Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peroxidasin | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.