Detailed information for compound 1586966

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.582 | Formula: C19H37N3S
  • H donors: 1 H acceptors: 0 LogP: 4.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H]([C@H]1CNC(=S)N1CC1CCN(CC1)CCC(C)(C)C)C
  • InChi: 1S/C19H37N3S/c1-6-15(2)17-13-20-18(23)22(17)14-16-7-10-21(11-8-16)12-9-19(3,4)5/h15-17H,6-14H2,1-5H3,(H,20,23)/t15-,17+/m0/s1
  • InChiKey: XIKKLTHWXDMFRI-DOTOQJQBSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0334 0.1074
Loa Loa (eye worm) hypothetical protein 0.0056 0.0397 0.1063
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1285 0.3441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Entamoeba histolytica cysteine protease, putative 0.027 0.2656 1
Plasmodium falciparum serine repeat antigen 7 0.005 0.0334 0.0989
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0211 0.0601
Echinococcus multilocularis raf serine:threonine protein kinase 0.0255 0.2506 0.2885
Giardia lamblia Cysteine protease 0.005 0.0334 0.1453
Echinococcus granulosus cysteine protease 0.0139 0.1275 0.1469
Echinococcus multilocularis cathepsin b 0.005 0.0334 0.0384
Leishmania major cathepsin L-like protease 0.0965 1 1
Giardia lamblia Cysteine protease 0.005 0.0334 0.1453
Entamoeba histolytica cysteine proteinase, putative 0.027 0.2656 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0176 0.0122
Schistosoma mansoni hypothetical protein 0.0025 0.0072 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.1715 0.6381
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.1978 0.7369
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0379 0.1427
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Toxoplasma gondii cathepsin B 0.005 0.0334 0.0989
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0334 0.1074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0877 0.235
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0211 0.0813
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Plasmodium vivax vivapain-3 0.0139 0.1275 0.4642
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.027 0.2656 0.7116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.1275 0.4693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0876 0.9058 0.9053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1095 0.1261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Plasmodium falciparum serine repeat antigen 3 0.005 0.0334 0.0989
Entamoeba histolytica cysteine proteinase, putative 0.0139 0.1275 0.4693
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Brugia malayi intermediate filament protein 0.0032 0.0148 0.0559
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0139 0.1275 0.3416
Loa Loa (eye worm) hypothetical protein 0.0054 0.0379 0.1015
Echinococcus multilocularis cathepsin b 0.005 0.0334 0.0384
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0391 0.1473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0391 0.1048
Plasmodium falciparum serine repeat antigen 2 0.005 0.0334 0.0989
Schistosoma mansoni cathepsin F (C01 family) 0.027 0.2656 0.7116
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0334 0.0894
Plasmodium vivax vivapain-2 0.027 0.2656 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0877 0.3302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1372 0.3676
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.0334 0.1074
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.0334 0.0989
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Loa Loa (eye worm) raf kinase 0.0253 0.2475 0.663
Plasmodium falciparum serine repeat antigen 1 0.005 0.0334 0.0989
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0211 0.0813
Echinococcus granulosus snurportin 1 0.0372 0.3733 0.4299
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Toxoplasma gondii cathepsin CPC1 0.005 0.0334 0.0989
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0054 0.0062
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0334 0.0281
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0605 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.1978 0.7394
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0303 0.0349
Toxoplasma gondii cathepsin CPC2 0.005 0.0334 0.0989
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.1978 0.5299
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Brugia malayi Phosphoglycerate kinase 0.0075 0.0605 0.2277
Loa Loa (eye worm) cysteine protease 0.027 0.2656 0.7116
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.1978 0.7394
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0054 0.0145
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0106 0.02
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0334 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.0334 0.1074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.075 0.2008
Trypanosoma cruzi cysteine peptidase, putative 0.027 0.2656 0.2616
Entamoeba histolytica cysteine proteinase 2 0.0139 0.1275 0.4693
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1285 0.3441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.1032 0.1188
Plasmodium falciparum cysteine proteinase falcipain 3 0.027 0.2656 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0397 0.1234
Schistosoma mansoni hypothetical protein 0.0205 0.1969 0.5274
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0211 0.0813
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Echinococcus multilocularis geminin 0.0205 0.1969 0.2267
Schistosoma mansoni lamin 0.0032 0.0148 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.1275 0.1228
Brugia malayi cathepsin L-like precursor 0.0181 0.1715 0.6455
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.1978 0.5299
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.0334 0.1074
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Plasmodium falciparum serine repeat antigen 4 0.005 0.0334 0.0989
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0334 0.1074
Plasmodium falciparum serine repeat antigen 9 0.005 0.0334 0.0989
Schistosoma mansoni intermediate filament proteins 0.0032 0.0148 0.0398
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0605 0.0554
Echinococcus multilocularis cathepsin L cysteine protease 0.027 0.2656 0.3059
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0334 0.1074
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Echinococcus multilocularis cathepsin l cysteine peptidase 0.027 0.2656 0.3059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Plasmodium falciparum serine repeat antigen 8 0.005 0.0334 0.0989
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0303 0.0349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0334 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0334 0.1074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0148 0.0398
Echinococcus multilocularis cysteine protease 0.027 0.2656 0.3059
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0334 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.027 0.2656 1
Schistosoma mansoni hypothetical protein 0.0047 0.0303 0.0812
Schistosoma mansoni hypothetical protein 0.0205 0.1969 0.5274
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1199 0.3211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.1978 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0334 0.1074
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0176 0.0377
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0079 0.0025
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.065 0.6668 0.7678
Brugia malayi Raf kinase 0.0247 0.2412 0.9081
Entamoeba histolytica hypothetical protein 0.0116 0.1032 0.3757
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.0334 0.0989
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.0334 0.0989
Trypanosoma cruzi cruzipain precursor, putative 0.0089 0.075 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0391 0.1048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0303 0.1141
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Loa Loa (eye worm) hypothetical protein 0.0148 0.1372 0.3676
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Trypanosoma brucei cysteine peptidase C (CPC) 0.005 0.0334 0.0281
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0054 0.0145
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3733 1
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.0334 0.0894
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.0334 0.0989
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.0334 0.1074
Onchocerca volvulus 0.027 0.2656 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.005 0.0334 0.0281
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Echinococcus granulosus cathepsin b 0.005 0.0334 0.0384
Loa Loa (eye worm) fibroinase 0.027 0.2656 0.7116
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0303 0.1141
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.1715 0.6381
Schistosoma mansoni hypothetical protein 0.0122 0.1095 0.2934
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0072 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0139 0.1275 0.4693
Schistosoma mansoni ran 0.0026 0.0079 0.0211
Entamoeba histolytica hypothetical protein 0.0116 0.1032 0.3757
Schistosoma mansoni cathepsin F (C01 family) 0.027 0.2656 0.7116
Plasmodium vivax vivapain-2 0.027 0.2656 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0089 0.075 0.2823
Trypanosoma cruzi cruzipain precursor, putative 0.0965 1 1
Schistosoma mansoni ap endonuclease 0.0038 0.0211 0.0564
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0211 0.0511
Echinococcus granulosus lamin 0.0032 0.0148 0.0171
Brugia malayi cathepsin B-like cysteine proteinase 0.005 0.0334 0.1257
Echinococcus granulosus lamin dm0 0.0032 0.0148 0.0171
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0209 0.0156
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0139 0.1275 0.3416
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Schistosoma mansoni ran 0.0026 0.0079 0.0211
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.1978 0.2278
Schistosoma mansoni ap endonuclease 0.0038 0.0211 0.0564
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0211 0.0564
Echinococcus multilocularis cathepsin L 0.005 0.0334 0.0384
Onchocerca volvulus Cathepsin L homolog 0.027 0.2656 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0211 0.0157
Giardia lamblia Cathepsin L-like protease 0.005 0.0334 0.1453
Plasmodium falciparum serine repeat antigen 6 0.005 0.0334 0.0989
Leishmania major cathepsin L-like protease 0.027 0.2656 0.2616
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.1978 0.7394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0211 0.0157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0391 0.1048
Echinococcus granulosus cathepsin l1 0.0181 0.1715 0.1975
Brugia malayi Cathepsin L-like precursor 0.0089 0.075 0.2823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.0334 0.0989
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.1978 1
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.2506 0.6712
Schistosoma mansoni hypothetical protein 0.0116 0.1032 0.2764
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Loa Loa (eye worm) hypothetical protein 0.0181 0.1715 0.4594
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0209 0.0507
Schistosoma mansoni hypothetical protein 0.0047 0.0303 0.0812
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1095 0.1261
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0471
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.0381
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.0334 0.0894
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Leishmania major cysteine peptidase A (CPA) 0.027 0.2656 0.2616
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.0334 0.0989
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0146 0.1345 0.3603
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1372 0.5165
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Trypanosoma cruzi cysteine peptidase, putative 0.0965 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.0334 0.1453
Echinococcus multilocularis GPCR, family 2 0.0047 0.0303 0.0349
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0334 0.0894
Brugia malayi hypothetical protein 0.0056 0.0397 0.1493
Entamoeba histolytica hypothetical protein 0.005 0.0334 0.1074
Plasmodium vivax unspecified product 0.0089 0.075 0.2603
Onchocerca volvulus Cathepsin F homolog 0.027 0.2656 1
Leishmania major cathepsin L-like protease 0.027 0.2656 0.2616
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.0334 0.0281
Brugia malayi cathepsin L precursor 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Brugia malayi Papain family cysteine protease containing protein 0.027 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.075 0.2008
Plasmodium falciparum cysteine proteinase falcipain 1 0.0139 0.1275 0.4642
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.0334 0.1257
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0079 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0079 0.0094
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0139 0.1275 0.1228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.1978 0.1935
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.0334 0.0989
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0072 0.0083
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Echinococcus multilocularis musashi 0.0032 0.0148 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0211 0.0793
Leishmania major cathepsin L-like protease 0.027 0.2656 0.2616
Plasmodium vivax unspecified product 0.0139 0.1275 0.4642
Giardia lamblia Cysteine protease 0.005 0.0334 0.1453
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.1275 0.1228
Echinococcus multilocularis cathepsin L 0.0139 0.1275 0.1469
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.0334 0.0894
Entamoeba histolytica cysteine proteinase, putative 0.0139 0.1275 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0334 0.1074
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.0334 0.0894
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.1978 0.1935
Giardia lamblia Phosphoglycerate kinase 0.0206 0.1978 1
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.1978 0.1935
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Onchocerca volvulus 0.027 0.2656 1
Onchocerca volvulus 0.027 0.2656 1
Onchocerca volvulus 0.005 0.0334 0.0739
Plasmodium falciparum cysteine proteinase falcipain 2b 0.027 0.2656 1
Onchocerca volvulus Cathepsin L homolog 0.027 0.2656 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.0334 0.0989
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.1978 0.1935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Entamoeba histolytica cysteine proteinase, putative 0.027 0.2656 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0303 0.0349
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Brugia malayi Phosphoglycerate kinase 0.0206 0.1978 0.7447
Loa Loa (eye worm) hypothetical protein 0.0089 0.075 0.2008
Echinococcus multilocularis dna polymerase eta 0.0054 0.0379 0.0436
Echinococcus granulosus importin subunit beta 1 0.0035 0.0176 0.0202
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Brugia malayi Cathepsin L-like cysteine proteinase 0.0181 0.1715 0.6455
Echinococcus multilocularis lamin dm0 0.0032 0.0148 0.0171
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0209 0.0156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0211 0.0242
Onchocerca volvulus Cathepsin L homolog 0.005 0.0334 0.0739
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.1978 0.7369
Leishmania major cathepsin L-like protease 0.027 0.2656 0.2616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.005 0.0334 0.0894
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0139 0.1275 0.3416
Brugia malayi Cathepsin L-like precursor 0.0181 0.1715 0.6455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Onchocerca volvulus 0.027 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.075 0.2008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.1199 0.138
Echinococcus multilocularis cathepsin l cysteine peptidase 0.027 0.2656 0.3059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0334 0.0894
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Onchocerca volvulus 0.027 0.2656 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Plasmodium vivax importin-beta 2, putative 0.0035 0.0176 0.0377
Trypanosoma cruzi cysteine peptidase, putative 0.0965 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0211 0.0601
Echinococcus multilocularis snurportin 1 0.0372 0.3733 0.4299
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Schistosoma mansoni cathepsin s 0.0089 0.075 0.2008
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0054 0.0204
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Trichomonas vaginalis ran, putative 0.0026 0.0079 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0841 0.8684 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Leishmania major hypothetical protein, conserved 0.0056 0.0397 0.0344
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.1978 0.7369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1199 0.3211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0391 0.0451
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0397 0.0344
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0334 0.0989
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.0334 0.0281
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0079 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.1715 0.6381
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0397 0.1234
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0176 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.1275 0.4801
Loa Loa (eye worm) hypothetical protein 0.0206 0.1978 0.5299
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.1978 1
Echinococcus multilocularis lamin 0.0032 0.0148 0.0171
Schistosoma mansoni cathepsin C 0.005 0.0334 0.0894
Giardia lamblia Encystation-specific protease 0.005 0.0334 0.1453
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.1032 0.2764
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0397 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0106 0.02
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0303 0.0349
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0176 0.0122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0841 0.8684 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.1275 0.1228
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0054 0.0062
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.1978 0.2278
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.1978 0.1935
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0211 0.0511
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0106 0.0052
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.1978 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.027 0.2656 0.3059
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0334 0.1074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Giardia lamblia Hypothetical protein 0.005 0.0334 0.1453
Echinococcus granulosus geminin 0.0205 0.1969 0.2267
Brugia malayi hypothetical protein 0.0036 0.0188 0.0708
Brugia malayi Importin beta-1 subunit 0.0035 0.0176 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Echinococcus granulosus cathepsin L 0.0139 0.1275 0.1469
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.1978 0.7369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0391 0.1048
Schistosoma mansoni importin beta-1 0.0035 0.0176 0.0471
Trypanosoma cruzi cysteine proteinase, putative 0.0139 0.1275 0.1228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.0398
Treponema pallidum phosphoglycerate kinase 0.0206 0.1978 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Schistosoma mansoni lamin 0.0032 0.0148 0.0398
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Plasmodium vivax unspecified product 0.005 0.0334 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0391 0.0451
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0079 0.0091
Leishmania major GTP-binding protein, putative 0.0026 0.0079 0.0025
Loa Loa (eye worm) cathepsin B 0.005 0.0334 0.0894
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0379 0.0327
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0089 0.075 0.2823
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.1275 0.4801
Trypanosoma cruzi cysteine peptidase, putative 0.0965 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.027 0.2656 1
Echinococcus granulosus cathepsin b 0.005 0.0334 0.0384
Toxoplasma gondii cathepsin CPL 0.027 0.2656 1
Schistosoma mansoni hypothetical protein 0.0047 0.0303 0.0812
Entamoeba histolytica hypothetical protein 0.0116 0.1032 0.3757
Giardia lamblia Hypothetical protein 0.005 0.0334 0.1453
Echinococcus granulosus dna polymerase kappa 0.0023 0.0054 0.0062
Brugia malayi MH2 domain containing protein 0.014 0.1285 0.4836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0397 0.0344
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0334 0.0894
Loa Loa (eye worm) ctsf protein 0.027 0.2656 0.7116
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.1978 0.5
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.0334 0.0894
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0379 0.0327
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0148 0.0398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.1032 0.1188
Brugia malayi RNA, U transporter 1 0.0099 0.0854 0.3214
Echinococcus multilocularis cathepsin L cysteine protease 0.027 0.2656 0.3059
Plasmodium falciparum serine repeat antigen 5 0.005 0.0334 0.0989
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.0334 0.0989
Schistosoma mansoni hypothetical protein 0.0372 0.3733 1
Giardia lamblia Cathepsin L-like protease 0.005 0.0334 0.1453
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0334 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.1275 0.4693
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0211 0.0157
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0334 0.1453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0303 0.0812
Echinococcus granulosus cathepsin L cysteine protease 0.0139 0.1275 0.1469
Brugia malayi hypothetical protein 0.0116 0.1032 0.3885
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Entamoeba histolytica cysteine proteinase 1, putative 0.0139 0.1275 0.4693
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0148 0.0559
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Leishmania major cathepsin L-like protease 0.0965 1 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1715 0.4594
Loa Loa (eye worm) hypothetical protein 0.0181 0.1715 0.4594
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0079 0.0091
Brugia malayi fibroinase precursor 0.005 0.0334 0.1257
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0397 0.1234
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0334 0.1257
Brugia malayi Cathepsin L-like precursor 0.0181 0.1715 0.6455
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Giardia lamblia Cysteine protease 0.005 0.0334 0.1453
Trypanosoma cruzi cysteine protease, putative 0.0139 0.1275 0.1228
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0334 0.0989
Entamoeba histolytica hypothetical protein 0.0116 0.1032 0.3757
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0079 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0211 0.0601
Trypanosoma cruzi major cysteine proteinase, putative 0.0745 0.7677 0.7665
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0334 0.1074
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0106 0.02
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0079 0.0296
Loa Loa (eye worm) papain family cysteine protease containing protein 0.027 0.2656 0.7116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0391 0.0451
Plasmodium vivax vivapain-1 0.0139 0.1275 0.4642
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0211 0.0242
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0079 0.0127
Schistosoma mansoni hypothetical protein 0.0047 0.0303 0.0812
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1372 0.5165
Echinococcus multilocularis cysteine protease 0.027 0.2656 0.3059
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0021 0.0031 0.0082
Echinococcus granulosus raf serine:threonine protein kinase 0.0255 0.2506 0.2885
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.0334 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0334 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.027 0.2656 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0054 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.075 0.0699
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0303 0.0812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.2656 1
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0397 0.1234
Schistosoma mansoni cathepsin F (C01 family) 0.0181 0.1715 0.4594
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0334 0.1257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0334 0.0989
Entamoeba histolytica cysteine protease, putative 0.0139 0.1275 0.4693
Entamoeba histolytica hypothetical protein 0.0028 0.0106 0.02
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0031 0.0115
Plasmodium falciparum importin beta, putative 0.0035 0.0176 0.0377
Entamoeba histolytica cysteine proteinase, putative 0.0139 0.1275 0.4693
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0334 0.1074
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Leishmania major importin beta-1 subunit, putative 0.0028 0.0106 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0391 0.0451
Onchocerca volvulus 0.0181 0.1715 0.6245
Entamoeba histolytica cysteine protease, putative 0.005 0.0334 0.1074
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0054 0.0062
Onchocerca volvulus 0.027 0.2656 1
Trypanosoma cruzi cysteine proteinase, putative 0.0139 0.1275 0.1228
Schistosoma mansoni DNA polymerase eta 0.0054 0.0379 0.1015
Toxoplasma gondii exonuclease III APE 0.0038 0.0211 0.0511
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0334 0.1453
Echinococcus granulosus cathepsin L 0.005 0.0334 0.0384
Brugia malayi Cathepsin L-like precursor 0.027 0.2656 1
Giardia lamblia Cathepsin B precursor 0.005 0.0334 0.1453
Echinococcus granulosus intermediate filament protein 0.0032 0.0148 0.0171
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.0334 0.0989
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0334 0.1257
Echinococcus granulosus cathepsin l cysteine peptidase 0.027 0.2656 0.3059
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.1978 0.5
Giardia lamblia Cathepsin L precursor 0.005 0.0334 0.1453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0965 1 1
Schistosoma mansoni hypothetical protein 0.0101 0.0877 0.235
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0334 0.1453
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0894
Leishmania major cathepsin L-like protease 0.027 0.2656 0.2616
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0605 0.0554
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0211 0.0157
Echinococcus granulosus GPCR family 2 0.0047 0.0303 0.0349
Echinococcus granulosus dna polymerase eta 0.0054 0.0379 0.0436
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.2656 1
Onchocerca volvulus 0.027 0.2656 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.0334 0.0989
Loa Loa (eye worm) hypothetical protein 0.027 0.2656 0.7116
Echinococcus granulosus cathepsin l1 0.027 0.2656 0.3059
Leishmania major DNA polymerase eta, putative 0.0054 0.0379 0.0327

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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