Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.5036 | 0.4797 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.5036 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.5036 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 0.5036 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.5036 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 0.5036 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1286 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.1286 | 0.0866 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1286 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.5036 | 0.4303 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1286 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.5036 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5036 | 0.4303 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5036 | 0.4303 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.5036 | 0.4797 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0079 | 0.5036 | 0.4303 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.5036 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 33.5875 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.