Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | initiation factor 2-associated protein. | 0.0127 | 0.0514 | 0.0513 |
Onchocerca volvulus | 0.0127 | 0.0514 | 0.3687 | |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0206 | 0.1022 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0206 | 0.1022 | 0.1022 |
Toxoplasma gondii | hypothetical protein | 0.0582 | 0.3465 | 0.3111 |
Trypanosoma brucei | Facilitates chromatin transcription complex subunit spt16 | 0.0127 | 0.0514 | 0.0384 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0127 | 0.0514 | 0.3687 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0127 | 0.0514 | 0.0423 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0384 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1589 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3376 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.1233 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0158 | 0.0064 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0133 | 0.0552 | 0.0552 |
Chlamydia trachomatis | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Onchocerca volvulus | 0.0263 | 0.1393 | 1 | |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | Pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.1393 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0423 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0069 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.1007 | 0.6223 | 1 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0127 | 0.0514 | 0.0384 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0263 | 0.1393 | 0.131 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0164 | 0.0749 | 0.6931 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1589 | 1 | 1 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0127 | 0.0514 | 0.0513 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.1007 | 0.6223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1218 | 0.1134 |
Leishmania major | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.1007 | 0.6223 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0181 | 0.0863 | 0.0863 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0091 | 0.028 | 0.1637 |
Entamoeba histolytica | peptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0069 | 0.0134 | 0.0216 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Plasmodium vivax | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3111 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0199 | 0.0982 | 0.9555 |
Treponema pallidum | methionine aminopeptidase (map) | 0.1007 | 0.6223 | 1 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0127 | 0.0514 | 0.0513 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0141 | 0.0604 | 0.5294 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0384 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1589 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1589 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.1589 | 1 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.1007 | 0.6223 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0069 | 0.0134 | 0.004 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0127 | 0.0514 | 0.0423 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0881 | 0.5407 | 0.8689 |
Trypanosoma cruzi | aminopeptidase P, putative | 0.0127 | 0.0514 | 0.0423 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0127 | 0.0514 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.1007 | 0.6223 | 0.6018 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0141 | 0.0604 | 0.5294 |
Onchocerca volvulus | Dipeptidase C homolog | 0.0127 | 0.0514 | 0.3687 |
Toxoplasma gondii | methionine aminopeptidase | 0.1007 | 0.6223 | 0.6018 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1589 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1589 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0164 | 0.0749 | 0.6931 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0582 | 0.3465 | 0.3111 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0127 | 0.0514 | 0.3687 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.1007 | 0.6223 | 1 |
Schistosoma mansoni | peptidase | 0.0127 | 0.0514 | 0.0825 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0133 | 0.0552 | 0.0041 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0127 | 0.0514 | 0.0825 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0206 | 0.1022 | 0.0936 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0582 | 0.3465 | 0.3403 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0206 | 0.1022 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1589 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0387 | 0.2197 | 0.1774 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0206 | 0.1022 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0127 | 0.0514 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.1218 | 0.0742 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0127 | 0.0514 | 0.0423 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0345 | 0.1924 | 0.1847 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0099 | 0.0332 | 0.646 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0127 | 0.0514 | 0.4273 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1007 | 0.6223 | 0.6018 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0552 | 0.0462 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.1007 | 0.6223 | 0.6018 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0387 | 0.2197 | 0.353 |
Entamoeba histolytica | aminopeptidase, putative | 0.0127 | 0.0514 | 0.4273 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.1007 | 0.6223 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0206 | 0.1022 | 1 |
Loa Loa (eye worm) | DNA-binding protein | 0.0127 | 0.0514 | 0.0423 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0881 | 0.5407 | 0.5158 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0127 | 0.0514 | 0.0384 |
Brugia malayi | hypothetical protein | 0.0236 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0514 | 0.0423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 90 nM | Binding affinity of the compound against PCP receptor | ChEMBL. | 1322987 |
Ki (binding) | = 159 nM | Binding affinity of the compound against sigma opioid receptor using [3H]-(+)-3-PPP as radioligand. | ChEMBL. | 1322987 |
Ki (binding) | = 2270 nM | Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand. | ChEMBL. | 1322987 |
Ratio (binding) | = 0.566 | Ratio of binding affinities of pcp receptor(ki(nM)) to sigma opioid receptor(ki(nM)) | ChEMBL. | 1322987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.