0849	0.3192	0.4784
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0089	0.015	0.0132
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0089	0.015	0.009
Echinococcus granulosus	oxysterol binding protein 1	0.0071	0.0076	0.0114
Brugia malayi	plexin A	0.0062	0.004	0.0038
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0071	0.0076	0.0022
Trypanosoma brucei	protein kinase, putative	0.0089	0.015	0.0097
Onchocerca volvulus		0.0071	0.0076	1
Schistosoma mansoni	serine/threonine-protein kinase	0.1719	0.6673	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0068	0.0063	0.0092
Entamoeba histolytica	protein kinase 2, putative	0.1648	0.6388	0.636
Trichomonas vaginalis	AGC family protein kinase	0.255	1	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0068	0.0063	0.0092
Leishmania major	folate/biopterin transporter, putative	0.0089	0.015	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0849	0.3192	0.4784
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0136	0.0202
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0086	0.0136	0.0204
Trichomonas vaginalis	centaurin/arf, putative	0.0071	0.0076	0.0014
Schistosoma mansoni	goodpasture antigen-binding protein	0.0071	0.0076	0.0112
Schistosoma mansoni	oxysterol-binding protein 1	0.0071	0.0076	0.0112
Brugia malayi	p70 ribosomal S6 kinase beta	0.2479	0.9715	0.9715
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0849	0.3192	0.3192
Schistosoma mansoni	60S ribosomal protein L21	0.0081	0.0115	0.0171
Brugia malayi	Hr1 repeat family protein	0.0849	0.3192	0.3192
Entamoeba histolytica	protein kinase, putative	0.255	1	1
Echinococcus multilocularis	dynamin 1	0.0071	0.0076	0.0114
Entamoeba histolytica	protein kinase, putative	0.0089	0.015	0.0074
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0086	0.0136	0.0135
Schistosoma mansoni	rho gtpase activating protein	0.0071	0.0076	0.0112
Schistosoma mansoni	voltage-gated potassium channel	0.0148	0.0386	0.0577
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0101	0.0198	0.0196
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0479	0.1709	0.1656
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0068	0.0063	0.5
Echinococcus multilocularis	myotubularin protein 13	0.0071	0.0076	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0063	0.0061
Mycobacterium ulcerans	regulatory protein	0.0068	0.0063	0.5
Leishmania major	serine/threonine-protein kinase a, putative	0.0089	0.015	1
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0068	0.0063	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.015	0.0088
Loa Loa (eye worm)	cytohesin 3	0.0071	0.0076	0.0075
Giardia lamblia	Kinase, AGC PKA	0.1648	0.6388	1
Entamoeba histolytica	protein kinase, putative	0.0089	0.015	0.0074
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0068	0.0063	0.0094
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0068	0.0063	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0101	0.0198	0.0296
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0101	0.0198	0.0136
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0136	0.0202
Entamoeba histolytica	PH domain containing protein kinase, putative	0.1719	0.6673	0.6647
Trichomonas vaginalis	centaurin beta, putative	0.0071	0.0076	0.0014
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0068	0.0063	0.0061
Schistosoma mansoni	hypothetical protein	0.0071	0.0076	0.0112
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0068	0.0063	0.0094
Schistosoma mansoni	oxysterol-binding protein 1	0.0071	0.0076	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Echinococcus multilocularis	beta 1 syntrophin	0.0071	0.0076	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Leishmania major	hypothetical protein, conserved	0.0071	0.0076	0.1566
Mycobacterium ulcerans	hypothetical protein	0.0068	0.0063	0.5
Entamoeba histolytica	protein kinase, putative	0.0089	0.015	0.0074
Trichomonas vaginalis	alpha chimerin, putative	0.0071	0.0076	0.0014
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0101	0.0198	0.0196
Toxoplasma gondii	hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	cGMP dependent protein kinase	0.0086	0.0136	0.0204
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0071	0.0076	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Mycobacterium ulcerans	transmembrane transport protein	0.0068	0.0063	0.5
Entamoeba histolytica	protein kinase, putative	0.0089	0.015	0.0074
Echinococcus granulosus	pleckstrin y domain containing family A	0.0071	0.0076	0.0114
Schistosoma mansoni	hypothetical protein	0.0071	0.0076	0.0112
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0071	0.0076	0.0075
Toxoplasma gondii	hypothetical protein	0.0071	0.0076	0.0014
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0071	0.0076	0.0114
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0101	0.0198	0.0296
Trypanosoma brucei	rac serine-threonine kinase, putative	0.255	1	1
Loa Loa (eye worm)	PH domain-containing protein	0.0071	0.0076	0.0075
Schistosoma mansoni	growth factor receptor-bound protein	0.0071	0.0076	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trypanosoma cruzi	Protein kinase B	0.1719	0.6673	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0071	0.0076	0.0014
Trichomonas vaginalis	centaurin alpha, putative	0.0071	0.0076	0.0014
Brugia malayi	Plekhf2 protein	0.0071	0.0076	0.0075
Brugia malayi	N-terminal motif family protein	0.0068	0.0063	0.0061
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1648	0.6388	0.9569
Echinococcus multilocularis	expressed conserved protein	0.0086	0.0136	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	centaurin/arf, putative	0.0071	0.0076	0.0014
Mycobacterium ulcerans	hypothetical protein	0.0068	0.0063	0.5
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0089	0.015	0.0132
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0101	0.0198	0.0296
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0068	0.0063	0.0092
Echinococcus multilocularis	Glutaredoxin protein 5	0.1629	0.6315	0.9464
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0089	0.015	0.0132
Trypanosoma brucei	cAMP response protein 1, putative	0.0068	0.0063	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0076	0.0075
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0101	0.0198	0.0136
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0089	0.015	0.0132
Brugia malayi	Variant SH3 domain containing protein	0.0071	0.0076	0.0075
Treponema pallidum	cyclic nucleotide binding protein	0.0068	0.0063	0.5
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0068	0.0063	0.0094
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0089	0.015	0.0088
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0071	0.0076	0.0014
Echinococcus granulosus	protein kinase c iota type	0.0849	0.3192	0.4784
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0076	0.0014
Echinococcus granulosus	Oxysterol binding protein 11	0.0071	0.0076	0.0114
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0849	0.3192	0.4784

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1898069

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1584204