Detailed information for compound 1588057

Basic information

Technical information
  • TDR Targets ID: 1588057
  • Name: [(5-methyl-2-propan-2-ylcyclohexyl)-phenylpho sphoryl]benzene
  • MW: 340.439 | Formula: C22H29OP
  • H donors: 0 H acceptors: 1 LogP: 5.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC(C(C1)P(=O)(c1ccccc1)c1ccccc1)C(C)C
  • InChi: 1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3
  • InChiKey: BPCNGVCAHAIZEE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2-isopropyl-5-methyl-cyclohexyl)-phenyl-phosphoryl]benzene
  • [(2-isopropyl-5-methylcyclohexyl)-phenylphosphoryl]benzene
  • [(5-methyl-2-propan-2-yl-cyclohexyl)-phenyl-phosphoryl]benzene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0056 0.0183 1
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.004 0.0116 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1162 0.1162
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0056 0.0183 0.0183
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0116 0.0217
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0021 0.0016
Schistosoma mansoni lysyl-tRNA synthetase 0.0056 0.0183 0.0344
Treponema pallidum aspartyl-tRNA synthetase 0.0056 0.0183 0.1169
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0024 0.0103
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0056 0.0183 1
Chlamydia trachomatis methionine--tRNA ligase 0.0332 0.1385 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0043
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0116 0.0434
Plasmodium falciparum aspartate--tRNA ligase 0.0056 0.0183 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0085 0.0175
Mycobacterium ulcerans hypothetical protein 0.004 0.0116 0.58
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0021 0.0089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0021 0.0021
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0413 0.1733 0.326
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0108 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.0894
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Schistosoma mansoni replication factor A 1 rfa1 0.1133 0.4862 0.9143
Mycobacterium ulcerans lipase LipD 0.004 0.0116 0.58
Brugia malayi mbt repeat family protein 0.0051 0.0162 0.0334
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0543 0.2299 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0021 0.0017
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0162 0.0306
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0197 0.0405
Echinococcus granulosus cpg binding protein 0.0121 0.0468 0.0468
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0024 0.001
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0053 0.017 0.9212
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0049 0.0101
Giardia lamblia Kinase, PLK 0.0092 0.0341 0.5065
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0039 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.004
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0021 0.0016
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0056 0.0183 0.0183
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0341 0.0642
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0091 0.0091
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0193 0.0193
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.0371 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0018 0.0017 0.0017
Leishmania major asparaginyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.004
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0017 0.0014 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0116 0.58
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0161 0.033
Plasmodium vivax lysine--tRNA ligase, putative 0.0056 0.0183 0.0795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0035 0.008
Onchocerca volvulus 0.0018 0.0017 0.0039
Loa Loa (eye worm) 63kd antigen 0.0056 0.0183 0.0376
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0543 0.2299 0.4729
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0116 0.0894
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0306 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0035
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.004 0.0116 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Plasmodium falciparum flap endonuclease 1 0.0031 0.0077 0.0334
Brugia malayi Flap endonuclease-1 0.0031 0.0077 0.0158
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0341 0.0702
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0139 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0108 0.0108
Brugia malayi CXXC zinc finger family protein 0.0115 0.044 0.0904
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.01 0.01
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1694 0.7301 0.7301
Echinococcus granulosus importin subunit beta 1 0.0031 0.0074 0.0074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0024 0.0049
Brugia malayi hypothetical protein 0.0147 0.0579 0.1191
Echinococcus multilocularis cpg binding protein 0.0121 0.0468 0.0468
Schistosoma mansoni glycyl-tRNA synthetase 0.0258 0.1062 0.1998
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0338
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0341 0.0702
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0193 0.0363
Schistosoma mansoni cpg binding protein 0.0121 0.0468 0.088
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0341 0.1421
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.0238
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0023
Brugia malayi methionyl-tRNA synthetase 0.0053 0.017 0.035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1162 0.1162
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0077 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0116 0.0238
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0072
Brugia malayi hypothetical protein 0.0033 0.0085 0.0174
Leishmania major importin beta-1 subunit, putative 0.0025 0.0049 0.0141
Loa Loa (eye worm) hypothetical protein 0.0053 0.017 0.035
Giardia lamblia GTOR 0.0018 0.0021 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.0026
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.004 0.0116 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0145 0.0298
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.007 0.007
Plasmodium vivax methionine--tRNA ligase, putative 0.0053 0.017 0.074
Plasmodium falciparum nucleic acid binding protein, putative 0.0056 0.0183 0.0795
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0116 0.0116
Loa Loa (eye worm) CHromoDomain protein family member 0.002 0.0028 0.0059
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Entamoeba histolytica hypothetical protein 0.0056 0.0183 0.0889
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0077 0.0374
Schistosoma mansoni hypothetical protein 0.0413 0.1733 0.326
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.004 0.0116 0.0116
Echinococcus granulosus muscleblind protein 0.0309 0.1283 0.1283
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0254 0.1043 0.2146
Leishmania major leucyl-tRNA synthetase, putative 0.0053 0.017 0.0672
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0049 0.0101
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0024 0.003
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0039 0.0169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0108 0.0203
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0056 0.0183 0.0183
Echinococcus multilocularis lysyl tRNA synthetase 0.0056 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0162 0.0334
Echinococcus multilocularis glutathione S transferase 0.0018 0.0017 0.0017
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.002 0.0028 0.0028
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.011 0.0417 0.096
Onchocerca volvulus 0.0018 0.0017 0.0039
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.0894
Schistosoma mansoni methionine-tRNA synthetase 0.0053 0.017 0.032
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0413 0.1733 0.1733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0108
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0021 0.0016
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative 0.0017 0.0014 0.0068
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Echinococcus multilocularis muscleblind protein 1 0.0309 0.1283 0.1283
Trichomonas vaginalis protein phosphatase-1, putative 0.004 0.0116 0.0238
Brugia malayi glycyl-tRNA synthetase 0.0258 0.1062 0.2185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1162 0.2185
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.004 0.0116 0.1578
Echinococcus multilocularis snurportin 1 0.033 0.1372 0.1372
Plasmodium falciparum asparagine--tRNA ligase 0.0056 0.0183 0.0795
Brugia malayi putative serine/threonine phosphatase 0.0025 0.0049 0.0101
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0306 0.0629
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0039 0.0169
Brugia malayi lysyl-tRNA synthetase 0.0056 0.0183 0.0376
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0162 0.0162
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0021 0.01
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0021 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0053 0.017 0.074
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0164 0.0714
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0061 0.0125
Loa Loa (eye worm) hypothetical protein 0.0413 0.1733 0.3565
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0077 0.0334
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0049 0.0101
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0341 0.1421
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0049 0.0101
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0021 0.01
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1162 0.1162
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0183 0.0795
Toxoplasma gondii elongation factor 1-gamma, putative 0.0018 0.0017 0.0073
Leishmania major lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0077 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.1162 0.239
Plasmodium vivax replication protein A1, large subunit, putative 0.0543 0.2299 1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0332 0.1385 0.6735
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0074 0.0074
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0162 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Schistosoma mansoni chromobox protein 0.0084 0.0306 0.0575
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0116 0.0116
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0074 0.0252
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0039 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.002 0.0028 0.0028
Schistosoma mansoni ran 0.0023 0.0039 0.0073
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0332 0.1385 0.1385
Leishmania major hypothetical protein, conserved 0.0052 0.0164 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Giardia lamblia Asparaginyl-tRNA synthetase 0.0056 0.0183 0.2615
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0111
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0025 0.0049 0.0142
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0164 0.0646
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0168 0.0315
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0053 0.017 0.035
Giardia lamblia Elongation factor 1-gamma 0.0018 0.0017 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni chromobox protein 0.0084 0.0306 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Echinococcus granulosus glutathione S transferase 0.0018 0.0017 0.0017
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0018 0.0017 0.0035
Echinococcus granulosus potassium voltage gated channel protein 0.0104 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0053 0.017 0.035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0116 0.0238
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0053 0.017 0.924
Schistosoma mansoni cpg binding protein 0.0115 0.044 0.0827
Onchocerca volvulus 0.0018 0.0017 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0039 0.0108 0.0469
Echinococcus granulosus chromobox protein 1 0.0084 0.0306 0.0306
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0025 0.0049 0.0101
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0193 0.0193
Brugia malayi Importin beta-1 subunit 0.0031 0.0074 0.0153
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0164 0.0714
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0024 0.0024
Brugia malayi chromobox protein homolog 3 0.0047 0.0145 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0197 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0077 0.0158
Brugia malayi beta-lactamase family protein 0.004 0.0116 0.0238
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.004
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0017 0.0014 0.0029
Schistosoma mansoni kinase 0.0047 0.0144 0.0271
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0161 0.033
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0051 0.0148
Entamoeba histolytica hypothetical protein 0.0025 0.0051 0.0246
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0039 0.0387
Leishmania major aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Schistosoma mansoni importin beta-1 0.0031 0.0074 0.014
Plasmodium vivax elongation factor 1-gamma, putative 0.0018 0.0017 0.0073
Plasmodium falciparum methionine--tRNA ligase 0.0053 0.017 0.074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0219 0.0892 0.388
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.0014 0.0014
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0056 0.0183 0.0104
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Entamoeba histolytica replication factor A, putative 0.011 0.0417 0.2029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0207
Schistosoma mansoni cpg binding protein 0.0121 0.0468 0.088
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0341 0.0785
Toxoplasma gondii hypothetical protein 0.0119 0.0457 0.1988
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0024 0.0024
Brugia malayi Pre-SET motif family protein 0.0039 0.0108 0.0222
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.028 0.1155 0.2376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Onchocerca volvulus 0.0018 0.0017 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0024 0.0049
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0051 0.0148
Echinococcus granulosus chromobox protein 1 0.0084 0.0306 0.0306
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.0137
Treponema pallidum methionyl-tRNA synthetase 0.0332 0.1385 1
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0889
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.01 0.01
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0116 0.0894
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0026
Leishmania major hypothetical protein, conserved 0.004 0.0116 0.0433
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0193 0.0397
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0021 0.0021
Leishmania major aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0049 0.0101
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0021 0.0016
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0000000065618 0.0000000065618
Trichomonas vaginalis esterase, putative 0.004 0.0116 0.0238
Schistosoma mansoni hypothetical protein 0.1237 0.5317 1
Echinococcus multilocularis dnaJ subfamily B 0.1237 0.5317 0.5317
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0056 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.1283 0.2639
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0056 0.0183 0.1542
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0391 0.0735
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.007 0.007
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.0026
Brugia malayi methionyl-tRNA synthetase 0.0332 0.1385 0.2849
Plasmodium falciparum methionine--tRNA ligase, putative 0.0053 0.017 0.074
Loa Loa (eye worm) hypothetical protein 0.0104 0.0391 0.0804
Plasmodium vivax methionine--tRNA ligase, putative 0.0053 0.017 0.074
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0051 0.022
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0053 0.017 0.0672
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Toxoplasma gondii serine/threonine phosophatase PP1 0.004 0.0116 0.0504
Loa Loa (eye worm) hypothetical protein 0.0059 0.0197 0.0405
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Onchocerca volvulus 0.0018 0.0017 0.0039
Leishmania major lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis ran, putative 0.0023 0.0039 0.008
Plasmodium vivax aspartate--tRNA ligase, putative 0.0056 0.0183 0.0795
Brugia malayi replication factor A 73 kDa subunit 0.1133 0.4862 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0162 0.0162
Entamoeba histolytica hypothetical protein 0.0056 0.0183 0.0889
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0341 0.1659
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0341 0.0341
Plasmodium vivax asparagine--tRNA ligase, putative 0.0056 0.0183 0.0795
Treponema pallidum asparaginyl-tRNA synthetase 0.0056 0.0183 0.1169
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0116 0.0433
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0053 0.017 0.9212
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0077 0.0263
Plasmodium vivax SET domain protein, putative 0.0039 0.0108 0.0469
Brugia malayi BRCA2 repeat family protein 0.0229 0.0934 0.1921
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.0238
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0258 0.1062 0.2185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni leucyl-tRNA synthetase 0.0053 0.017 0.032
Loa Loa (eye worm) hypothetical protein 0.0332 0.1385 0.2849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0145 0.0334
Trichomonas vaginalis helicase, putative 0.0026 0.0053 0.011
Loa Loa (eye worm) serine/threonine-protein phosphatase PP1-beta 0.0017 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.011 0.0417 0.0858
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0061 0.0125
Brugia malayi Pre-SET motif family protein 0.0254 0.1043 0.2146
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.004 0.0116 0.0504
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0116 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Plasmodium vivax hypothetical protein, conserved 0.004 0.0116 0.0503
Trypanosoma brucei protein phosphatase 1 0.0025 0.0049 0.0142
Schistosoma mansoni ap endonuclease 0.0019 0.0024 0.0045
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0376
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0285 0.1177 0.5118
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0116 0.0238
Schistosoma mansoni protein phosphatase-1 0.0025 0.0049 0.0093
Plasmodium falciparum asparagine--tRNA ligase 0.0056 0.0183 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0056 0.0183 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0113 0.0233
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0025 0.0049 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0116 0.0217
Leishmania major methionyl-tRNA synthetase, putative 0.0053 0.017 0.0672
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Echinococcus granulosus stringent starvation protein A 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Loa Loa (eye worm) BRCA2 repeat family protein 0.0229 0.0934 0.1921
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0162 0.0306
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0021 0.0016
Leishmania major replication factor A, 51kDa subunit, putative 0.0543 0.2299 1
Onchocerca volvulus 0.0052 0.0168 0.0386
Onchocerca volvulus 0.0018 0.0017 0.0039
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0332 0.1384 0.2604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1162 0.2185
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0116 0.0238
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0021 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0024 0.0152
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Echinococcus granulosus Chromobox protein 3 0.0014 0.0000000065618 0.0000000065618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0024 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0047
Brugia malayi Muscleblind-like protein 0.0309 0.1283 0.2639
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1133 0.4862 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0258 0.1062 0.1062
Brugia malayi hypothetical protein 0.0018 0.0017 0.0035
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0024 0.0049
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.1133 0.4862 0.4862
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0116 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0056 0.0183 0.1542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0162 0.0162
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.044 0.0904
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0047
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0049 0.0101
Brugia malayi CHD4 protein 0.002 0.0028 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0341 0.1421
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0077 0.0263
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0021 0.0021
Onchocerca volvulus 0.004 0.0116 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0116 0.0433
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0021 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0049 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Onchocerca volvulus 0.0115 0.044 0.1012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0197 0.0405
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0053 0.017 0.0672
Brugia malayi beta-lactamase family protein 0.004 0.0116 0.0238
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0021 0.0016
Giardia lamblia Leucyl-tRNA synthetase 0.0053 0.017 0.242
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0049 0.0101
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0021 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.1162 0.239
Trypanosoma brucei protein phosphatase 1 0.0025 0.0049 0.0142
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0051 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0183 0.0727
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0077 0.0334
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0021 0.0021
Trypanosoma cruzi Replication factor A protein 1 0.0543 0.2299 1
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0056 0.0183 1
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0116 0.0238
Schistosoma mansoni hypothetical protein 0.0413 0.1733 0.326
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0164 0.0714
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0413 0.1733 0.3565
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0258 0.1062 0.2185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni protein phosphatase-1 0.004 0.0116 0.0218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0026
Echinococcus granulosus glycyl tRNA synthetase 0.0258 0.1062 0.1062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0024 0.0103
Schistosoma mansoni hypothetical protein 0.0023 0.0041 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0116 0.0238
Schistosoma mansoni ran 0.0023 0.0039 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0024 0.003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0162 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0021 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0043
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0049 0.0101
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0098 0.0203
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.1014 0.4345 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0306 0.0306
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0104 0.0391 0.0391
Toxoplasma gondii lysine-tRNA ligase 0.0056 0.0183 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0017 0.0035
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.1133 0.4862 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.007 0.007
Echinococcus granulosus methionine tRNA synthetase 0.0053 0.017 0.017
Schistosoma mansoni protein phosphatase-1 0.0025 0.0049 0.0093
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0021 0.0016
Entamoeba histolytica Ran family GTPase 0.0023 0.0039 0.0189
Schistosoma mansoni hypothetical protein 0.004 0.0116 0.0218
Echinococcus granulosus GPCR family 2 0.0019 0.0021 0.0021
Plasmodium falciparum importin beta, putative 0.0031 0.0074 0.0323
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0193 0.0193
Schistosoma mansoni protein phosphatase type 1 0.004 0.0116 0.0218
Schistosoma mansoni protein phosphatase type 1 0.0025 0.0049 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0021 0.0042
Mycobacterium tuberculosis Conserved protein 0.004 0.0116 0.0894
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0049 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0116 0.0238
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase 0.0017 0.0014 0.0014
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0039 0.0039
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0039 0.0097
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.004 0.0116 0.0504
Echinococcus multilocularis geminin 0.0332 0.1384 0.1384
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0049 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.0104
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0024 0.0062
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0161 0.037
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0021 0.0016
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0021 0.0021
Trichomonas vaginalis protein phosphatase-5, putative 0.0025 0.0049 0.0101
Echinococcus granulosus dnaJ subfamily B 0.1237 0.5317 0.5317
Schistosoma mansoni hypothetical protein 0.0413 0.1733 0.326
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0116 0.0894
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0193 0.0193
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.0833 0.0833
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1077 0.4619 0.9501
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Entamoeba histolytica replication factor A protein 1, putative 0.0487 0.2057 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1162 0.2185
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0113 0.0233
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0309 0.1283 0.2639
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0021 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0021 0.0042
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0116 0.0894
Schistosoma mansoni protein phosphatase-1 0.004 0.0116 0.0218
Giardia lamblia Lysyl-tRNA synthetase 0.0056 0.0183 0.2615
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.1005 0.1891
Schistosoma mansoni apoptosis regulator bax 0.0413 0.1733 0.326
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase 0.0017 0.0014 0.0014
Brugia malayi hypothetical protein 0.0052 0.0164 0.0338
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Plasmodium falciparum elongation factor 1-gamma, putative 0.0018 0.0017 0.0073
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.1133 0.4862 0.4862
Entamoeba histolytica hypothetical protein 0.0025 0.0049 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0039 0.0097
Plasmodium falciparum replication protein A1, large subunit 0.0543 0.2299 1
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.004 0.0116 0.0116
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0024 0.0049
Brugia malayi SET domain containing protein 0.0018 0.0017 0.0034
Schistosoma mansoni ap endonuclease 0.0019 0.0024 0.0045
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0051 0.0051
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0104 0.0391 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Giardia lamblia Aspartyl-tRNA synthetase 0.0056 0.0183 0.2615
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0043
Onchocerca volvulus 0.0018 0.0017 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1133 0.4862 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.007 0.0132
Giardia lamblia Methionyl-tRNA synthetase 0.0053 0.017 0.242
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0183 0.0183
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0183 0.0183
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.1372 0.2823
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0026
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0413 0.1733 0.1733
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Giardia lamblia Hypothetical protein 0.0166 0.066 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0116 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0116 0.0433
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0053 0.017 0.924
Schistosoma mansoni elongation factor 1-gamma 0.0018 0.0017 0.0032
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0039 0.0097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0101
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative 0.0017 0.0014 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0116 0.0894
Trypanosoma brucei polo-like protein kinase 0.0092 0.0341 0.1421
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0116 0.0434
Onchocerca volvulus 0.0289 0.1194 0.2748
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0021 0.0016
Schistosoma mansoni protein phosphatase type 1 0.004 0.0116 0.0218
Toxoplasma gondii aspartate-tRNA ligase 0.0056 0.0183 0.0795
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0108 0.0203
Toxoplasma gondii tRNA ligases class I (M) protein 0.0053 0.017 0.074
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0162 0.0162
Loa Loa (eye worm) apoptosis regulator protein 0.0413 0.1733 0.3565
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0024 0.0115
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0023
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.004 0.0116 0.0116
Onchocerca volvulus 0.004 0.0116 0.0266
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0341 0.0341
Brugia malayi Heterochromatin protein 1 0.0084 0.0306 0.0629
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Brugia malayi RNA, U transporter 1 0.0088 0.0322 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0056 0.0183 0.0889
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Trichomonas vaginalis protein phosphatase 2A, caeel, putative 0.0017 0.0014 0.0029
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0025 0.0049 0.0101
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0116 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0113 0.0233
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0056 0.0183 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0021 0.0044
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.004 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0018 0.0033
Echinococcus multilocularis methionine tRNA synthetase 0.0053 0.017 0.017
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0023
Chlamydia trachomatis lysine--tRNA ligase 0.0056 0.0183 0.0104
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0258 0.1062 0.2185
Onchocerca volvulus 0.0037 0.0101 0.0232
Schistosoma mansoni hypothetical protein 0.0056 0.0183 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Toxoplasma gondii ABC1 family protein 0.004 0.0116 0.0503
Trypanosoma brucei protein phosphatase 1, putative 0.004 0.0116 0.0434
Loa Loa (eye worm) MBCTL1 0.0058 0.0193 0.0397
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0116 0.0238
Echinococcus granulosus lysyl tRNA synthetase 0.0056 0.0183 0.0183
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0026
Plasmodium falciparum lysine--tRNA ligase 0.0056 0.0183 0.0795
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0021 0.0021
Leishmania major GTP-binding protein, putative 0.0023 0.0039 0.0097
Plasmodium vivax asparagine--tRNA ligase, putative 0.0056 0.0183 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.007 0.007
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0053 0.017 0.035
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0074 0.0323
Schistosoma mansoni flap endonuclease-1 0.0028 0.0064 0.012
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.0391 0.0391
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0047
Schistosoma mansoni hypothetical protein 0.0315 0.1308 0.2461
Trichomonas vaginalis hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0383 0.1605 0.3301
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0039 0.008
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.0833 0.0833
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0053 0.017 0.8123
Trichomonas vaginalis set domain proteins, putative 0.0289 0.1194 0.2456
Echinococcus multilocularis chromobox protein 1 0.0084 0.0306 0.0306
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0164 0.0714
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0139 0.0285
Echinococcus multilocularis muscleblind protein 0.0309 0.1283 0.1283
Echinococcus granulosus snurportin 1 0.033 0.1372 0.1372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0108 0.0203
Echinococcus multilocularis leucyl tRNA synthetase 0.0053 0.017 0.017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.1061 1
Echinococcus granulosus geminin 0.0332 0.1384 0.1384
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0021 0.0039
Trypanosoma brucei Replication factor A protein 1 0.0543 0.2299 1
Schistosoma mansoni methionine-tRNA synthetase 0.0332 0.1385 0.2605
Treponema pallidum leucyl-tRNA synthetase 0.0053 0.017 0.1076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0116 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0145 0.0298
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0021 0.0016
Onchocerca volvulus 0.0014 0.0000000065618 0.000000015102
Loa Loa (eye worm) hypothetical protein 0.0058 0.0193 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Onchocerca volvulus 0.004 0.0116 0.0266
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0074 0.0252
Leishmania major replication Factor A 28 kDa subunit, putative 0.0056 0.0183 0.0727
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0056 0.0183 0.0183
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0077 0.0974
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0332 0.1385 0.1385
Schistosoma mansoni aspartyl-tRNA synthetase 0.0056 0.0183 0.0344
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0116 0.0238
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0021 0.0016
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0018 0.0017 0.0017
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0056 0.0183 0.0376
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0391 0.0735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1162 0.1162
Echinococcus granulosus flap endonuclease 1 0.0031 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0024 0.0413
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0051 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0021 0.0017
Trichomonas vaginalis protein phosphatase, caeel, putative 0.004 0.0116 0.0238
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0053 0.017 0.1421
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0051 0.0051
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0116 0.58
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.004 0.0116 0.0116
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0021 0.0039
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0041 0.0041
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0018 0.0017 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0116 0.0238
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0049 0.0101
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0049 0.0141
Schistosoma mansoni hypothetical protein 0.0332 0.1384 0.2604
Brugia malayi mbt repeat family protein 0.0051 0.0162 0.0334
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0049 0.0101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0024 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0056 0.0183 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Schistosoma mansoni lysyl-tRNA synthetase 0.0056 0.0183 0.0344
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0049 0.0101
Mycobacterium ulcerans beta-lactamase 0.004 0.0116 0.58
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0047
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0162 0.0334
Echinococcus granulosus serine:threonine protein phosphatase 0.0015 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0341 0.0702
Echinococcus multilocularis GPCR, family 2 0.0019 0.0021 0.0021
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0116 0.0238
Brugia malayi beta-lactamase 0.004 0.0116 0.0238
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0039 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0021 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0306 0.0629
Brugia malayi Aspartyl-tRNA synthetase 0.0056 0.0183 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0145 0.0298
Brugia malayi protein ZK524.3 0.0053 0.017 0.035
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0049 0.0142
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0025 0.0049 0.0142
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0021 0.0021
Toxoplasma gondii exonuclease III APE 0.0019 0.0024 0.0103
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0021 0.0016
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0049 0.0101
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0077 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0164 0.0646
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2315 1 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0026
Plasmodium vivax importin-beta 2, putative 0.0031 0.0074 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0376
Loa Loa (eye worm) histone methyltransferase 0.0037 0.01 0.0207
Onchocerca volvulus 0.0051 0.0162 0.0374
Schistosoma mansoni hypothetical protein 0.033 0.1372 0.2581
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0056 0.0183 0.0727
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0026
Toxoplasma gondii methionyl-tRNA synthetase 0.0053 0.017 0.074
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0047
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0056 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0238
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0028 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0085 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0053 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0164 0.0646
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0044

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 23.7781 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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