Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0289 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0289 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0289 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0289 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0289 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0289 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0289 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.