Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4565 | 0.4565 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4565 | 0.405 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4565 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4565 | 0.4565 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4565 | 0.405 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4565 | 0.405 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4565 | 0.4565 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4565 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.