Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | fatty acid elongase, putative | 0.0276 | 0.122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0195 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0054 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0195 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0276 | 0.122 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0276 | 0.122 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0054 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2124 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0054 | 0.0054 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2124 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.2124 | 1 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.2124 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.2124 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0276 | 0.122 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.2124 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0276 | 0.122 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0003 | 0.0139 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0195 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0054 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0054 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0054 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0105 | 0.5368 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0054 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0105 | 0.5368 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0054 | 0.2763 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0054 | 0.2763 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0195 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.2124 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.