Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.0045 | 0.0165 | 0.0165 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0629 | 0.681 | 0.6756 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.091 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.091 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0045 | 0.0165 | 0.0165 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0527 | 0.5643 | 0.557 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.091 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0045 | 0.0165 | 0.0165 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.091 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0629 | 0.681 | 0.6756 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0045 | 0.0165 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0045 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0045 | 0.0165 | 0.5 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.0165 | 0.0165 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0045 | 0.0165 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0045 | 0.0165 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0045 | 0.0165 | 0.0165 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.091 | 1 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0606 | 0.654 | 0.6482 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | steroid hormone receptor | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.0165 | 0.0165 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.091 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.091 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.091 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0527 | 0.5643 | 0.557 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0045 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0045 | 0.0165 | 0.0165 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.0165 | 0.0165 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.