Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | rotamase, putative | 0.004 | 0.0296 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0241 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.0241 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | rotamase | 0.004 | 0.0296 | 0.0296 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0208 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.004 | 0.0296 | 0.0296 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0241 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.0241 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0296 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0241 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0208 | 1 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0039 | 0.0241 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0208 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0208 | 1 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.004 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 0.0296 | 0.0296 |
Trichomonas vaginalis | rotamase, putative | 0.0039 | 0.0241 | 0.8146 |
Echinococcus multilocularis | acetylcholinesterase | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0208 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.004 | 0.0296 | 0.0296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.