Detailed information for compound 1588041

Basic information

Technical information
  • TDR Targets ID: 1588041
  • Name: 2-[(8-chloro-4-oxo-2,3-dihydro-1H-cyclopenta[ c]chromen-7-yl)oxy]-N-(3-imidazol-1-ylpropyl) propanamide
  • MW: 415.87 | Formula: C21H22ClN3O4
  • H donors: 1 H acceptors: 3 LogP: 2.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1cc2oc(=O)c3c(c2cc1Cl)CCC3)C)NCCCn1cncc1
  • InChi: 1S/C21H22ClN3O4/c1-13(20(26)24-6-3-8-25-9-7-23-12-25)28-19-11-18-16(10-17(19)22)14-4-2-5-15(14)21(27)29-18/h7,9-13H,2-6,8H2,1H3,(H,24,26)
  • InChiKey: TZWDQBJQUINVNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(8-chloro-4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]-N-[3-(1-imidazolyl)propyl]propanamide
  • 2-[(8-chloro-4-keto-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]-N-(3-imidazol-1-ylpropyl)propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0044 0.0131
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0349 0.1873 0.1871
Echinococcus multilocularis dna polymerase eta 0.0019 0.0007 0.0004
Toxoplasma gondii ABC1 family protein 0.0075 0.0323 0.2063
Brugia malayi protein ZK524.3 0.0056 0.0213 0.0634
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0611 0.3357 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0006 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0056 0.0213 0.135
Echinococcus granulosus cpg binding protein 0.0092 0.0416 0.0601
Echinococcus granulosus snurportin 1 0.0299 0.1588 0.2307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.003 0.0069 0.0066
Plasmodium vivax importin-beta 2, putative 0.0028 0.0057 0.0344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.0937 0.1359
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0006 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1226 0.178
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0157
Trichomonas vaginalis protein phosphatase-5, putative 0.0026 0.0044 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0028
Schistosoma mansoni importin beta-1 0.0028 0.0057 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1226 0.178
Trypanosoma brucei Replication factor A protein 1 0.0293 0.1556 1
Brugia malayi CXXC zinc finger family protein 0.0087 0.0388 0.1156
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0044 0.0121
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0006 0.0004
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0046 0.0278
Schistosoma mansoni ap endonuclease 0.0038 0.0115 0.0163
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0611 0.3357 1
Trichomonas vaginalis ran, putative 0.0021 0.0015 0.0035
Echinococcus multilocularis lysyl tRNA synthetase 0.003 0.0069 0.0066
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.013 0.0388
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0197 0.0193
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0006 0.0009
Mycobacterium tuberculosis Conserved protein 0.0075 0.0323 0.1212
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0197 0.0281
Trypanosoma brucei protein phosphatase 1, putative 0.0041 0.013 0.0818
Giardia lamblia Methionyl-tRNA synthetase 0.0056 0.0213 0.523
Brugia malayi hypothetical protein 0.0019 0.0003 0.0009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.0075
Brugia malayi replication factor A 73 kDa subunit 0.0611 0.3357 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.003 0.0069 0.1943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Toxoplasma gondii hypothetical protein 0.0064 0.0261 0.1664
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.002 0.0024
Plasmodium falciparum asparagine--tRNA ligase 0.003 0.0069 0.0423
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0006 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0197 0.0281
Mycobacterium ulcerans beta-lactamase 0.0075 0.0323 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0547 0.2993 1
Brugia malayi beta-lactamase family protein 0.0075 0.0323 0.0964
Toxoplasma gondii methionyl-tRNA synthetase 0.0056 0.0213 0.135
Echinococcus granulosus dna polymerase eta 0.0019 0.0007 0.0006
Plasmodium vivax lysine--tRNA ligase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.003 0.0069 0.0196
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0056 0.0213 0.6252
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0057 0.0344
Brugia malayi hypothetical protein 0.0028 0.0056 0.0166
Brugia malayi putative serine/threonine phosphatase 0.0026 0.0044 0.0131
Loa Loa (eye worm) BRCA2 repeat family protein 0.0123 0.0597 0.177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0006 0.0019
Onchocerca volvulus 0.0087 0.0388 0.1287
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0581 0.3186 0.9491
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0007 0.0028
Schistosoma mansoni methionine-tRNA synthetase 0.0349 0.1873 0.2722
Giardia lamblia GTOR 0.0019 0.0006 0.0073
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.079 0.4367 0.4365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0159
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0293 0.1556 0.4631
Loa Loa (eye worm) hypothetical protein 0.006 0.0238 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0019 0.0003 0.0009
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.003 0.0069 0.0096
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0271 0.1432 0.4262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0057 0.0344
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0022
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Loa Loa (eye worm) histone methyltransferase 0.0027 0.005 0.0139
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.0162
Treponema pallidum aspartyl-tRNA synthetase 0.003 0.0069 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0323 0.2063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Echinococcus granulosus lysyl tRNA synthetase 0.003 0.0069 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0007 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0323 0.0955
Trichomonas vaginalis helicase, putative 0.002 0.0009 0.0018
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Brugia malayi RNA, U transporter 1 0.008 0.0348 0.1038
Loa Loa (eye worm) hypothetical protein 0.0041 0.013 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Schistosoma mansoni replication factor A 1 rfa1 0.0611 0.3357 0.488
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0046 0.0063
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0044 0.0121
Trichomonas vaginalis protein phosphatase-1, putative 0.0041 0.013 0.0379
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0294 0.1559 0.4639
Entamoeba histolytica hypothetical protein 0.003 0.0069 0.0336
Brugia malayi methionyl-tRNA synthetase 0.0349 0.1873 0.5581
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0141 0.0695 0.207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0027 0.007
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.013 0.0185
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0041 0.013 0.3168
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0349 0.1873 0.2722
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.013 0.0818
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0028
Loa Loa (eye worm) apoptosis regulator protein 0.0141 0.0695 0.2063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0115 0.0163
Loa Loa (eye worm) beta-lactamase 0.0075 0.0323 0.0955
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.003 0.0069 0.0066
Leishmania major lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0007 0.0004
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.013 0.0127
Giardia lamblia Hypothetical protein 0.0089 0.0404 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0041 0.013 0.0185
Schistosoma mansoni hypothetical protein 0.003 0.0069 0.0096
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0006 0.0019
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0115 0.0469
Entamoeba histolytica hypothetical protein 0.0026 0.0046 0.0216
Echinococcus multilocularis geminin 0.0205 0.1056 0.1053
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0056 0.0213 1
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0041 0.013 0.0818
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Toxoplasma gondii aspartate-tRNA ligase 0.003 0.0069 0.0423
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0006 0.0004
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0611 0.3357 0.488
Brugia malayi BRCA2 repeat family protein 0.0123 0.0597 0.1778
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0216 0.1117 0.1115
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0028
Mycobacterium ulcerans hypothetical protein 0.0075 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0013
Treponema pallidum leucyl-tRNA synthetase 0.0056 0.0213 0.1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0349 0.1873 1
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0141 0.0695 0.1007
Brugia malayi glycyl-tRNA synthetase 0.0271 0.1432 0.4267
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0046 0.0043
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.013 0.0379
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.003 0.0069 0.1943
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0115 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0006 0.0019
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0056 0.034
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0007 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0323 0.1212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0196
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Brugia malayi lysyl-tRNA synthetase 0.003 0.0069 0.0205
Giardia lamblia DINP protein human, muc B family 0.0019 0.0007 0.0107
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0006 0.0009
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0028 0.008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0046 0.0278
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1226 0.178
Schistosoma mansoni protein phosphatase-1 0.0041 0.013 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0115 0.5329
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0056 0.0213 0.6498
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Mycobacterium ulcerans lysyl-tRNA synthetase 0.003 0.0069 0.1943
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0028 0.0162
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.1233 0.6875 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.0044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0026 0.0145
Chlamydia trachomatis leucine--tRNA ligase 0.0056 0.0213 0.1
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0056 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0026 0.0044 0.0121
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0006 0.0019
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0141 0.0695 0.0692
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0027 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0006 0.0019
Schistosoma mansoni methionine-tRNA synthetase 0.0056 0.0213 0.0305
Plasmodium falciparum asparagine--tRNA ligase 0.003 0.0069 0.0423
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0197 0.0193
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0213 0.0625
Mycobacterium leprae Probable lipase LipE 0.0075 0.0323 1
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0041 0.013 0.0127
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0056 0.0213 0.0625
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.002 0.0017
Echinococcus granulosus glycyl tRNA synthetase 0.0271 0.1432 0.208
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0015 0.0075
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0006 0.0004
Echinococcus granulosus methionine tRNA synthetase 0.0056 0.0213 0.0305
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.013 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.005 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0069 0.0423
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0009 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Echinococcus granulosus dna polymerase kappa 0.0019 0.0007 0.0006
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0293 0.1556 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0057 0.0168
Leishmania major replication factor A, 51kDa subunit, putative 0.0293 0.1556 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Schistosoma mansoni cpg binding protein 0.0087 0.0388 0.056
Echinococcus multilocularis methionine tRNA synthetase 0.0056 0.0213 0.021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0115 0.2787
Schistosoma mansoni hypothetical protein 0.0205 0.1056 0.1532
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0197 0.0577
Entamoeba histolytica Ran family GTPase 0.0021 0.0015 0.0047
Onchocerca volvulus 0.0053 0.0197 0.0647
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0235 0.1226 0.3647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0015 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0115 0.072
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0028 0.0162
Loa Loa (eye worm) MBCTL1 0.006 0.0238 0.07
Plasmodium vivax aspartate--tRNA ligase, putative 0.003 0.0069 0.0423
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.002 0.0017
Leishmania major replication Factor A 28 kDa subunit, putative 0.003 0.0069 0.0423
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0115 0.0333
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0101 0.0472 0.2494
Schistosoma mansoni glycyl-tRNA synthetase 0.0271 0.1432 0.208
Loa Loa (eye worm) hypothetical protein 0.0349 0.1873 0.5577
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.003 0.0069 0.0423
Trypanosoma cruzi Replication factor A protein 1 0.0293 0.1556 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0115 0.072
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.003 0.0069 0.0235
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0323 0.1212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0006 0.0019
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0056 0.034
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.003 0.0069 0.0096
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0216 0.1117 0.1622
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0044 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1226 0.1223
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0041 0.013 0.0379
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0044 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Leishmania major hypothetical protein, conserved 0.0075 0.0323 0.2063
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Plasmodium vivax methionine--tRNA ligase, putative 0.0056 0.0213 0.135
Leishmania major leucyl-tRNA synthetase, putative 0.0056 0.0213 0.135
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0019 0.0003 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0056 0.034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0046 0.0138
Leishmania major aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1588 0.4727
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0057 0.0344
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0323 0.1212
Mycobacterium tuberculosis Conserved protein 0.0075 0.0323 0.1212
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0044 0.0121
Schistosoma mansoni hypothetical protein 0.0205 0.1056 0.1532
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0026 0.0044 0.0262
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0044 0.0131
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0115 0.0412
Entamoeba histolytica replication factor A, putative 0.0059 0.0233 0.1218
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Schistosoma mansoni protein phosphatase type 1 0.0041 0.013 0.0185
Leishmania major methionyl-tRNA synthetase, putative 0.0056 0.0213 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0056 0.0213 0.6498
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0046 0.0129
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0238 0.0342
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0044 0.0131
Brugia malayi methionyl-tRNA synthetase 0.0056 0.0213 0.0634
Schistosoma mansoni ap endonuclease 0.0038 0.0115 0.0163
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0197 0.0281
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0101 0.0472 0.2494
Schistosoma mansoni protein phosphatase type 1 0.0041 0.013 0.0185
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0015 0.0017
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.003 0.0069 0.0235
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0115 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.0299 0.1588 0.2307
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0041 0.013 0.0388
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0056 0.0213 1
Leishmania major asparaginyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0006 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0323 0.0466
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0007 0.0013
Schistosoma mansoni protein phosphatase type 1 0.0026 0.0044 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0056 0.034
Echinococcus multilocularis asparaginyl tRNA synthetase 0.003 0.0069 0.0066
Entamoeba histolytica hypothetical protein 0.003 0.0069 0.0336
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.0291
Echinococcus multilocularis snurportin 1 0.0299 0.1588 0.1586
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0323 0.1212
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0197 0.0281
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0006 0.002
Giardia lamblia Aspartyl-tRNA synthetase 0.003 0.0069 0.1639
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0006 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0115 0.3399
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0007 0.0006
Onchocerca volvulus 0.0075 0.0323 0.1071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1226 0.178
Schistosoma mansoni protein phosphatase-1 0.0026 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0141 0.0695 0.2063
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0154 0.0767 0.4921
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0235 0.1226 0.3653
Plasmodium falciparum aspartate--tRNA ligase 0.003 0.0069 0.0423
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0141 0.0695 0.1007
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0082 0.036 0.1065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0323 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0044 0.0121
Brugia malayi Aspartyl-tRNA synthetase 0.003 0.0069 0.0205
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0323 0.2063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0238 0.0342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.002 0.0024
Echinococcus granulosus dnaJ subfamily B 0.1233 0.6875 1
Onchocerca volvulus 0.0082 0.036 0.1195
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.036 0.052
Loa Loa (eye worm) hypothetical protein 0.0101 0.0472 0.1397
Leishmania major GTP-binding protein, putative 0.0021 0.0015 0.0075
Giardia lamblia Leucyl-tRNA synthetase 0.0056 0.0213 0.523
Plasmodium falciparum lysine--tRNA ligase 0.003 0.0069 0.0423
Schistosoma mansoni cpg binding protein 0.0092 0.0416 0.0601
Plasmodium falciparum replication protein A1, large subunit 0.0293 0.1556 1
Echinococcus granulosus geminin 0.0205 0.1056 0.1532
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0115 0.0583
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0115 0.0342
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0041 0.013 0.0185
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0044 0.0121
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0006 0.0019
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.013 0.0379
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.003 0.0069 0.1375
Leishmania major lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.0035
Toxoplasma gondii lysine-tRNA ligase 0.003 0.0069 0.0423
Leishmania major importin beta-1 subunit, putative 0.0023 0.0027 0.0151
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0006 0.002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0057 0.0053
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0006 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0115 0.072
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0041 0.013 0.0379
Giardia lamblia Asparaginyl-tRNA synthetase 0.003 0.0069 0.1639
Loa Loa (eye worm) hypothetical protein 0.0056 0.0213 0.0625
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0041 0.013 0.0127
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0323 0.0466
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.007
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0238 0.0235
Brugia malayi beta-lactamase family protein 0.0075 0.0323 0.0964
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Mycobacterium ulcerans lipase LipD 0.0075 0.0323 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Trypanosoma brucei protein phosphatase 1 0.0026 0.0044 0.0262
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0197 0.0647
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0213 0.135
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.003 0.0069 0.0196
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0044 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0323 0.0955
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0026 0.0044 0.0203
Brugia malayi beta-lactamase 0.0075 0.0323 0.0964
Plasmodium falciparum nucleic acid binding protein, putative 0.003 0.0069 0.0423
Trypanosoma brucei protein phosphatase 1 0.0026 0.0044 0.0262
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0056 0.034
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.002 0.0024
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0015 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0041 0.013 0.0185
Treponema pallidum methionyl-tRNA synthetase 0.0349 0.1873 1
Plasmodium vivax asparagine--tRNA ligase, putative 0.003 0.0069 0.0423
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0323 0.1212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Plasmodium falciparum importin beta, putative 0.0028 0.0057 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0328 0.1755 0.255
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0056 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0115 0.0333
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0028 0.0162
Plasmodium falciparum methionine--tRNA ligase 0.0056 0.0213 0.135
Brugia malayi mbt repeat family protein 0.0053 0.0197 0.0585
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0271 0.1432 0.4267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.005 0.0047
Schistosoma mansoni hypothetical protein 0.0141 0.0695 0.1007
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.013 0.0818
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.013 0.0379
Leishmania major hypothetical protein, conserved 0.0028 0.0056 0.034
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0056 0.0213 0.0625
Plasmodium vivax methionine--tRNA ligase, putative 0.0056 0.0213 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0323 0.032
Chlamydia trachomatis lysine--tRNA ligase 0.003 0.0069 0.022
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.036 0.0357
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0115 0.0112
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0006 0.0019
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0041 0.013 0.0127
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0611 0.3357 0.3355
Leishmania major aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0026 0.0044 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.2615 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0006 0.0003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Echinococcus granulosus importin subunit beta 1 0.0028 0.0057 0.0078
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0323 1
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Toxoplasma gondii exonuclease III APE 0.0038 0.0115 0.072
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0028 0.0162
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0044 0.0131
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0056 0.0213 0.0788
Plasmodium falciparum methionine--tRNA ligase, putative 0.0056 0.0213 0.135
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0323 0.2063
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0059 0.0233 0.077
Onchocerca volvulus 0.0075 0.0323 0.1071
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0006 0.0019
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0197 0.0281
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0611 0.3357 1
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.003 0.0069 0.0196
Schistosoma mansoni ran 0.0021 0.0015 0.0017
Schistosoma mansoni lysyl-tRNA synthetase 0.003 0.0069 0.0096
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0007 0.0028
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0015 0.0075
Leishmania major DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Echinococcus multilocularis cpg binding protein 0.0092 0.0416 0.0413
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0323 0.0955
Schistosoma mansoni cpg binding protein 0.0092 0.0416 0.0601
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.003 0.0069 0.0096
Schistosoma mansoni hypothetical protein 0.0141 0.0695 0.1007
Treponema pallidum asparaginyl-tRNA synthetase 0.003 0.0069 0.022
Plasmodium vivax replication protein A1, large subunit, putative 0.0293 0.1556 1
Plasmodium vivax asparagine--tRNA ligase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0009 0.0018
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.079 0.4367 0.6351
Echinococcus multilocularis dnaJ subfamily B 0.1233 0.6875 0.6874
Schistosoma mansoni leucyl-tRNA synthetase 0.0056 0.0213 0.0305
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0041 0.013 0.0818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1226 0.1223
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0323 0.0964
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0238 0.0235
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.013 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0238 0.0342
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0044 0.0121
Schistosoma mansoni protein phosphatase-1 0.0026 0.0044 0.0059
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0044 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0046 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0141 0.0695 0.1007
Schistosoma mansoni DNA polymerase eta 0.0019 0.0007 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0323 0.1212
Echinococcus multilocularis glycyl tRNA synthetase 0.0271 0.1432 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0577
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0323 0.1212
Echinococcus multilocularis leucyl tRNA synthetase 0.0056 0.0213 0.021
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0336
Entamoeba histolytica replication factor A protein 1, putative 0.0263 0.1385 0.7386
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0323 0.0466
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.003 0.0069 0.0336
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0007 0.0028
Giardia lamblia Lysyl-tRNA synthetase 0.003 0.0069 0.1639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Toxoplasma gondii tRNA ligases class I (M) protein 0.0056 0.0213 0.135
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0015 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.003 0.0069 0.1375
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.003 0.0069 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0323 0.2063
Loa Loa (eye worm) hypothetical protein 0.0075 0.0323 0.0955
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0028 0.0658
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0004
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.003 0.0069 0.0066
Loa Loa (eye worm) 63kd antigen 0.003 0.0069 0.0196
Schistosoma mansoni lysyl-tRNA synthetase 0.003 0.0069 0.0096
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0115 0.072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0115 0.072
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0323 0.0955
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0048 0.0143
Onchocerca volvulus 0.0075 0.0323 0.1071
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0238 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Schistosoma mansoni ran 0.0021 0.0015 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0323 0.0955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0046 0.0278
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.036 0.1073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0323 0.0955
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.036 0.052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0388 0.1148
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0056 0.0213 0.135
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.013 0.0379
Toxoplasma gondii serine/threonine phosophatase PP1 0.0041 0.013 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.1197
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.003 0.0069 0.0205
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Schistosoma mansoni aspartyl-tRNA synthetase 0.003 0.0069 0.0096
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0026 0.0044 0.0262
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Leishmania major DNA polymerase eta, putative 0.0019 0.0007 0.0028
Trypanosoma brucei unspecified product 0.0019 0.0007 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0006 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1226 0.178
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0028 0.0658
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Trichomonas vaginalis esterase, putative 0.0075 0.0323 0.0955
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0028
Brugia malayi mbt repeat family protein 0.0053 0.0197 0.0585
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0028 0.0162
Schistosoma mansoni apoptosis regulator bax 0.0141 0.0695 0.1007
Chlamydia trachomatis methionine--tRNA ligase 0.0349 0.1873 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0067
Schistosoma mansoni protein phosphatase-1 0.0041 0.013 0.0185
Toxoplasma gondii histone lysine methyltransferase SET1 0.0164 0.0826 0.5301
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0323 1
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.003 0.0069 0.0423
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Mycobacterium tuberculosis Conserved protein 0.0075 0.0323 0.1212
Loa Loa (eye worm) hypothetical protein 0.0059 0.0233 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0006 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0007 0.0007
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.003 0.0069 0.0423
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0271 0.1432 0.4262
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.003 0.0069 0.3133
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0015 0.0012

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8356 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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