Detailed information for compound 1586633

Basic information

Technical information
  • TDR Targets ID: 1586633
  • Name: N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxo ethyl]-N-methyl-3H-imidazole-4-sulfonamide
  • MW: 381.425 | Formula: C16H20FN5O3S
  • H donors: 1 H acceptors: 4 LogP: 0.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccccc1F)CN(S(=O)(=O)c1c[nH]cn1)C
  • InChi: 1S/C16H20FN5O3S/c1-20(26(24,25)15-10-18-12-19-15)11-16(23)22-8-6-21(7-9-22)14-5-3-2-4-13(14)17/h2-5,10,12H,6-9,11H2,1H3,(H,18,19)
  • InChiKey: CFXVBMDPNXSSGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxo-ethyl]-N-methyl-3H-imidazole-4-sulfonamide
  • N-[2-[4-(2-fluorophenyl)-1-piperazinyl]-2-oxoethyl]-N-methyl-3H-imidazole-4-sulfonamide
  • N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-keto-ethyl]-N-methyl-3H-imidazole-4-sulfonamide
  • MLS000521933
  • SMR000132341

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0102 0.0628 0.0628
Mycobacterium ulcerans formate hydrogenlyase HycD 0.0083 0.0503 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0114 0.0114
Echinococcus granulosus acyl carrier protein mitochondrial 0.0102 0.0628 0.0625
Toxoplasma gondii acyl carrier protein ACP 0.0102 0.0628 1
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.1477 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0036 0.0182 0.0182
Brugia malayi Fli-1 protein 0.006 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0241 0.158 1
Echinococcus multilocularis GA binding protein alpha chain 0.002 0.0069 0.0066
Loa Loa (eye worm) transcription factor SMAD2 0.0103 0.0638 0.0638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0026 0.0114 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.0024 0.002
Brugia malayi hypoxia-induced factor 1 0.0127 0.0803 0.0803
Onchocerca volvulus Fatty acid synthase homolog 0.0102 0.0628 0.1166
Loa Loa (eye worm) runx1 0.0014 0.0027 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0102 0.0628 0.0628
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0102 0.0628 0.3948
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0792 0.533 1
Loa Loa (eye worm) TAR-binding protein 0.0036 0.0182 0.0182
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0102 0.0628 0.0132
Loa Loa (eye worm) fli-1 protein 0.006 0.0344 0.0344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0026 0.0114 0.0111
Echinococcus granulosus AMP dependent ligase 0.0102 0.0628 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.0024 0.0024
Mycobacterium ulcerans Type I modular polyketide synthase 0.0102 0.0628 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.0024 0.0024
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.031 0.2047 0.1932
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.1477 1 1
Brugia malayi bHLH-PAS transcription factor 0.003 0.0142 0.0142
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0108 0.067 0.067
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0102 0.0628 0.0625
Mycobacterium leprae Polyketide synthase Pks13 0.0102 0.0628 0.3948
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0024 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0.1068 0.1065
Brugia malayi hypothetical protein 0.0178 0.1149 0.1149
Brugia malayi Ets-domain containing protein 0.002 0.0069 0.0069
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0102 0.0628 0.0493
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.0024 0.002
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0102 0.0628 0.0132
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0102 0.0628 0.0493
Brugia malayi Serotonin receptor 0.0095 0.0585 0.0585
Echinococcus granulosus single minded 2 0.003 0.0142 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0182 0.0182
Echinococcus granulosus NADH dehydrogenase 0.0102 0.0628 0.0625
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0102 0.0628 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0064 0.0369 0.0369
Echinococcus granulosus FTZ F1 alpha 0.0013 0.0024 0.002
Brugia malayi Pre-SET motif family protein 0.0051 0.028 0.028
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0011 0.0007 0.0004
Chlamydia trachomatis acyl carrier protein 0.0102 0.0628 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0102 0.0628 0.0132
Schistosoma mansoni hypothetical protein 0.0198 0.1287 0.1287
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Onchocerca volvulus 0.0108 0.067 0.1244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0024 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0013 0.0024 0.0031
Brugia malayi ecdysteroid receptor 0.0013 0.0024 0.0024
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0102 0.0628 0.0493
Brugia malayi hypothetical protein 0.0138 0.0876 0.0876
Toxoplasma gondii type I fatty acid synthase, putative 0.0102 0.0628 1
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0102 0.0628 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.0024 0.0024
Brugia malayi hypothetical protein 0.0014 0.0032 0.0032
Mycobacterium ulcerans polyketide synthase 0.0102 0.0628 0.0493
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.0024 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0026 0.0114 0.0114
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.1477 1 1
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0182 0.0182
Echinococcus multilocularis tar DNA binding protein 0.0036 0.0182 0.0179
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0369 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.0024 0.0024
Mycobacterium ulcerans acyl carrier protein 0.0102 0.0628 0.0493
Schistosoma mansoni aryl hydrocarbon receptor 0.0041 0.0215 0.0215
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.1477 1 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0102 0.0628 0.0132
Schistosoma mansoni hypothetical protein 0.0036 0.0182 0.0182
Plasmodium vivax acyl carrier protein, putative 0.0102 0.0628 1
Onchocerca volvulus 0.0058 0.0328 0.0602
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0102 0.0628 0.0132
Schistosoma mansoni gabp alpha 0.002 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Echinococcus granulosus survival motor neuron protein 1 0.0178 0.1149 0.1146
Schistosoma mansoni microtubule-associated protein tau 0.0182 0.1172 0.1172
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0102 0.0628 0.0132
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.0102 0.0628 0.0493
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0102 0.0628 0.0493
Mycobacterium ulcerans polyketide synthase Pks13 0.0102 0.0628 0.0493
Brugia malayi nuclear receptor NHR-88 0.0013 0.0024 0.0024
Mycobacterium ulcerans polyketide synthase 0.0102 0.0628 0.0493
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.0024 0.002
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0628 0.0628
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0628 0.0132
Plasmodium falciparum acyl carrier protein 0.0102 0.0628 1
Echinococcus granulosus geminin 0.0198 0.1287 0.1283
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.0024 0.0024
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0011 0.0007 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0102 0.0628 0.0493
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0628 0.0132
Schistosoma mansoni acyl carrier protein 0.0102 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Echinococcus multilocularis AMP dependent ligase 0.0102 0.0628 0.0625
Loa Loa (eye worm) hypothetical protein 0.0064 0.0369 0.0369
Brugia malayi nuclear hormone receptor 0.0013 0.0024 0.0024
Brugia malayi bZIP transcription factor family protein 0.0016 0.0043 0.0043
Schistosoma mansoni NADH dehydrogenase subunit 1 0.0083 0.0503 0.0503
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.031 0.2047 0.1625
Schistosoma mansoni hypothetical protein 0.0198 0.1287 0.1287
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.1477 1 1
Schistosoma mansoni amine GPCR 0.0071 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0147
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0102 0.0628 0.0493
Brugia malayi RNA binding protein 0.0036 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0013 0.0022 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.0024 0.0024
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.1477 1 1
Brugia malayi MH2 domain containing protein 0.0103 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0141
Loa Loa (eye worm) acyl carrier protein 0.0102 0.0628 0.0628
Echinococcus granulosus jun protein 0.0016 0.0043 0.0039
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.1477 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0147
Mycobacterium leprae Probable polyketide synthase Pks1 0.0102 0.0628 0.3948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0102 0.0628 0.0132
Brugia malayi Phosphopantetheine attachment site family protein 0.0102 0.0628 0.0628
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.0024 0.0024
Onchocerca volvulus 0.0036 0.0182 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0102 0.0628 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0014 0.003 0.003
Schistosoma mansoni transcription factor LCR-F1 0.001 0.0004 0.0004
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.1477 1 1
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0628 0.0628
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0141 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.0024 0.0024
Echinococcus multilocularis aryl hydrocarbon receptor 0.0011 0.0007 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0024 0.0024
Echinococcus granulosus NADH dehydrogenase subunit 1 0.031 0.2047 0.2044
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0102 0.0628 0.3948
Echinococcus multilocularis geminin 0.0198 0.1287 0.1283
Leishmania major acyl carrier protein, putative 0.0102 0.0628 0.0621
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0102 0.0628 0.0132
Schistosoma mansoni hypothetical protein 0.031 0.2047 0.2047
Onchocerca volvulus Huntingtin homolog 0.0031 0.0147 0.0262
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.0024 0.002
Schistosoma mansoni lozenge 0.0014 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0114 0.0114
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.0024 0.002
Onchocerca volvulus 0.0013 0.0024 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0102 0.0628 0.3948
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0051 0.028 0.028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0024 0.0024
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0102 0.0628 0.3948
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0102 0.0628 0.0493
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.0024 0.0024
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0102 0.0628 0.0493
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0013 0.0024 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.0024 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0237 0.1547 0.1544
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0182 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0182 0.0182
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0102 0.0628 0.0628
Echinococcus multilocularis microtubule associated protein 2 0.0182 0.1172 0.1169
Schistosoma mansoni single-minded 0.0041 0.0215 0.0215
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0102 0.0628 0.0132
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.031 0.2047 0.1513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0102 0.0628 0.0598
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0141
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.1477 1 1
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0628 0.3948
Loa Loa (eye worm) hypothetical protein 0.0102 0.0628 0.0628
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0178 0.1149 0.1149
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0024 0.0024
Mycobacterium ulcerans proteasome PrcA 0.0241 0.158 0.1459
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0032 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.0013 0.0024 0.0031
Onchocerca volvulus 0.0083 0.0503 0.0931
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0013 0.0024 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0016 0.0043 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.0024 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0026 0.0114 0.0114
Loa Loa (eye worm) RNA binding protein 0.0036 0.0182 0.0182
Echinococcus multilocularis serotonin receptor 0.003 0.0141 0.0138
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0102 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0108 0.067 0.067
Toxoplasma gondii type I fatty acid synthase, putative 0.0102 0.0628 1
Treponema pallidum nitrogen fixation protein (rnfC) 0.0329 0.2178 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0014 0.003 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0102 0.0628 0.0493
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0024
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0102 0.0628 0.0493
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.1477 1 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.002 0.0069 0.0069
Echinococcus multilocularis transfer RNA-Lys 0.003 0.0142 0.0139
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0102 0.0628 0.0628
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.0024 0.0024
Mycobacterium ulcerans polyketide synthase Pks9 0.0102 0.0628 0.0493
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0102 0.0628 0.0132
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.0628 1
Brugia malayi PAS domain containing protein 0.0041 0.0215 0.0215
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0638 0.0638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0026 0.0114 0.0111
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0102 0.0628 0.0132
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0102 0.0628 0.0132
Echinococcus granulosus aryl hydrocarbon receptor 0.0011 0.0007 0.0004
Echinococcus granulosus GA binding protein alpha chain 0.002 0.0069 0.0066
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0102 0.0628 0.0132
Echinococcus multilocularis NADH dehydrogenase 0.0102 0.0628 0.0625
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.0024 0.002
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0102 0.0628 0.0628
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.0628 0.0493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.0024 0.002
Brugia malayi NADH dehydrogenase subunit 1 0.0083 0.0503 0.0503
Onchocerca volvulus 0.0083 0.0503 0.0931
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0102 0.0628 0.0628
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.1477 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.0024 0.0024
Onchocerca volvulus 0.003 0.0142 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.0024 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.0024 0.002
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0182 0.0182
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0102 0.0628 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0024 0.002
Brugia malayi RNA recognition motif domain containing protein 0.0036 0.0182 0.0182
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0102 0.0628 1
Echinococcus multilocularis conserved hypothetical protein 0.0133 0.084 0.0837
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0016 0.0043 0.0039
Onchocerca volvulus 0.0102 0.0628 0.1166
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0102 0.0628 0.1166
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0024 0.0024
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.1477 1 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0127 0.0803 0.0803
Echinococcus granulosus hypothetical protein 0.014 0.0887 0.0883
Mycobacterium ulcerans membrane protein ComEA 0.0329 0.2178 0.2065
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0058 0.0328 0.032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.0024 0.002
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0102 0.0628 0.0132
Mycobacterium ulcerans acyl carrier protein 0.0102 0.0628 0.0493
Loa Loa (eye worm) acyl carrier protein 0.0102 0.0628 0.0628
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.0083 0.0503 0.0503
Schistosoma mansoni jun-related protein 0.0013 0.0022 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.0024 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0141 0.0141
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.1477 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0329 0.2178 0.1764
Loa Loa (eye worm) hypothetical protein 0.0138 0.0876 0.0876
Echinococcus multilocularis serotonin receptor 0.003 0.0141 0.0138
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.1477 1 1
Brugia malayi NADH dehydrogenase subunit 1, identical 0.0083 0.0503 0.0503
Brugia malayi Ets-domain containing protein 0.002 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.0024 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.0628 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0102 0.0628 0.0132
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0102 0.0628 0.3948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.0024 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.0024 0.002
Schistosoma mansoni ets-related 0.006 0.0344 0.0344
Schistosoma mansoni survival motor neuron protein 0.0036 0.0182 0.0182
Echinococcus granulosus tar DNA binding protein 0.0036 0.0182 0.0179
Echinococcus granulosus microtubule associated protein 2 0.0182 0.1172 0.1169
Onchocerca volvulus Huntingtin homolog 0.0031 0.0147 0.0262
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0241 0.158 0.1134
Leishmania major hypothetical protein, conserved 0.0014 0.0032 0.0024
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0102 0.0628 0.0132
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0102 0.0628 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0026 0.0114 0.0111
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0102 0.0628 1
Brugia malayi steroid hormone receptor 0.0013 0.0024 0.0024
Mycobacterium ulcerans polyketide synthase MbtD 0.0102 0.0628 0.0493
Onchocerca volvulus 0.0102 0.0628 0.1166
Brugia malayi hypothetical protein 0.0108 0.067 0.067
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0032 0.0024
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0102 0.0628 0.0132
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.0024 0.0024
Onchocerca volvulus 0.0102 0.0628 0.1166
Echinococcus multilocularis survival motor neuron protein 1 0.0178 0.1149 0.1146
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0032
Brugia malayi hypothetical protein 0.0083 0.0503 0.0503
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0.1068 0.1065
Brugia malayi TAR-binding protein 0.0036 0.0182 0.0182
Echinococcus multilocularis jun protein 0.0016 0.0043 0.0039
Onchocerca volvulus 0.0012 0.002 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0024 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0014 0.003 0.003
Brugia malayi hypothetical protein 0.0012 0.002 0.002
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0102 0.0628 0.0621
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0102 0.0628 0.3948
Brugia malayi hypothetical protein 0.0031 0.0147 0.0147
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0102 0.0628 0.3948
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0102 0.0628 0.3948
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0024 0.002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0102 0.0628 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0026 0.0114 0.0114
Mycobacterium ulcerans Type I modular polyketide synthase 0.0102 0.0628 0.0493
Schistosoma mansoni coup transcription factor 0.0013 0.0024 0.0024
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0102 0.0628 0.0493
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0102 0.0628 0.0132
Echinococcus multilocularis Protein lozenge 0.0014 0.0027 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.0024 0.0024

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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