Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.013 | 0.266 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0016 | 0.0016 |
Brugia malayi | TAR-binding protein | 0.0188 | 0.4566 | 0.4566 |
Brugia malayi | RNA binding protein | 0.0188 | 0.4566 | 0.4566 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.6344 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0036 | 0.0036 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0016 | 0.0016 |
Echinococcus granulosus | tar DNA binding protein | 0.0188 | 0.4566 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.21 | 0.4581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.21 | 0.4581 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0036 | 0.0036 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0112 | 0.21 | 0.21 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.21 | 0.4581 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 0.4566 | 0.4558 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.013 | 0.266 | 0.4179 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.21 | 0.4581 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0243 | 0.6344 | 0.6344 |
Echinococcus multilocularis | tar DNA binding protein | 0.0188 | 0.4566 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0074 | 0.0854 | 1 |
Brugia malayi | CD36 family protein | 0.013 | 0.266 | 0.266 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0112 | 0.21 | 0.21 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0355 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.6344 | 0.6338 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0854 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0112 | 0.21 | 0.4581 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0854 | 0.084 |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 0.4566 | 0.4558 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 0.4566 | 0.4566 |
Echinococcus multilocularis | GPCR, family 2 | 0.0112 | 0.21 | 0.4581 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 0.4566 | 0.4558 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.013 | 0.266 | 0.4179 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.013 | 0.266 | 0.581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0112 | 0.21 | 0.2088 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Schistosoma mansoni | cd36 antigen | 0.0049 | 0.0036 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.21 | 0.2088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.013 | 0.266 | 0.4179 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0355 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0016 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.2 nM | Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 3.2 nM | Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 6.6 nM | Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 6.6 nM | Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 8.5 nM | Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 8.5 nM | Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 12 nM | Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 12 nM | Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 446 nM | Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 446 nM | Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 h exposure | ChEMBL. | 9022794 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9022794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.