TDR Targets

Basic information

Technical information

TDR Targets ID: 1587718
Name: 1-(2,3-dimethylphenyl)-3-(4H-furo[2,3-d]pyrro le-5-carbonylamino)urea
MW: 312.323 | Formula: C16H16N4O3
H donors: 4 H acceptors: 2 LogP: 2.44 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1C)C)NNC(=O)c1[nH]c2c(c1)occ2
InChi: 1S/C16H16N4O3/c1-9-4-3-5-11(10(9)2)18-16(22)20-19-15(21)13-8-14-12(17-13)6-7-23-14/h3-8,17H,1-2H3,(H,19,21)(H2,18,20,22)
InChiKey: KKTMYJNFPKLJBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2,3-dimethylphenyl)-3-[(4H-furo[2,3-d]pyrrol-5-yl-oxomethyl)amino]urea
1-(2,3-dimethylphenyl)-3-(4H-furo[2,3-d]pyrrol-5-ylcarbonylamino)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0019	0.0019
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0965	0.1885
Onchocerca volvulus		0.0083	0.0994	0.2567
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0083	0.0994	0.1211
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0083	0.0994	0.1942
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Echinococcus granulosus	nAChR subunit	0.0045	0.0291	0.0355
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0371	0.6296	0.767
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0038	0.0173	0.0173
Brugia malayi	mbt repeat family protein	0.0094	0.1203	0.3194
Onchocerca volvulus		0.0045	0.0291	0.0718
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.2153	0.2623
Brugia malayi	follicle stimulating hormone receptor	0.0233	0.3766	1
Schistosoma mansoni	zinc finger protein	0.0046	0.032	0.032
Onchocerca volvulus		0.0045	0.0291	0.0718
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0094	0.1203	0.3117
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0965	0.0965
Onchocerca volvulus		0.0236	0.3818	1
Brugia malayi	Pre-SET motif family protein	0.0208	0.329	0.8737
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0083	0.0994	0.264
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0227	0.3655	0.4452
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0038	0.0173	0.0461
Schistosoma mansoni	zinc finger protein	0.0063	0.0622	0.0622
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0051	0.0417	0.0417
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0107	0.1443	0.1757
Echinococcus multilocularis	neuropeptide s receptor	0.0475	0.8209	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Loa Loa (eye worm)	PHD-finger family protein	0.0062	0.0616	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0051	0.0417	0.0417
Echinococcus granulosus	histone lysine methyltransferase setb	0.0081	0.0965	0.1176
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0051	0.0417	0.0508
Trypanosoma cruzi	ISWI complex protein	0.0046	0.032	0.5
Schistosoma mansoni	bromodomain containing protein	0.0194	0.3048	0.3048
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0083	0.0994	0.264
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0083	0.0994	0.264
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1443	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1203	0.235
Echinococcus multilocularis	polycomb protein SCMH1	0.0094	0.1203	0.1465
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0083	0.0994	0.264
Onchocerca volvulus		0.0155	0.2324	0.6069
Onchocerca volvulus		0.0155	0.2324	0.6069
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0038	0.0173	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0107	0.1443	0.1757
Echinococcus granulosus	polycomb protein SCMH1	0.0094	0.1203	0.1465
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Echinococcus multilocularis	zinc finger protein	0.0063	0.0622	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Brugia malayi	hypothetical protein	0.0038	0.0173	0.0461
Loa Loa (eye worm)	bromodomain containing protein	0.0057	0.0516	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0155	0.2324	0.454
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0083	0.0994	0.1942
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.005	0.0384	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.329	0.6426
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0019	0.0019
Trypanosoma brucei	ISWI complex protein	0.0046	0.032	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0173	0.0173
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0227	0.3655	0.4452
Loa Loa (eye worm)	acetylcholine receptor protein	0.0038	0.0173	0.0339
Schistosoma mansoni	neurotransmitter gated ion channel	0.0045	0.0291	0.0291
Echinococcus granulosus	neuropeptide receptor A26	0.0475	0.8209	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Leishmania major	hypothetical protein, conserved	0.0046	0.032	0.5
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0083	0.0994	0.1211
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.0994	0.264
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0173	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0227	0.3655	0.4452
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0045	0.0291	0.0774
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0184	0.2849	0.3471
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Echinococcus granulosus	glycine receptor subunit beta	0.0083	0.0994	0.1211
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0068	0.0722	0.0722
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0045	0.0291	0.0291
Brugia malayi	Bromodomain containing protein	0.023	0.3698	0.982
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.005	0.0384	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0083	0.0994	0.0994
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0083	0.0994	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.2153	0.2153
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0965	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0307	0.512	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0227	0.3655	0.4452
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1797	0.351
Schistosoma mansoni	hypothetical protein	0.0046	0.032	0.032
Echinococcus multilocularis	snurportin 1	0.0307	0.512	0.6236
Onchocerca volvulus		0.0094	0.1203	0.3117
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0108	0.1465	0.1784
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0188	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0083	0.0994	0.264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Loa Loa (eye worm)	ACC-1 protein	0.0083	0.0994	0.1942
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.2153	0.2623
Plasmodium vivax	SET domain protein, putative	0.003	0.0019	0.0485
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0045	0.0291	0.0291
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.2153	0.2623
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0038	0.0173	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3396	0.6633
Brugia malayi	PHD-finger family protein	0.0079	0.0918	0.2439
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0019	0.0023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.2153	0.2153
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0184	0.2849	0.3471
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Echinococcus granulosus	neuropeptide s receptor	0.0475	0.8209	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0083	0.0994	0.1211
Brugia malayi	hypothetical protein	0.0038	0.0173	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0107	0.1443	0.1757
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.2262	0.2755
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0083	0.0994	0.1211
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0019	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.0994	0.264
Echinococcus multilocularis	nAChR subunit	0.0083	0.0994	0.1211
Loa Loa (eye worm)	ACC-1 protein	0.0083	0.0994	0.1942
Echinococcus multilocularis	glycine receptor subunit beta	0.0083	0.0994	0.1211
Brugia malayi	hypothetical protein	0.0038	0.0173	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0155	0.2324	0.454
Schistosoma mansoni	neurotransmitter gated ion channel	0.0038	0.0173	0.0173
Loa Loa (eye worm)	acetyltransferase	0.0152	0.2262	0.4418
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.0994	0.0994
Echinococcus granulosus	histone acetyltransferase MYST2	0.0107	0.1443	0.1757
Echinococcus granulosus	zinc finger protein	0.0063	0.0622	0.0758
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0081	0.0965	0.1176
Schistosoma mansoni	neurotransmitter gated ion channel	0.0038	0.0173	0.0173
Brugia malayi	excitatory GABA receptor EXP-1A	0.0083	0.0994	0.264
Schistosoma mansoni	sex comb on midleg homolog	0.0094	0.1203	0.1203
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0051	0.0417	0.0508
Onchocerca volvulus		0.0155	0.2324	0.6069
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Echinococcus granulosus	fetal alzheimer antigen falz	0.0068	0.0722	0.0879
Brugia malayi	hypothetical protein	0.0038	0.0173	0.0461
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0173	0.0461
Onchocerca volvulus		0.0083	0.0994	0.2567
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1903	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0083	0.0994	0.1211
Brugia malayi	hypothetical protein	0.0038	0.0173	0.0461
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0045	0.0291	0.0774
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0227	0.3655	0.4452
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	glycine receptor subunit beta	0.0083	0.0994	0.1211
Schistosoma mansoni	sex comb on midleg homolog	0.0094	0.1203	0.1203
Brugia malayi	Bromodomain containing protein	0.0119	0.1661	0.4412
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0068	0.0722	0.0879
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0227	0.3655	0.4452
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.2262	0.2262
Brugia malayi	Cation transporter family protein	0.0083	0.0994	0.264
Echinococcus granulosus	nAChR subunit	0.0083	0.0994	0.1211
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0108	0.1465	0.1784
Schistosoma mansoni	nAChR subunit	0.0038	0.0173	0.0173
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.3818	1
Brugia malayi	RNA, U transporter 1	0.0082	0.0976	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.2262	0.6007
Loa Loa (eye worm)	hypothetical protein	0.0227	0.3655	0.7139
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0371	0.6296	0.767
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0107	0.1443	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.0994	0.264
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Echinococcus multilocularis	nAChR subunit	0.0045	0.0291	0.0355
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0083	0.0994	0.1211
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0083	0.0994	0.1942
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0038	0.0173	0.0211
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0173	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0083	0.0994	0.1211
Brugia malayi	mbt repeat family protein	0.0094	0.1203	0.3194
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0173	0.0211
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0155	0.2324	0.2324
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.0994	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0038	0.0173	0.0461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.2153	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Onchocerca volvulus		0.0038	0.0173	0.0407
Echinococcus granulosus	histone acetyltransferase KAT2B	0.005	0.0384	0.0468
Brugia malayi	Cation transporter family protein	0.0155	0.2324	0.6172
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0083	0.0994	0.264
Echinococcus granulosus	SAM and MBT domain containing protein	0.0094	0.1203	0.1465
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0173	0.0461
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0227	0.3655	0.9705
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0107	0.1443	0.3831
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0146	0.2153	0.5717
Loa Loa (eye worm)	GABA receptor subunit	0.0045	0.0291	0.0569
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Trypanosoma cruzi	ISWI complex protein	0.0046	0.032	0.5
Onchocerca volvulus		0.0083	0.0994	0.2567
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0291	0.0569
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0038	0.0173	0.0211
Echinococcus multilocularis	neuropeptide receptor A26	0.0475	0.8209	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.16	0.3126
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0155	0.2324	0.2324
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0094	0.1203	0.1465
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Entamoeba histolytica	hypothetical protein	0.0045	0.0291	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0233	0.3766	0.7356
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Onchocerca volvulus	Putative nachr subunit	0.0227	0.3655	0.9571
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0083	0.0994	0.1211
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0188	0.5
Onchocerca volvulus		0.0038	0.0173	0.0407
Brugia malayi	Cation transporter family protein	0.0083	0.0994	0.264
Brugia malayi	Pre-SET motif family protein	0.003	0.0019	0.005
Onchocerca volvulus		0.0038	0.0173	0.0407
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0227	0.3655	0.7139
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0045	0.0291	0.0774
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.0994	0.0994
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.005	0.0384	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0045	0.0291	0.0774
Schistosoma mansoni	hypothetical protein	0.0307	0.512	0.512
Loa Loa (eye worm)	LGC-31 protein	0.0083	0.0994	0.1942
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.0994	0.264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.2153	0.2153
Echinococcus granulosus	snurportin 1	0.0307	0.512	0.6236
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0173	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0094	0.1203	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0146	0.2153	0.4206
Loa Loa (eye worm)	MBCTL1	0.0107	0.1443	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.2056	0.2505
Schistosoma mansoni	hypothetical protein	0.0062	0.0616	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1622	0.3168
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.0994	0.0994
Loa Loa (eye worm)	mbt repeat family protein	0.0094	0.1203	0.235
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0083	0.0994	0.1942
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0083	0.0994	0.1942
Schistosoma mansoni	acetylcholine receptor-related	0.0038	0.0173	0.0173
Schistosoma mansoni	nAChR subunit	0.0083	0.0994	0.0994
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0038	0.0173	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0994	0.1942
Echinococcus multilocularis	glycine receptor subunit beta	0.0083	0.0994	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0173	0.0339

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1890816

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1587718