Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.8268 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.8268 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4403 | 0.4729 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.8268 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4688 | 0.4688 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.8268 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Plasmodium falciparum | zinc finger protein, putative | 0.0003 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.8268 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4403 | 0.4403 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4688 | 0.5299 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0956 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.8268 | 1 |
Onchocerca volvulus | 0.0029 | 0.4403 | 0.5 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0127 | 0.0127 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4688 | 0.5299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.8268 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0956 | 0.04 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.8268 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4403 | 0.4715 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.8268 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.8268 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.8268 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.8268 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.8268 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.8869 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.8268 | 0.8268 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4688 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.8268 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.8268 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0651 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.8268 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0542 | 0.0635 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.8268 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.8268 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.