Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | zinc finger protein | 0.0073 | 0.0435 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.9262 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0221 | 0.736 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0133 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0065 | 0.0106 | 0.0114 |
Brugia malayi | Bromodomain containing protein | 0.0142 | 0.3667 | 0.2673 |
Echinococcus granulosus | zinc finger protein | 0.0073 | 0.0435 | 0.0592 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0084 | 0.0947 | 0.1188 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0618 | 0.0774 |
Schistosoma mansoni | bromodomain containing protein | 0.0234 | 0.7978 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0084 | 0.0947 | 0.1287 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0221 | 0.736 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0133 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4087 | 0.4413 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0084 | 0.0947 | 0.1287 |
Echinococcus multilocularis | zinc finger protein | 0.0073 | 0.0435 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4417 | 0.4769 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0105 | 0.1955 | 0.2111 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.3679 | 0.3972 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1585 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.