Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.8338 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.8338 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4837 | 0.4837 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4837 | 0.5802 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4837 | 0.4837 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.3982 | 0.4775 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.3982 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.8338 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.8338 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.8338 | 0.8338 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.8338 | 0.8338 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.8338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.3982 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.8338 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.