Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0357 | 0.2534 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0101 | 0.0101 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0974 | 0.8937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.8937 | 0.8937 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.081 | 0.7236 | 0.7236 |
Brugia malayi | Trypsin family protein | 0.0974 | 0.8937 | 0.8878 |
Onchocerca volvulus | 0.0974 | 0.8937 | 1 | |
Schistosoma mansoni | integrin alpha-ps | 0.0123 | 0.0101 | 0.0113 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0974 | 0.8937 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0797 | 0.7104 | 1 |
Schistosoma mansoni | integrin alpha | 0.0526 | 0.4282 | 0.4792 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.311 | 0.311 |
Echinococcus multilocularis | integrin alpha ps | 0.0236 | 0.1273 | 0.1792 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0164 | 0.0525 | 0.0525 |
Echinococcus multilocularis | integrin alpha 3 | 0.0403 | 0.3009 | 0.4236 |
Schistosoma mansoni | integrin beta subunit | 0.0634 | 0.5407 | 0.605 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0525 | 0.0525 |
Echinococcus granulosus | integrin beta 2 | 0.0797 | 0.7104 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.1092 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.8937 | 0.8937 |
Echinococcus granulosus | integrin alpha ps | 0.0236 | 0.1273 | 0.1792 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0398 | 0.2954 | 0.2563 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.1092 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2954 | 0.2954 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0357 | 0.2534 | 0.5 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0139 | 0.0271 | 0.5 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0357 | 0.2534 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0357 | 0.2534 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0139 | 0.0271 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0236 | 0.1273 | 0.1792 |
Echinococcus granulosus | integrin alpha 3 | 0.0403 | 0.3009 | 0.4236 |
Loa Loa (eye worm) | integrin beta-2 | 0.1076 | 1 | 1 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.1092 | 0.3627 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.1092 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0526 | 0.4282 | 0.3965 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0139 | 0.0271 | 0.0303 |
Schistosoma mansoni | integrin alpha-ps | 0.0236 | 0.1273 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.1837 | 0.1837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 uM | Tested for the inhibition against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase | ChEMBL. | No reference |
IC50 (binding) | = 150 uM | Tested for the inhibition against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase | ChEMBL. | No reference |
Kd (binding) | uM | Tested for the dissociation constant against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
Kd (binding) | ND 0 uM | Tested for the dissociation constant against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
Ki (binding) | = 78 uM | Tested for the inhibition against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase versus phosphoenolpyruvate | ChEMBL. | No reference |
Ki (binding) | = 78 uM | Tested for the inhibition against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase versus phosphoenolpyruvate | ChEMBL. | No reference |
Koff (binding) | ND 0 s-1 | Tested for the dissociation rate against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
Kon (binding) | ND 0 uM-1 s-1 | Tested for the rate of association against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
k_off (binding) | s-1 | Tested for the dissociation rate against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
k_on (binding) | uM-1 s-1 | Tested for the rate of association against E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase ; Not determined. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.