Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0839 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0142 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0839 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0839 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0839 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0142 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0901 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0901 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0839 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0839 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0839 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0839 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0142 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0839 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0142 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0839 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0142 | 0 | 0.5 |
Onchocerca volvulus | 0.0142 | 0 | 0.5 | |
Onchocerca volvulus | 0.0142 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0839 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0142 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.