TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.536 | Formula: C24H32N4O3
H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nc2n(c1N(CCC(C)C)C)cc(cc2)C(=O)Nc1ccc(c(c1)OC)OC
InChi: 1S/C24H32N4O3/c1-7-19-24(27(4)13-12-16(2)3)28-15-17(8-11-22(28)26-19)23(29)25-18-9-10-20(30-5)21(14-18)31-6/h8-11,14-16H,7,12-13H2,1-6H3,(H,25,29)
InChiKey: FOBCIBFUMRVCON-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	Rap guanine nucleotide exchange factor (GEF) 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131726	All targets in OG5_131726
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	Get druggable targets OG5_131726	All targets in OG5_131726
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	N-terminal motif family protein	Get druggable targets OG5_131726	All targets in OG5_131726

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0017	0.0444	0.5
Brugia malayi	MH2 domain containing protein	0.0144	0.6311	0.6305
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0017	0.0444	0.0427
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0017	0.0444	0.0289
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0117	0.0117
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0159	0.0142
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0224	1	1
Echinococcus multilocularis	smad	0.001	0.0117	0.01
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0117	0.01
Echinococcus multilocularis	Smad4	0.001	0.0117	0.01
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0117	0.01
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0017	0.0444	0.0427
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0017	0.0444	0.0427
Plasmodium falciparum	proteasome subunit beta type-5	0.0224	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0017	0.0444	0.0427
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0017	0.0444	0.0427
Brugia malayi	MH1 domain containing protein	0.001	0.0117	0.01
Loa Loa (eye worm)	hypothetical protein	0.0218	0.9715	0.9714
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0017	0.0444	0.0444
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0017	0.0444	0.0427
Echinococcus granulosus	proteasome subunit alpha type 6	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0017	0.0444	0.0427
Brugia malayi	Smad1	0.001	0.0117	0.01
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0017	0.0444	0.0427
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0159	0.0142
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0017	0.0444	0.0427
Schistosoma mansoni	z-protein (S1r protein)	0.0011	0.0159	0.0159
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0017	0.0444	0.0444
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Echinococcus granulosus	segment polarity protein dishevelled	0.0011	0.0159	0.0142
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0017	0.0444	0.0427
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0017	0.0017
Brugia malayi	proteasome subunit alpha type 2	0.0017	0.0444	0.0427
Toxoplasma gondii	peptidase, T1 family protein	0.0017	0.0444	0.0289
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0017	0.0444	0.0289
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0017	0.0444	0.0444
Toxoplasma gondii	proteasome beta subunit	0.0017	0.0444	0.0289
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0017	0.0444	0.0427
Brugia malayi	20S proteasome alpha5 subunit	0.0017	0.0444	0.0427
Echinococcus granulosus	Smad4	0.001	0.0117	0.01
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0017	0.0444	0.0289
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0224	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0011	0.0159	0.0159
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0017	0.0444	0.0444
Onchocerca volvulus		0.0011	0.0159	0.0146
Loa Loa (eye worm)	Smad1	0.001	0.0117	0.01
Mycobacterium ulcerans	proteasome PrcB	0.0224	1	1
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Brugia malayi	regulator of G-protein signaling egl-10	0.0011	0.0159	0.0142
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0117	0.01
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0017	0.0444	0.0444
Brugia malayi	proteasome subunit alpha type 4	0.0017	0.0444	0.0427
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0011	0.0159	0.0142
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0224	1	1
Schistosoma mansoni	smad	0.001	0.0117	0.0117
Brugia malayi	Proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Leishmania major	proteasome beta 5 subunit, putative	0.0224	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0017	0.0444	0.0444
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0017	0.0444	0.0427
Brugia malayi	Proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Loa Loa (eye worm)	DIX domain-containing protein	0.0011	0.0159	0.0142
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0017	0.0444	0.0427
Brugia malayi	Proteasome subunit alpha type 7-1	0.0017	0.0444	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0159	0.0142
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0017	0.0444	0.0427
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.6311	0.6305
Schistosoma mansoni	dishevelled	0.0011	0.0159	0.0159
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0017	0.0444	0.0427
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0017	0.0444	0.0444
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0017	0.0444	0.0427
Brugia malayi	MH2 domain containing protein	0.001	0.0117	0.01
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0117	0.01
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Brugia malayi	proteasome subunit alpha type 3	0.0017	0.0444	0.0427
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0017	0.0444	0.0444
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0159	0.0142
Schistosoma mansoni	ras GTP exchange factor	0.0008	0.0017	0.0017
Brugia malayi	proteasome subunit beta type 3	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0017	0.0444	0.0444
Echinococcus multilocularis	segment polarity protein dishevelled	0.0011	0.0159	0.0142
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0017	0.0444	0.0427
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0011	0.0159	0.0142
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0011	0.0159	0.0142
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0017	0.0444	0.0427
Brugia malayi	N-terminal motif family protein	0.0218	0.9715	0.9714
Brugia malayi	Proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0017	0.0444	0.0427
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0017	0.0444	0.0289
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0008	0.0017	0.0017
Echinococcus granulosus	Proteasome subunit alpha beta	0.0017	0.0444	0.0427
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0011	0.0159	0.0142
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0017	0.0444	0.0427
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0017	0.0444	0.0427
Schistosoma mansoni	smad1 5 8 and	0.001	0.0117	0.0117
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0017	0.0444	0.0289
Echinococcus granulosus	proteasome subunit beta type 7	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0017	0.0444	0.0427
Brugia malayi	DIX domain containing protein	0.0011	0.0159	0.0142
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Echinococcus granulosus	proteasome subunit beta t family	0.0017	0.0444	0.0427
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0224	1	1
Brugia malayi	MH2 domain containing protein	0.001	0.0117	0.01
Schistosoma mansoni	smad1 5 8 and	0.001	0.0117	0.0117
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0017	0.0444	0.0427
Brugia malayi	Proteasome subunit alpha type 1	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Brugia malayi	hypothetical protein	0.0011	0.0159	0.0142
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0159	0.0159
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit beta type, putative	0.0224	1	1
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0017	0.0444	0.0427
Echinococcus multilocularis	proteasome subunit beta type 7	0.0017	0.0444	0.0427
Echinococcus granulosus	proteasome subunit alpha type 2	0.0017	0.0444	0.0427
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0011	0.0159	0.0142
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0017	0.0444	0.0427
Schistosoma mansoni	smad1 5 8 and	0.001	0.0117	0.0117
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0017	0.0444	0.0444
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0017	0.0444	0.0427
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0218	0.9715	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0117	0.01
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0017	0.0444	0.0289
Brugia malayi	hypothetical protein	0.0011	0.0159	0.0142
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	Smad4	0.001	0.0117	0.0117
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0224	1	1
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0017	0.0444	0.0444
Loa Loa (eye worm)	PAS-3 protein	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	dep domain containing protein	0.0011	0.0159	0.0159
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0017	0.0444	0.0427
Brugia malayi	proteasome subunit alpha type 6	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0017	0.0444	0.0427
Brugia malayi	proteasome subunit alpha type 1	0.0017	0.0444	0.0427
Onchocerca volvulus	Notchless protein homolog	0.0017	0.0444	0.044
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0159	0.0142
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0017	0.0444	0.0427
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0224	1	1
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0017	0.0444	0.0289
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0017	0.0444	0.0427
Brugia malayi	MH1 domain containing protein	0.001	0.0117	0.01
Echinococcus multilocularis	segment polarity protein dishevelled	0.0011	0.0159	0.0142
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0017	0.0444	0.0427
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0017	0.0444	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0159	0.0142
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0224	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.6311	0.6305
Echinococcus granulosus	smad	0.001	0.0117	0.01
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0224	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0017	0.0444	0.0444
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0017	0.0444	0.0427
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0117	0.01
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0017	0.0444	0.0444
Echinococcus granulosus	proteasome subunit beta type 6	0.0017	0.0444	0.0427
Brugia malayi	proteasome subunit beta type 2	0.0017	0.0444	0.0427
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0017	0.0444	0.0427
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0017	0.0444	0.0427
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0224	1	1
Echinococcus multilocularis	proteasome subunit beta type 6	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0224	1	1
Echinococcus granulosus	proteasome prosome macropain	0.0224	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0017	0.0444	0.0444
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0017	0.0444	0.0444
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0017	0.0444	0.0289
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0017	0.0444	0.0427
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Toxoplasma gondii	heat shock protein hslv, putative	0.0017	0.0444	0.0289
Echinococcus granulosus	segment polarity protein dishevelled	0.0011	0.0159	0.0142
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0224	1	1
Brugia malayi	proteasome subunit beta type 1	0.0017	0.0444	0.0427
Toxoplasma gondii	proteasome subunit	0.0017	0.0444	0.0289
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0017	0.0017
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0017	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0159	0.0142
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0017	0.0444	0.0289
Schistosoma mansoni	dishevelled	0.0011	0.0159	0.0159
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0017	0.0444	0.0427
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0017	0.0444	0.0444
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0017	0.0444	0.0444
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0224	1	1
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0017	0.0017
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0017	0.0444	0.0427
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0017	0.0444	0.0427
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0017	0.0444	0.0427
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0011	0.0159	0.0146
Trypanosoma cruzi	20S proteasome subunit	0.0017	0.0444	0.0427
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0017	0.0444	0.0427
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0017	0.0444	0.0427
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0017	0.0444	0.0427

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1897969

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1586703