Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.362 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.362 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0029 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0029 | 0.362 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0503 | 0.139 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.362 | 0.5 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0029 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.362 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0503 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0029 | 0.362 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0503 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0029 | 0.362 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.362 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.362 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0029 | 0.362 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.362 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0503 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0029 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.362 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0029 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.