Detailed information for compound 1588052

Basic information

Technical information
  • TDR Targets ID: 1588052
  • Name: 2-chloro-N-(3-methoxy-5-oxo-1-cyclohepta-1,3, 6-trienyl)acetamide
  • MW: 227.644 | Formula: C10H10ClNO3
  • H donors: 1 H acceptors: 2 LogP: 0.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCC(=O)Nc1ccc(=O)cc(c1)OC
  • InChi: 1S/C10H10ClNO3/c1-15-9-4-7(12-10(14)6-11)2-3-8(13)5-9/h2-5H,6H2,1H3,(H,12,14)
  • InChiKey: PNRQXRJHRPVJHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(5-keto-3-methoxy-1-cyclohepta-1,3,6-trienyl)acetamide
  • 2-chloro-N-(3-methoxy-5-oxo-1-cyclohepta-1,3,6-trienyl)ethanamide
  • NSC149046

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Echinococcus multilocularis methionine tRNA synthetase 0.0032 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0411
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0335 0.1567
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0014 0.0016
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Schistosoma mansoni methionine-tRNA synthetase 0.02 0.0808 0.1519
Giardia lamblia Hypothetical protein 0.0148 0.0583 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0335 0.0624
Loa Loa (eye worm) hypothetical protein 0.0098 0.0364 0.0817
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0042 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1682 0.7298 0.7296
Loa Loa (eye worm) hypothetical protein 0.005 0.0153 0.0333
Loa Loa (eye worm) MBCTL1 0.0058 0.0187 0.0411
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.004 0.0109 0.0448
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.005 0.0153 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Entamoeba histolytica hypothetical protein 0.0043 0.0124 0.0636
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.004 0.0109 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0109 0.0464
Schistosoma mansoni methionine-tRNA synthetase 0.0032 0.0073 0.0128
Schistosoma mansoni hypothetical protein 0.041 0.1728 0.3261
Brugia malayi BRCA2 repeat family protein 0.0205 0.083 0.1872
Echinococcus granulosus cpg binding protein 0.012 0.046 0.046
Loa Loa (eye worm) 63kd antigen 0.005 0.0153 0.0333
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0074
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.004 0.0109 0.1765
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0043 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0067 0.0258
Leishmania major leucyl-tRNA synthetase, putative 0.0032 0.0073 0.0287
Schistosoma mansoni protein phosphatase type 1 0.004 0.0109 0.0196
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0439
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0032 0.0073 0.4108
Brugia malayi hypothetical protein 0.002 0.002 0.0013
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.041 0.1728 0.1728
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0234
Brugia malayi protein ZK524.3 0.0032 0.0073 0.0135
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0042
Leishmania major replication Factor A 28 kDa subunit, putative 0.005 0.0153 0.0677
Trypanosoma brucei protein phosphatase 1 0.0025 0.0042 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0109 0.0197
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0109 0.0234
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0009
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.004 0.0109 0.0109
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0156 0.0341
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0005
Schistosoma mansoni protein phosphatase-1 0.0025 0.0042 0.0071
Schistosoma mansoni apoptosis regulator bax 0.041 0.1728 0.3261
Leishmania major GTP-binding protein, putative 0.0023 0.0032 0.009
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0109 0.0894
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0109 0.6811
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0068 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1153 0.1147
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0032 0.0073 0.415
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.02 0.0808 0.0808
Echinococcus multilocularis glycyl tRNA synthetase 0.0155 0.0613 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.1055 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0109 0.0463
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0044 0.0147
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0233
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0067 0.0243
Schistosoma mansoni hypothetical protein 0.041 0.1728 0.3261
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0014 0.0014
Brugia malayi hypothetical protein 0.003 0.0067 0.0121
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.005 0.0153 1
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0067 0.0258
Trichomonas vaginalis protein phosphatase-1, putative 0.004 0.0109 0.0233
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0233
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0057 0.005
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0168 0.0669 0.1515
Schistosoma mansoni hypothetical protein 0.0327 0.1367 0.2578
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 0.0159
Plasmodium vivax replication protein A1, large subunit, putative 0.0486 0.2062 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0109 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Schistosoma mansoni hypothetical protein 0.0043 0.0124 0.0225
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1014 0.4374 1
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0109
Brugia malayi beta-lactamase 0.004 0.0109 0.0218
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.005 0.0153 0.0792
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0335 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0043 0.0081
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0156 0.0149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0139
Brugia malayi mbt repeat family protein 0.0051 0.0156 0.0326
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0124 0.0117
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.004 0.0109 0.0448
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0153 0.0662
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0153 0.0677
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0042 0.0081
Giardia lamblia Asparaginyl-tRNA synthetase 0.005 0.0153 0.2526
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0042 0.0081
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0187 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0156 0.0149
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.009
Brugia malayi RNA, U transporter 1 0.0087 0.0316 0.0691
Plasmodium vivax asparagine--tRNA ligase, putative 0.005 0.0153 0.0662
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0044 0.0147
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0187 0.0344
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0088 0.0185
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0187 0.0187
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0044 0.0147
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0335 0.0751
Entamoeba histolytica hypothetical protein 0.0025 0.0043 0.0193
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0792
Toxoplasma gondii tRNA ligases class I (M) protein 0.0032 0.0073 0.0287
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0486 0.2062 1
Schistosoma mansoni kinase 0.0047 0.0138 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0043 0.0081
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0068 0.0263
Trypanosoma brucei protein phosphatase 1 0.0025 0.0042 0.0139
Trichomonas vaginalis esterase, putative 0.004 0.0109 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0011
Entamoeba histolytica hypothetical protein 0.005 0.0153 0.0792
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0335 0.0328
Mycobacterium ulcerans hypothetical protein 0.004 0.0109 0.6811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0241 0.099 0.1864
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0153 0.2526
Echinococcus multilocularis dnaJ subfamily B 0.1223 0.5289 0.5286
Schistosoma mansoni hypothetical protein 0.1223 0.5289 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0047 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1153 0.1153
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.0011
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.005 0.0153 0.0153
Schistosoma mansoni glycyl-tRNA synthetase 0.0155 0.0613 0.115
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0042 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0057 0.005
Schistosoma mansoni protein phosphatase type 1 0.0025 0.0042 0.0071
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.005 0.0153 0.0153
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Treponema pallidum asparaginyl-tRNA synthetase 0.005 0.0153 0.1712
Plasmodium vivax methionine--tRNA ligase, putative 0.0032 0.0073 0.0272
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0032 0.0074
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0153 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0021
Brugia malayi beta-lactamase family protein 0.004 0.0109 0.0218
Schistosoma mansoni DNA polymerase eta 0.0019 0.0016 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1153 0.2173
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0109 0.6811
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.005 0.0153 0.0153
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0042 0.0081
Brugia malayi putative serine/threonine phosphatase 0.0025 0.0042 0.0065
Mycobacterium ulcerans beta-lactamase 0.004 0.0109 0.6811
Giardia lamblia Methionyl-tRNA synthetase 0.0032 0.0073 0.1141
Mycobacterium leprae conserved hypothetical protein 0.004 0.0109 0.455
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.1014 0.4374 0.4374
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0156 0.0341
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0156 0.0286
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.005 0.0153 0.0333
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0081
Schistosoma mansoni cpg binding protein 0.012 0.046 0.0861
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0044 0.0037
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0014 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0088 0.0081
Trichomonas vaginalis ran, putative 0.0023 0.0032 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0049
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Schistosoma mansoni hypothetical protein 0.033 0.138 0.2601
Leishmania major hypothetical protein, conserved 0.004 0.0109 0.0464
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0155 0.0613 0.1373
Leishmania major methionyl-tRNA synthetase, putative 0.0032 0.0073 0.0287
Schistosoma mansoni cpg binding protein 0.0114 0.0432 0.0807
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Entamoeba histolytica hypothetical protein 0.005 0.0153 0.0792
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0109 0.0464
Entamoeba histolytica hypothetical protein 0.0025 0.0044 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1153 0.2173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0025 0.0042 0.0139
Treponema pallidum methionyl-tRNA synthetase 0.02 0.0808 1
Entamoeba histolytica hypothetical protein 0.0043 0.0124 0.0636
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0021
Chlamydia trachomatis methionine--tRNA ligase 0.02 0.0808 1
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0486 0.2062 0.4706
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0025 0.0042 0.0192
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0109 0.0464
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0109 0.0894
Giardia lamblia Kinase, PLK 0.0092 0.0335 0.5694
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0029 0.0071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0032 0.0025
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0109 0.0233
Schistosoma mansoni hypothetical protein 0.0313 0.1303 0.2456
Schistosoma mansoni protein phosphatase type 1 0.004 0.0109 0.0196
Echinococcus multilocularis dna polymerase eta 0.0019 0.0016 0.0009
Giardia lamblia GTOR 0.0018 0.0014 0.012
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.005 0.0153 0.0333
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0156 0.0123
Schistosoma mansoni hypothetical protein 0.005 0.0153 0.0279
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.004 0.0109 0.0102
Treponema pallidum leucyl-tRNA synthetase 0.0032 0.0073 0.0703
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.009
Plasmodium vivax aspartate--tRNA ligase, putative 0.005 0.0153 0.0662
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0021
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.005 0.0153 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0086 0.0164
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0109 0.0894
Schistosoma mansoni protein phosphatase-1 0.004 0.0109 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Plasmodium falciparum nucleic acid binding protein, putative 0.005 0.0153 0.0662
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Brugia malayi CXXC zinc finger family protein 0.0114 0.0432 0.0958
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0335 0.1567
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0156 0.0286
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0335 0.0335
Trypanosoma brucei polo-like protein kinase 0.0092 0.0335 0.1567
Schistosoma mansoni leucyl-tRNA synthetase 0.0032 0.0073 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0023
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0109 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0234
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0124 0.0124
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0153 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0335 0.1786
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0044 0.0074
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0908 0.3908 1
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0156 0.0156
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0023
Plasmodium falciparum methionine--tRNA ligase 0.0032 0.0073 0.0272
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0153 0.0662
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0025 0.0042 0.0081
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0014 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Loa Loa (eye worm) beta-lactamase 0.004 0.0109 0.0234
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0032 0.009
Schistosoma mansoni replication factor A 1 rfa1 0.1014 0.4374 0.8268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0017 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Echinococcus granulosus glycyl tRNA synthetase 0.0155 0.0613 0.0613
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0263
Leishmania major importin beta-1 subunit, putative 0.0025 0.0043 0.0139
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0067 0.0243
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0109 0.0218
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.0011
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0032 0.0073 0.0287
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0153 0.0146
Plasmodium vivax importin-beta 2, putative 0.0031 0.0068 0.0248
Loa Loa (eye worm) apoptosis regulator protein 0.041 0.1728 0.3941
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0023
Echinococcus granulosus dnaJ subfamily B 0.1223 0.5289 0.5289
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0109 0.0894
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0014 0.0014
Entamoeba histolytica replication factor A protein 1, putative 0.0436 0.1843 1
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0964 0.4155 0.9499
Entamoeba histolytica replication factor A, putative 0.0098 0.0364 0.1944
Echinococcus multilocularis leucyl tRNA synthetase 0.0032 0.0073 0.0066
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0067 0.0243
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Echinococcus multilocularis snurportin 1 0.0327 0.1367 0.1361
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0032 0.0073 0.4108
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0017 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0016
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1014 0.4374 1
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0153 0.0153
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0335 0.1567
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Plasmodium falciparum replication protein A1, large subunit 0.0486 0.2062 1
Trichomonas vaginalis protein phosphatase-5, putative 0.0025 0.0042 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Schistosoma mansoni importin beta-1 0.0031 0.0068 0.0119
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0255 0.1049 0.5055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.02 0.0808 0.0801
Plasmodium falciparum importin beta, putative 0.0031 0.0068 0.0248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0109 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.041 0.1728 0.3261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.0432 0.0972
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0153 0.1085
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0017 0.0016
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0025 0.0042 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0098 0.0364 0.0671
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.041 0.1728 0.3931
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.1153 0.2624
Echinococcus granulosus importin subunit beta 1 0.0031 0.0068 0.0068
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0014 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0017 0.0009
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0153 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0014 0.0007
Brugia malayi mbt repeat family protein 0.0051 0.0156 0.0326
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.005 0.0153 1
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.005 0.0153 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0109 0.0234
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0032 0.0032
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.1014 0.4374 0.437
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0109 0.0109
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0042 0.0081
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0073 0.0272
Trypanosoma brucei protein phosphatase 1, putative 0.004 0.0109 0.0463
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0109 0.0102
Onchocerca volvulus 0.0114 0.0432 0.0849
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.015
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.004 0.0109 0.0109
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0009
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0032 0.0073 0.0287
Plasmodium falciparum aspartate--tRNA ligase 0.005 0.0153 0.0662
Loa Loa (eye worm) hypothetical protein 0.02 0.0808 0.1834
Loa Loa (eye worm) BRCA2 repeat family protein 0.0205 0.083 0.1885
Brugia malayi glycyl-tRNA synthetase 0.0155 0.0613 0.1373
Brugia malayi replication factor A 73 kDa subunit 0.1014 0.4374 1
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.02 0.0808 0.4362
Echinococcus granulosus snurportin 1 0.0327 0.1367 0.1367
Trypanosoma cruzi Replication factor A protein 1 0.0486 0.2062 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0109 0.0449
Plasmodium falciparum asparagine--tRNA ligase 0.005 0.0153 0.0662
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.0007 0.0007
Onchocerca volvulus 0.0051 0.0156 0.0123
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0187 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Giardia lamblia Leucyl-tRNA synthetase 0.0032 0.0073 0.1141
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0057 0.0057
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0032 0.0073 0.415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0044 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0132 0.0287
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0047 0.009
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0042 0.0081
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.1014 0.4374 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0014 0.0016
Leishmania major aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0335 0.0595
Toxoplasma gondii serine/threonine phosophatase PP1 0.004 0.0109 0.0463
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0016
Leishmania major asparaginyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Leishmania major replication factor A, 51kDa subunit, putative 0.0486 0.2062 1
Schistosoma mansoni protein phosphatase-1 0.0025 0.0042 0.0071
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0011
Echinococcus granulosus dna polymerase eta 0.0019 0.0016 0.0016
Leishmania major DNA polymerase eta, putative 0.0019 0.0016 0.0011
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0155 0.0613 0.1387
Loa Loa (eye worm) hypothetical protein 0.041 0.1728 0.3941
Mycobacterium leprae Probable lipase LipE 0.004 0.0109 0.455
Schistosoma mansoni hypothetical protein 0.041 0.1728 0.3261
Brugia malayi methionyl-tRNA synthetase 0.0032 0.0073 0.0135
Mycobacterium ulcerans lipase LipD 0.004 0.0109 0.6811
Echinococcus granulosus methionine tRNA synthetase 0.0032 0.0073 0.0073
Treponema pallidum aspartyl-tRNA synthetase 0.005 0.0153 0.1712
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.004 0.0109 0.0102
Brugia malayi methionyl-tRNA synthetase 0.02 0.0808 0.1821
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Brugia malayi Aspartyl-tRNA synthetase 0.005 0.0153 0.0318
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0042 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0017
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0014 0.0007
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0155 0.0613 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0057 0.0057
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0016
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0233
Leishmania major hypothetical protein, conserved 0.003 0.0067 0.0258
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0042 0.0065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.1367 0.3114
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0124 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Plasmodium falciparum asparagine--tRNA ligase 0.005 0.0153 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0088 0.0088
Giardia lamblia Aspartyl-tRNA synthetase 0.005 0.0153 0.2526
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0016
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0057 0.0099
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0132 0.0287
Schistosoma mansoni ran 0.0023 0.0032 0.0052
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.005 0.0153 0.1312
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0263
Schistosoma mansoni hypothetical protein 0.033 0.138 0.2601
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0017 0.0055
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0021
Trichomonas vaginalis protein phosphatase, caeel, putative 0.004 0.0109 0.0233
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0109 0.0894
Brugia malayi hypothetical protein 0.0043 0.0124 0.0252
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0187 0.018
Brugia malayi beta-lactamase family protein 0.004 0.0109 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Echinococcus multilocularis asparaginyl tRNA synthetase 0.005 0.0153 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0067 0.0258
Plasmodium falciparum methionine--tRNA ligase, putative 0.0032 0.0073 0.0272
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.005
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0042 0.0065
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0014 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0109 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0044 0.0085
Entamoeba histolytica Ran family GTPase 0.0023 0.0032 0.0138
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2299 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0017 0.0071
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0025 0.0042 0.0139
Schistosoma mansoni protein phosphatase-1 0.004 0.0109 0.0196
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0032 0.0073 0.0545
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0153 0.0279
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.004 0.0109 0.0102
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0124 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1153 0.1147
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.004 0.0109 0.0217
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0042 0.0065
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0042 0.0081
Brugia malayi Importin beta-1 subunit 0.0031 0.0068 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0153 0.0279
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0032 0.0073 0.015
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Toxoplasma gondii aspartate-tRNA ligase 0.005 0.0153 0.0677
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0153 0.0333
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0043 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.009
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.0827 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0187 0.0187
Schistosoma mansoni aspartyl-tRNA synthetase 0.005 0.0153 0.0279
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0156 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.009
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0067 0.0258
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.041 0.1728 0.1722
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0102
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.005 0.0153 0.0146
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Plasmodium vivax methionine--tRNA ligase, putative 0.0032 0.0073 0.0272
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.005 0.0153 0.1312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Entamoeba histolytica hypothetical protein 0.0043 0.0124 0.0636
Leishmania major aspartyl-tRNA synthetase, putative 0.005 0.0153 0.0677
Trichomonas vaginalis helicase, putative 0.0026 0.0047 0.009
Schistosoma mansoni cpg binding protein 0.012 0.046 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0153 0.0677
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0109
Brugia malayi lysyl-tRNA synthetase 0.005 0.0153 0.0318
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1153 0.2173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.005 0.0153 0.0677
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0751
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.005 0.0153 0.0318
Schistosoma mansoni ran 0.0023 0.0032 0.0052
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.0827 0.082
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.004 0.0109 0.0109
Toxoplasma gondii hypothetical protein 0.0107 0.04 0.1884
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.005 0.0153 0.1085
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0016 0.0011
Echinococcus multilocularis geminin 0.033 0.138 0.1373
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0234
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Toxoplasma gondii ABC1 family protein 0.004 0.0109 0.0464
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0042 0.0065
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0032 0.0073 0.015
Plasmodium vivax asparagine--tRNA ligase, putative 0.005 0.0153 0.0662
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.1153 0.2613
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0042 0.0139
Toxoplasma gondii histone lysine methyltransferase SET1 0.0216 0.0877 0.4215
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0109 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0016
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0011
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.005 0.0153 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.015
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0233
Echinococcus granulosus geminin 0.033 0.138 0.138
Trypanosoma brucei Replication factor A protein 1 0.0486 0.2062 1
Toxoplasma gondii methionyl-tRNA synthetase 0.0032 0.0073 0.0287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1153 0.1153
Echinococcus multilocularis cpg binding protein 0.012 0.046 0.0453
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0109 0.0463

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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