Detailed information for compound 1586986

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.393 | Formula: C18H22N4O2
  • H donors: 1 H acceptors: 3 LogP: 0.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@H]1CCCN1C(=O)[C@H](CCC(=O)N1Cc2c(C1)cccc2)N
  • InChi: 1S/C18H22N4O2/c19-10-15-6-3-9-22(15)18(24)16(20)7-8-17(23)21-11-13-4-1-2-5-14(13)12-21/h1-2,4-5,15-16H,3,6-9,11-12,20H2/t15-,16+/m1/s1
  • InChiKey: IHHYZDAZOXJYIO-CVEARBPZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0376 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0223 0.0479
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0223 0.0479
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0032 0.0283 0.2406
Giardia lamblia DINP protein human, muc B family 0.002 0.0044 0.0408
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0252 0.466 0.9324
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0032 0.0034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0314 0.0485
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0314 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0314 0.0674
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0032 0.005
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0252 0.466 1
Onchocerca volvulus 0.0032 0.0283 0.0438
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1178 0.1255
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0069
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1675 0.1675
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0314 0.0674
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0509 0.0509
Echinococcus granulosus dna polymerase eta 0.002 0.0044 0.0044
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0142 0.0581
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0376 0.3193
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.521 0.521
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.3786 0.3786
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0283 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0142 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0509 0.096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.148 0.2288
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0032 0.0417
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1644 0.1644
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1178 0.1255
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0044
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trypanosoma brucei oligopeptidase b 0.0033 0.0314 0.0674
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.3786 0.3786
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.521 0.521
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0314 0.0674
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.8724 0.8724
Trichomonas vaginalis set domain proteins, putative 0.0269 0.4996 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0314 0.0335
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Onchocerca volvulus 0.0049 0.062 0.0958
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0223 0.1896
Loa Loa (eye worm) hypothetical protein 0.01 0.1644 0.2542
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0314 0.0674
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1178 0.2527
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Brugia malayi hypothetical protein 0.0018 0.0022 0.0034
Trypanosoma cruzi oligopeptidase b 0.0033 0.0314 0.0674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0039 0.0042
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0314 0.2666
Echinococcus multilocularis expressed conserved protein 0.0094 0.1524 0.1524
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Onchocerca volvulus 0.0032 0.0283 0.0438
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.062 0.3647
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Onchocerca volvulus 0.0077 0.1178 0.1821
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Schistosoma mansoni DNA polymerase eta 0.002 0.0044 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1178 0.1255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.148 0.148
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0142 0.022
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0019 0.0039 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0044 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0044 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1178 0.2308
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0314 0.0314
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.2498 0.2498
Leishmania major hypothetical protein, conserved 0.0077 0.1178 0.2527
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0032 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0314 0.0674
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.3786 0.8124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0771 0.0821
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0314 0.0674
Loa Loa (eye worm) hypothetical protein 0.0034 0.0328 0.0507
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.3786 0.8124
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0509 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi Serine carboxypeptidase S28 family protein 0.0025 0.0142 0.022
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.148 0.2288
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.3538 0.547
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0314 0.0674
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0328 0.0328
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0142 0.0222
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1178 0.2527
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0044
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Onchocerca volvulus 0.0269 0.4996 0.7723
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0032 0.0069
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0039 0.0334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0032 0.0069
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0314 0.1281
Mycobacterium leprae Probable lipase LipE 0.0077 0.1178 1
Toxoplasma gondii hypothetical protein 0.0033 0.0314 0.1281
Echinococcus multilocularis geminin 0.0521 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1644 0.1644
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.062 0.133
Loa Loa (eye worm) hypothetical protein 0.0033 0.0314 0.0485
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.521 0.521
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0142 0.0222
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0965 0.5787
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0252 0.466 0.466
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0142 0.0222
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.3786 0.3786
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0303 0.0303
Toxoplasma gondii exonuclease III APE 0.0019 0.0032 0.0131
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0314 0.0568
Echinococcus multilocularis dna polymerase kappa 0.002 0.0044 0.0044
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0314 0.0314
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0025 0.0142 0.0142
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0509 0.0786
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0032 0.0283 0.0608
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0314 0.2666
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0044 0.0071
Brugia malayi hypothetical protein 0.0343 0.6469 1
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1178 0.2527
Echinococcus multilocularis dna polymerase eta 0.002 0.0044 0.0044
Brugia malayi CHE-14 protein 0.0043 0.0509 0.0786
Loa Loa (eye worm) hypothetical protein 0.0043 0.0509 0.0786
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0314 0.0485
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0142 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.062 0.5265
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0328 0.1339
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Onchocerca volvulus 0.0025 0.0142 0.022
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0032 0.0283 0.0608
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0314 0.0674
Mycobacterium ulcerans lipase LipD 0.0077 0.1178 0.2527
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1178 0.1178
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0032 0.005
Echinococcus granulosus AMP dependent ligase 0.0019 0.0039 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.148 0.148
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0314 0.0674
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Loa Loa (eye worm) hypothetical protein 0.0195 0.3538 0.547
Onchocerca volvulus 0.0343 0.6469 1
Leishmania major hypothetical protein, conserved 0.0029 0.0223 0.0479
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.062 0.3647
Toxoplasma gondii ABC1 family protein 0.0077 0.1178 0.4806
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Loa Loa (eye worm) hypothetical protein 0.0108 0.1791 0.2769
Onchocerca volvulus 0.0034 0.0328 0.0507
Loa Loa (eye worm) hypothetical protein 0.01 0.165 0.255
Mycobacterium ulcerans hypothetical protein 0.0049 0.062 0.133
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1178 0.1255
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0314 0.0485
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0044 0.0047
Treponema pallidum nitrogen fixation protein (rnfC) 0.0056 0.0771 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1178 0.2308
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0032 0.0069
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0314 0.0568
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0142 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0061
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1178 1
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1178 0.1255
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0032 0.0283 0.0302
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Brugia malayi beta-lactamase 0.0077 0.1178 0.1821
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi hypothetical protein 0.0029 0.0223 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1178 1
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Brugia malayi prolyl oligopeptidase family protein 0.028 0.521 0.8054
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0252 0.466 0.466
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0252 0.466 0.7204
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0314 0.0674
Schistosoma mansoni patched 1 0.0043 0.0509 0.0509
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0314 0.0335
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.062 0.5265
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.8724 0.8724
Onchocerca volvulus 0.0077 0.1178 0.1821
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0135 0.2338 0.3614
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.521 0.8054
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0044 0.0047
Plasmodium vivax SET domain protein, putative 0.0034 0.0328 0.2786
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0328 0.0328
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Schistosoma mansoni hypothetical protein 0.0521 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Leishmania major DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi beta-lactamase family protein 0.0077 0.1178 0.1821
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0067
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Echinococcus granulosus dna polymerase kappa 0.002 0.0044 0.0044
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.062 0.133
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0252 0.466 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0314 0.1748
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0314 0.0314
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0252 0.466 0.7204
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans membrane protein ComEA 0.0056 0.0771 0.1654
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.062 0.0661
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1178 0.1178
Echinococcus granulosus expressed conserved protein 0.0094 0.1524 0.1524
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1178 0.1178
Giardia lamblia Thymus-specific serine protease precursor 0.0025 0.0142 0.391
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0376 1
Loa Loa (eye worm) beta-lactamase 0.0077 0.1178 0.1821
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0032 0.0283 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.148 0.148
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0039 0.0161
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0328 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0283 0.0608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0223 0.5939
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0314 0.1748
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0328 0.0328
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.4347 0.6721
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1178 0.1821
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0283 0.0438
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0044 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.062 0.0661
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0252 0.466 0.4967
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0032 0.0283 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Leishmania major oligopeptidase b 0.0033 0.0314 0.0674
Schistosoma mansoni hypothetical protein 0.0521 1 1
Onchocerca volvulus 0.0077 0.1178 0.1821
Onchocerca volvulus 0.0032 0.0283 0.0438
Leishmania major DNA polymerase eta, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0032 0.0283 0.0608
Echinococcus multilocularis AMP dependent ligase 0.0019 0.0039 0.0039
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0142 0.022
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0314 1
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0252 0.466 1
Trichomonas vaginalis esterase, putative 0.0077 0.1178 0.2308
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1178 0.1255
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0252 0.466 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0044 0.0023
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0142 0.0305
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0314 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.521 0.8054
Brugia malayi Pre-SET motif family protein 0.0034 0.0328 0.0507
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.062 0.133
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.062 0.133
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0314 0.0314
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0032 0.0032
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1178 0.1178
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0314 0.1748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.8724 0.8724
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0252 0.466 0.9324
Giardia lamblia Serine peptidase, putative 0.0025 0.0142 0.391
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1644 0.2542
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.2498 0.2498
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0044 0.0023
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0314 0.1281
Echinococcus multilocularis protein patched 0.0043 0.0509 0.0509
Brugia malayi beta-lactamase family protein 0.0077 0.1178 0.1821
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0283 0.0438
Trypanosoma brucei unspecified product 0.002 0.0044 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0343 0.6469 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1178 0.2527
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1644 1
Plasmodium falciparum peptidase, putative 0.0033 0.0314 0.835
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0039 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Brugia malayi N-terminal motif family protein 0.0195 0.3538 0.547
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0044 0.0094
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0223 0.0911
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0314 0.0674
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Brugia malayi hypothetical protein 0.0108 0.1791 0.2769
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0855
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0142 0.0222
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.245 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0039 0.0061
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0044 0.0094
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0252 0.466 0.466
Loa Loa (eye worm) hypothetical protein 0.0053 0.0701 0.1083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0345
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0223 0.0479
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0019 0.0039 0.0084
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1178 0.1821
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0223 0.5939
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.9383 1
Trypanosoma cruzi oligopeptidase b 0.0033 0.0314 0.0674
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0019 0.0039 0.0084
Mycobacterium ulcerans hypothetical protein 0.0077 0.1178 0.2527
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0314 0.0314
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1178 0.2527
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Brugia malayi Pre-SET motif family protein 0.0236 0.4347 0.6721
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.3786 0.5853
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0032 0.0283 0.0302
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0273
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0032 0.0283 0.0302
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0314 0.0568
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0509 0.0509
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1178 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Echinococcus multilocularis protein dispatched 1 0.0049 0.0629 0.0629
Mycobacterium ulcerans beta-lactamase 0.0077 0.1178 0.2527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.148 0.148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0376 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0376 0.0401
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0142 0.0305
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0032 0.0283 0.0608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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