TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 530.658 | Formula: C31H38N4O4
H donors: 2 H acceptors: 4 LogP: 3.01 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccc(cc1)C(=O)N(C1CCCC1)C)Cc1cccc(c1)NC(=O)C1CCCN(C1)C(=O)C1CC1
InChi: 1S/C31H38N4O4/c1-34(27-9-2-3-10-27)30(38)22-13-15-25(16-14-22)32-28(36)19-21-6-4-8-26(18-21)33-29(37)24-7-5-17-35(20-24)31(39)23-11-12-23/h4,6,8,13-16,18,23-24,27H,2-3,5,7,9-12,17,19-20H2,1H3,(H,32,36)(H,33,37)
InChiKey: CHPXWVCKRXCCBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0175	0.161	0.161
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0175	0.161	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0279	0.0279
Brugia malayi	Carboxylesterase family protein	0.1037	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0279	0.0279
Echinococcus granulosus	carboxylesterase 5A	0.1037	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0279	0.0279
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	para nitrobenzyl esterase	0.0175	0.161	0.161
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0175	0.161	0.161
Echinococcus granulosus	serotonin receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0279	0.0279
Brugia malayi	Serotonin receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1308	0.1308
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuroligin	0.0175	0.161	0.161
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0175	0.161	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0279	0.0279
Schistosoma mansoni	acetylcholinesterase	0.0175	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	acetylcholinesterase	0.1037	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0279	0.0279
Mycobacterium ulcerans	carboxylesterase, LipT	0.0175	0.161	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0279	0.0279
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0175	0.161	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0279
Brugia malayi	neuropeptide F receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0279
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	sex peptide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	BC026374 protein S09 family	0.0175	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0279
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	somatostatin receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0279	0.0279
Brugia malayi	neuropeptide F receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0279	0.0279
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0279	0.0279
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0175	0.161	0.161
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0175	0.161	0.161
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0279	0.0279
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0279	0.0279
Brugia malayi	MH2 domain containing protein	0.0144	0.1308	0.1308
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	acetylcholinesterase 1	0.1037	1	1
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0175	0.161	0.161
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0279
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	RE15519p	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0279
Brugia malayi	G-protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0175	0.161	1
Schistosoma mansoni	myosin xvIII	0.0038	0.0279	0.0279
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Echinococcus granulosus	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0175	0.161	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	gliotactin	0.0175	0.161	0.161
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	putative neuropeptide receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0279	0.0279
Loa Loa (eye worm)	carboxylesterase	0.0175	0.161	0.161
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0175	0.161	0.5
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0279	0.0279
Brugia malayi	Carboxylesterase family protein	0.0175	0.161	0.161
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0279	0.0279
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0279	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Echinococcus multilocularis	serotonin receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	larval opioid receptor	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	carboxylesterase	0.0175	0.161	0.161
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Brugia malayi	Carboxylesterase family protein	0.0175	0.161	0.161
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Brugia malayi	Carboxylesterase family protein	0.0175	0.161	0.161
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0279	0.0279
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0175	0.161	0.161
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0175	0.161	1
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	acetylcholinesterase	0.1037	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0279	0.0279
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0175	0.161	0.161
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.1037	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	adenoreceptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0175	0.161	0.161
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1308	0.1308
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	Carboxylesterase family protein	0.0175	0.161	0.161
Brugia malayi	hypothetical protein	0.0175	0.161	0.161
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0279	0.0279
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0279
Schistosoma mansoni	BC026374 protein (S09 family)	0.0175	0.161	0.161
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1037	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	carboxylesterase	0.1037	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0279	0.0279
Brugia malayi	G protein-coupled receptor	0.0038	0.0279	0.0279
Brugia malayi	AKH receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	acetylcholinesterase	0.1037	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0175	0.161	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0279	0.0279
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0279	0.0279
Echinococcus granulosus	acetylcholinesterase	0.1037	1	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0175	0.161	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0279	0.0279
Brugia malayi	GnHR receptor homolog	0.0038	0.0279	0.0279
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	carboxylesterase 5A	0.1037	1	1
Brugia malayi	Dopamine receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	sulfakinin receptor protein	0.0038	0.0279	0.0279
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	para nitrobenzyl esterase	0.0175	0.161	0.161
Echinococcus multilocularis	serotonin receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0279	0.0279
Echinococcus granulosus	neuroligin	0.0175	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0175	0.161	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.1037	1	1
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0279
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0279	0.0279
Brugia malayi	Serotonin receptor	0.0038	0.0279	0.0279
Brugia malayi	G-protein coupled receptor	0.0038	0.0279	0.0279

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5012 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1888008

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1587029