Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Bradykinin B2 receptor | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Rhodopsin, putative | Bradykinin B2 receptor | 372 aa | 323 aa | 20.4 % |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 323 aa | 20.7 % | |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 383 aa | 20.9 % | |
Schistosoma mansoni | adenoreceptor | Bradykinin B2 receptor | 372 aa | 361 aa | 21.1 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Bradykinin B2 receptor | 372 aa | 335 aa | 22.7 % |
Echinococcus multilocularis | neuropeptide receptor | Bradykinin B2 receptor | 372 aa | 305 aa | 24.6 % |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 305 aa | 24.3 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Bradykinin B2 receptor | 372 aa | 355 aa | 21.4 % |
Echinococcus granulosus | neuropeptide receptor | Bradykinin B2 receptor | 372 aa | 338 aa | 24.0 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bradykinin receptor B2 | 391 aa | 354 aa | 19.2 % |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Bradykinin B2 receptor | 372 aa | 326 aa | 22.7 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Bradykinin B2 receptor | 372 aa | 337 aa | 25.5 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Bradykinin B2 receptor | 372 aa | 339 aa | 23.9 % |
Loa Loa (eye worm) | hypothetical protein | Bradykinin B2 receptor | 372 aa | 311 aa | 23.5 % |
Brugia malayi | putative neuropeptide receptor NPR1 | Bradykinin B2 receptor | 372 aa | 312 aa | 24.0 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Bradykinin B2 receptor | 372 aa | 313 aa | 19.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0071 | 0.0468 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 0.3077 | 0.4528 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.1424 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.1424 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0826 | 0.6796 | 0.6796 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1208 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0071 | 0.0468 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.0468 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.1424 |
Schistosoma mansoni | tar DNA-binding protein | 0.0407 | 0.3288 | 0.4838 |
Schistosoma mansoni | tar DNA-binding protein | 0.0407 | 0.3288 | 0.4838 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.6796 | 0.6796 |
Schistosoma mansoni | hypothetical protein | 0.0826 | 0.6796 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0071 | 0.0468 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0071 | 0.0468 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0407 | 0.3288 | 0.4838 |
Schistosoma mansoni | tar DNA-binding protein | 0.0407 | 0.3288 | 0.4838 |
Brugia malayi | TAR-binding protein | 0.0407 | 0.3288 | 0.3288 |
Echinococcus multilocularis | GPCR, family 2 | 0.0382 | 0.3077 | 0.9359 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0407 | 0.3288 | 0.3288 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0382 | 0.3077 | 0.3077 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0071 | 0.0468 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0407 | 0.3288 | 0.4838 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0071 | 0.0468 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.1424 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0071 | 0.0468 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0382 | 0.3077 | 0.3077 |
Echinococcus multilocularis | tar DNA binding protein | 0.0407 | 0.3288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3077 | 0.3077 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.0689 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0382 | 0.3077 | 0.9359 |
Loa Loa (eye worm) | RNA binding protein | 0.0407 | 0.3288 | 0.3288 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0077 | 0.0077 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 0.3077 | 0.4528 |
Loa Loa (eye worm) | TAR-binding protein | 0.0407 | 0.3288 | 0.3288 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0407 | 0.3288 | 0.3288 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.019 | 0.1469 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0382 | 0.3077 | 0.9359 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0077 | 0.0077 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0071 | 0.0468 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0071 | 0.0468 | 0.1424 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.1424 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0382 | 0.3077 | 0.3077 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0005 | 0.0005 |
Echinococcus granulosus | GPCR family 2 | 0.0382 | 0.3077 | 0.9359 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0071 | 0.0468 | 1 |
Brugia malayi | N-terminal motif family protein | 0.019 | 0.1469 | 0.1469 |
Brugia malayi | RNA binding protein | 0.0407 | 0.3288 | 0.3288 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1208 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 0.3077 | 0.4528 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 0.3077 | 0.4528 |
Echinococcus granulosus | tar DNA binding protein | 0.0407 | 0.3288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1469 | 0.1469 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0382 | 0.3077 | 0.9359 |
Brugia malayi | Isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.0468 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0071 | 0.0468 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0071 | 0.0468 | 0.0468 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0382 | 0.3077 | 0.9359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.68 nM | Inhibition of [3H]-BK (1.0 nM) binding to the human bradykinin receptor B2, expressed in CHO cells | ChEMBL. | 15139763 |
IC50 (binding) | = 0.68 nM | Inhibition of [3H]-BK (1.0 nM) binding to the human bradykinin receptor B2, expressed in CHO cells | ChEMBL. | 15139763 |
IC50 (binding) | = 6.3 nM | Concentration required to inhibit specific binding of [3H]-BK(0.06 nM) to the bradykinin receptor B2 | ChEMBL. | 15139763 |
IC50 (binding) | = 6.3 nM | Concentration required to inhibit specific binding of [3H]-BK(0.06 nM) to the bradykinin receptor B2 | ChEMBL. | 15139763 |
Relative agonistic activity (functional) | = 89.5 % | Relative agonistic activity of the compound (10 uM) induced PGE-2 production in human fibroblast WI-38 cells compared to bradykinin (100 nM) | ChEMBL. | 15139763 |
Relative agonistic activity (functional) | = 89.5 % | Relative agonistic activity of the compound (10 uM) induced PGE-2 production in human fibroblast WI-38 cells compared to bradykinin (100 nM) | ChEMBL. | 15139763 |
Relative agonistic activity (functional) | = 114 % | Relative agonistic activity of the compound (1 uM) induced PGE-2 production in human fibroblast WI-38 cells compared to bradykinin (100 nM) | ChEMBL. | 15139763 |
Relative agonistic activity (functional) | = 114 % | Relative agonistic activity of the compound (1 uM) induced PGE-2 production in human fibroblast WI-38 cells compared to bradykinin (100 nM) | ChEMBL. | 15139763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.