Detailed information for compound 1588053

Basic information

Technical information
  • TDR Targets ID: 1588053
  • Name: ethyl 4-[[2-[4-(4-methoxyphenyl)piperazin-1-y l]-2-oxoethyl]-methylsulfamoyl]-2,5-dimethyl- 1H-pyrrole-3-carboxylate
  • MW: 492.588 | Formula: C23H32N4O6S
  • H donors: 1 H acceptors: 4 LogP: 1.97 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)[nH]c(c1S(=O)(=O)N(CC(=O)N1CCN(CC1)c1ccc(cc1)OC)C)C
  • InChi: 1S/C23H32N4O6S/c1-6-33-23(29)21-16(2)24-17(3)22(21)34(30,31)25(4)15-20(28)27-13-11-26(12-14-27)18-7-9-19(32-5)10-8-18/h7-10,24H,6,11-15H2,1-5H3
  • InChiKey: CDVUSGLMMZNWNC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxo-ethyl]-methyl-sulfamoyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate
  • 4-[[2-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]-methylsulfamoyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
  • 4-[[2-keto-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-methyl-sulfamoyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0041 0.0082 0.0217
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.0082 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Toxoplasma gondii aspartate-tRNA ligase 0.0054 0.0127 0.0716
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0162
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0025 0.0019
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0032 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Toxoplasma gondii ABC1 family protein 0.0041 0.0083 0.0449
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0118 0.0286
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0318
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0083 0.0218
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0083 0.0449
Plasmodium vivax asparagine--tRNA ligase, putative 0.0054 0.0127 0.0716
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Plasmodium vivax asparagine--tRNA ligase, putative 0.0054 0.0127 0.0716
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0041 0.0082 0.0217
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0032 0.0075
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0335
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.0007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0083 0.0895
Mycobacterium ulcerans lipase LipD 0.0041 0.0083 0.0693
Leishmania major DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0011 0.0011
Entamoeba histolytica replication factor A, putative 0.0107 0.0298 0.1965
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Onchocerca volvulus 0.0115 0.0326 0.1008
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0253 0.1474
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Echinococcus multilocularis cpg binding protein 0.0122 0.0347 0.0342
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0018 0.0008 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.0871 0.0871
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0549 0.1741 0.4354
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0054 0.0127 0.0716
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0032 0.0075
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0053 0.0124 0.142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.0871 0.0866
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0011 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0011 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0011 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Treponema pallidum asparaginyl-tRNA synthetase 0.0054 0.0127 0.1107
Echinococcus granulosus dna polymerase eta 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0217
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0032 0.0075
Schistosoma mansoni hypothetical protein 0.0332 0.1033 0.2578
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Mycobacterium ulcerans hypothetical protein 0.0041 0.0083 0.0693
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0012 0.0019
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0816
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0025 0.0025
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0082 0.0217
Schistosoma mansoni hypothetical protein 0.0334 0.1041 0.2599
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0046
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Mycobacterium tuberculosis Conserved protein 0.0041 0.0083 0.0895
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0054 0.0127 0.0127
Giardia lamblia Lysyl-tRNA synthetase 0.0054 0.0127 0.2588
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Loa Loa (eye worm) hypothetical protein 0.0059 0.0141 0.0384
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.11 0.354 0.354
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0022
Plasmodium falciparum aspartate--tRNA ligase 0.0054 0.0127 0.0716
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0032 0.0146
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0118 0.0113
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.0082 0.0447
Leishmania major lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0253 0.0777
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.0082 0.0077
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0012 0.0021
Loa Loa (eye worm) beta-lactamase 0.0041 0.0083 0.0218
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0335 0.1042 0.1037
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0083 0.0449
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.026 0.0798 0.2238
Giardia lamblia Hypothetical protein 0.0161 0.0475 1
Trichomonas vaginalis helicase, putative 0.0026 0.0035 0.0084
Brugia malayi beta-lactamase family protein 0.0041 0.0083 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0014
Leishmania major GTP-binding protein, putative 0.0023 0.0025 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.0625 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0025 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Leishmania major hypothetical protein, conserved 0.0027 0.0039 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0079
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Giardia lamblia Aspartyl-tRNA synthetase 0.0054 0.0127 0.2588
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0054 0.0127 0.0816
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0012 0.0027
Echinococcus granulosus geminin 0.0334 0.1041 0.1041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Brugia malayi putative serine/threonine phosphatase 0.0025 0.0032 0.007
Brugia malayi glycyl-tRNA synthetase 0.026 0.0798 0.2238
Brugia malayi protein ZK524.3 0.0053 0.0124 0.033
Loa Loa (eye worm) glutaminase 0.033 0.1027 0.289
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0253 0.07
Echinococcus granulosus dnaJ subfamily B 0.124 0.3995 0.3995
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Echinococcus multilocularis dnaJ subfamily B 0.124 0.3995 0.3992
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0013 0.0031
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0053 0.0124 0.0335
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0023
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0041 0.0082 0.0082
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0083 0.0693
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0253 0.1663
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0041 0.0082 0.0077
Schistosoma mansoni hypothetical protein 0.0334 0.1041 0.2599
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0011 0.0017
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0025 0.01
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0054 0.0127 0.0122
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0127 0.0716
Plasmodium vivax aspartate--tRNA ligase, putative 0.0054 0.0127 0.0716
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0344
Brugia malayi beta-lactamase family protein 0.0041 0.0083 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0141 0.0136
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0253 0.1474
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0022 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0054 0.0127 0.0127
Leishmania major aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Plasmodium falciparum lysine--tRNA ligase 0.0054 0.0127 0.0716
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0141 0.0141
Trichomonas vaginalis protein phosphatase-5, putative 0.0025 0.0032 0.0075
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0031
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0053 0.0124 0.1099
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0032 0.0076
Plasmodium falciparum asparagine--tRNA ligase 0.0054 0.0127 0.0716
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Plasmodium vivax methionine--tRNA ligase, putative 0.0053 0.0124 0.0697
Schistosoma mansoni ran 0.0023 0.0025 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Entamoeba histolytica hypothetical protein 0.0025 0.0032 0.0179
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0051 0.0046
Leishmania major importin beta-1 subunit, putative 0.0025 0.0032 0.0146
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0054 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0549 0.1741 0.1737
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0083 0.0449
Schistosoma mansoni leucyl-tRNA synthetase 0.0053 0.0124 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0253 0.0253
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0025 0.0032 0.0075
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0025 0.0032 0.0146
Brugia malayi beta-lactamase 0.0041 0.0083 0.0213
Schistosoma mansoni protein phosphatase-1 0.0041 0.0082 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Chlamydia trachomatis methionine--tRNA ligase 0.0335 0.1042 1
Chlamydia trachomatis lysine--tRNA ligase 0.0054 0.0127 0.0035
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0054 0.0127 0.0122
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0053 0.0124 0.9283
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0039 0.0186
Leishmania major asparaginyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Toxoplasma gondii tRNA ligases class I (M) protein 0.0053 0.0124 0.0697
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0039 0.0186
Echinococcus multilocularis glycyl tRNA synthetase 0.026 0.0798 0.0793
Schistosoma mansoni apoptosis regulator bax 0.0549 0.1741 0.4354
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0011 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0039 0.0186
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0032 0.0075
Brugia malayi hypothetical protein 0.0027 0.0039 0.0089
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0053 0.0124 0.9733
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.013
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0032 0.007
Entamoeba histolytica hypothetical protein 0.0054 0.0127 0.0816
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0118 0.0318
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0326 0.0907
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0013 0.0031
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0011 0.0005
Schistosoma mansoni hypothetical protein 0.0549 0.1741 0.4354
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Leishmania major methionyl-tRNA synthetase, putative 0.0053 0.0124 0.0697
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.11 0.354 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Toxoplasma gondii methionyl-tRNA synthetase 0.0053 0.0124 0.0697
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0083 0.0218
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0032 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0025 0.01
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0007
Plasmodium falciparum replication protein A1, large subunit 0.0527 0.1671 1
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0041 0.0082 0.0447
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0124 0.0697
Schistosoma mansoni hypothetical protein 0.0054 0.0127 0.0308
Brugia malayi methionyl-tRNA synthetase 0.0053 0.0124 0.033
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0012 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.0871 0.0871
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0065 0.0163
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.1033 0.2906
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Echinococcus granulosus glycyl tRNA synthetase 0.026 0.0798 0.0798
Mycobacterium ulcerans glutaminase 0.033 0.1027 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0141 0.0136
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0025 0.0032 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis ran, putative 0.0023 0.0025 0.0054
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0527 0.1671 0.4711
Brugia malayi Importin beta-1 subunit 0.0031 0.0051 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0083 0.0218
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.0082 0.0082
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0041 0.0082 0.0077
Echinococcus granulosus lysyl tRNA synthetase 0.0054 0.0127 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0253 0.0624
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0083 0.0895
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.0748 0.1864
Schistosoma mansoni cpg binding protein 0.0115 0.0326 0.0807
Loa Loa (eye worm) hypothetical protein 0.0107 0.0298 0.0827
Schistosoma mansoni protein phosphatase type 1 0.0025 0.0032 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1706 0.5515 0.5513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0019
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0281 0.0868 0.244
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0032 0.007
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0083 0.0895
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0041 0.0082 0.0082
Brugia malayi CXXC zinc finger family protein 0.0115 0.0326 0.0902
Schistosoma mansoni ran 0.0023 0.0025 0.0052
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0041 0.0082 0.0212
Echinococcus granulosus glutathione S transferase 0.0018 0.0008 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0261
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0013 0.001
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0118 0.0286
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0032 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0043 0.0043
Leishmania major hypothetical protein, conserved 0.0041 0.0083 0.0449
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0011 0.0017
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0527 0.1671 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.0871 0.2446
Toxoplasma gondii histone lysine methyltransferase SET1 0.0218 0.0663 0.3937
Schistosoma mansoni protein phosphatase-1 0.0041 0.0082 0.0196
Giardia lamblia Methionyl-tRNA synthetase 0.0053 0.0124 0.252
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0025 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0053 0.0124 0.1099
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.01 0.0267
Echinococcus granulosus methionine tRNA synthetase 0.0053 0.0124 0.0124
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0033 0.0153
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Schistosoma mansoni kinase 0.0047 0.0104 0.0251
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0025 0.01
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0011 0.0017
Plasmodium vivax methionine--tRNA ligase, putative 0.0053 0.0124 0.0697
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.0871 0.245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Schistosoma mansoni cpg binding protein 0.0122 0.0347 0.0861
Loa Loa (eye worm) hypothetical protein 0.0335 0.1042 0.2932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Brugia malayi glutaminase DH11.1 0.033 0.1027 0.2886
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0054 0.0127 0.146
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0025 0.0407
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0054 0.0127 0.0035
Trypanosoma brucei polo-like protein kinase 0.0093 0.0253 0.1474
Onchocerca volvulus 0.0041 0.0083 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0083 0.0197
Schistosoma mansoni hypothetical protein 0.0549 0.1741 0.4354
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0335 0.1042 0.6963
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.01 0.0267
Brugia malayi BRCA2 repeat family protein 0.0222 0.0675 0.189
Echinococcus multilocularis geminin 0.0334 0.1041 0.1036
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0118 0.0118
Schistosoma mansoni protein phosphatase type 1 0.0041 0.0082 0.0196
Schistosoma mansoni glutaminase 0.033 0.1027 0.2564
Trypanosoma brucei protein phosphatase 1 0.0025 0.0032 0.0146
Trichomonas vaginalis glutaminase, putative 0.033 0.1027 0.289
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0043 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0083 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0011 0.001
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0032 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0083 0.0895
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0127 0.0308
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0083 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0054 0.0127 0.0816
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0039 0.0186
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0218
Trypanosoma brucei Replication factor A protein 1 0.0527 0.1671 1
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0018 0.0008 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0344
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0118 0.0286
Trypanosoma brucei protein phosphatase 1 0.0025 0.0032 0.0146
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0141 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.0871 0.2174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0011 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0033 0.0153
Schistosoma mansoni methionine-tRNA synthetase 0.0053 0.0124 0.03
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0261
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0025 0.0032 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0054 0.0127 0.113
Toxoplasma gondii serine/threonine phosophatase PP1 0.0041 0.0082 0.0447
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Echinococcus multilocularis lysyl tRNA synthetase 0.0054 0.0127 0.0122
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Loa Loa (eye worm) BRCA2 repeat family protein 0.0222 0.0675 0.1894
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0054 0.0127 1
Plasmodium falciparum asparagine--tRNA ligase 0.0054 0.0127 0.0716
Trypanosoma brucei unspecified product 0.0019 0.0012 0.0027
Echinococcus multilocularis leucyl tRNA synthetase 0.0053 0.0124 0.0118
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0054 0.0127 0.146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0054 0.0127 1
Entamoeba histolytica hypothetical protein 0.0026 0.0033 0.0187
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0083 0.0895
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0127 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0043 0.0038
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0041 0.0082 0.0447
Brugia malayi RNA, U transporter 1 0.0088 0.0238 0.0654
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0018 0.0008 0.0002
Mycobacterium ulcerans beta-lactamase 0.0041 0.0083 0.0693
Giardia lamblia DINP protein human, muc B family 0.0019 0.0012 0.0146
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0011 0.0017
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0041 0.0082 0.0077
Brugia malayi mbt repeat family protein 0.0052 0.0118 0.0313
Leishmania major leucyl-tRNA synthetase, putative 0.0053 0.0124 0.0697
Plasmodium vivax lysine--tRNA ligase, putative 0.0054 0.0127 0.0716
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0066 0.0061
Giardia lamblia GTOR 0.0019 0.0011 0.0111
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0118 0.0113
Echinococcus granulosus snurportin 1 0.0332 0.1033 0.1033
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0053 0.0124 0.0697
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0083 0.0218
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0032 0.0075
Brugia malayi lysyl-tRNA synthetase 0.0054 0.0127 0.0339
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0032 0.0076
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0025 0.01
Echinococcus granulosus stringent starvation protein A 0.0018 0.0008 0.0008
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.308 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0075
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0082 0.0217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0011 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0011 0.0015
Onchocerca volvulus 0.0041 0.0083 0.0237
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0011 0.0017
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0032 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0253 0.0248
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0011 0.0011
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0054 0.0127 0.0344
Plasmodium falciparum nucleic acid binding protein, putative 0.0054 0.0127 0.0716
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Trypanosoma brucei protein phosphatase 1, putative 0.0041 0.0082 0.0447
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0127 0.113
Schistosoma mansoni protein phosphatase-1 0.0025 0.0032 0.0071
Brugia malayi methionyl-tRNA synthetase 0.0335 0.1042 0.2928
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0053 0.0124 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0033 0.0074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0043 0.0099
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0041 0.0082 0.0082
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0011 0.0035
Giardia lamblia Elongation factor 1-gamma 0.0018 0.0008 0.0052
Schistosoma mansoni glycyl-tRNA synthetase 0.026 0.0798 0.199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0032 0.0075
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0011 0.0017
Treponema pallidum methionyl-tRNA synthetase 0.0335 0.1042 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0012 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0051 0.0261
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0039 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Leishmania major lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Echinococcus multilocularis methionine tRNA synthetase 0.0053 0.0124 0.0118
Entamoeba histolytica Ran family GTPase 0.0023 0.0025 0.0128
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0011 0.0017
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0012 0.0007
Trichomonas vaginalis protein phosphatase-1, putative 0.0041 0.0082 0.0217
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0107 0.0298 0.0919
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0083 0.0218
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0011 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Treponema pallidum leucyl-tRNA synthetase 0.0053 0.0124 0.1076
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0033 0.0074
Brugia malayi replication factor A 73 kDa subunit 0.11 0.354 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0054 0.0127 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0011 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0253 0.1474
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0083 0.0213
Mycobacterium tuberculosis Conserved protein 0.0041 0.0083 0.0895
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0039 0.0186
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0032 0.007
Giardia lamblia Kinase, PLK 0.0093 0.0253 0.527
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.0871 0.2174
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0027
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0053 0.0124 0.0697
Trichomonas vaginalis esterase, putative 0.0041 0.0083 0.0218
Schistosoma mansoni protein phosphatase type 1 0.0041 0.0082 0.0196
Schistosoma mansoni aspartyl-tRNA synthetase 0.0054 0.0127 0.0308
Onchocerca volvulus 0.0052 0.0118 0.0349
Loa Loa (eye worm) glycyl-tRNA synthetase 0.026 0.0798 0.2242
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0549 0.1741 0.4908
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0083 0.0077
Mycobacterium tuberculosis Conserved protein 0.0041 0.0083 0.0895
Leishmania major replication factor A, 51kDa subunit, putative 0.0527 0.1671 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0549 0.1741 0.1741
Plasmodium falciparum methionine--tRNA ligase 0.0053 0.0124 0.0697
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0025 0.0032 0.0075
Plasmodium falciparum methionine--tRNA ligase, putative 0.0053 0.0124 0.0697
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0031
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0012 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0066 0.0172
Giardia lamblia Leucyl-tRNA synthetase 0.0053 0.0124 0.252
Leishmania major DNA polymerase eta, putative 0.0019 0.0012 0.0027
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.0871 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0041 0.0082 0.0082
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0041 0.0082 0.0077
Echinococcus granulosus cpg binding protein 0.0122 0.0347 0.0347
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0011 0.0017
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0118 0.0349
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0033 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0083 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0027
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0053 0.0124 0.9733
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0031
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0141 0.0344
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0011 0.0017
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0018 0.0008 0.0002
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0033 0.0033
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0276 0.0852 0.5076
Schistosoma mansoni methionine-tRNA synthetase 0.0335 0.1042 0.2601
Loa Loa (eye worm) hypothetical protein 0.0549 0.1741 0.4911
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0041 0.0082 0.0217
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0054 0.0127 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.0798 1
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.11 0.354 1
Schistosoma mansoni hypothetical protein 0.0317 0.0985 0.2457
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0083 0.0693
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0011 0.0005
Plasmodium vivax replication protein A1, large subunit, putative 0.0527 0.1671 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.0625 0.062
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0127 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0043 0.0038
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0013
Loa Loa (eye worm) glutaminase 2 0.033 0.1027 0.289
Plasmodium falciparum importin beta, putative 0.0031 0.0051 0.0261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.0871 0.2174
Loa Loa (eye worm) 63kd antigen 0.0054 0.0127 0.0344
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0008
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0253 0.0695
Schistosoma mansoni hypothetical protein 0.0549 0.1741 0.4354
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0033 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 0.0437
Echinococcus multilocularis glutathione S transferase 0.0018 0.0008 0.0002
Schistosoma mansoni replication factor A 1 rfa1 0.11 0.354 0.8861
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0011 0.0017
Brugia malayi Aspartyl-tRNA synthetase 0.0054 0.0127 0.0339
Onchocerca volvulus 0.0041 0.0083 0.0237
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0054 0.0127 0.0122
Brugia malayi hypothetical protein 0.0018 0.0008 0.0002
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.11 0.354 0.3537
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0025 0.01
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0335
Leishmania major replication Factor A 28 kDa subunit, putative 0.0054 0.0127 0.0716
Loa Loa (eye worm) MBCTL1 0.0059 0.0141 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Echinococcus granulosus importin subunit beta 1 0.0031 0.0051 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.0016
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0013 0.0051
Brugia malayi mbt repeat family protein 0.0052 0.0118 0.0313
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0011 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0084
Toxoplasma gondii hypothetical protein 0.0116 0.0327 0.1919
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Trypanosoma cruzi Replication factor A protein 1 0.0527 0.1671 1
Echinococcus multilocularis snurportin 1 0.0332 0.1033 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0041 0.0082 0.0217
Leishmania major aspartyl-tRNA synthetase, putative 0.0054 0.0127 0.0716
Schistosoma mansoni elongation factor 1-gamma 0.0018 0.0008 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0083 0.0449
Toxoplasma gondii exonuclease III APE 0.0019 0.0013 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0007
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.026 0.0798 0.2242
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Plasmodium vivax importin-beta 2, putative 0.0031 0.0051 0.0261
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0039 0.0186
Toxoplasma gondii lysine-tRNA ligase 0.0054 0.0127 0.0716
Schistosoma mansoni protein phosphatase-1 0.0025 0.0032 0.0071
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0041 0.0082 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0035 0.0084
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0025 0.0049
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.11 0.354 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0012 0.0021
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0083 0.0895
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.07
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0054 0.0127 0.0122
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0985 0.3163 1
Treponema pallidum aspartyl-tRNA synthetase 0.0054 0.0127 0.1107
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0054 0.0127 0.0339
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0032 0.0146
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0011 0.0017
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0011 0.0017
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0335 0.1042 0.1042
Echinococcus multilocularis dna polymerase eta 0.0019 0.0012 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0066 0.0066
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0012 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0011 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0083 0.0083
Echinococcus granulosus dna polymerase kappa 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0012 0.0027
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1046 0.3363 0.9499
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0012 0.0019
Loa Loa (eye worm) apoptosis regulator protein 0.0549 0.1741 0.4911
Schistosoma mansoni cpg binding protein 0.0122 0.0347 0.0861
Schistosoma mansoni importin beta-1 0.0031 0.0051 0.0119
Entamoeba histolytica replication factor A protein 1, putative 0.0473 0.1494 1
Giardia lamblia Asparaginyl-tRNA synthetase 0.0054 0.0127 0.2588
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0011 0.0017
Schistosoma mansoni hypothetical protein 0.124 0.3995 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0011 0.0017
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0041 0.0082 0.1635

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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