TDR Targets

Basic information

Technical information

TDR Targets ID: 158421
Name: N-[2-[4-[[5-oxo-3-propyl-1-[2-(trifluoromethy l)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]ph enyl]sulfonylcyclopropanecarboxamide
MW: 584.609 | Formula: C29H27F3N4O4S
H donors: 1 H acceptors: 4 LogP: 5.15 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)C1CC1)c1ccccc1C(F)(F)F
InChi: 1S/C29H27F3N4O4S/c1-2-7-26-33-36(24-10-5-4-9-23(24)29(30,31)32)28(38)35(26)18-19-12-14-20(15-13-19)22-8-3-6-11-25(22)41(39,40)34-27(37)21-16-17-21/h3-6,8-15,21H,2,7,16-18H2,1H3,(H,34,37)
InChiKey: OILHOKMGGIVWPB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[4-[[5-keto-3-propyl-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylcyclopropanecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Angiotensin II type 2 (AT-2) receptor	Starlite/ChEMBL	References
Oryctolagus cuniculus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	342 aa	24.6 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	364 aa	20.9 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	307 aa	22.5 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	20.9 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	311 aa	23.8 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	27.3 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	25.6 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	305 aa	21.6 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 2 (AT-2) receptor	363 aa	328 aa	22.0 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	333 aa	21.3 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.5 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.2 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	23.1 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.3 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	341 aa	22.0 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	340 aa	24.1 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	335 aa	23.0 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.1 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	356 aa	23.3 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.8 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.4 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II type 1a (AT-1a) receptor	359 aa	342 aa	22.2 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	20.3 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	341 aa	23.2 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	22.1 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	328 aa	20.7 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.1 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II type 1a (AT-1a) receptor	359 aa	295 aa	27.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.3 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	18.2 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	296 aa	23.0 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	310 aa	23.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0044	0.0183	0.0195
Loa Loa (eye worm)	RNA binding protein	0.0471	0.4172	0.4172
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0038	0.0038
Brugia malayi	MH1 domain containing protein	0.0052	0.0254	0.0254
Echinococcus multilocularis	Smad4	0.0052	0.0254	0.0271
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0049	0.023	0.0245
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0025	0	0.5
Brugia malayi	TAR-binding protein	0.0471	0.4172	0.4172
Brugia malayi	hypothetical protein	0.0044	0.0183	0.0183
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0044	0.0183	0.0195
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0044	0.0183	0.0195
Trypanosoma cruzi	PAB1-binding protein , putative	0.011	0.0796	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.011	0.0796	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0052	0.0254	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0183
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0035	0.0101	0.1265
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0044	0.0183	0.0195
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0044	0.0183	1
Loa Loa (eye worm)	G protein alpha subunit 3	0.0044	0.0183	0.0183
Onchocerca volvulus		0.0044	0.0183	0.121
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0044	0.0183	0.0195
Loa Loa (eye worm)	TAR-binding protein	0.0471	0.4172	0.4172
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0044	0.0183	0.0195
Schistosoma mansoni	hypothetical protein	0.0346	0.3007	0.3206
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0025	0	0.5
Echinococcus multilocularis	geminin	0.0498	0.4425	0.4718
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0044	0.0183	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0044	0.0183	0.0195
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1094	1	1
Schistosoma mansoni	hypothetical protein	0.0748	0.6763	0.7211
Echinococcus granulosus	GPCR family 2	0.0346	0.3007	0.3206
Schistosoma mansoni	hypothetical protein	0.0346	0.3007	0.3206
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0044	0.0183	0.0195
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0044	0.0183	0.0195
Onchocerca volvulus		0.0044	0.0183	0.121
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0044	0.0183	0.0183
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0044	0.0183	0.0183
Brugia malayi	MH2 domain containing protein	0.076	0.6879	0.6879
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0044	0.0183	1
Schistosoma mansoni	Smad4	0.0052	0.0254	0.0271
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1027	0.938	1
Echinococcus granulosus	Smad4	0.0052	0.0254	0.0271
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0044	0.0183	0.0183
Brugia malayi	N-terminal motif family protein	0.0186	0.1511	0.1511
Brugia malayi	hypothetical protein	0.0147	0.1141	0.1141
Echinococcus granulosus	geminin	0.0498	0.4425	0.4718
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0044	0.0183	0.0195
Schistosoma mansoni	tar DNA-binding protein	0.0471	0.4172	0.4448
Leishmania major	DNA polymerase eta, putative	0.0035	0.0101	0.1265
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0044	0.0183	1
Brugia malayi	Smad1	0.0052	0.0254	0.0254
Schistosoma mansoni	tar DNA-binding protein	0.0471	0.4172	0.4448
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1027	0.938	1
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0044	0.0183	0.0183
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0096	0.0103
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0471	0.4172	0.4172
Brugia malayi	ImpB/MucB/SamB family protein	0.005	0.0241	0.0241
Echinococcus multilocularis	expressed protein	0.0044	0.0183	0.0195
Leishmania major	DNA polymerase eta, putative	0.005	0.0241	0.3023
Entamoeba histolytica	hypothetical protein	0.0035	0.0096	0.5273
Plasmodium falciparum	ataxin-2 like protein, putative	0.011	0.0796	1
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0044	0.0183	0.0195
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0052	0.0254	0.0271
Brugia malayi	hypothetical protein	0.011	0.0796	0.0796
Schistosoma mansoni	smad1 5 8 and	0.0052	0.0254	0.0271
Brugia malayi	RNA recognition motif domain containing protein	0.0471	0.4172	0.4172
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0044	0.0183	0.0195
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0044	0.0183	0.0183
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0044	0.0183	0.0195
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0044	0.0183	0.0195
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.1027	0.938	0.938
Brugia malayi	latrophilin 2 splice variant baaae	0.0748	0.6763	0.6763
Echinococcus multilocularis	tar DNA binding protein	0.0471	0.4172	0.4448
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1027	0.938	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0346	0.3007	0.3007
Brugia malayi	RNA binding protein	0.0471	0.4172	0.4172
Entamoeba histolytica	hypothetical protein	0.0035	0.0096	0.5273
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0044	0.0183	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0183
Brugia malayi	MH1 domain containing protein	0.0052	0.0254	0.0254
Echinococcus multilocularis	dna polymerase eta	0.005	0.0241	0.0256
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0044	0.0183	0.0183
Onchocerca volvulus		0.0147	0.1141	0.7552
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0044	0.0183	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0052	0.0254	0.0271
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0025	0	0.5
Entamoeba histolytica	hypothetical protein	0.0035	0.0096	0.5273
Echinococcus granulosus	smad	0.0052	0.0254	0.0271
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1094	1	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0044	0.0183	0.0195
Brugia malayi	MH1 domain containing protein	0.0029	0.0038	0.0038
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0346	0.3007	0.3206
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0096	0.0103
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0025	0	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.076	0.6879	0.6879
Giardia lamblia	Hypothetical protein	0.0025	0	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0035	0.0101	0.1265
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.1027	0.938	0.938
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1027	0.938	1
Echinococcus multilocularis	GPCR, family 2	0.0346	0.3007	0.3206
Brugia malayi	MH2 domain containing protein	0.0052	0.0254	0.0254
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0049	0.023	0.0245
Echinococcus multilocularis	smad	0.0052	0.0254	0.0271
Loa Loa (eye worm)	MH2 domain-containing protein	0.0052	0.0254	0.0254
Brugia malayi	hypothetical protein	0.0071	0.0432	0.0432
Schistosoma mansoni	hypothetical protein	0.0346	0.3007	0.3206
Trypanosoma cruzi	DNA polymerase eta, putative	0.005	0.0241	0.3023
Schistosoma mansoni	hypothetical protein	0.0346	0.3007	0.3206
Leishmania major	hypothetical protein, conserved	0.011	0.0796	1
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0044	0.0183	0.0183
Trypanosoma brucei	DNA polymerase eta, putative	0.005	0.0241	0.3023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1027	0.938	1
Entamoeba histolytica	G protein alpha subunit, putative	0.0044	0.0183	1
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0044	0.0183	0.0195
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0044	0.0183	0.0195
Schistosoma mansoni	tar DNA-binding protein	0.0471	0.4172	0.4448
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0346	0.3007	0.3206
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0044	0.0183	0.0195
Brugia malayi	hypothetical protein	0.0035	0.0096	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.011	0.0796	1
Schistosoma mansoni	smad	0.0052	0.0254	0.0271
Brugia malayi	MH1 domain containing protein	0.0029	0.0038	0.0038
Giardia lamblia	DUB-1	0.0025	0	0.5
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0044	0.0183	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0183
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0044	0.0183	0.0183
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0044	0.0183	0.0183
Loa Loa (eye worm)	Smad1	0.0052	0.0254	0.0254
Onchocerca volvulus		0.0044	0.0183	0.121
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0044	0.0183	1
Schistosoma mansoni	smad1 5 8 and	0.0052	0.0254	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1511	0.1511
Plasmodium vivax	ataxin-2 like protein, putative	0.011	0.0796	1
Loa Loa (eye worm)	nuclear factor I	0.0029	0.0038	0.0038
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0044	0.0183	0.0183
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0346	0.3007	0.3206
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0044	0.0183	0.0195
Loa Loa (eye worm)	MH1 domain-containing protein	0.0052	0.0254	0.0254
Echinococcus granulosus	dna polymerase eta	0.005	0.0241	0.0256
Echinococcus granulosus	tar DNA binding protein	0.0471	0.4172	0.4448
Loa Loa (eye worm)	hypothetical protein	0.1094	1	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0796	0.0796
Loa Loa (eye worm)	hypothetical protein	0.005	0.0241	0.0241
Brugia malayi	Latrophilin receptor protein 2	0.0346	0.3007	0.3007
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0044	0.0183	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0096	0.5273
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1141	0.1141
Schistosoma mansoni	hypothetical protein	0.0498	0.4425	0.4718
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1027	0.938	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0096	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0748	0.6763	0.6763
Schistosoma mansoni	DNA polymerase eta	0.005	0.0241	0.0256
Brugia malayi	MH2 domain containing protein	0.0052	0.0254	0.0254
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0346	0.3007	0.3206
Toxoplasma gondii	LsmAD domain-containing protein	0.011	0.0796	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0044	0.0183	0.0195
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0044	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0049	0.023	0.0245
Loa Loa (eye worm)	MH2 domain-containing protein	0.076	0.6879	0.6879
Brugia malayi	G-protein alpha subunit	0.0044	0.0183	0.0183
Echinococcus granulosus	expressed protein	0.0044	0.0183	0.0195
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0186	0.1511	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0346	0.3007	0.3007
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0183
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0096	0.0103
Schistosoma mansoni	tar DNA-binding protein	0.0471	0.4172	0.4448
Schistosoma mansoni	tar DNA-binding protein	0.0471	0.4172	0.4448
Loa Loa (eye worm)	hypothetical protein	0.0346	0.3007	0.3007
Trypanosoma brucei	PAB1-binding protein , putative	0.011	0.0796	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0052	0.0254	0.0271
Echinococcus granulosus	mothers against decapentaplegic 5	0.0052	0.0254	0.0271
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1027	0.938	1
Schistosoma mansoni	hypothetical protein	0.0498	0.4425	0.4718
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0044	0.0183	0.0183
Schistosoma mansoni	smad1 5 8 and	0.0052	0.0254	0.0271
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0044	0.0183	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0795	0.7202	0.7679
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0044	0.0183	0.0195
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0044	0.0183	0.0195

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 18 nM	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	ChEMBL.	8064808
IC50 (binding)	= 18 nM	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	ChEMBL.	8064808
IC50 (binding)	= 410 nM	In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII	ChEMBL.	8064808
IC50 (binding)	= 410 nM	In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII	ChEMBL.	8064808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL319955
PubChem: 10099830

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 158421