Detailed information for compound 1587196

Basic information

Technical information
  • TDR Targets ID: 1587196
  • Name: N'-[1-(4-bromophenyl)-2,5-dioxopyrrolidin-3-y l]-2-phenylacetohydrazide
  • MW: 402.242 | Formula: C18H16BrN3O3
  • H donors: 2 H acceptors: 3 LogP: 2.75 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)NNC1CC(=O)N(C1=O)c1ccc(cc1)Br
  • InChi: 1S/C18H16BrN3O3/c19-13-6-8-14(9-7-13)22-17(24)11-15(18(22)25)20-21-16(23)10-12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,21,23)
  • InChiKey: BSSQEQFNHZSSBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[1-(4-bromophenyl)-2,5-dioxo-pyrrolidin-3-yl]-2-phenyl-acetohydrazide
  • N'-[1-(4-bromophenyl)-2,5-dioxo-3-pyrrolidinyl]-2-phenylacetohydrazide
  • N'-[1-(4-bromophenyl)-2,5-diketo-pyrrolidin-3-yl]-2-phenyl-acetohydrazide
  • N'-[1-(4-bromophenyl)-2,5-dioxo-pyrrolidin-3-yl]-2-phenyl-ethanehydrazide
  • BAS 01318163
  • AG-690/13779044
  • Phenyl-acetic acid N'-[1-(4-bromo-phenyl)-2,5-dioxo-pyrrolidin-3-yl]-hydrazide
  • MLS000566988
  • SMR000176844

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi RE15519p 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0111 0.3549 0.362
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0377 0.1061
Echinococcus granulosus somatostatin receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0303 0.0854
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0057 0.016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.016
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0057 0.016
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0377 0.6423
Schistosoma mansoni myosin xvIII 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0111 0.3549 0.3549
Echinococcus multilocularis serotonin receptor 0.0012 0.0057 0.016
Echinococcus multilocularis GPCR, family 2 0.0016 0.0197 0.0556
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0421 0.1186
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0303 0.0854
Onchocerca volvulus 0.0021 0.0377 0.8782
Brugia malayi Dopamine receptor protein 2 0.0012 0.0057 0.0142
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi FAD binding domain containing protein 0.0027 0.0586 0.1636
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.016
Trichomonas vaginalis abcb9, putative 0.0022 0.0421 0.7147
Leishmania major cytochrome p450-like protein 0.0111 0.3549 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0111 0.3549 0.3549
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0057 0.0142
Brugia malayi Melatonin receptor type 1A 0.0012 0.0057 0.0142
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1764 0.4969
Plasmodium falciparum nitric oxide synthase, putative 0.0027 0.0586 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Schistosoma mansoni amine oxidase 0.0021 0.0377 0.1061
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0111 0.3549 0.3549
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0303 0.5
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0377 0.6423
Loa Loa (eye worm) hypothetical protein 0.0016 0.0197 0.0538
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0197 0.0556
Schistosoma mansoni cytochrome P450 0.0111 0.3549 1
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0007 0.0158
Brugia malayi Cytochrome P450 family protein 0.0111 0.3549 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1242 0.3498
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni multidrug resistance protein 0.0022 0.0421 0.1186
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.0409 0.1151
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0057 0.0142
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.016
Trichomonas vaginalis abcb9, putative 0.0022 0.0421 0.7147
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0057 0.016
Trichomonas vaginalis taga, putative 0.0022 0.0421 0.7147
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0057 0.016
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0421 0.1186
Trichomonas vaginalis sulfite reductase, putative 0.0027 0.0586 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus allatostatin A receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0303 0.0303
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.016
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0057 0.016
Leishmania major hypothetical protein, conserved 0.001 0.0007 0.0019
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Leishmania major cytochrome p450-like protein 0.0111 0.3549 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Mycobacterium leprae putative cytochrome p450 0.0111 0.3549 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0421 0.1186
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0027 0.0586 0.1652
Brugia malayi G-protein coupled receptor 0.0012 0.0057 0.0142
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0421 0.1186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Trypanosoma brucei cytochrome P450, putative 0.0111 0.3549 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0377 0.1061
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0421 0.718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0197 0.0556
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0421 0.7147
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0421 0.7147
Echinococcus granulosus cytochrome P450 2K1 0.0111 0.3549 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0421 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0111 0.3549 0.3549
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0111 0.3549 0.3549
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus multilocularis 0.0021 0.0377 0.1061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.016
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0111 0.3549 0.362
Echinococcus granulosus methionine synthase reductase 0.0016 0.0227 0.064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0421 0.7147
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0189 0.0531
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.001 0.0007 0.0019
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0189 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0111 0.3549 0.362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Brugia malayi neuropeptide F receptor 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0377 0.1061
Schistosoma mansoni cytochrome P450 reductase 0.0027 0.0586 0.1652
Brugia malayi larval opioid receptor 0.0012 0.0057 0.0142
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0057 0.0142
Brugia malayi G-protein coupled receptor 0.0012 0.0057 0.0142
Brugia malayi hypothetical protein 0.0021 0.0377 0.1044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0057 0.016
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0421 0.7147
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0421 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0016 0.0227 0.064
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0377 0.0082
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0111 0.3549 0.362
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.016
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0586 0.1652
Plasmodium vivax flavodoxin domain containing protein 0.0024 0.048 0.818
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0377 0.6423
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0057 0.0142
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0111 0.3549 0.362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0111 0.3549 0.3549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.001 0.0007 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0057 0.016
Schistosoma mansoni multidrug resistance protein 0.0022 0.0421 0.1186
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0303 0.5112
Brugia malayi sulfakinin receptor protein 0.0012 0.0057 0.0142
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0421 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0421 0.1169
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Plasmodium vivax hypothetical protein, conserved 0.001 0.0007 0.0113
Brugia malayi ABC transporter family protein 0.0022 0.0421 0.1169
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0057 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0057 0.016
Schistosoma mansoni hypothetical protein 0.0016 0.0197 0.0556
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0111 0.3549 0.362
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0057 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0303 0.0836
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0111 0.3549 0.362
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0111 0.3549 0.3549
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0111 0.3549 0.3549
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.001 0.0007 0.0113
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.3549 1
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni NADPH flavin oxidoreductase 0.0013 0.012 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0111 0.3549 0.362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.016
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0421 0.1186
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0421 0.1186
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0057 0.016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Echinococcus multilocularis serotonin receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0303 0.0854
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0421 0.1186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0111 0.3549 0.3549
Schistosoma mansoni ap endonuclease 0.0019 0.0303 0.0854
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0057 0.0142
Brugia malayi Cytochrome P450 family protein 0.0111 0.3549 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Loa Loa (eye worm) FAD binding domain-containing protein 0.0027 0.0586 0.1636
Brugia malayi AKH receptor 0.0012 0.0057 0.0142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0303 0.0854
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0057 0.0142
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0057 0.016
Brugia malayi SWIRM domain containing protein 0.0021 0.0377 0.1044
Echinococcus granulosus hypothetical protein 0.0012 0.0057 0.016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.3549 1
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0057 0.016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0421 0.7147
Leishmania major UDP-galactopyranose mutase 0.0021 0.0377 0.1061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0377 0.0082
Leishmania major p450 reductase, putative 0.0027 0.0586 0.1652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1242 0.3498
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0057 0.0142
Echinococcus granulosus serotonin receptor 0.0012 0.0057 0.016
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.016
Schistosoma mansoni hypothetical protein 0.0016 0.0197 0.0556
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0421 0.1186
Schistosoma mansoni hypothetical protein 0.0111 0.3549 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0024 0.048 0.8159
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0111 0.3549 0.3549
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0377 0.6423
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0027 0.0586 0.1652
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1764 0.4969
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0057 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0057 0.016
Brugia malayi FAD binding domain containing protein 0.0016 0.0227 0.0623
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0189 0.0531
Brugia malayi Serotonin receptor 0.0012 0.0057 0.0142
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.3549 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Leishmania major cytochrome P450 reductase, putative 0.0024 0.048 0.1351
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0421 0.7147
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0421 0.1186
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0421 0.1169
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.016
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0057 0.016
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0111 0.3549 0.362
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0421 0.1186
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0057 0.016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0057 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0057 0.016
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0303 0.0854
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0057 0.016
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0421 0.718
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0007 0.0158
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.016
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0111 0.3549 0.362
Brugia malayi Dopamine receptor protein 1 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0057 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0057 0.016
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0057 0.016
Brugia malayi cytochrome P450 0.0111 0.3549 1
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0421 0.1186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Toxoplasma gondii flavodoxin domain-containing protein 0.0013 0.0113 0.0319
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0586 0.1652
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Schistosoma mansoni histamine h1 receptor 0.0012 0.0057 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.016
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.016
Schistosoma mansoni ap endonuclease 0.0019 0.0303 0.0854
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0057 0.0142
Echinococcus multilocularis 0.0111 0.3549 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.001 0.0007 0.0113
Brugia malayi putative neuropeptide receptor 0.0012 0.0057 0.0142
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0057 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.001 0.0007 0.0019
Echinococcus granulosus fmrfamide receptor 0.0012 0.0057 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0274 0.9271 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0377 0.1061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1242 0.3498
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0111 0.3549 0.362
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0111 0.3549 0.362
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0111 0.3549 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0057 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1764 0.1764
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0057 0.016
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0057 0.016
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.016
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0057 0.016
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0377 0.1061
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0057 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0057 0.016
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0007 0.0158
Brugia malayi Serotonin receptor 0.0012 0.0057 0.0142
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0586 0.1652
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0111 0.3549 0.3549
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0057 0.016
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0377 0.1061
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0111 0.3549 0.362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi neuropeptide F receptor 0.0012 0.0057 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0111 0.3549 0.362
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0057 0.016
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0111 0.3549 0.3549
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0377 0.1061
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0057 0.016
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0057 0.016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Toxoplasma gondii flavodoxin domain-containing protein 0.0013 0.0113 0.0319
Giardia lamblia Hypothetical protein 0.0024 0.048 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0027 0.0586 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0377 0.1061
Trypanosoma cruzi p450 reductase, putative 0.0027 0.0586 0.1652
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0057 0.016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0189 0.3139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1242 0.3486
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0057 0.016
Trichomonas vaginalis abcb9, putative 0.0022 0.0421 0.7147
Echinococcus granulosus sex peptide receptor 0.0012 0.0057 0.016
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1764 0.4969
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Leishmania major cytochrome p450-like protein 0.0111 0.3549 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0421 0.1169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0377 0.6423
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1242 0.3498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0303 0.5167
Schistosoma mansoni adenoreceptor 0.0012 0.0057 0.016
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0303 0.5167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0197 0.0556
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0057 0.016
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0007 0.0158
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0111 0.3549 0.3549
Brugia malayi Cytochrome P450 family protein 0.0111 0.3549 1
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0377 0.0377
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0057 0.016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0057 0.016
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0057 0.016
Onchocerca volvulus 0.0022 0.0421 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0111 0.3549 0.3549
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0421 0.0132
Trypanosoma cruzi cytochrome P450, putative 0.0111 0.3549 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0057 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0586 0.1636
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0303 0.7198
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0421 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0111 0.3549 0.362
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0057 0.016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1242 0.3486
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0111 0.3549 0.362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0057 0.016
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0057 0.0142
Schistosoma mansoni smdr2 0.0022 0.0421 0.1186
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.0409 0.1151
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0027 0.0586 0.1652
Toxoplasma gondii exonuclease III APE 0.0019 0.0303 0.0854
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0057 0.0142
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0111 0.3549 1
Schistosoma mansoni amine oxidase 0.0021 0.0377 0.1061
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0111 0.3549 0.3549
Brugia malayi multidrug resistance protein 3 0.0022 0.0421 0.1169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0027 0.0586 0.0586
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.016
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.016
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0057 0.016
Brugia malayi Cytochrome P450 family protein 0.0111 0.3549 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0197 0.0538
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0111 0.3549 0.3549
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Mycobacterium ulcerans oxidoreductase 0.0021 0.0377 0.0377
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0421 0.1186
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0111 0.3549 0.362
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0057 0.0142
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0421 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0027 0.0586 0.1652
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.3549 1
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.016
Echinococcus multilocularis methionine synthase reductase 0.0016 0.0227 0.064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1242 0.3498
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0057 0.016
Mycobacterium leprae Conserved hypothetical protein 0.0111 0.3549 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0377 0.771
Brugia malayi flavodoxin family protein 0.0027 0.0586 0.1636
Trypanosoma cruzi cytochrome P450, putative 0.0111 0.3549 1
Schistosoma mansoni hypothetical protein 0.0016 0.0197 0.0556
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0377 0.6423
Loa Loa (eye worm) hypothetical protein 0.0049 0.1385 0.389
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0057 0.016
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0421 0.1186
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0377 0.0377
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1764 0.1629
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0007 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1385 0.389
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0197 0.0538
Loa Loa (eye worm) FAD binding domain-containing protein 0.0016 0.0227 0.0623
Schistosoma mansoni hypothetical protein 0.0034 0.0835 0.2353
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0111 0.3549 0.362
Brugia malayi ORL1-like opioid receptor 0.0012 0.0057 0.0142
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0111 0.3549 0.3549
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0057 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0057 0.016
Mycobacterium ulcerans dehydrogenase 0.0021 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1242 0.3498
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0377 0.1044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Giardia lamblia Nitric oxide synthase, inducible 0.0024 0.048 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0197 0.0556
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0057 0.016
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0057 0.016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1764 0.4969
Schistosoma mansoni diflavin oxidoreductase 0.0013 0.0113 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0111 0.3549 0.362
Brugia malayi hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.016
Brugia malayi GnHR receptor homolog 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0034 0.0835 0.2339
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0057 0.016
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0377 0.1061
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.016
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0421 0.1186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1385 0.389
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0421 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0111 0.3549 0.3549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1764 0.1764
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0421 1
Echinococcus granulosus orexin receptor type 2 0.0012 0.0057 0.016
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0111 0.3549 0.3549
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.3549 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0421 0.7147
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0421 0.1186
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0111 0.3549 0.3549
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1764 0.1764
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0111 0.3549 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0835 0.2339
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.016
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0421 1
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0057 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.016
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0377 0.6423
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1385 0.389
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0111 0.3549 0.362
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1764 0.4969
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0197 0.0538
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.001 0.0007 0.0019
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0421 0.1186
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0057 0.016
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.016
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1242 0.3498
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0421 0.1186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0057 0.0142
Leishmania major p-glycoprotein 0.0022 0.0421 0.1186
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0111 0.3549 0.3549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0057 0.0142
Schistosoma mansoni hypothetical protein 0.0016 0.0197 0.0556
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0377 0.1061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0421 0.1169
Toxoplasma gondii cytochrome p450 superfamily protein 0.0111 0.3549 1
Echinococcus granulosus GPCR family 2 0.0016 0.0197 0.0556
Echinococcus multilocularis sex peptide receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.016
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0027 0.0586 0.1652
Loa Loa (eye worm) hypothetical protein 0.0022 0.0409 0.1134
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0057 0.0142
Loa Loa (eye worm) CYP4Cod1 0.0111 0.3549 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0027 0.0586 0.1652
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.016
Schistosoma mansoni multidrug resistance protein 0.0022 0.0421 0.1186
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0057 0.0142
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1764 0.4969
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0057 0.0142
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0027 0.0586 0.1652
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0586 0.1652
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus neuropeptide receptor 0.0012 0.0057 0.016
Loa Loa (eye worm) cytochrome P450 0.0111 0.3549 1
Brugia malayi Dopamine receptor 0.0012 0.0057 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0303 0.0854
Echinococcus multilocularis somatostatin receptor 0.0012 0.0057 0.016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0421 0.7147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Brugia malayi G protein-coupled receptor 0.0012 0.0057 0.0142
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0421 0.7147
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0303 0.5112
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0377 0.1044
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0027 0.0586 0.1652
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0295 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142
Echinococcus granulosus neuropeptide receptor 0.0012 0.0057 0.016
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0303 0.0836
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0142

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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