Detailed information for compound 1588056

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.812 | Formula: C20H16ClN3O3
  • H donors: 1 H acceptors: 4 LogP: 4.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(/C=C(\c2onc(n2)c2ccc(cc2)C)/C#N)cc(c1O)Cl
  • InChi: 1S/C20H16ClN3O3/c1-3-26-17-10-13(9-16(21)18(17)25)8-15(11-22)20-23-19(24-27-20)14-6-4-12(2)5-7-14/h4-10,25H,3H2,1-2H3/b15-8-
  • InChiKey: UIHDCUCMRNIWKT-NVNXTCNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0087 0.0166
Schistosoma mansoni protein phosphatase-1 0.0018 0.0049 0.0094
Schistosoma mansoni cpg binding protein 0.003 0.012 0.023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.005 0.0096
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0071 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Treponema pallidum methionyl-tRNA synthetase 0.0196 0.115 1
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0049 0.0094
Schistosoma mansoni cpg binding protein 0.0028 0.011 0.0211
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0087 0.0351
Echinococcus multilocularis methionine tRNA synthetase 0.0031 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0005 0.0009
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0005 0.0019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0071 0.0999
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Entamoeba histolytica Ran family GTPase 0.0022 0.0071 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0239 0.0458
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0042 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0012 0.0012 0.0024
Plasmodium falciparum methionine--tRNA ligase 0.0031 0.0129 0.0522
Entamoeba histolytica replication factor A protein 1, putative 0.0367 0.2209 1
Trypanosoma cruzi Replication factor A protein 1 0.0409 0.247 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0152 0.0879 0.1682
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1156 0.2214
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0281 0.0539
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0096 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni methionine-tRNA synthetase 0.0031 0.0129 0.0247
Mycobacterium ulcerans hypothetical protein 0.0039 0.0175 0.8557
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.003 0.0119 0.0481
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0175 0.0884
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0196 0.115 0.115
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0071 0.0287
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0046 0.0087
Brugia malayi replication factor A 73 kDa subunit 0.0854 0.5222 1
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.003 0.0119 0.0119
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0046 0.0087
Brugia malayi hypothetical protein 0.0026 0.0096 0.0184
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0042 0.0196 0.0376
Leishmania major lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.003 0.0119 0.0227
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0071 0.0136
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0239 0.0513
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0239 0.0458
Loa Loa (eye worm) hypothetical protein 0.0021 0.0066 0.0125
Schistosoma mansoni replication factor A 1 rfa1 0.0854 0.5222 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0306 0.0586
Entamoeba histolytica replication factor A, putative 0.0083 0.0448 0.1983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni hypothetical protein 0.0137 0.0783 0.15
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0812 0.4962 0.9501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Echinococcus multilocularis leucyl tRNA synthetase 0.0031 0.0129 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0096 0.0389
Loa Loa (eye worm) 63kd antigen 0.0042 0.0196 0.0376
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.005 0.0096
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Plasmodium vivax replication protein A1, large subunit, putative 0.0409 0.247 1
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0042 0.0196 0.1033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.005 0.0705
Leishmania major hypothetical protein, conserved 0.0039 0.0175 0.0709
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0087 0.0166
Plasmodium falciparum asparagine--tRNA ligase 0.0042 0.0196 0.0795
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0239 0.0458
Brugia malayi hypothetical protein 0.0017 0.0039 0.0075
Schistosoma mansoni leucyl-tRNA synthetase 0.0031 0.0129 0.0247
Plasmodium falciparum aspartate--tRNA ligase 0.0042 0.0196 0.0795
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0042 0.0196 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0854 0.5222 1
Mycobacterium ulcerans lipase LipD 0.0039 0.0175 0.8557
Chlamydia trachomatis lysine--tRNA ligase 0.0042 0.0196 0.066
Mycobacterium tuberculosis Conserved protein 0.0039 0.0175 0.0884
Trichomonas vaginalis protein phosphatase-1, putative 0.003 0.0119 0.0227
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0247
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0046 0.0046
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0083 0.0448 0.096
Mycobacterium tuberculosis Conserved protein 0.0039 0.0175 0.0884
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0165 0.0956 0.1831
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Leishmania major importin beta-1 subunit, putative 0.0024 0.0085 0.0342
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.1068 0.2046
Schistosoma mansoni hypothetical protein 0.0137 0.0783 0.15
Schistosoma mansoni hypothetical protein 0.0302 0.1806 0.3458
Trichomonas vaginalis protein phosphatase-1, putative 0.0018 0.0049 0.0094
Trichomonas vaginalis protein phosphatase 2A, caeel, putative 0.0012 0.0012 0.0024
Giardia lamblia Leucyl-tRNA synthetase 0.0031 0.0129 0.1818
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.003 0.0119 0.0119
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0071 0.0136
Schistosoma mansoni lysyl-tRNA synthetase 0.0042 0.0196 0.0376
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0071 0.0287
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.005 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni protein phosphatase-1 0.003 0.0119 0.0227
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0175 0.0884
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1156 0.1156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1068 0.2046
Plasmodium vivax methionine--tRNA ligase, putative 0.0031 0.0129 0.0522
Onchocerca volvulus 0.0049 0.0239 0.0513
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0018 0.0049 0.02
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0008 0.0008
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.003 0.0119 0.0227
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0281 0.0539
Mycobacterium tuberculosis Conserved protein 0.0039 0.0175 0.0884
Onchocerca volvulus 0.0039 0.0175 0.0375
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0196 0.0795
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.003 0.0119 0.0227
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.1897 0.3632
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0239 0.0458
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0152 0.0879 0.1682
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0005 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0071 0.0136
Schistosoma mansoni hypothetical protein 0.0137 0.0783 0.15
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0046 0.0185
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Schistosoma mansoni ran 0.0022 0.0071 0.0136
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.2424 0.2424
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.005 0.0202
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Toxoplasma gondii lysine-tRNA ligase 0.0042 0.0196 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase 0.0012 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0175 0.0709
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.1466 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0768 0.4692 0.4692
Onchocerca volvulus 0.0028 0.011 0.0236
Treponema pallidum leucyl-tRNA synthetase 0.0031 0.0129 0.0717
Leishmania major aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0071 0.0287
Schistosoma mansoni hypothetical protein 0.0402 0.2424 0.4642
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.003 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0042 0.0196 0.0376
Brugia malayi Aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0046 0.0185
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0046 0.0185
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0137 0.0783 0.15
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1068 0.2046
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0239 0.0458
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.003 0.0119 0.0227
Loa Loa (eye worm) hypothetical protein 0.0083 0.0448 0.0858
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0768 0.4692 0.8984
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0031 0.0129 0.6567
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.005 0.0202
Schistosoma mansoni importin beta-1 0.003 0.0119 0.0228
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0854 0.5222 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Brugia malayi glycyl-tRNA synthetase 0.0152 0.0879 0.1682
Echinococcus granulosus serine:threonine protein phosphatase 0.0011 0.0005 0.0009
Leishmania major replication factor A, 51kDa subunit, putative 0.0409 0.247 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0137 0.0783 0.15
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0042 0.0196 0.0376
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0175 0.0335
Entamoeba histolytica hypothetical protein 0.0042 0.0196 0.0837
Echinococcus granulosus methionine tRNA synthetase 0.0031 0.0129 0.0247
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0046 0.0087
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0087 0.0087
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0196 0.115 0.5177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0175 0.0335
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0096 0.0389
Loa Loa (eye worm) apoptosis regulator protein 0.0137 0.0783 0.15
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0046 0.0185
Giardia lamblia Methionyl-tRNA synthetase 0.0031 0.0129 0.1818
Echinococcus granulosus lysyl tRNA synthetase 0.0042 0.0196 0.0376
Loa Loa (eye worm) beta-lactamase 0.0039 0.0175 0.0335
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0012 0.0012 0.0012
Schistosoma mansoni protein phosphatase-1 0.003 0.0119 0.0227
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0281 0.0539
Echinococcus granulosus snurportin 1 0.0317 0.1897 0.3632
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0247
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0175 0.8557
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0066 0.0265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0046 0.0087
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0031 0.0129 0.5393
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0087 0.0166
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0018 0.0049 0.0168
Leishmania major GTP-binding protein, putative 0.0022 0.0071 0.0287
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0015
Mycobacterium leprae Probable lipase LipE 0.0039 0.0175 0.6867
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0046 0.0185
Schistosoma mansoni apoptosis regulator bax 0.0137 0.0783 0.15
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni protein phosphatase-1 0.0018 0.0049 0.0094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.005 0.0202
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0175 0.0884
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0085 0.0162
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0031 0.0129 0.0522
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0042 0.0196 1
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0042 0.0196 0.066
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0031 0.0129 0.0522
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0096 0.0389
Echinococcus granulosus dnaJ subfamily B 0.0402 0.2424 0.4642
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.003 0.0119 0.1675
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0215 0.1264 0.5118
Echinococcus granulosus cpg binding protein 0.003 0.012 0.023
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0087 0.0351
Brugia malayi RNA, U transporter 1 0.0084 0.0458 0.0877
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0046 0.0185
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0046 0.0185
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0239 0.0239
Echinococcus multilocularis snurportin 1 0.0317 0.1897 0.1897
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0049 0.0094
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0012 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0376
Mycobacterium ulcerans beta-lactamase 0.0039 0.0175 0.8557
Plasmodium falciparum replication protein A1, large subunit 0.0409 0.247 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0119 0.0228
Trichomonas vaginalis protein phosphatase-1, putative 0.0018 0.0049 0.0094
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0175 0.6867
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0018 0.0049 0.0094
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.003 0.0119 0.0481
Schistosoma mansoni lysyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Schistosoma mansoni ap endonuclease 0.0018 0.005 0.0096
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0046 0.0087
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0042 0.0196 0.0795
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0376
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0239 0.0458
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0409 0.247 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.005 0.0202
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0042 0.0196 0.0196
Toxoplasma gondii ABC1 family protein 0.0039 0.0175 0.0709
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0175 0.0709
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0018 0.0049 0.0094
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0042 0.0196 0.0196
Onchocerca volvulus 0.0039 0.0175 0.0375
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0087 0.0166
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0046 0.0185
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0018 0.0049 0.0094
Leishmania major hypothetical protein, conserved 0.0026 0.0096 0.0389
Brugia malayi mbt repeat family protein 0.0049 0.0239 0.0458
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0175 0.0884
Toxoplasma gondii serine/threonine phosophatase PP1 0.003 0.0119 0.0481
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0175 0.0335
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0046 0.0151
Giardia lamblia Asparaginyl-tRNA synthetase 0.0042 0.0196 0.2769
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0049 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Toxoplasma gondii aspartate-tRNA ligase 0.0042 0.0196 0.0795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1068 0.2046
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0031 0.0129 0.0247
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0228
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.005 0.0096
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0196 0.115 0.2201
Echinococcus multilocularis importin subunit beta 1 0.003 0.0119 0.0119
Leishmania major asparaginyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0071 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Loa Loa (eye worm) serine/threonine-protein phosphatase PP1-beta 0.0012 0.0012 0.0024
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0042 0.0196 0.0376
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0175 0.0884
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0018 0.0049 0.0094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0046 0.0185
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0175 0.8557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Brugia malayi CXXC zinc finger family protein 0.0028 0.011 0.0211
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.003 0.0119 0.0227
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0175 0.0335
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.005 0.0202
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0042 0.0196 0.0837
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.003 0.0119 0.0227
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0042 0.0196 1
Leishmania major aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Echinococcus multilocularis lysyl tRNA synthetase 0.0042 0.0196 0.0196
Giardia lamblia GTOR 0.0018 0.0046 0.0643
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0005 0.0019
Brugia malayi beta-lactamase family protein 0.0039 0.0175 0.0335
Giardia lamblia Hypothetical protein 0.0125 0.0709 1
Trypanosoma brucei protein phosphatase 1 0.0018 0.0049 0.02
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0018 0.0049 0.0094
Brugia malayi methionyl-tRNA synthetase 0.0196 0.115 0.2201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1068 0.1068
Plasmodium vivax asparagine--tRNA ligase, putative 0.0042 0.0196 0.0795
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0175 0.0884
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0854 0.5222 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.005 0.2547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0119 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trichomonas vaginalis ran, putative 0.0022 0.0071 0.0136
Giardia lamblia Aspartyl-tRNA synthetase 0.0042 0.0196 0.2769
Echinococcus multilocularis glycyl tRNA synthetase 0.0152 0.0879 0.0879
Brugia malayi beta-lactamase 0.0039 0.0175 0.0335
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0042 0.0196 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0854 0.5222 0.5222
Schistosoma mansoni ap endonuclease 0.0018 0.005 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Loa Loa (eye worm) hypothetical protein 0.0137 0.0783 0.15
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0042 0.0196 0.0376
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0018 0.0049 0.0094
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0175 0.0884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1068 0.1068
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0046 0.0185
Plasmodium falciparum importin beta, putative 0.003 0.0119 0.0483
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0085 0.0342
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Leishmania major leucyl-tRNA synthetase, putative 0.0031 0.0129 0.0522
Toxoplasma gondii hypothetical protein 0.009 0.0491 0.1987
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0854 0.5222 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0096 0.0389
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0281 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0227
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0018 0.0049 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0046 0.0087
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.005 0.0202
Schistosoma mansoni cpg binding protein 0.003 0.012 0.023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0175 0.0335
Loa Loa (eye worm) hypothetical protein 0.0196 0.115 0.2201
Plasmodium vivax methionine--tRNA ligase, putative 0.0031 0.0129 0.0522
Schistosoma mansoni protein phosphatase type 1 0.003 0.0119 0.0227
Echinococcus multilocularis cpg binding protein 0.003 0.012 0.012
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0018 0.0049 0.0094
Trypanosoma brucei protein phosphatase 1 0.0018 0.0049 0.02
Loa Loa (eye worm) MBCTL1 0.0056 0.0281 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Brugia malayi putative serine/threonine phosphatase 0.0018 0.0049 0.0094
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.005 0.0171
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0046 0.0185
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Schistosoma mansoni ran 0.0022 0.0071 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0096 0.0389
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Plasmodium falciparum asparagine--tRNA ligase 0.0042 0.0196 0.0795
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0175 0.0335
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.003 0.0119 0.0227
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.003 0.0119 0.0481
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0765 0.4667 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0031 0.0129 0.6567
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.011 0.0211
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0046 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Plasmodium falciparum lysine--tRNA ligase 0.0042 0.0196 0.0795
Trichomonas vaginalis esterase, putative 0.0039 0.0175 0.0335
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase 0.0012 0.0012 0.0012
Leishmania major methionyl-tRNA synthetase, putative 0.0031 0.0129 0.0522
Schistosoma mansoni protein phosphatase type 1 0.003 0.0119 0.0227
Giardia lamblia Lysyl-tRNA synthetase 0.0042 0.0196 0.2769
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Treponema pallidum aspartyl-tRNA synthetase 0.0042 0.0196 0.133
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.003 0.0119 0.0119
Giardia lamblia Phosphatase 0.0012 0.0012 0.0175
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0175 0.0335
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0119 0.0227
Brugia malayi methionyl-tRNA synthetase 0.0031 0.0129 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1068 0.2046
Loa Loa (eye worm) hypothetical protein 0.0056 0.0281 0.0539
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0046 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Onchocerca volvulus 0.0039 0.0175 0.0375
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0175 0.0175
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0046 0.0185
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0175 0.0335
Leishmania major replication Factor A 28 kDa subunit, putative 0.0042 0.0196 0.0795
Plasmodium vivax lysine--tRNA ligase, putative 0.0042 0.0196 0.0795
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Entamoeba histolytica hypothetical protein 0.0024 0.0087 0.0338
Brugia malayi protein ZK524.3 0.0031 0.0129 0.0247
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0119 0.0227
Plasmodium falciparum nucleic acid binding protein, putative 0.0042 0.0196 0.0795
Schistosoma mansoni hypothetical protein 0.0317 0.1897 0.3632
Brugia malayi Importin beta-1 subunit 0.003 0.0119 0.0228
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0376
Plasmodium vivax asparagine--tRNA ligase, putative 0.0042 0.0196 0.0795
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0409 0.247 0.4729
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0137 0.0783 0.15
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.005 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0046 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0175 0.0335
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0152 0.0879 0.1682
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Leishmania major lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0175 0.0709
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0137 0.0783 0.0783
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0049 0.02
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0031 0.0129 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Schistosoma mansoni protein phosphatase type 1 0.0018 0.0049 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0046 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0046 0.0185
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0018 0.0049 0.0094
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0837
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0046 0.0185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.1068 0.2046
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0196 0.0795
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0042 0.0196 0.1033
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0096 0.0389
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0046 0.0185
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0071 0.0071
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.003 0.0119 0.0227
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0281 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1068 0.2046
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0018 0.0049 0.0094
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0031 0.0129 0.5393
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0175 0.0709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0085 0.0162
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0119 0.0483
Chlamydia trachomatis methionine--tRNA ligase 0.0196 0.115 1
Toxoplasma gondii tRNA ligases class I (M) protein 0.0031 0.0129 0.0522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0184
Trypanosoma brucei Replication factor A protein 1 0.0409 0.247 1
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.003 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0009
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0119 0.0483
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0018 0.0049 0.02
Loa Loa (eye worm) BRCA2 repeat family protein 0.0173 0.1003 0.1921
Schistosoma mansoni glycyl-tRNA synthetase 0.0152 0.0879 0.1682
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.003 0.0119 0.0481
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0071 0.0287
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0085 0.0162
Schistosoma mansoni aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0046 0.0046
Brugia malayi mbt repeat family protein 0.0049 0.0239 0.0458
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0042 0.0196 1
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0042 0.0196 1
Toxoplasma gondii exonuclease III APE 0.0018 0.005 0.0202
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0239 0.0458
Entamoeba histolytica hypothetical protein 0.0024 0.0085 0.0328
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0281 0.0281
Plasmodium vivax importin-beta 2, putative 0.003 0.0119 0.0483
Brugia malayi beta-lactamase family protein 0.0039 0.0175 0.0335
Brugia malayi lysyl-tRNA synthetase 0.0042 0.0196 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0119 0.0483
Trichomonas vaginalis protein phosphatase, caeel, putative 0.003 0.0119 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Toxoplasma gondii methionyl-tRNA synthetase 0.0031 0.0129 0.0522
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0239 0.0239
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0031 0.0129 0.0247
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.003 0.0119 0.0227
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0129 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Entamoeba histolytica hypothetical protein 0.0042 0.0196 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0046 0.0087
Plasmodium vivax aspartate--tRNA ligase, putative 0.0042 0.0196 0.0795
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0046 0.0185
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0267 0.108
Treponema pallidum asparaginyl-tRNA synthetase 0.0042 0.0196 0.133
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0087 0.0351
Schistosoma mansoni methionine-tRNA synthetase 0.0196 0.115 0.2201
Trypanosoma brucei protein phosphatase 1, putative 0.003 0.0119 0.0481
Echinococcus granulosus glycyl tRNA synthetase 0.0152 0.0879 0.1682
Plasmodium falciparum methionine--tRNA ligase, putative 0.0031 0.0129 0.0522
Brugia malayi BRCA2 repeat family protein 0.0173 0.1003 0.1921
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0175 0.0335
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0042 0.0196 0.0376
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0042 0.0196 0.0795
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0335
Trichomonas vaginalis protein phosphatase-5, putative 0.0018 0.0049 0.0094
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0046 0.0151
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0042 0.0196 0.0196

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 99 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] ChEMBL. No reference
IC50 (functional) > 99 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) > 99 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] ChEMBL. No reference
IC50 (functional) > 99 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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