Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | hypothetical protein | 0.0861 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0145 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0861 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 0 | 0.5 | |
Onchocerca volvulus | 0.0145 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0861 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0828 | 0.0828 |
Onchocerca volvulus | 0.0145 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0145 | 0 | 0.5 |
Onchocerca volvulus | 0.0145 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0861 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0828 | 0.0828 |
Echinococcus granulosus | geminin | 0.0205 | 0.0828 | 0.0828 |
Onchocerca volvulus | 0.0145 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0861 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0861 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0145 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0145 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0861 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0861 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0145 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0861 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0861 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0861 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0861 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0145 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.