Detailed information for compound 1585698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.837 | Formula: C19H23ClO4
  • H donors: 0 H acceptors: 1 LogP: 4.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1CC2=C(C(O1)c1ccc(cc1)Cl)C(=O)OC(O2)(C)C
  • InChi: 1S/C19H23ClO4/c1-4-5-6-14-11-15-16(18(21)24-19(2,3)23-15)17(22-14)12-7-9-13(20)10-8-12/h7-10,14,17H,4-6,11H2,1-3H3
  • InChiKey: IGBHDJDWQNUBBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans bacterioferritin BfrA 0.0036 0.0069 0.106
Trypanosoma brucei trypanothione reductase 0.0046 0.0102 0.2012
Schistosoma mansoni lipoxygenase 0.0059 0.0146 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0154 0.0474 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0165 0.0157
Echinococcus multilocularis excitatory amino acid transporter 2 0.0751 0.2536 0.253
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0013 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0017 0.0035
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0333 0.1093 0.1086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0305 0.0916
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0132 0.2659
Treponema pallidum glutamate transporter 0.0333 0.1093 1
Mycobacterium tuberculosis Probable esterase LipL 0.0154 0.0474 0.1423
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0165 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0017 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0782 0.3073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0017 0.0009
Onchocerca volvulus 0.0154 0.0474 0.1816
Echinococcus multilocularis RUN 0.0021 0.0016 0.0008
Brugia malayi MH2 domain containing protein 0.0035 0.0065 0.0224
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0036 0.0069 0.0223
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0009 0.0026
Echinococcus granulosus neutral amino acid transporter A 0.0751 0.2536 0.253
Brugia malayi hypothetical protein 0.0194 0.0615 0.2401
Schistosoma mansoni lipoxygenase 0.0021 0.0016 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0016 0.0277
Schistosoma mansoni ferritin light chain 0.0036 0.0069 0.0061
Chlamydia trachomatis neutral amino acid transporter 0.0333 0.1093 0.4302
Echinococcus granulosus sodium:dicarboxylate symporter 0.0751 0.2536 0.253
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0165 0.1715
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0064 0.0056
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.0507 0.0499
Brugia malayi Excitatory amino acid transporter 0.0751 0.2536 1
Loa Loa (eye worm) Smad1 0.0035 0.0065 0.0243
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0305 0.0916
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0244 0.0236
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0198 0.0627 0.0619
Brugia malayi glutathione reductase 0.0046 0.0102 0.0372
Onchocerca volvulus 0.0035 0.0064 0.019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0017 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0017 0.0055
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0017 0.0009
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0016 0.1012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0333 0.1093 0.1086
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0132 0.2659
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0474 0.5097
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0008 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0277 0.0269
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0751 0.2536 0.253
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0017 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0023 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0102 0.2012
Echinococcus granulosus neutral amino acid transporter A 0.0751 0.2536 0.253
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0751 0.2536 0.253
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0009 0.0005
Echinococcus granulosus survival motor neuron protein 1 0.0489 0.1633 0.1627
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0016 0.0008
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0008 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0065 0.0057
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0013 0.0052
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0016 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0017 0.0009
Brugia malayi nuclear hormone receptor 0.0021 0.0017 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0017 0.0009
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0072 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0023 0.0165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0023 0.0165
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0021
Echinococcus multilocularis neuropeptide s receptor 0.052 0.1739 0.1732
Chlamydia trachomatis glutamate symporter 0.0751 0.2536 1
Schistosoma mansoni aldehyde dehydrogenase 0.0198 0.0627 0.0619
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0023 0.006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0922 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0751 0.2536 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0102 0.2104
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0289 0.1109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0013 0.0093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0194 0.0615 0.0607
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0002
Echinococcus multilocularis excitatory amino acid transporter 2 0.0751 0.2536 0.253
Echinococcus granulosus neuropeptide receptor A26 0.052 0.1739 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0017 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0132 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0422 0.8842
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0064 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.011 0.1572
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0036 0.0069 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0017 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0154 0.0474 1
Echinococcus multilocularis Smad4 0.0035 0.0065 0.0057
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0422 0.6708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0277 0.0269
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0023 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0017 0.0035
Plasmodium vivax SET domain protein, putative 0.0035 0.0064 0.1295
Schistosoma mansoni aldehyde dehydrogenase 0.0198 0.0627 0.0619
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0627 1
Schistosoma mansoni microtubule-associated protein tau 0.2913 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0013 0.0039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0017 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0194 0.0615 0.0607
Onchocerca volvulus 0.0021 0.0017 0.0003
Entamoeba histolytica hypothetical protein 0.0194 0.0615 0.6642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0017 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0017 0.0035
Toxoplasma gondii ABC1 family protein 0.0154 0.0474 0.7506
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0079
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0013 0.0047
Schistosoma mansoni apoferritin-2 0.0036 0.0069 0.0061
Echinococcus granulosus excitatory amino acid transporter 2 0.0751 0.2536 0.253
Trichomonas vaginalis set domain proteins, putative 0.0276 0.0897 0.973
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0474 0.5097
Schistosoma mansoni hypothetical protein 0.01 0.0289 0.0281
Schistosoma mansoni ferritin 0.0036 0.0069 0.0061
Entamoeba histolytica hypothetical protein 0.0194 0.0615 0.6642
Echinococcus multilocularis beta LACTamase domain containing family member 0.0154 0.0474 0.0466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0017 0.0035
Echinococcus multilocularis Excitatory amino acid transporter 0.0751 0.2536 0.253
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0165 0.062
Leishmania major hypothetical protein, conserved 0.0154 0.0474 0.7523
Brugia malayi nuclear receptor NHR-88 0.0021 0.0017 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0013 0.0753
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0013 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0017 0.0055
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0132 0.1944
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0017 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.0321
Echinococcus granulosus Excitatory amino acid transporter 0.0751 0.2536 0.253
Schistosoma mansoni ferritin 0.0036 0.0069 0.0061
Mycobacterium leprae Probable lipase LipE 0.0154 0.0474 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Brugia malayi Cytochrome P450 family protein 0.0037 0.0073 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0017 0.0035
Brugia malayi hypothetical protein 0.0055 0.0132 0.0491
Echinococcus granulosus excitatory amino acid transporter 2 0.0751 0.2536 0.253
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.0507 0.1972
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi Pre-SET motif family protein 0.0243 0.0782 0.3059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0017 0.0009
Echinococcus granulosus Excitatory amino acid transporter 0.0751 0.2536 0.253
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0065 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0064 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0132 0.2743
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0013 0.007
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.002
Echinococcus multilocularis Excitatory amino acid transporter 0.0751 0.2536 0.253
Loa Loa (eye worm) hypothetical protein 0.0055 0.0132 0.051
Trichomonas vaginalis esterase, putative 0.0154 0.0474 0.5097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0188 0.0592 0.2324
Mycobacterium tuberculosis Probable lipase LipE 0.0154 0.0474 0.1423
Brugia malayi beta-lactamase 0.0154 0.0474 0.1842
Brugia malayi hypothetical protein 0.0021 0.0016 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0086
Mycobacterium ulcerans lipase LipD 0.0154 0.0474 0.7545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0064 0.0056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0154 0.0474 0.1423
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0087 0.0244 0.0236
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0016 0.0052
Brugia malayi Doublecortin family protein 0.0021 0.0016 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0277 0.0269
Loa Loa (eye worm) hypothetical protein 0.0051 0.012 0.0462
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0146 0.0138
Onchocerca volvulus 0.0154 0.0474 0.1816
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0017 0.0009
Echinococcus multilocularis neutral amino acid transporter A 0.0751 0.2536 0.253
Schistosoma mansoni polycystin 1-related 0.0021 0.0016 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0132 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0064 0.0056
Schistosoma mansoni hypothetical protein 0.0087 0.0244 0.0236
Schistosoma mansoni hypothetical protein 0.0188 0.0592 0.0584
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0023 0.0321
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0013 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0017 0.0035
Onchocerca volvulus 0.0023 0.0023 0.0028
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0102 0.0391
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0003 0.001
Brugia malayi beta-lactamase family protein 0.0154 0.0474 0.1842
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0017 0.0003
Mycobacterium tuberculosis Conserved protein 0.0154 0.0474 0.1423
Mycobacterium tuberculosis Conserved protein 0.0154 0.0474 0.1423
Loa Loa (eye worm) hypothetical protein 0.0489 0.1633 0.6435
Onchocerca volvulus 0.0276 0.0897 0.3496
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0017 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0017 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0244 0.0932
Mycobacterium tuberculosis Probable lipase LipD 0.0154 0.0474 0.1423
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0751 0.2536 0.7618
Brugia malayi MH1 domain containing protein 0.0035 0.0065 0.0224
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0096 0.0958
Echinococcus multilocularis neutral amino acid transporter A 0.0751 0.2536 0.253
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0627 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0154 0.0474 0.1842
Brugia malayi Smad1 0.0035 0.0065 0.0224
Schistosoma mansoni hypothetical protein 0.0194 0.0615 0.0607
Echinococcus multilocularis excitatory amino acid transporter 3 0.0751 0.2536 0.253
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0922 1
Echinococcus multilocularis neutral amino acid transporter A 0.0751 0.2536 0.253
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.011 0.1572
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0241
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0017 0.0009
Brugia malayi MH2 domain containing protein 0.0514 0.1717 0.6758
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0017 0.0009
Plasmodium falciparum thioredoxin reductase 0.0046 0.0102 0.767
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0305 0.0916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.3359
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0244 0.095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0277 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0102 0.2104
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0017 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0275 0.0892 0.3508
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0023 0.0321
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0102 0.0094
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0016 0.0008
Echinococcus granulosus GPCR family 2 0.0087 0.0244 0.0236
Echinococcus granulosus excitatory amino acid transporter 3 0.0751 0.2536 0.253
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0198 0.0627 0.0619
Brugia malayi MH2 domain containing protein 0.0035 0.0065 0.0224
Leishmania major hypothetical protein, conserved 0.0055 0.0132 0.2
Brugia malayi ecdysteroid receptor 0.0021 0.0017 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0023 0.0237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0017 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0017 0.0055
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0096 0.7163
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0017 0.0009
Toxoplasma gondii thioredoxin reductase 0.0046 0.0102 0.1454
Brugia malayi Thioredoxin reductase 0.0046 0.0102 0.0372
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0036 0.0069 0.0208
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.0491 0.0483
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0345 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0017 0.0035
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0065 0.0243
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0017 0.0035
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0333 0.1093 0.1086
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.012 0.0112
Echinococcus granulosus ferritin 0.0036 0.0069 0.0061
Loa Loa (eye worm) transcription factor SMAD2 0.0514 0.1717 0.6764
Schistosoma mansoni smad 0.0035 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0013 0.0093
Echinococcus multilocularis GPCR, family 2 0.0087 0.0244 0.0236
Brugia malayi MH1 domain containing protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0017 0.0055
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0008 0.002
Schistosoma mansoni Smad4 0.0035 0.0065 0.0057
Toxoplasma gondii aldehyde dehydrogenase 0.0198 0.0627 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0023 0.006
Echinococcus multilocularis microtubule associated protein 2 0.2913 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0275 0.0892 0.3495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0017 0.0055
Loa Loa (eye worm) nuclear factor I 0.0019 0.0011 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0064 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.0321
Brugia malayi hypothetical protein 0.0021 0.0016 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0008 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0013 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0198 0.0627 1
Mycobacterium ulcerans beta-lactamase 0.0154 0.0474 0.7545
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0345 0.1037
Mycobacterium tuberculosis Conserved protein 0.0154 0.0474 0.1423
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0023 0.0321
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0017 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0305 0.0916
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0154 0.0474 0.1423
Loa Loa (eye worm) excitatory amino acid transporter 0.0751 0.2536 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0064 0.0834
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0065 0.0057
Onchocerca volvulus 0.0154 0.0474 0.1816
Schistosoma mansoni hypothetical protein 0.0087 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni rab6-interacting 0.0021 0.0016 0.0008
Mycobacterium ulcerans hypothetical protein 0.0023 0.0023 0.0321
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0073 0.0277
Schistosoma mansoni smad1 5 8 and 0.0035 0.0065 0.0057
Echinococcus multilocularis expressed protein 0.0036 0.0069 0.0061
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0305 0.625
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.011 0.1109
Schistosoma mansoni ferritin light chain 0.0036 0.0069 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0514 0.1717 0.6764
Echinococcus multilocularis ferritin 0.0036 0.0069 0.0061
Echinococcus granulosus tumor protein p63 0.0349 0.1148 0.1141
Treponema pallidum bacterioferrin (TpF1) 0.0036 0.0069 0.0522
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0474 0.5097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0013 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0017 0.0003
Onchocerca volvulus 0.01 0.0289 0.1081
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.3359
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0016 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0009 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0277 0.0269
Onchocerca volvulus 0.0051 0.012 0.0413
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0277 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0064 0.0056
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0023 0.0165
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0009 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0244 0.0236
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0017 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0017 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0474 0.0466
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0029 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0277 0.1081
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0422 0.1267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0017 0.0009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0165 0.0638
Loa Loa (eye worm) hypothetical protein 0.0087 0.0244 0.095
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0489 0.1633 0.1627
Echinococcus multilocularis expressed protein 0.0362 0.1193 0.1186
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0017 0.0009
Plasmodium falciparum glutathione reductase 0.0046 0.0102 0.767
Loa Loa (eye worm) hypothetical protein 0.0275 0.0892 0.3508
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2622 0.8994 0.8993
Schistosoma mansoni survival motor neuron protein 0.01 0.0289 0.0281
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0017 0.0009
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0102 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0474 1
Echinococcus granulosus RUN 0.0021 0.0016 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0002
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0036 0.0069 0.1023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0017 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0017 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0981 0.333 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Loa Loa (eye worm) glutathione reductase 0.0046 0.0102 0.0391
Brugia malayi Calcitonin receptor-like protein seb-1 0.0275 0.0892 0.3495
Mycobacterium ulcerans esterase/lipase LipP 0.0154 0.0474 0.7545
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0751 0.2536 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0023 0.006
Mycobacterium ulcerans bacterioferritin BfrB 0.0036 0.0069 0.106
Echinococcus granulosus neuropeptide s receptor 0.052 0.1739 0.1732
Schistosoma mansoni ferritin 0.0036 0.0069 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0023 0.007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.011 0.2258
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0102 0.0307
Schistosoma mansoni rab6-interacting 0.0021 0.0016 0.0008
Echinococcus granulosus expressed protein 0.0362 0.1193 0.1186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0627 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0023 0.007
Schistosoma mansoni hypothetical protein 0.0021 0.0016 0.0008
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0922 0.8416
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0333 0.1093 0.1086
Brugia malayi hypothetical protein 0.0035 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Brugia malayi Pre-SET motif family protein 0.0035 0.0064 0.0221
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0023 0.0237
Brugia malayi latrophilin 2 splice variant baaae 0.0188 0.0592 0.2309
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0013 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0154 0.0474 0.7545
Loa Loa (eye worm) acetyltransferase 0.0163 0.0507 0.1988
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Entamoeba histolytica hypothetical protein 0.0194 0.0615 0.6642
Trypanosoma brucei hypothetical protein, conserved 0.0154 0.0474 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0277 0.1063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0146 0.0138
Echinococcus granulosus Smad4 0.0035 0.0065 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0194 0.0615 0.0607
Echinococcus granulosus expressed protein 0.0036 0.0069 0.0061
Schistosoma mansoni loxhd1 0.0021 0.0016 0.0008
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0065 0.0057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0065 0.0057
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0013 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0154 0.0474 0.1423
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0017 0.0009
Mycobacterium ulcerans hypothetical protein 0.0154 0.0474 0.7545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0013 0.0093
Schistosoma mansoni apoferritin-2 0.0036 0.0069 0.0061
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0029 0.002
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0072 0.0064
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.0507 0.0499
Leishmania major trypanothione reductase 0.0046 0.0102 0.1514
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0922 1
Echinococcus granulosus smad 0.0035 0.0065 0.0057
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.1739 0.1732
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0016 0.0008
Mycobacterium tuberculosis Probable reductase 0.0105 0.0305 0.0916
Entamoeba histolytica hypothetical protein 0.0194 0.0615 0.6642
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0474 0.5097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0017 0.0035
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.3359
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0008 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0474 0.5097
Brugia malayi beta-lactamase family protein 0.0154 0.0474 0.1842
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0165 0.2527
Treponema pallidum glutamate/aspartate transporter 0.0333 0.1093 1
Brugia malayi MH1 domain containing protein 0.0035 0.0065 0.0224
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0017 0.0055
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0345 0.7144
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0244 0.0932
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0009 0.0005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0198 0.0627 0.1884
Brugia malayi hypothetical protein 0.0489 0.1633 0.6428
Echinococcus multilocularis smad 0.0035 0.0065 0.0057
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0096 0.0954
Schistosoma mansoni hypothetical protein 0.0087 0.0244 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0474 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0244 0.0236
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0017 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.011 0.0101
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0009 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0065 0.0243
Trichomonas vaginalis ferritin, putative 0.0036 0.0069 0.0669
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0023 0.0321
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0154 0.0474 0.1858
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0016 0.0008
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0165 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0017 0.0009
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0751 0.2536 0.253
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0154 0.0474 0.1423
Loa Loa (eye worm) beta-lactamase 0.0154 0.0474 0.1858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Schistosoma mansoni smad1 5 8 and 0.0035 0.0065 0.0057
Echinococcus granulosus neutral amino acid transporter 0.0751 0.2536 0.253
Brugia malayi steroid hormone receptor 0.0021 0.0017 0.0035
Schistosoma mansoni coup transcription factor 0.0021 0.0017 0.0009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0345 0.1037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0017 0.0009
Schistosoma mansoni ferritin 0.0036 0.0069 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.011 0.1109
Echinococcus granulosus beta LACTamase domain containing family member 0.0154 0.0474 0.0466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0017 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0922 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0017 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0017 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0017 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0132 0.2659
Schistosoma mansoni smad1 5 8 and 0.0035 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1858
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0474 0.0466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0079
Echinococcus multilocularis tumor protein p63 0.0349 0.1148 0.1141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0305 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0017 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0277 0.0269

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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