Detailed information for compound 1588042

Basic information

Technical information
  • TDR Targets ID: 1588042
  • Name: 2-(7-methoxynaphthalen-2-yl)oxy-N-(5-methyl-1 ,2-oxazol-3-yl)acetamide
  • MW: 312.32 | Formula: C17H16N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc(cc2)OCC(=O)Nc1noc(c1)C
  • InChi: 1S/C17H16N2O4/c1-11-7-16(19-23-11)18-17(20)10-22-15-6-4-12-3-5-14(21-2)8-13(12)9-15/h3-9H,10H2,1-2H3,(H,18,19,20)
  • InChiKey: XJCAQSCMZLVHIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(7-methoxy-2-naphthyl)oxy]-N-(5-methylisoxazol-3-yl)acetamide
  • 2-[(7-methoxy-2-naphthyl)oxy]-N-(5-methyl-3-isoxazolyl)acetamide
  • 2-(7-methoxynaphthalen-2-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)ethanamide
  • ZINC05365561
  • T5429423

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis methionine tRNA synthetase 0.0043 0.007 0.0066
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Echinococcus granulosus lysyl tRNA synthetase 0.0052 0.0094 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0028 0.008
Toxoplasma gondii aspartate-tRNA ligase 0.0052 0.0094 0.0671
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0158 0.0483
Schistosoma mansoni protein phosphatase-1 0.0026 0.0027 0.0077
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0175 0.0175
Entamoeba histolytica hypothetical protein 0.0025 0.0024 0.017
Brugia malayi RNA, U transporter 1 0.0088 0.0189 0.0674
Loa Loa (eye worm) beta-lactamase 0.0076 0.0158 0.0567
Echinococcus granulosus dna polymerase kappa 0.002 0.001 0.001
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0027 0.0076
Onchocerca volvulus 0.0076 0.0158 0.0256
Loa Loa (eye worm) hypothetical protein 0.0052 0.0094 0.0331
Loa Loa (eye worm) hypothetical protein 0.0053 0.0099 0.0347
Plasmodium vivax methionine--tRNA ligase, putative 0.0043 0.007 0.0417
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0027 0.0082
Schistosoma mansoni protein phosphatase-1 0.0026 0.0027 0.0077
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.02 0.02
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0175 0.0625
Schistosoma mansoni protein phosphatase type 1 0.0042 0.0069 0.0206
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0028 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.006 0.0402
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0027 0.0082
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0034 0.0034
Trypanosoma brucei protein phosphatase 1 0.0026 0.0027 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0052 0.0094 0.1163
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0042 0.0069 0.0236
Loa Loa (eye worm) hypothetical protein 0.0682 0.1748 0.6431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0158 1
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0052 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Loa Loa (eye worm) apoptosis regulator protein 0.0682 0.1748 0.6431
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0052 0.0094 0.0671
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.006 0.006
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0026 0.0027 0.0141
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0158 0.1207
Treponema pallidum asparaginyl-tRNA synthetase 0.0052 0.0094 0.1163
Echinococcus multilocularis geminin 0.034 0.085 0.0845
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0051 0.0166
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Brugia malayi BRCA2 repeat family protein 0.0212 0.0515 0.1879
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0052 0.0052
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0099 0.0299
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0052 0.0094 0.5673
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Onchocerca volvulus 0.0076 0.0158 0.0256
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0043 0.007 0.0243
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0004
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.1051 0.2716 1
Leishmania major aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Plasmodium falciparum methionine--tRNA ligase 0.0043 0.007 0.0417
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0032 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0682 0.1748 0.5394
Echinococcus multilocularis dna polymerase kappa 0.002 0.001 0.0006
Leishmania major hypothetical protein, conserved 0.0076 0.0158 0.1175
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.006 0.5442
Mycobacterium leprae Probable lipase LipE 0.0076 0.0158 1
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0027 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0052 0.0094 0.0685
Schistosoma mansoni protein phosphatase-1 0.0042 0.0069 0.0206
Leishmania major asparaginyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0504 0.128 0.4704
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0024 0.0071
Toxoplasma gondii tRNA ligases class I (M) protein 0.0043 0.007 0.0484
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.001 0.0021
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0043 0.007 0.4071
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0052 0.0094 0.009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.006 0.0334
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0504 0.128 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0019 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Toxoplasma gondii ABC1 family protein 0.0076 0.0158 0.1175
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0043 0.007 0.0243
Entamoeba histolytica hypothetical protein 0.0052 0.0094 0.0787
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.001 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0011
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0052 0.0094 0.5392
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0158 0.0567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.07 0.0696
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0209 0.0506 0.1844
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0039 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.07 0.2157
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.006 0.0205
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0226 0.0551 0.2015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0219 0.0534 0.4133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.02 0.1507
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0042 0.0069 0.0064
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0175 0.0171
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.001
Leishmania major aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0034 0.0029
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0043 0.007 0.6834
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0175 0.0536
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0158 0.0567
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1694 0.4404 0.4402
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.02 0.1507
Entamoeba histolytica replication factor A, putative 0.0102 0.0225 0.1939
Giardia lamblia Hypothetical protein 0.0154 0.0361 1
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0118 0.0114
Loa Loa (eye worm) 63kd antigen 0.0052 0.0094 0.0331
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0269 0.0663 0.0663
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0042 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.0122 0.028 0.0858
Trypanosoma cruzi Replication factor A protein 1 0.0504 0.128 1
Entamoeba histolytica hypothetical protein 0.0023 0.0019 0.0129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0034 0.0099
Giardia lamblia Asparaginyl-tRNA synthetase 0.0052 0.0094 0.2511
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.006 0.0056
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0043 0.007 0.0491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0042 0.0069 0.1795
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.006 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0027 0.0082
Leishmania major replication Factor A 28 kDa subunit, putative 0.0052 0.0094 0.0671
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0042 0.0069 0.0236
Toxoplasma gondii methionyl-tRNA synthetase 0.0043 0.007 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0158 0.1175
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0027 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0158 0.1207
Schistosoma mansoni DNA polymerase eta 0.002 0.001 0.0026
Chlamydia trachomatis leucine--tRNA ligase 0.0043 0.007 0.0795
Giardia lamblia Methionyl-tRNA synthetase 0.0043 0.007 0.1847
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0042 0.0069 0.0402
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0094 0.5673
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0158 0.0154
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0027 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0018 0.007
Mycobacterium ulcerans hypothetical protein 0.0076 0.0158 1
Giardia lamblia Kinase, PLK 0.0092 0.02 0.5487
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0158 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.02 0.0437
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.02 0.1719
Schistosoma mansoni cpg binding protein 0.0116 0.0262 0.0804
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0099 0.0347
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0052 0.0094 0.0605
Plasmodium falciparum lysine--tRNA ligase 0.0052 0.0094 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0027 0.0076
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0094 0.009
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.001 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus granulosus methionine tRNA synthetase 0.0043 0.007 0.007
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0042 0.0069 0.0069
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0034 0.0029
Giardia lamblia DINP protein human, muc B family 0.002 0.001 0.016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0009 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.001 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.07 0.0696
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0027 0.0082
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0043 0.007 0.3685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0027 0.0082
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0331
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0219 0.0532 0.0532
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0682 0.1748 0.1748
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.001 0.0021
Schistosoma mansoni protein phosphatase type 1 0.0026 0.0027 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0094 0.0671
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0246 0.0603 0.1857
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0024 0.0071
Trypanosoma brucei polo-like protein kinase 0.0092 0.02 0.1507
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Brugia malayi methionyl-tRNA synthetase 0.0043 0.007 0.0238
Brugia malayi beta-lactamase family protein 0.0076 0.0158 0.0561
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0158 0.1207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0043 0.007 0.0484
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0018 0.0013
Echinococcus multilocularis snurportin 1 0.033 0.0823 0.0819
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0078 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0236
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0052 0.0094 0.5392
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Mycobacterium tuberculosis Conserved protein 0.0076 0.0158 0.1207
Brugia malayi beta-lactamase family protein 0.0076 0.0158 0.0561
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0158 0.1207
Onchocerca volvulus 0.0076 0.0158 0.0256
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0158 0.1207
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0094 0.0285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Treponema pallidum leucyl-tRNA synthetase 0.0043 0.007 0.0795
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.1051 0.2716 0.2713
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0027 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0042 0.0069 0.0064
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0028 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Schistosoma mansoni cpg binding protein 0.0122 0.028 0.0858
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0028 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0262 0.095
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0209 0.0506 0.1849
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0042 0.0069 0.0402
Echinococcus granulosus geminin 0.034 0.085 0.085
Schistosoma mansoni hypothetical protein 0.0052 0.0094 0.0285
Leishmania major importin beta-1 subunit, putative 0.0025 0.0024 0.0118
Schistosoma mansoni leucyl-tRNA synthetase 0.0043 0.007 0.0212
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0034 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.125 0.3239 0.3236
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0118 0.0114
Echinococcus granulosus dnaJ subfamily B 0.125 0.3239 0.3239
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Loa Loa (eye worm) hypothetical protein 0.0269 0.0663 0.243
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0158 0.0567
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0019 0.0011
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0094 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0158 0.0567
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0026 0.0027 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0039 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0032 0.0115
Echinococcus multilocularis glycyl tRNA synthetase 0.0209 0.0506 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.07 0.2566
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0158 0.0158
Giardia lamblia Aspartyl-tRNA synthetase 0.0052 0.0094 0.2511
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0042 0.0069 0.047
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0118 0.0413
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0158 0.1207
Plasmodium vivax asparagine--tRNA ligase, putative 0.0052 0.0094 0.0605
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.07 0.2562
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.02 0.0196
Plasmodium vivax lysine--tRNA ligase, putative 0.0052 0.0094 0.0605
Plasmodium vivax asparagine--tRNA ligase, putative 0.0052 0.0094 0.0605
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0018 0.0373
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.001 0.0011
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0118 0.0359
Brugia malayi putative serine/threonine phosphatase 0.0026 0.0027 0.0076
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0042 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0128
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0026 0.0027 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.02 0.0717
Toxoplasma gondii serine/threonine phosophatase PP1 0.0042 0.0069 0.047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0083 0.0175 0.063
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0024 0.0071
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0043 0.007 0.0484
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.02 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Plasmodium falciparum asparagine--tRNA ligase 0.0052 0.0094 0.0605
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1051 0.2716 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0028 0.008
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0052 0.0094 0.0094
Plasmodium falciparum importin beta, putative 0.0031 0.0039 0.017
Plasmodium falciparum replication protein A1, large subunit 0.0504 0.128 1
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0042 0.0069 0.0069
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0043 0.007 0.6834
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0682 0.1748 0.1744
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0209 0.0506 0.1849
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Entamoeba histolytica Ran family GTPase 0.0023 0.0018 0.0117
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0018 0.0072
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0094 0.0285
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Schistosoma mansoni apoptosis regulator bax 0.0682 0.1748 0.5394
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Schistosoma mansoni ran 0.0023 0.0018 0.005
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0052 0.0094 0.0094
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0219 0.0532 0.0528
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0052 0.0094 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0158 1
Trichomonas vaginalis protein phosphatase-1, putative 0.0042 0.0069 0.0236
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Plasmodium falciparum asparagine--tRNA ligase 0.0052 0.0094 0.0605
Trichomonas vaginalis ran, putative 0.0023 0.0018 0.0049
Onchocerca volvulus 0.0116 0.0262 0.0703
Plasmodium falciparum methionine--tRNA ligase, putative 0.0043 0.007 0.0417
Toxoplasma gondii lysine-tRNA ligase 0.0052 0.0094 0.0671
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0042 0.0069 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0052 0.0094 0.009
Leishmania major hypothetical protein, conserved 0.0028 0.0032 0.0185
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0269 0.0663 0.5781
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0099 0.0094
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0019 0.0074
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Schistosoma mansoni ap endonuclease 0.0039 0.006 0.018
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0042 0.0069 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.1051 0.2716 0.2716
Echinococcus granulosus glycyl tRNA synthetase 0.0209 0.0506 0.0506
Brugia malayi methionyl-tRNA synthetase 0.0269 0.0663 0.2425
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0016
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0099 0.0099
Echinococcus multilocularis leucyl tRNA synthetase 0.0043 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0682 0.1748 0.5394
Loa Loa (eye worm) BRCA2 repeat family protein 0.0212 0.0515 0.1883
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.0823 0.302
Entamoeba histolytica hypothetical protein 0.0027 0.0028 0.0204
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0028 0.0149
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0682 0.1748 0.6429
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.02 0.1507
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0099 0.0299
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0019 0.0082
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1051 0.2716 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.001 0.0015
Mycobacterium ulcerans lipase LipD 0.0076 0.0158 1
Brugia malayi CXXC zinc finger family protein 0.0116 0.0262 0.0945
Plasmodium vivax replication protein A1, large subunit, putative 0.0504 0.128 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.007 0.0243
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.006 0.0205
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0264 0.0651 0.5052
Chlamydia trachomatis methionine--tRNA ligase 0.0269 0.0663 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.001 0.0011
Toxoplasma gondii exonuclease III APE 0.0039 0.006 0.0402
Echinococcus granulosus importin subunit beta 1 0.0031 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0018 0.0018
Schistosoma mansoni ap endonuclease 0.0039 0.006 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.07 0.2157
Leishmania major replication factor A, 51kDa subunit, putative 0.0504 0.128 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0032 0.0185
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0032 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0102 0.0225 0.0545
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Brugia malayi replication factor A 73 kDa subunit 0.1051 0.2716 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0331
Echinococcus multilocularis lysyl tRNA synthetase 0.0052 0.0094 0.009
Plasmodium falciparum nucleic acid binding protein, putative 0.0052 0.0094 0.0605
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0787
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0158 0.1175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0158 0.0567
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Schistosoma mansoni replication factor A 1 rfa1 0.1051 0.2716 0.8383
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0019 0.0082
Trypanosoma brucei protein phosphatase 1 0.0026 0.0027 0.0141
Schistosoma mansoni importin beta-1 0.0031 0.0039 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0042 0.0069 0.0236
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0027 0.0083
Leishmania major GTP-binding protein, putative 0.0023 0.0018 0.007
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.094 0.2426 1
Plasmodium falciparum aspartate--tRNA ligase 0.0052 0.0094 0.0605
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0158 0.0561
Loa Loa (eye worm) hypothetical protein 0.0061 0.0118 0.0419
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Trypanosoma brucei unspecified product 0.002 0.001 0.0011
Trypanosoma brucei protein phosphatase 1, putative 0.0042 0.0069 0.047
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0118 0.0118
Brugia malayi protein ZK524.3 0.0043 0.007 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.006 0.0402
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.006 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Brugia malayi glycyl-tRNA synthetase 0.0209 0.0506 0.1844
Echinococcus granulosus dna polymerase eta 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0102 0.0225 0.0815
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0009 0.0038
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0682 0.1748 0.5394
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0999 0.258 0.9498
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0043 0.007 0.4071
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0016
Schistosoma mansoni hypothetical protein 0.125 0.3239 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0018 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0158 0.0567
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.006 0.3366
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.1236 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.006 0.0402
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0019 0.061
Schistosoma mansoni hypothetical protein 0.033 0.0823 0.2538
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0018 0.0043
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0018 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.006 0.0199
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0042 0.0069 0.0064
Leishmania major DNA polymerase eta, putative 0.002 0.001 0.0011
Entamoeba histolytica replication factor A protein 1, putative 0.0452 0.1144 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Toxoplasma gondii hypothetical protein 0.011 0.0248 0.188
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.001 0.001
Schistosoma mansoni methionine-tRNA synthetase 0.0269 0.0663 0.2043
Brugia malayi Aspartyl-tRNA synthetase 0.0052 0.0094 0.0325
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.02 0.0722
Treponema pallidum aspartyl-tRNA synthetase 0.0052 0.0094 0.1163
Giardia lamblia Lysyl-tRNA synthetase 0.0052 0.0094 0.2511
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0026 0.0027 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.07 0.2157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0009 0.0022
Trichomonas vaginalis protein phosphatase-5, putative 0.0026 0.0027 0.0082
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0052 0.0094 0.0331
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0026 0.0027 0.0082
Mycobacterium ulcerans beta-lactamase 0.0076 0.0158 1
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0042 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0027 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0043 0.007 0.0417
Brugia malayi lysyl-tRNA synthetase 0.0052 0.0094 0.0325
Echinococcus multilocularis cpg binding protein 0.0122 0.028 0.0275
Echinococcus granulosus snurportin 1 0.033 0.0823 0.0823
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Schistosoma mansoni hypothetical protein 0.034 0.085 0.2619
Schistosoma mansoni protein phosphatase type 1 0.0042 0.0069 0.0206
Schistosoma mansoni hypothetical protein 0.0682 0.1748 0.5394
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0042 0.0069 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Mycobacterium tuberculosis Conserved protein 0.0076 0.0158 0.1207
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.001 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0078 0.0271
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.006 0.1555
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0027 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.07 0.07
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0269 0.0663 0.0659
Schistosoma mansoni protein phosphatase-1 0.0042 0.0069 0.0206
Entamoeba histolytica hypothetical protein 0.0052 0.0094 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Plasmodium vivax importin-beta 2, putative 0.0031 0.0039 0.017
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0158 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0158 0.1207
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0042 0.0069 0.0236
Brugia malayi mbt repeat family protein 0.0053 0.0099 0.0341
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.006 0.0406
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0028 0.0149
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.001 0.0006
Trypanosoma brucei Replication factor A protein 1 0.0504 0.128 1
Schistosoma mansoni methionine-tRNA synthetase 0.0043 0.007 0.0212
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0052 0.0048
Brugia malayi beta-lactamase 0.0076 0.0158 0.0561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0039 0.0239
Treponema pallidum methionyl-tRNA synthetase 0.0269 0.0663 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0032 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0158 0.0483
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0158 0.1112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0103
Brugia malayi hypothetical protein 0.0028 0.0032 0.0097
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0052 0.0094 0.0685
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0021
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0032 0.0185
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0042 0.0069 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0158 0.1175
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0099 0.0299
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0052 0.0094 0.0325
Echinococcus granulosus cpg binding protein 0.0122 0.028 0.028
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0094 0.5673
Plasmodium vivax methionine--tRNA ligase, putative 0.0043 0.007 0.0417
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.001 0.0026
Leishmania major DNA polymerase kappa, putative 0.002 0.001 0.0011
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0042 0.0069 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.006 0.0402
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.001 0.005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0158 0.0567
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0004
Leishmania major leucyl-tRNA synthetase, putative 0.0043 0.007 0.0484
Onchocerca volvulus 0.0083 0.0175 0.033
Schistosoma mansoni kinase 0.0047 0.0081 0.0246
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.001
Giardia lamblia GTOR 0.0019 0.0009 0.0122
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0024 0.0118
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0027 0.0076
Leishmania major methionyl-tRNA synthetase, putative 0.0043 0.007 0.0484
Chlamydia trachomatis lysine--tRNA ligase 0.0052 0.0094 0.1163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.07 0.07
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0009 0.0022
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0042 0.0069 0.0236
Trichomonas vaginalis esterase, putative 0.0076 0.0158 0.0567
Giardia lamblia Leucyl-tRNA synthetase 0.0043 0.007 0.1847
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0019 0.0082
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3825 1 1
Trichomonas vaginalis helicase, putative 0.0026 0.0027 0.0083
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0094 0.0285
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Plasmodium vivax aspartate--tRNA ligase, putative 0.0052 0.0094 0.0605
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0019 0.061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.006 0.0487
Brugia malayi Importin beta-1 subunit 0.0031 0.0039 0.0122
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0032 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0016
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0018 0.007
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0027 0.0141
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0009
Schistosoma mansoni glycyl-tRNA synthetase 0.0209 0.0506 0.1557
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0042 0.0069 0.0236
Loa Loa (eye worm) MBCTL1 0.0061 0.0118 0.0419
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0052 0.0094 0.0787
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0099 0.0099
Echinococcus multilocularis dna polymerase eta 0.002 0.001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.02 0.0613
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0094 0.0671
Schistosoma mansoni hypothetical protein 0.0333 0.0832 0.2565
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0027 0.0083
Brugia malayi mbt repeat family protein 0.0053 0.0099 0.0341
Schistosoma mansoni ran 0.0023 0.0018 0.005
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0094 0.0094
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0099 0.0094
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0027 0.0082
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0039 0.0239
Loa Loa (eye worm) hypothetical protein 0.0043 0.007 0.0243
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0019 0.0011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.034 0.085 0.2619
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.006 0.0334

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.058 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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