Detailed information for compound 1588051

Basic information

Technical information
  • TDR Targets ID: 1588051
  • Name: N-[4-[5-[(4-chlorophenyl)methylsulfanyl]-4-me thyl-1,2,4-triazol-3-yl]phenyl]-3-phenylpropa namide
  • MW: 462.994 | Formula: C25H23ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 5.12 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)c1nnc(n1C)SCc1ccc(cc1)Cl)CCc1ccccc1
  • InChi: 1S/C25H23ClN4OS/c1-30-24(28-29-25(30)32-17-19-7-12-21(26)13-8-19)20-10-14-22(15-11-20)27-23(31)16-9-18-5-3-2-4-6-18/h2-8,10-15H,9,16-17H2,1H3,(H,27,31)
  • InChiKey: OFZVUSIBTQLAKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]-3-phenyl-propanamide
  • N-[4-[5-[(4-chlorophenyl)methylthio]-4-methyl-1,2,4-triazol-3-yl]phenyl]-3-phenylpropanamide
  • N-[4-[5-[(4-chlorobenzyl)thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]-3-phenyl-propionamide
  • AN-648/14913047

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Trypanosoma brucei protein phosphatase 1 0.0026 0.0026 0.0127
Brugia malayi methionyl-tRNA synthetase 0.0042 0.007 0.022
Trichomonas vaginalis ran, putative 0.0023 0.002 0.0053
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0026 0.0069
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3872 1 1
Plasmodium vivax asparagine--tRNA ligase, putative 0.0056 0.0105 0.0637
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0014
Trichomonas vaginalis protein phosphatase-1, putative 0.0041 0.0066 0.0214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0157 1
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Toxoplasma gondii tRNA ligases class I (M) protein 0.0042 0.007 0.0449
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0056 0.0105 0.6427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.0702 0.0702
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0027 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0009
Schistosoma mansoni kinase 0.0048 0.0084 0.025
Plasmodium falciparum methionine--tRNA ligase 0.0042 0.007 0.0378
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0169 0.0165
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0041 0.0066 0.0214
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0058 0.018
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0056 0.0105 0.0346
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.007 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0105 0.01
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0058 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.001
Echinococcus granulosus geminin 0.0339 0.0838 0.0838
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.0005
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.001
Brugia malayi protein ZK524.3 0.0042 0.007 0.022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0019 0.0074
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0041 0.0241
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0048
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Plasmodium falciparum nucleic acid binding protein, putative 0.0056 0.0105 0.0637
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0026 0.0026 0.0074
Echinococcus multilocularis snurportin 1 0.0336 0.0832 0.0828
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0056 0.0105 0.0346
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0056 0.0105 0.6202
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0214
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0056 0.0105 0.0781
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Brugia malayi glycyl-tRNA synthetase 0.0207 0.0496 0.1693
Leishmania major hypothetical protein, conserved 0.0028 0.0031 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0053
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0095 0.0313
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0058 0.0363
Schistosoma mansoni importin beta-1 0.0032 0.0041 0.0119
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0058 0.0396
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0026 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0266 0.065 0.223
Schistosoma mansoni protein phosphatase type 1 0.0041 0.0066 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.008 0.0262
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0056 0.0105 0.01
Schistosoma mansoni hypothetical protein 0.0339 0.0838 0.2598
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0041 0.0066 0.1605
Schistosoma mansoni hypothetical protein 0.069 0.1749 0.5432
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.0066 0.0208
Leishmania major lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Schistosoma mansoni hypothetical protein 0.0325 0.0803 0.2489
Echinococcus multilocularis cpg binding protein 0.0123 0.028 0.0276
Chlamydia trachomatis leucine--tRNA ligase 0.0042 0.007 0.0808
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0041 0.0066 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0028 0.0083
Mycobacterium ulcerans beta-lactamase 0.0076 0.0157 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0026 0.0127
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0028 0.0083
Echinococcus granulosus lysyl tRNA synthetase 0.0056 0.0105 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Schistosoma mansoni lysyl-tRNA synthetase 0.0056 0.0105 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.0702 0.2174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0009
Treponema pallidum methionyl-tRNA synthetase 0.0266 0.065 1
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0056 0.0105 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.1223 1
Mycobacterium ulcerans hypothetical protein 0.0076 0.0157 1
Schistosoma mansoni cpg binding protein 0.0117 0.0263 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Echinococcus granulosus cpg binding protein 0.0123 0.028 0.028
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0056 0.0105 0.0105
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0026 0.0026 0.0069
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0056 0.0105 0.0105
Trichomonas vaginalis esterase, putative 0.0076 0.0157 0.0528
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0041 0.0066 0.0066
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0031 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0031 0.0167
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0105 0.0637
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0026 0.0069
Onchocerca volvulus 0.0076 0.0157 0.0249
Plasmodium vivax lysine--tRNA ligase, putative 0.0056 0.0105 0.0637
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0031 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0031 0.0094
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0266 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0052 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0157 0.048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0157 0.1216
Echinococcus granulosus importin subunit beta 1 0.0032 0.0041 0.0041
Trypanosoma brucei Replication factor A protein 1 0.0544 0.1369 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0225
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0058 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0157 0.1216
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0041 0.0066 0.0062
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0157 0.1216
Entamoeba histolytica hypothetical protein 0.0056 0.0105 0.0822
Plasmodium falciparum importin beta, putative 0.0032 0.0041 0.0168
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0019
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0056 0.0105 0.1363
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0157 0.0528
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0157 0.048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0019
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0056 0.0105 0.0822
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0095 0.0286
Plasmodium falciparum aspartate--tRNA ligase 0.0056 0.0105 0.0637
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0026 0.0074
Brugia malayi replication factor A 73 kDa subunit 0.1134 0.2901 1
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0031 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0031 0.0094
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.011 0.0245 0.0599
Plasmodium vivax aspartate--tRNA ligase, putative 0.0056 0.0105 0.0637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.0702 0.2174
Leishmania major replication factor A, 51kDa subunit, putative 0.0544 0.1369 1
Schistosoma mansoni ap endonuclease 0.0038 0.0058 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Leishmania major GTP-binding protein, putative 0.0023 0.002 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0058 0.0185
Brugia malayi Importin beta-1 subunit 0.0032 0.0041 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0058 0.0363
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0266 0.065 0.5294
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0285 0.0699 0.5071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Plasmodium vivax replication protein A1, large subunit, putative 0.0544 0.1369 1
Echinococcus multilocularis leucyl tRNA synthetase 0.0042 0.007 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0157 0.1216
Toxoplasma gondii hypothetical protein 0.0119 0.0269 0.191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.0082
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1134 0.2901 1
Giardia lamblia Kinase, PLK 0.0094 0.0204 0.5169
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0045
Schistosoma mansoni hypothetical protein 0.0056 0.0105 0.0316
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.069 0.1749 0.6023
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0027 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0058 0.0185
Schistosoma mansoni protein phosphatase-1 0.0041 0.0066 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0019 0.0591
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0019 0.0591
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.0832 0.2857
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0019 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0058 0.0291
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.002 0.0009
Schistosoma mansoni hypothetical protein 0.1257 0.3218 1
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0157 1
Entamoeba histolytica replication factor A protein 1, putative 0.0488 0.1224 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0058 0.0439
Giardia lamblia Leucyl-tRNA synthetase 0.0042 0.007 0.1693
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0019
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.069 0.1749 0.5432
Trypanosoma brucei unspecified product 0.0019 0.001 0.001
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1078 0.2756 0.9499
Entamoeba histolytica replication factor A, putative 0.011 0.0245 0.197
Schistosoma mansoni glycyl-tRNA synthetase 0.0207 0.0496 0.1533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0058 0.457
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0058 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0114 0.0373
Plasmodium vivax hypothetical protein, conserved 0.0042 0.007 0.0378
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0014
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0066 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0114 0.0114
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0204 0.1433
Schistosoma mansoni ran 0.0023 0.002 0.0052
Plasmodium falciparum asparagine--tRNA ligase 0.0056 0.0105 0.0637
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0027 0.0134
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.1015 0.2592 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0157 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0041 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0041 0.0066 0.0208
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.002 0.0015
Schistosoma mansoni replication factor A 1 rfa1 0.1134 0.2901 0.9013
Brugia malayi mbt repeat family protein 0.0052 0.0095 0.0308
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0095 0.0095
Plasmodium vivax asparagine--tRNA ligase, putative 0.0056 0.0105 0.0637
Brugia malayi beta-lactamase family protein 0.0076 0.0157 0.0523
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.0066 0.0066
Brugia malayi BRCA2 repeat family protein 0.0229 0.0554 0.1892
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0019 0.0074
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Treponema pallidum asparaginyl-tRNA synthetase 0.0056 0.0105 0.1363
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0026 0.0026 0.0176
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.069 0.1749 0.1749
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Leishmania major DNA polymerase eta, putative 0.0019 0.001 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.0082
Entamoeba histolytica Ran family GTPase 0.0023 0.002 0.0126
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.069 0.1749 0.1746
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0207 0.0496 0.1698
Trypanosoma cruzi Replication factor A protein 1 0.0544 0.1369 1
Toxoplasma gondii serine/threonine phosophatase PP1 0.0041 0.0066 0.0424
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0225
Schistosoma mansoni protein phosphatase type 1 0.0026 0.0026 0.0071
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0041 0.0241
Giardia lamblia Lysyl-tRNA synthetase 0.0056 0.0105 0.2602
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0009 0.0017
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.1134 0.2901 0.2901
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Trichomonas vaginalis helicase, putative 0.0026 0.0028 0.0083
Schistosoma mansoni methionine-tRNA synthetase 0.0042 0.007 0.0207
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0169 0.0564
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0041 0.0066 0.0062
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0204 0.1433
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0041 0.0037
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.0066 0.0214
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0026 0.0074
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.0513 0.0509
Schistosoma mansoni hypothetical protein 0.0336 0.0832 0.2578
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0027 0.0074
Giardia lamblia Asparaginyl-tRNA synthetase 0.0056 0.0105 0.2602
Treponema pallidum leucyl-tRNA synthetase 0.0042 0.007 0.0808
Schistosoma mansoni hypothetical protein 0.069 0.1749 0.5432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0021
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0076 0.0157 0.1216
Chlamydia trachomatis methionine--tRNA ligase 0.0266 0.065 1
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.1134 0.2901 0.2898
Echinococcus granulosus glycyl tRNA synthetase 0.0207 0.0496 0.0496
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0041 0.0066 0.0062
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.0005
Leishmania major replication Factor A 28 kDa subunit, putative 0.0056 0.0105 0.0706
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.002 0.0082
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0058 0.0291
Schistosoma mansoni methionine-tRNA synthetase 0.0266 0.065 0.2013
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.001
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.0066 0.0066
Brugia malayi hypothetical protein 0.0028 0.0031 0.0088
Echinococcus multilocularis lysyl tRNA synthetase 0.0056 0.0105 0.01
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0056 0.0105 0.0706
Onchocerca volvulus 0.0117 0.0263 0.0671
Leishmania major methionyl-tRNA synthetase, putative 0.0042 0.007 0.0449
Plasmodium falciparum lysine--tRNA ligase 0.0056 0.0105 0.0637
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0019 0.0074
Schistosoma mansoni hypothetical protein 0.0339 0.0838 0.2598
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trichomonas vaginalis protein phosphatase-5, putative 0.0026 0.0026 0.0074
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0042 0.007 0.3676
Brugia malayi CXXC zinc finger family protein 0.0117 0.0263 0.0887
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0207 0.0496 0.1698
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0066 0.0214
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0204 0.1633
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Schistosoma mansoni cpg binding protein 0.0123 0.028 0.0861
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.0066 0.0424
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0009 0.0034
Leishmania major leucyl-tRNA synthetase, putative 0.0042 0.007 0.0449
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1134 0.2901 1
Entamoeba histolytica hypothetical protein 0.0056 0.0105 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0157 0.1094
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0157 0.1216
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0157 0.1216
Brugia malayi beta-lactamase family protein 0.0076 0.0157 0.0523
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0026 0.0074
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0026 0.0026 0.0074
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.0066 0.0062
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0114 0.0345
Brugia malayi mbt repeat family protein 0.0052 0.0095 0.0308
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0095 0.0091
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0399
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0286 0.0702 0.2405
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0095 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Loa Loa (eye worm) hypothetical protein 0.0059 0.0114 0.0378
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0157 0.0523
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.0066 0.0062
Schistosoma mansoni lysyl-tRNA synthetase 0.0056 0.0105 0.0316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0286 0.0702 0.2409
Leishmania major hypothetical protein, conserved 0.0076 0.0157 0.1094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Echinococcus multilocularis glycyl tRNA synthetase 0.0207 0.0496 0.0492
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0128
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0031 0.0167
Mycobacterium ulcerans lipase LipD 0.0076 0.0157 1
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0026 0.0026 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0105 0.0706
Schistosoma mansoni ran 0.0023 0.002 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0157 0.0528
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0114 0.011
Echinococcus granulosus dnaJ subfamily B 0.1257 0.3218 0.3218
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0204 0.0624
Brugia malayi methionyl-tRNA synthetase 0.0266 0.065 0.2226
Brugia malayi lysyl-tRNA synthetase 0.0056 0.0105 0.0341
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0035 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.1257 0.3218 0.3215
Schistosoma mansoni protein phosphatase type 1 0.0041 0.0066 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.001
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0042 0.007 0.5927
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0095 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Toxoplasma gondii lysine-tRNA ligase 0.0056 0.0105 0.0706
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0074
Giardia lamblia Aspartyl-tRNA synthetase 0.0056 0.0105 0.2602
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0263 0.0891
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0204 0.1433
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0157 0.1094
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0204 0.0204
Onchocerca volvulus 0.0076 0.0157 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0157 0.0528
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Leishmania major aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Schistosoma mansoni protein phosphatase-1 0.0041 0.0066 0.0196
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0204 0.0434
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0042 0.007 0.0492
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0042 0.007 0.0225
Giardia lamblia GTOR 0.0019 0.0009 0.0109
Schistosoma mansoni protein phosphatase-1 0.0026 0.0026 0.0071
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0157 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0157 1
Echinococcus granulosus methionine tRNA synthetase 0.0042 0.007 0.007
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0041 0.0066 0.0353
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0074
Echinococcus granulosus snurportin 1 0.0336 0.0832 0.0832
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.008 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Giardia lamblia Methionyl-tRNA synthetase 0.0042 0.007 0.1693
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0017 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0157 0.1094
Loa Loa (eye worm) hypothetical protein 0.0052 0.0095 0.0313
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0042 0.007 0.405
Loa Loa (eye worm) hypothetical protein 0.0076 0.0157 0.0528
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0026 0.0074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0248 0.0602 0.1864
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0056 0.0105 0.6427
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.001
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Chlamydia trachomatis lysine--tRNA ligase 0.0056 0.0105 0.1363
Schistosoma mansoni apoptosis regulator bax 0.069 0.1749 0.5432
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0224 0.054 0.185
Toxoplasma gondii methionyl-tRNA synthetase 0.0042 0.007 0.0449
Onchocerca volvulus 0.0076 0.0157 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.0702 0.0698
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0026 0.0074
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0009 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Giardia lamblia DINP protein human, muc B family 0.0019 0.001 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0035 0.0035
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0026 0.0026 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.0702 0.2174
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0058 0.0058
Loa Loa (eye worm) BRCA2 repeat family protein 0.0229 0.0554 0.1896
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.0702 0.0698
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0207 0.0496 0.1693
Plasmodium vivax importin-beta 2, putative 0.0032 0.0041 0.0168
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0004
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0056 0.0105 0.0341
Toxoplasma gondii ABC1 family protein 0.0076 0.0157 0.1094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.007 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0105 0.0105
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0019 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0028 0.0083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0157 0.0153
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0042 0.007 0.405
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0095 0.0286
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0058 0.0623
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0544 0.1369 1
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0026 0.0026 0.0127
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0204 0.0688
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0042 0.007 0.0225
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Leishmania major aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0066 0.0214
Leishmania major importin beta-1 subunit, putative 0.0026 0.0026 0.0127
Plasmodium falciparum replication protein A1, large subunit 0.0544 0.1369 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0105 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0058 0.1389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0027 0.0072
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0105 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0041 0.0066 0.0214
Schistosoma mansoni ap endonuclease 0.0038 0.0058 0.0171
Brugia malayi putative serine/threonine phosphatase 0.0026 0.0026 0.0069
Echinococcus multilocularis methionine tRNA synthetase 0.0042 0.007 0.0065
Treponema pallidum aspartyl-tRNA synthetase 0.0056 0.0105 0.1363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0035 0.0099
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0544 0.1369 0.4713
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.0066 0.0424
Schistosoma mansoni cpg binding protein 0.0123 0.028 0.0861
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0266 0.065 0.0646
Entamoeba histolytica hypothetical protein 0.0023 0.0019 0.0116
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0114 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0078
Giardia lamblia Hypothetical protein 0.0166 0.039 1
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0026 0.0026 0.0074
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.173 0.4445 0.4442
Trypanosoma brucei polo-like protein kinase 0.0094 0.0204 0.1433
Loa Loa (eye worm) hypothetical protein 0.011 0.0245 0.083
Onchocerca volvulus 0.0081 0.0169 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0157 0.0528
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0035 0.0031
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0042 0.007 0.5927
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0009 0.0034
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0095 0.0095
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0204 0.0683
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0041 0.0066 0.0066
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0169 0.0517
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0021
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0027 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.0534 0.3858
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0041 0.0066 0.0353
Loa Loa (eye worm) hypothetical protein 0.069 0.1749 0.6025
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0157 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0056 0.0105 0.6202
Trypanosoma brucei protein phosphatase 1 0.0026 0.0026 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Entamoeba histolytica hypothetical protein 0.0026 0.0027 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0058 0.0185
Trypanosoma brucei protein phosphatase 1, putative 0.0041 0.0066 0.0424
Loa Loa (eye worm) hypothetical protein 0.0081 0.0169 0.0569
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0026 0.0026 0.0069
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0204 0.0199
Schistosoma mansoni protein phosphatase-1 0.0026 0.0026 0.0071
Schistosoma mansoni leucyl-tRNA synthetase 0.0042 0.007 0.0207
Plasmodium falciparum asparagine--tRNA ligase 0.0056 0.0105 0.0637
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0056 0.0105 0.0822
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.001
Trichomonas vaginalis protein phosphatase-1, putative 0.0026 0.0026 0.0074
Mycobacterium tuberculosis Conserved protein 0.0076 0.0157 0.1216
Loa Loa (eye worm) beta-lactamase 0.0076 0.0157 0.0528
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0157 0.0528
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0026 0.0026 0.0127
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0083
Brugia malayi RNA, U transporter 1 0.009 0.0192 0.0643
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0056 0.0105 0.6427
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0042 0.007 0.0449
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0346
Brugia malayi Aspartyl-tRNA synthetase 0.0056 0.0105 0.0341
Entamoeba histolytica hypothetical protein 0.0026 0.0026 0.0176
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0157 0.1028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0058 0.3258
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0157 0.0528
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0004
Schistosoma mansoni hypothetical protein 0.069 0.1749 0.5432
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.001 0.001
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.1134 0.2901 1
Leishmania major lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0042 0.007 0.0449
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0093
Toxoplasma gondii aspartate-tRNA ligase 0.0056 0.0105 0.0706
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.001
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0021
Mycobacterium leprae Probable lipase LipE 0.0076 0.0157 1
Plasmodium falciparum methionine--tRNA ligase, putative 0.0042 0.007 0.0378
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0204 0.0688
Loa Loa (eye worm) MBCTL1 0.0059 0.0114 0.0378
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0053 0.0169
Loa Loa (eye worm) 63kd antigen 0.0056 0.0105 0.0346
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.0513 0.0513
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0056 0.0105 0.0346
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0053 0.0049
Leishmania major asparaginyl-tRNA synthetase, putative 0.0056 0.0105 0.0706
Echinococcus multilocularis geminin 0.0339 0.0838 0.0834
Brugia malayi beta-lactamase 0.0076 0.0157 0.0523
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0056 0.0105 0.0781
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0026 0.0026 0.0074
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0056 0.0105 0.01
Toxoplasma gondii exonuclease III APE 0.0038 0.0058 0.0363
Loa Loa (eye worm) apoptosis regulator protein 0.069 0.1749 0.6025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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