Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.184 | 0.184 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0312 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0312 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.184 | 0.184 |
Mycobacterium ulcerans | proteasome PrcB | 0.0312 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0312 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.184 | 0.184 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.184 | 0.184 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.184 | 0.184 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.184 | 0.184 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.184 | 0.184 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0312 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.184 | 0.184 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0312 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1275 | 0.1275 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4189 | 0.4189 |
Onchocerca volvulus | Notchless protein homolog | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0312 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1275 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1275 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0613 | 0.0613 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0312 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0312 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.184 | 0.184 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0312 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0312 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.184 | 0.184 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4189 | 0.4189 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0312 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.184 | 0.184 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0312 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0312 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0312 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0613 | 0.0613 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0312 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.184 | 0.184 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4189 | 0.4189 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.184 | 0.184 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1275 | 0.1275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3548 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.